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EP1168919A4 - Oligonucleotide antisens a faible teneur en adenosine, compositions, kit et procede pour le traitement d'affections des voies aeriennes associees a la bronchoconstriction, a l'inflammation pulmonaire, aux allergies et a la depletion de surfactant - Google Patents

Oligonucleotide antisens a faible teneur en adenosine, compositions, kit et procede pour le traitement d'affections des voies aeriennes associees a la bronchoconstriction, a l'inflammation pulmonaire, aux allergies et a la depletion de surfactant

Info

Publication number
EP1168919A4
EP1168919A4 EP00919668A EP00919668A EP1168919A4 EP 1168919 A4 EP1168919 A4 EP 1168919A4 EP 00919668 A EP00919668 A EP 00919668A EP 00919668 A EP00919668 A EP 00919668A EP 1168919 A4 EP1168919 A4 EP 1168919A4
Authority
EP
European Patent Office
Prior art keywords
bronchoconstriction
allergies
kit
compositions
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP00919668A
Other languages
German (de)
English (en)
Other versions
EP1168919A2 (fr
Inventor
Jonathan W Nyce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
East Carolina University
Original Assignee
East Carolina University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by East Carolina University filed Critical East Carolina University
Publication of EP1168919A2 publication Critical patent/EP1168919A2/fr
Publication of EP1168919A4 publication Critical patent/EP1168919A4/fr
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP00919668A 1999-04-06 2000-03-24 Oligonucleotide antisens a faible teneur en adenosine, compositions, kit et procede pour le traitement d'affections des voies aeriennes associees a la bronchoconstriction, a l'inflammation pulmonaire, aux allergies et a la depletion de surfactant Ceased EP1168919A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12795899P 1999-04-06 1999-04-06
US127958P 1999-04-06
PCT/US2000/008020 WO2000062736A2 (fr) 1999-04-06 2000-03-24 Oligonucleotide antisens a faible teneur en adenosine, compositions, kit et procede pour le traitement d'affections des voies aeriennes associees a la bronchoconstriction, a l'inflammation pulmonaire, aux allergies et a la depletion de surfactant

Publications (2)

Publication Number Publication Date
EP1168919A2 EP1168919A2 (fr) 2002-01-09
EP1168919A4 true EP1168919A4 (fr) 2002-03-06

Family

ID=22432865

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00919668A Ceased EP1168919A4 (fr) 1999-04-06 2000-03-24 Oligonucleotide antisens a faible teneur en adenosine, compositions, kit et procede pour le traitement d'affections des voies aeriennes associees a la bronchoconstriction, a l'inflammation pulmonaire, aux allergies et a la depletion de surfactant

Country Status (9)

Country Link
EP (1) EP1168919A4 (fr)
JP (1) JP2003515525A (fr)
CN (1) CN1330513A (fr)
AU (1) AU4031700A (fr)
BR (1) BR0006019A (fr)
CA (1) CA2330022A1 (fr)
HK (1) HK1042017A1 (fr)
IL (1) IL140054A0 (fr)
WO (1) WO2000062736A2 (fr)

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US6737040B1 (en) 1998-08-04 2004-05-18 Diadexus, Inc. Method and antibody for imaging breast cancer
US6730477B1 (en) 1998-08-04 2004-05-04 Diadexus, Inc. Method of diagnosing, monitoring and staging breast cancer
CA2369458A1 (fr) * 1999-03-26 2000-10-05 Craig A. Rosen 47 proteines humaines secretees
DE10049549A1 (de) * 2000-10-06 2002-05-02 Markus Hecker Modulation der Transkription pro-inflammatorischer Genprodukte
CA2451738C (fr) 2001-07-06 2013-09-17 Topigen Pharmaceutique Inc. Procedes d'augmentation de l'efficacite in vivo d'oligonucleotides et d'inhibition de l'inflammation chez les mammiferes au moyen de 2-amino-2'-deoxyadenosine
WO2004086052A2 (fr) * 2003-03-28 2004-10-07 Bayer Healthcare Ag Produits de diagnostic et de therapeutique pour des maladies liees au recepteur de l'adenosine a2b couple a la proteine g (adora2b)
US7671182B2 (en) * 2003-03-31 2010-03-02 Council Of Scientific & Industrial Research Gene variants of signal transducer and activator of transcription-6 (STAT 6) variants and process of detection the same
US8034789B2 (en) * 2003-12-03 2011-10-11 Coda Therapeutics, Inc. Antisense compounds targeted to connexins and methods of use thereof
WO2006010492A1 (fr) * 2004-07-28 2006-02-02 Bayer Healthcare Ag Diagnostics et therapeutiques pour des maladies associees a tryptase 1 (tps1)
US8673268B2 (en) 2004-10-15 2014-03-18 Galapagos N.V. Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
US7485468B2 (en) 2004-10-15 2009-02-03 Galapagos Bv Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
ES2392449T3 (es) 2004-10-20 2012-12-10 Antisense Therapeutics Ltd Modulación antisentido de la expresión de la integrina alfa-4
AU2005299218B2 (en) 2004-10-29 2012-04-12 Pharmaxis Ltd Antisense oligonucleotides for treating allergy and neoplastic cell proliferation
ATE492563T1 (de) 2004-11-17 2011-01-15 Amgen Inc Vollständige humane monoklonale antikörper gegen il-13
WO2006107826A2 (fr) 2005-04-04 2006-10-12 The Board Of Regents Of The University Of Texas System Microarn regulant des cellules musculaires
ES2766770T3 (es) * 2006-08-10 2020-06-15 Roy C Levitt Anakinra para uso en el tratamiento del síndrome de bronquiolitis obliterante
EP2411518A2 (fr) * 2009-03-27 2012-02-01 Merck Sharp&Dohme Corp. Inhibition à médiation par l'interférence arn de l'expression du gène de la chaîne alpha du récepteur à haute affinité pour les ige (fcerla) faisant appel à de courts acides nucléiques interférents (ansi)
WO2014170497A2 (fr) * 2013-04-19 2014-10-23 Epiontis Gmbh Méthode d'identification de la composition cellulaire quantitative d'un échantillon biologique
CN112969799A (zh) * 2018-09-26 2021-06-15 奥姆生命科技公司 2′fana修饰的foxp3反义寡核苷酸及其使用方法
CN109260217A (zh) * 2018-09-30 2019-01-25 深圳松乐生物科技有限公司 3`-脱氧次黄嘌呤核苷在制备用于多种疾病药品、食品或保健品中的应用
CN114591963B (zh) * 2022-05-10 2022-07-19 上海优替济生生物医药有限公司 sgRNA及利用其构建GM-CSF(-)细胞的方法

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WO1993010820A1 (fr) * 1991-11-26 1993-06-10 Gilead Sciences, Inc. Formation amelioree de triple et double helices a l'aide d'oligomeres contenant des pyrimidines modifiees
WO1993012756A2 (fr) * 1991-12-17 1993-07-08 The Regents Of The University Of California Transfection pulmonaire par administration transgenique aerosol
WO1994002605A1 (fr) * 1992-07-22 1994-02-03 Duke University Adn codant le recepteur de l'adenosine a1 humaine
WO1996040162A1 (fr) * 1995-06-07 1996-12-19 East Carolina University Procede de traitement de maladies pulmonaires au moyen d'oligonucleotides antisens
WO1996040266A1 (fr) * 1995-06-07 1996-12-19 East Carolina University Procede de traitement de l'asthme
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WO2000009525A2 (fr) * 1998-08-03 2000-02-24 East Carolina University Agent comprenant des oligonucleotides antisens a faible teneur en adenosine, composition, trousse et traitements

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WO1993012756A2 (fr) * 1991-12-17 1993-07-08 The Regents Of The University Of California Transfection pulmonaire par administration transgenique aerosol
WO1994002605A1 (fr) * 1992-07-22 1994-02-03 Duke University Adn codant le recepteur de l'adenosine a1 humaine
WO1996040162A1 (fr) * 1995-06-07 1996-12-19 East Carolina University Procede de traitement de maladies pulmonaires au moyen d'oligonucleotides antisens
WO1996040266A1 (fr) * 1995-06-07 1996-12-19 East Carolina University Procede de traitement de l'asthme
WO1998011211A2 (fr) * 1996-09-10 1998-03-19 Hybridon, Inc. METHODES D'UTILISATION D'OLIGONUCLEOTIDES POSSEDANT DES DINUCLEOSIDES CpG MODIFIES
WO1998023294A1 (fr) * 1996-11-26 1998-06-04 East Carolina University Agent et methode de traitement de maladies et d'etats pathologiques associes a des malaises respiratoires et a une inflammation pulmonaire
WO1999060166A1 (fr) * 1998-05-21 1999-11-25 Isis Pharmaceuticals, Inc. Compositions et methodes d'administration aux poumons d'acides nucleiques
WO2000009525A2 (fr) * 1998-08-03 2000-02-24 East Carolina University Agent comprenant des oligonucleotides antisens a faible teneur en adenosine, composition, trousse et traitements

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Also Published As

Publication number Publication date
BR0006019A (pt) 2001-03-13
WO2000062736A2 (fr) 2000-10-26
CA2330022A1 (fr) 2000-10-26
JP2003515525A (ja) 2003-05-07
WO2000062736A3 (fr) 2001-10-11
IL140054A0 (en) 2002-02-10
EP1168919A2 (fr) 2002-01-09
CN1330513A (zh) 2002-01-09
AU4031700A (en) 2000-11-02
HK1042017A1 (zh) 2002-08-02

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