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EP1109584A1 - Composition susceptible d'absorber un fluide - Google Patents

Composition susceptible d'absorber un fluide

Info

Publication number
EP1109584A1
EP1109584A1 EP99938200A EP99938200A EP1109584A1 EP 1109584 A1 EP1109584 A1 EP 1109584A1 EP 99938200 A EP99938200 A EP 99938200A EP 99938200 A EP99938200 A EP 99938200A EP 1109584 A1 EP1109584 A1 EP 1109584A1
Authority
EP
European Patent Office
Prior art keywords
composition
water
gel
polymers
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99938200A
Other languages
German (de)
English (en)
Inventor
Brian Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coloplast AS
Original Assignee
Coloplast AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coloplast AS filed Critical Coloplast AS
Publication of EP1109584A1 publication Critical patent/EP1109584A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/246—Intercrosslinking of at least two polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels

Definitions

  • a composition capable of absorbing fluid capable of absorbing fluid.
  • the present invention relates to a composition, which is capable of absorbing fluids and at the same time forming a coherent gel.
  • the composition may be used as an absorber in wound care products, sanitary articles, continence care, ostomy care or as an absorber in general.
  • Powders, pastes, or fibre dressings for wound care which are capable of forming gels or foams when contacted with aqueous fluid are disclosed in several publications. Most of the references disclose dried gels, e.g. calcium alginate fibres and powders/pastes comprising cross-linked swellable particles. Usually these compositions comprises particles or fibres of dried gels being capable of absorbing wound exudate, but during the absorption there is little or no interaction or cross-linking between the involved molecules, and thus the wetted material will have a poor cohesion. The gel forming process does not take place when the composition is absorbing wound exudate from a wound, but during the prepara- tion of the composition before application to the wound.
  • dried gels e.g. calcium alginate fibres and powders/pastes comprising cross-linked swellable particles.
  • these compositions comprises particles or fibres of dried gels being capable of absorbing wound exudate, but during the absorption there is little or no interaction or cross-linking between the involved
  • European patent No. EP 0 048 323 discloses a wound treatment composition which comprises e.g. acrylpolymers and gellable polysaccharides. The compounds are brought in solution and mixed, and hereby form a gel. The gel is then dried and pulverised. When this powder is applied to a wound, the particles will swell absorbing the wound exudate, but remain insoluble and with no cohesion.
  • EP 0 380 253 A2 is disclosed a method for preparing a gel formed-in-place in the wound.
  • the gel is formed by adding two liquids to the wound, said liquids reacting to form a gel with high cohesion.
  • the composition comprises an alginate (polysaccharide) and a cross-linking agent selected from di- or trivalent metal ions.
  • the present invention relates to a composition capable of forming a coherent gel when contacted with an aqueous fluid, said composition comprising a water soluble polymer, said polymer, when dissolved in an aqueous fluid forms a water insoluble gel, to a method of preparation of such a composition and the use of such a composition for forming, in situ in a wound, a water insoluble, coherent gel.
  • the polymers are only soluble in water when the functional groups are charged. This means that the polymers usually are in the form of a salt, such as sodium alginate instead of alginic acid.
  • the composition may also comprise a solubiliser.
  • the composition e.g. comprises alginic acid and chitosan glutamate
  • the right amount of sodium hydroxide may be incorporated in the composition.
  • the sodium hydroxide solubilises the alginic acid by turning it into sodium alginate. Solubilised sodium alginate and chitosan glutamate will then form a gel.
  • the polymer powders are homogeneously dispersed in a substantially non-aqueous, liquid carrier, giving a composition in the form of a more or less viscous cream/paste.
  • the paste or cream is brought in contact with an exuding wound, absorbs the wound exudate and turns into a coherent gel.
  • solubiliser has influence on the absorption and cohesion properties of the gel.
  • composition of the invention still has a high absorption capacity after the gel is formed combined with a strong cohesion.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention se rapporte à une composition susceptible de former un gel consistant lorsqu'elle est en contact avec un fluide aqueux. Cette composition contient un polymère soluble, aqueux, qui lorsqu'il est dissous dans un fluide aqueux, forme un gel insoluble dans l'eau. Elle se caractérise en ce qu'elle contient un mélange non aqueux d'au moins deux polymères solubles dans l'eau ou un sel de ces polymères. Les polymères en question possèdent des charges opposées et forment, lorsqu'ils sont dissous dans un fluide aqueux, un gel consistant, insoluble dans l'eau et susceptible d'absorber l'eau.
EP99938200A 1998-08-31 1999-08-25 Composition susceptible d'absorber un fluide Withdrawn EP1109584A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK98010 1998-08-31
DKPA199801094 1998-08-31
PCT/DK1999/000451 WO2000012144A1 (fr) 1998-08-31 1999-08-25 Composition susceptible d'absorber un fluide

Publications (1)

Publication Number Publication Date
EP1109584A1 true EP1109584A1 (fr) 2001-06-27

Family

ID=8100930

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99938200A Withdrawn EP1109584A1 (fr) 1998-08-31 1999-08-25 Composition susceptible d'absorber un fluide

Country Status (3)

Country Link
EP (1) EP1109584A1 (fr)
AU (1) AU5279299A (fr)
WO (1) WO2000012144A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10003397A1 (de) * 2000-01-27 2001-08-09 Hartmann Paul Ag Polyelektrolyt-Feststoffsystem, Verfahren zur Herstellung desselben sowie Wundverband
GB2384187A (en) * 2002-01-22 2003-07-23 Johnson & Johnson Medical Ltd Particulate wound dressing
CN101117392B (zh) * 2007-07-26 2011-02-09 复旦大学 一种天然两性聚电解质电场敏感性水凝胶及其制备方法
CN109602944A (zh) 2011-11-13 2019-04-12 克里斯龙公司 原位可交联的聚合物组合物及其方法
CN102772821B (zh) * 2012-08-01 2015-07-01 苏州博创同康生物工程有限公司 一种具有组织诱导性且可吸收、止血的多功能颗粒及其制备和应用
CN104353103B (zh) * 2014-10-16 2017-05-24 湖北杰明凯林科技有限公司 一种抗菌性医用水凝胶敷料及其制备方法
RU2750648C2 (ru) 2015-06-22 2021-06-30 Кресилон, Инк. Высокоэффективный гемостатический адгезивный полимерный каркас
CN104984402B (zh) * 2015-07-14 2016-10-05 青岛大学 一种用于修复角膜眼表损伤的羟乙基壳聚糖原位水凝胶

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948575A (en) * 1989-01-24 1990-08-14 Minnesota Mining And Manufacturing Company Alginate hydrogel foam wound dressing
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5578661A (en) * 1994-03-31 1996-11-26 Nepera, Inc. Gel forming system for use as wound dressings

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0012144A1 *

Also Published As

Publication number Publication date
WO2000012144A1 (fr) 2000-03-09
AU5279299A (en) 2000-03-21

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