EP1126833A4 - Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives - Google Patents

Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives

Info

Publication number: EP1126833A4
Authority: EP; European Patent Office
Prior art keywords: thiadiazole; oxadiazole; combinatorial libraries; triazole derivatives; triazole
Prior art date: 1998-10-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99971314A

Other languages

German (de)

English (en)

Other versions

EP1126833A2 (fr

Inventor

R Normand Hebert

Amy L Hannah

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Trega Biosciences Inc

Original Assignee

Trega Biosciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-29

Filing date

1999-10-28

Publication date

2004-09-08

1999-10-28 Application filed by Trega Biosciences Inc filed Critical Trega Biosciences Inc

2001-08-29 Publication of EP1126833A2 publication Critical patent/EP1126833A2/fr

2004-09-08 Publication of EP1126833A4 publication Critical patent/EP1126833A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Structural Engineering (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EP99971314A 1998-10-29 1999-10-28 Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives Withdrawn EP1126833A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US183222		1994-01-14
US18322298A	1998-10-29	1998-10-29
PCT/US1999/025331 WO2000025768A1 (fr)	1998-10-29	1999-10-28	Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives

Publications (2)

Publication Number	Publication Date
EP1126833A2 EP1126833A2 (fr)	2001-08-29
EP1126833A4 true EP1126833A4 (fr)	2004-09-08

Family

ID=22671958

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99971314A Withdrawn EP1126833A4 (fr)	1998-10-29	1999-10-28	Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives

Country Status (3)

Country	Link
EP (1)	EP1126833A4 (fr)
AU (1)	AU1455500A (fr)
WO (1)	WO2000025768A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5891600A (en) *	1999-07-01	2001-01-22	Chemrx Advanced Technologies, Inc.	Process for synthesizing oxadiazoles
WO2001054503A1 (fr) *	2000-01-28	2001-08-02	Akkadix Corporation	Procedes de destruction des nematodes et des oeufs de nematodes a l'aide de derives 4-phenoxy-6-aminopyrimidine
US6683191B2 (en) *	2000-06-05	2004-01-27	Ortho-Mcneil Pharmaceuticals, Inc.	Method for synthesis of substituted azole libraries
US6951948B2 (en)	2000-06-05	2005-10-04	Ortho-Mcneil Pharmaceutical, Inc.	Method for synthesis of substituted azole libraries
US6482829B2 (en)	2000-06-08	2002-11-19	Hoffmann-La Roche Inc.	Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
US7390813B1 (en)	2001-12-21	2008-06-24	Xenon Pharmaceuticals Inc.	Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
CN104056278B (zh)	2003-04-11	2017-01-18	Ptc 治疗公司	1,2,4‑噁二唑苯甲酸化合物
AU2004261252C1 (en)	2003-07-30	2009-09-17	Xenon Pharmaceuticals Inc.	Pyridazine derivatives and their use as therapeutic agents
GB0325956D0 (en) *	2003-11-06	2003-12-10	Addex Pharmaceuticals Sa	Novel compounds
EP1697333A4 (fr)	2003-12-17	2009-07-08	Merck & Co Inc	Carboxylates propanoiques 3,4-disusbstitues utilises en tant qu'agonistes du recepteur s1p (edg)
US7453002B2 (en)	2004-06-15	2008-11-18	Bristol-Myers Squibb Company	Five-membered heterocycles useful as serine protease inhibitors
AR051091A1 (es)	2004-09-20	2006-12-20	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
CN101083992A (zh)	2004-09-20	2007-12-05	泽农医药公司	抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
CN101083994A (zh)	2004-09-20	2007-12-05	泽农医药公司	杂环衍生物及其用作硬脂酰CoA去饱和酶抑制剂的用途
CA2580762A1 (fr)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Derives heterocycliques et leur utilisation comme agents therapeutiques
AR051093A1 (es)	2004-09-20	2006-12-20	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa
JP2008513515A (ja)	2004-09-20	2008-05-01	ゼノン・ファーマシューティカルズ・インコーポレイテッド	複素環誘導体および治療薬としてのそれらの使用
GB0508319D0 (en)	2005-04-25	2005-06-01	Novartis Ag	Organic compounds
MX2007015216A (es)	2005-06-03	2008-02-22	Xenon Pharmaceuticals Inc	Derivados de aminotiazol y sus usos como agentes terapeuticos.
US9289398B2 (en)	2006-03-30	2016-03-22	Ptc Therapeutics, Inc.	Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith
US9090604B2 (en)	2006-07-27	2015-07-28	E I Du Pont De Nemours And Company	Fungicidal azocyclic amides
WO2008013622A2 (fr)	2006-07-27	2008-01-31	E. I. Du Pont De Nemours And Company	Amides azocycliques fongicides
KR20090040478A (ko)	2006-08-24	2009-04-24	노파르티스 아게	２-(피라진-２-일)-티아졸 및 ２-(１Ｈ-피라졸-３-일)-티아졸 유도체, 및 대사, 심혈관 및 기타 장애의 치료를 위한 스테아로일-ＣｏＡ 데새투라제(ＳＣＤ) 억제제로서의 관련 화합물
JP2010513283A (ja)	2006-12-15	2010-04-30	アボット・ラボラトリーズ	新規なオキサジアゾール化合物
US8969342B2 (en)	2009-03-20	2015-03-03	Brandeis University	Compounds and methods for treating mammalian gastrointestinal microbial infections
AR081626A1 (es)	2010-04-23	2012-10-10	Cytokinetics Inc	Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2560488B1 (fr)	2010-04-23	2015-10-28	Cytokinetics, Inc.	Aminopyridines et aminotriazines, leurs compositions et leurs procédés d'utilisation
AR081331A1 (es)	2010-04-23	2012-08-08	Cytokinetics Inc	Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
US8759380B2 (en)	2011-04-22	2014-06-24	Cytokinetics, Inc.	Certain heterocycles, compositions thereof, and methods for their use
WO2014028931A2 (fr)	2012-08-17	2014-02-20	Brandeis University	Composés et procédés de traitement d'infections microbiennes gastro-intestinales de mammifère
EP3113619A4 (fr)	2014-03-06	2017-09-13	PTC Therapeutics, Inc.	Compositions pharmaceutiques et sels d'un acide benzoïque 1,2,4-oxadiazole
BR112018008838A8 (pt)	2015-10-30	2019-02-26	Ptc Therapeutics Inc	método para tratar, prevenir, melhorar ou administrar uma doença epiléptica
CN112010828B (zh) *	2020-09-27	2023-01-31	中国医科大学	Cdk7小分子抑制剂的化合物及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994019330A1 (fr) *	1993-02-18	1994-09-01	Warner-Lambert Company	AMIDES ALKYLE SUBSTITUES HETEROCYCLIQUES EXERÇANT UNE ACTIVITE INHIBITRICE DE L'ACYLE-CoA: CHOLESTEROL ACYLTRANSFERASE
WO1996022997A1 (fr) *	1995-01-27	1996-08-01	Novo Nordisk A/S	Composes ayant des proprietes de liberation de l'hormone de croissance
WO1997014671A1 (fr) *	1995-10-18	1997-04-24	Merck & Co., Inc.	Antagonistes des recepteurs de la cyclopentyle-tachykinine
WO1997016433A1 (fr) *	1995-10-30	1997-05-09	Smithkline Beecham Corporation	Inhibiteurs de proteases
WO1998037068A1 (fr) *	1997-02-21	1998-08-27	Bristol-Myers Squibb Company	Derives d'acide benzoïque et composes apparentes utilises comme agents antiarythmiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8801289D0 (en) *	1988-01-21	1988-02-17	Shell Int Research	Oxadiazole compounds their preparation & their use as pesticides
US5242890A (en) *	1988-07-07	1993-09-07	Korea Research Institute Of Chemical Technology	1,2,4-oxadiazole derivative, useful as selective herbicide

1999
- 1999-10-28 AU AU14555/00A patent/AU1455500A/en not_active Abandoned
- 1999-10-28 WO PCT/US1999/025331 patent/WO2000025768A1/fr not_active Application Discontinuation
- 1999-10-28 EP EP99971314A patent/EP1126833A4/fr not_active Withdrawn

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994019330A1 (fr) *	1993-02-18	1994-09-01	Warner-Lambert Company	AMIDES ALKYLE SUBSTITUES HETEROCYCLIQUES EXERÇANT UNE ACTIVITE INHIBITRICE DE L'ACYLE-CoA: CHOLESTEROL ACYLTRANSFERASE
WO1996022997A1 (fr) *	1995-01-27	1996-08-01	Novo Nordisk A/S	Composes ayant des proprietes de liberation de l'hormone de croissance
WO1997014671A1 (fr) *	1995-10-18	1997-04-24	Merck & Co., Inc.	Antagonistes des recepteurs de la cyclopentyle-tachykinine
WO1997016433A1 (fr) *	1995-10-30	1997-05-09	Smithkline Beecham Corporation	Inhibiteurs de proteases
WO1998037068A1 (fr) *	1997-02-21	1998-08-27	Bristol-Myers Squibb Company	Derives d'acide benzoïque et composes apparentes utilises comme agents antiarythmiques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO0025768A1 *
SUSANNA BORG: "synthesis of 1,2,4-oxadiazole-", JOURNAL OF ORGANIC CHEMISTRY., vol. 60, no. 10, 1995, USAMERICAN CHEMICAL SOCIETY. EASTON., pages 3112 - 20, XP002288337 *

Also Published As

Publication number	Publication date
WO2000025768A8 (fr)	2000-08-24
WO2000025768A1 (fr)	2000-05-11
EP1126833A2 (fr)	2001-08-29
AU1455500A (en)	2000-05-22

Publication	Publication Date	Title
EP1126833A4 (fr)	2004-09-08	Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives
AU4509699A (en)	1999-12-30	Loading arrangement
AU5376198A (en)	1998-08-25	Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
HUP0200814A3 (en)	2003-01-28	Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
GB9801396D0 (en)	1998-03-18	Loading buoys
AU5374098A (en)	1998-08-25	Combinatorial libraries of imidazol-pyrido-indoles and imidazol-pyrido-benzothiophene derivatives
AU3272295A (en)	1996-02-22	Soluble combinatorial libraries
AU9383198A (en)	1999-03-22	Amine compounds and combinatorial libraries comprising same
ZA99800B (en)	1999-08-03	Benzothiadiazoles and derivatives.
AUPP737298A0 (en)	1998-12-24	Combinatorial libraries
EP1097244A4 (fr)	2002-08-07	Banques de ribozymes sensiblement completes
EP1218739A4 (fr)	2003-06-04	Derives de 2-aminopyridine et bibliotheques combinatoires
IL135039A0 (en)	2001-05-20	Combinatorial antisense library
AU4243601A (en)	2001-09-12	3-aza-6,8-dioxabicyclo(3.2.1)octanes and analogues and combinatorial libraries
IL131147A0 (en)	2001-01-28	Propellent for large-calibre ammunition
AU3487500A (en)	2000-08-25	Thiazole derivatives and combinatorial libraries thereof
AU2002305029A1 (en)	2002-10-15	2-aminobenzoxazole derivatives and combinatorial libraries thereof
AU2002219318A1 (en)	2002-06-11	System and methord for combinatorial library design
GB9820893D0 (en)	1998-11-18	Combinatorial synthesiser
AU8849398A (en)	1999-03-16	Combinatorial library
AU4170100A (en)	2000-09-21	Combinatorial chelator array
ZA984176B (en)	1999-01-08	Cyclohexanediol derivatives
AU7624298A (en)	1998-06-29	Aminobenzenedicarboxylic acid-based combinatorial libraries
AU2001281995A1 (en)	2002-02-05	Bicyclic hydantoin derivatives and combinatorial libraries thereof
GB9714303D0 (en)	1997-09-10	5-(3-phenyl-3-oxo-propyl)-1H-tetrazole derivatives

Legal Events

Date	Code	Title	Description
2001-07-13	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-08-29	17P	Request for examination filed	Effective date: 20010509
2001-08-29	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-09-05	RIN1	Information on inventor provided before grant (corrected)	Inventor name: HANNAH, AMY, L. Inventor name: HEBERT, R., NORMAND
2004-09-01	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61P 43/00 B Ipc: 7C 07D 271/10 B Ipc: 7C 07D 271/06 B Ipc: 7A 61K 31/10 B Ipc: 7A 61K 31/075 A
2004-09-08	A4	Supplementary search report drawn up and despatched	Effective date: 20040723
2004-10-01	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2004-11-17	18D	Application deemed to be withdrawn	Effective date: 20040501
2007-08-08	RIN1	Information on inventor provided before grant (corrected)	Inventor name: HANNAH, AMY, L. Inventor name: HEBERT, R., NORMAND