EP1123306A4 - Inhibitors of platelet activation and recruitment - Google Patents

Inhibitors of platelet activation and recruitment

Info

Publication number: EP1123306A4
Authority: EP; European Patent Office
Prior art keywords: recruitment; inhibitors; platelet activation; platelet; activation
Prior art date: 1998-10-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99951733A

Other languages

German (de)

French (fr)

Other versions

EP1123306A1 (en

Inventor

Charles R Maliszewski

Richard B Gayle Iii

Virginia L Price

Steven D Gimpel

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Immunex Corp

Original Assignee

Immunex Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-13

Publication date

2002-07-03

1999-10-13 Application filed by Immunex Corp filed Critical Immunex Corp

2001-08-16 Publication of EP1123306A1 publication Critical patent/EP1123306A1/en

2002-07-03 Publication of EP1123306A4 publication Critical patent/EP1123306A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
- C12Y306/01005—Apyrase (3.6.1.5), i.e. ATP diphosphohydrolase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Wood Science & Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Biophysics (AREA)
Cell Biology (AREA)
Urology & Nephrology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

EP99951733A 1998-10-16 1999-10-13 Inhibitors of platelet activation and recruitment Withdrawn EP1123306A4 (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US10458598P	1998-10-16	1998-10-16
US104585P		1998-10-16
US10746698P	1998-11-06	1998-11-06
US107466P		1998-11-06
US14901099P	1999-08-13	1999-08-13
US149010P		1999-08-13
PCT/US1999/022955 WO2000023459A1 (en)	1998-10-16	1999-10-13	Inhibitors of platelet activation and recruitment

Publications (2)

Publication Number	Publication Date
EP1123306A1 EP1123306A1 (en)	2001-08-16
EP1123306A4 true EP1123306A4 (en)	2002-07-03

Family

ID=27379766

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99951733A Withdrawn EP1123306A4 (en)	1998-10-16	1999-10-13	Inhibitors of platelet activation and recruitment

Country Status (7)

Country	Link
EP (1)	EP1123306A4 (en)
JP (1)	JP2002527096A (en)
AU (2)	AU772460B2 (en)
CA (1)	CA2345382A1 (en)
IL (1)	IL142539A0 (en)
NZ (1)	NZ511488A (en)
WO (2)	WO2000023094A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2686899B1 (en)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
GB9526733D0 (en)	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
US7264809B1 (en)	1998-10-16	2007-09-04	Immunex Corporation	Methods of inhibiting platelet activation and recruitment
EE200100372A (en)	1999-01-15	2002-10-15	Biogen, Incorporated	TWEAK Protein and TWEAK Protein Receptor Antagonists and Their Use in the Treatment of Immune Diseases
GB9914326D0 (en) *	1999-06-18	1999-08-18	Rademacher Group Limited	Materials and methods relating to the diagnosis and treatment of pre-eclampsia
US6946134B1 (en)	2000-04-12	2005-09-20	Human Genome Sciences, Inc.	Albumin fusion proteins
EP2067488A1 (en)	2000-04-12	2009-06-10	Human Genome Sciences, Inc.	Albumin fusion proteins
WO2002014369A2 (en) *	2000-07-24	2002-02-21	Attenuon, Llc	Human kininogen d5 domain polypeptides and their use
MY128992A (en) *	2000-08-25	2007-03-30	Merck Patent Gmbh	Saratin for inhibiting platelet adhesion to collagen
US7507413B2 (en)	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
WO2003052121A2 (en) *	2001-12-17	2003-06-26	Beth Israel Deaconess Medical Center	Method of reducing angiogenesis
CA2471363C (en)	2001-12-21	2014-02-11	Human Genome Sciences, Inc.	Albumin fusion proteins
EP2138575B8 (en)	2002-02-20	2013-07-24	Mersana Therapeutics, Inc.	Conjugates comprising a biodegradable polymer and uses therefor
EP1997512B1 (en)	2002-04-09	2013-12-04	Biogen Idec MA Inc.	Methods for treating TWEAK-related conditions
MXPA05002219A (en)	2002-08-28	2005-07-05	Immunex Corp	Compositions and methods for treating cardiovascular disease.
CA2498651C (en)	2002-09-13	2011-08-30	Universite Laval	Nucleoside triphosphate diphosphohydrolase and uses thereof
US7247300B1 (en)	2002-11-07	2007-07-24	Apt Therapeutics, Inc.	Therapeutic use of soluble CD39L3
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
WO2005085468A1 (en)	2004-02-27	2005-09-15	Apt Therapeutics, Inc.	Design and therapeutic use of adpase enhanced apyrases
DK2332408T3 (en)	2005-02-17	2013-12-02	Biogen Idec Inc	Treatment of neurological diseases
ES2432564T3 (en)	2005-05-10	2013-12-04	Biogen Idec Ma Inc.	Treatment and evaluation of inflammatory disorders
DK1888113T3 (en) *	2005-05-27	2014-09-01	Biogen Idec Inc	TWEAK BINDING ANTIBODIES
WO2006138219A2 (en)	2005-06-13	2006-12-28	Biogen Idec Ma Inc.	Methods of diagnosis / prognosis of inflammatory conditions
DE102006046410A1 (en) *	2006-09-20	2008-03-27	Eberhard-Karls-Universität Tübingen Universitätsklinikum	Medicaments for the prophylaxis or treatment or diagnosis of ischemic diseases
GB201522541D0 (en) *	2015-12-21	2016-02-03	Inst Research In Biomedicine	Compositions
CN108203457B (en) *	2016-12-20	2022-09-06	山西医科大学	Antithrombotic small peptide omega KWR for targeted inhibition of platelet aggregation
EP3424957A1 (en) *	2017-07-03	2019-01-09	advanceCOR GmbH	Fusion protein
UY38299A (en) *	2018-07-18	2020-02-28	Novartis Ag	SOLUBILIZED APIRASES, METHODS AND USES
EP4562151A1 (en) *	2022-07-29	2025-06-04	Novartis AG	Improved production of cd39 variants

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0416673A1 (en) *	1989-08-03	1991-03-13	Centro De Ingenieria Genetica Y Biotecnologia	Method for the expression of heterologous proteins produced in fused form in E. coli, use thereof, expression vectors and recombinant strains
US5073627A (en) *	1989-08-22	1991-12-17	Immunex Corporation	Fusion proteins comprising GM-CSF and IL-3
WO1996030532A1 (en) *	1995-03-24	1996-10-03	Novartis Ag	Gene therapy for transplantation and inflammatory or thrombotic conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5506126A (en) *	1988-02-25	1996-04-09	The General Hospital Corporation	Rapid immunoselection cloning method
WO1996032471A2 (en) *	1995-04-10	1996-10-17	Universite De Sherbrooke	Atp-diphosphohydrolases, process of purification thereof and process of producing thereof by recombinant technology

1999
- 1999-10-13 WO PCT/US1999/023641 patent/WO2000023094A2/en active Application Filing
- 1999-10-13 AU AU64115/99A patent/AU772460B2/en not_active Ceased
- 1999-10-13 CA CA002345382A patent/CA2345382A1/en not_active Abandoned
- 1999-10-13 WO PCT/US1999/022955 patent/WO2000023459A1/en not_active Application Discontinuation
- 1999-10-13 IL IL14253999A patent/IL142539A0/en unknown
- 1999-10-13 EP EP99951733A patent/EP1123306A4/en not_active Withdrawn
- 1999-10-13 JP JP2000577185A patent/JP2002527096A/en active Pending
- 1999-10-13 AU AU64256/99A patent/AU6425699A/en not_active Abandoned
- 1999-10-13 NZ NZ511488A patent/NZ511488A/en unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0416673A1 (en) *	1989-08-03	1991-03-13	Centro De Ingenieria Genetica Y Biotecnologia	Method for the expression of heterologous proteins produced in fused form in E. coli, use thereof, expression vectors and recombinant strains
US5073627A (en) *	1989-08-22	1991-12-17	Immunex Corporation	Fusion proteins comprising GM-CSF and IL-3
WO1996030532A1 (en) *	1995-03-24	1996-10-03	Novartis Ag	Gene therapy for transplantation and inflammatory or thrombotic conditions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHADWICK B P ET AL: "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster", GENOMICS,US,ACADEMIC PRESS, SAN DIEGO, vol. 50, no. 3, 15 June 1998 (1998-06-15), pages 357 - 367, XP002117226, ISSN: 0888-7543 *
CULLEN B. R.: "expression of a cloned human interleukin-2 cdna is emhanced by the substitution of a heterologous mrna leader region", DNA, vol. 7, no. 9, 1988, pages 645 - 650, XP000892169 *
MALISZESKI ET AL: "The CD39 Lymphoid Cell Activation Antigen", JOURNAL OF IMMUNOLOGY, vol. 153, 15 October 1994 (1994-10-15), pages 3574 - 3583 *
MARCUS AARON J ET AL: "The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.", JOURNAL OF CLINICAL INVESTIGATION 1997, vol. 99, no. 6, 1997, pages 1351 - 1360, XP002136366, ISSN: 0021-9738 *
See also references of WO0023459A1 *

Also Published As

Publication number	Publication date
AU772460B2 (en)	2004-04-29
AU6411599A (en)	2000-05-08
AU6425699A (en)	2000-05-08
EP1123306A1 (en)	2001-08-16
WO2000023094A3 (en)	2000-07-27
WO2000023094A2 (en)	2000-04-27
CA2345382A1 (en)	2000-04-27
WO2000023459A1 (en)	2000-04-27
NZ511488A (en)	2003-10-31
JP2002527096A (en)	2002-08-27
IL142539A0 (en)	2002-03-10

Publication	Publication Date	Title
IL142539A0 (en)	2002-03-10	Inhibitors of platelet activation and recruitment
IL122814A0 (en)	1998-08-16	Inhibitors of platelet aggregation
IL128739A0 (en)	2000-01-31	Inhibition of blood platelet aggregation
PL334846A1 (en)	2000-03-27	Sulphamidic inhibitors of metaloproteases
IL127873A0 (en)	1999-10-28	Amidinoindoles amidinoazoles and analogs thereof as inhibitors of factor xa and of thrombin
HUP0104379A3 (en)	2003-01-28	New crystalline form of omeprazole and medicament containing it
PL328868A1 (en)	1999-03-01	Inhibitors of pharnesil protein transferase
GB9800795D0 (en)	1998-03-11	Prevention of multiple use of limited use devices
HU9700602D0 (en)	1997-05-28	New inhibitors of bone-resorption and vitronectine-receptor-antagonists
HUP0100366A3 (en)	2002-03-28	Homopolymers and copolymers of ethylene and applying them
IL122813A0 (en)	1998-08-16	Thrombin inhibitors their preparation and use
GB9227026D0 (en)	1993-02-17	Dual inhibitors of no synthase and cycloosygenase
GB9809869D0 (en)	1998-07-08	Inhibition of protein kinases
PL341335A1 (en)	2001-04-09	Combination of ace and mmp inhibitors
EP0806958A4 (en)	2002-09-25	Inhibition of platelet binding
PL334517A1 (en)	2000-02-28	Clavulate and one or more of exicipients containing granules
GB9930659D0 (en)	2000-02-16	Inhibitors of complement activation
GB2345125B (en)	2002-05-01	Intumescent downlighter cover and method of manufacturing same
EP0983958A4 (en)	2002-08-21	Treadboard device of man-conveyer and man-conveyer
ZA983065B (en)	1998-10-20	Inhibitors of protein farnesyltranferase
EP1098659A4 (en)	2004-11-24	Libraries of polyhydroxamates and their analogs
PL341222A1 (en)	2001-03-26	Substitute derivatives of isoquinoline and their application as anticonvulsants
PL342733A1 (en)	2001-07-02	Biocement of improved properties
HUP9800146A3 (en)	2000-06-28	Thalidomide-derivatives and use of them
EP1140121A4 (en)	2004-07-14	Cryogranulation of activated protein c

Legal Events

Date	Code	Title	Description
2001-06-29	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-08-16	17P	Request for examination filed	Effective date: 20010516
2001-08-16	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-08-16	AX	Request for extension of the european patent	Free format text: AL;LT;LV;MK;RO;SI
2002-07-03	A4	Supplementary search report drawn up and despatched	Effective date: 20020522
2002-07-03	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-07-03	RIC1	Information provided on ipc code assigned before grant	Free format text: 7C 07H 21/02 A, 7A 61K 38/46 B, 7A 61K 38/46 J, 7A 61K 31:60 J
2003-07-16	17Q	First examination report despatched	Effective date: 20030528
2005-01-14	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2005-03-02	18D	Application deemed to be withdrawn	Effective date: 20040821