EP1094788A4 - Croscarmellose comme masquant de saveur - Google Patents

Croscarmellose comme masquant de saveur

Info

Publication number: EP1094788A4
Authority: EP; European Patent Office
Prior art keywords: croscarmellose sodium; croscarmellose; preparing; taste; taste masking
Prior art date: 1998-07-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP99932362A

Other languages

German (de)

English (en)

Other versions

EP1094788A1 (fr

EP1094788B1 (fr

Inventor

Michael Augello

Sheila M Dell

George E Reier

Howard J Stamato

Lynn M Dimemmo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

RP Scherer Technologies LLC

Original Assignee

RP Scherer Technologies LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-08

Filing date

1999-07-08

Publication date

2003-04-02

1999-07-08 Application filed by RP Scherer Technologies LLC filed Critical RP Scherer Technologies LLC

2001-05-02 Publication of EP1094788A1 publication Critical patent/EP1094788A1/fr

2003-04-02 Publication of EP1094788A4 publication Critical patent/EP1094788A4/fr

2004-03-10 Application granted granted Critical

2004-03-10 Publication of EP1094788B1 publication Critical patent/EP1094788B1/fr

2019-07-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Seasonings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP99932362A 1998-07-08 1999-07-08 Croscarmellose comme masquant de saveur Expired - Lifetime EP1094788B1 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US9199698P	1998-07-08	1998-07-08
US91996P		1998-07-08
US330445		1999-06-11
US09/330,445 US6099865A (en)	1998-07-08	1999-06-11	Croscarmellose taste masking
PCT/US1999/015510 WO2000002536A1 (fr)	1998-07-08	1999-07-08	Croscarmellose comme masquant de saveur

Publications (3)

Publication Number	Publication Date
EP1094788A1 EP1094788A1 (fr)	2001-05-02
EP1094788A4 true EP1094788A4 (fr)	2003-04-02
EP1094788B1 EP1094788B1 (fr)	2004-03-10

Family

ID=26784551

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99932362A Expired - Lifetime EP1094788B1 (fr)	1998-07-08	1999-07-08	Croscarmellose comme masquant de saveur

Country Status (9)

Country	Link
US (1)	US6099865A (fr)
EP (1)	EP1094788B1 (fr)
AT (1)	ATE261299T1 (fr)
CA (1)	CA2336570C (fr)
DE (1)	DE69915478T2 (fr)
DK (1)	DK1094788T3 (fr)
ES (1)	ES2217774T3 (fr)
PT (1)	PT1094788E (fr)
WO (1)	WO2000002536A1 (fr)

Families Citing this family (40)

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US8071128B2 (en)	1996-06-14	2011-12-06	Kyowa Hakko Kirin Co., Ltd.	Intrabuccally rapidly disintegrating tablet and a production method of the tablets
FR2785538B1 (fr) *	1998-11-06	2004-04-09	Prographarm Laboratoires	Comprime a delitement rapide perfectionne
US6982251B2 (en) *	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
CN100509058C (zh)	2001-01-26	2009-07-08	先灵公司	过氧化物酶体增殖物激活受体(ppar)活化剂和甾醇吸收抑制剂的组合药以及对于血管适应症的治疗
US7417039B2 (en)	2001-01-26	2008-08-26	Schering Corporation	Use of substituted azetidinone compounds for the treatment of sitosterolemia
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US7132415B2 (en)	2001-09-21	2006-11-07	Schering Corporation	Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
CN100364515C (zh) *	2001-09-28	2008-01-30	麦克内尔-Ppc股份有限公司	具有不同形状内核和外壳的剂型
US9358214B2 (en)	2001-10-04	2016-06-07	Adare Pharmaceuticals, Inc.	Timed, sustained release systems for propranolol
US8603514B2 (en)	2002-04-11	2013-12-10	Monosol Rx, Llc	Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US10285910B2 (en)	2001-10-12	2019-05-14	Aquestive Therapeutics, Inc.	Sublingual and buccal film compositions
US20190328679A1 (en)	2001-10-12	2019-10-31	Aquestive Therapeutics, Inc.	Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8765167B2 (en)	2001-10-12	2014-07-01	Monosol Rx, Llc	Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20110033542A1 (en)	2009-08-07	2011-02-10	Monosol Rx, Llc	Sublingual and buccal film compositions
US7357891B2 (en)	2001-10-12	2008-04-15	Monosol Rx, Llc	Process for making an ingestible film
US11207805B2 (en)	2001-10-12	2021-12-28	Aquestive Therapeutics, Inc.	Process for manufacturing a resulting pharmaceutical film
AR040588A1 (es) *	2002-07-26	2005-04-13	Schering Corp	Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
CA2504878A1 (fr)	2002-11-06	2004-05-27	Schering Corporation	Inhibiteurs d'absorption du cholesterol pour le traitement de la demyelination
US8367111B2 (en) *	2002-12-31	2013-02-05	Aptalis Pharmatech, Inc.	Extended release dosage forms of propranolol hydrochloride
MXPA05009501A (es)	2003-03-07	2005-10-18	Schering Corp	Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP5137228B2 (ja)	2003-03-07	2013-02-06	メルク・シャープ・アンド・ドーム・コーポレーション	高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用
JP2006519869A (ja)	2003-03-07	2006-08-31	シェーリング　コーポレイション	置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
BRPI0413881A (pt) *	2003-08-28	2006-10-24	Sandoz Ag	composição farmacêutica compreendendo anticonvulsivante com revestimento de mascaramento de gosto
US8747895B2 (en)	2004-09-13	2014-06-10	Aptalis Pharmatech, Inc.	Orally disintegrating tablets of atomoxetine
US9884014B2 (en)	2004-10-12	2018-02-06	Adare Pharmaceuticals, Inc.	Taste-masked pharmaceutical compositions
EP1802285B1 (fr) *	2004-10-21	2013-02-27	Aptalis Pharmatech, Inc.	Compositions pharmaceutiques a saveur masquee avec substances porogenes gastrosolubles
US20060105038A1 (en) *	2004-11-12	2006-05-18	Eurand Pharmaceuticals Limited	Taste-masked pharmaceutical compositions prepared by coacervation
US9161918B2 (en)	2005-05-02	2015-10-20	Adare Pharmaceuticals, Inc.	Timed, pulsatile release systems
US7842312B2 (en)	2005-12-29	2010-11-30	Cordis Corporation	Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
AU2010315414B2 (en) *	2009-10-28	2015-07-09	Mcneil-Ppc, Inc.	Fast dissolving/disintegrating coating compositions
EP2506836B1 (fr)	2009-12-02	2018-02-14	Adare Pharmaceuticals S.R.L.	Microcapsules de fexofénadine et compositions les contenant
WO2011087705A2 (fr) *	2009-12-22	2011-07-21	Fmc Corporation	Croscarmellose à particules fines et utilisations associées
TW201127375A (en) *	2010-01-08	2011-08-16	Eurand Inc	Taste masked topiramate composition and an orally disintegrating tablet comprising the same
US9149959B2 (en)	2010-10-22	2015-10-06	Monosol Rx, Llc	Manufacturing of small film strips
CN102258490B (zh) *	2011-07-01	2012-10-03	中美天津史克制药有限公司	布洛芬咀嚼片
US20140341988A1 (en) *	2013-05-15	2014-11-20	Apr Applied Pharma Research Sa	Orally dispersible drug formulations
KR20190005199A (ko)	2016-05-05	2019-01-15	어퀘스티브 테라퓨틱스, 아이엔씨.	강화된 전달 에프네프린 조성물
US11273131B2 (en)	2016-05-05	2022-03-15	Aquestive Therapeutics, Inc.	Pharmaceutical compositions with enhanced permeation

Citations (4)

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Publication number	Priority date	Publication date	Assignee	Title
US5320848A (en) *	1991-05-28	1994-06-14	Affinity Biotech, Inc.	Chewable drug-delivery composition
WO1995025521A1 (fr) *	1994-03-24	1995-09-28	The Procter & Gamble Company	Formes galeniques solides renfermant du bismuth
US5681590A (en) *	1992-12-02	1997-10-28	Merck & Co., Inc.	Dry mix formulation for bisphosphonic acids
WO1999044581A2 (fr) *	1998-03-04	1999-09-10	Ortho-Mcneil Pharmaceutical, Inc.	Composition pharmaceutique de topiramate

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JP3130058B2 (ja) *	1991-02-15	2001-01-31	第一製薬株式会社	マスクされた粒状物
US5874418A (en) *	1997-05-05	1999-02-23	Cydex, Inc.	Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use

1999
- 1999-06-11 US US09/330,445 patent/US6099865A/en not_active Expired - Fee Related
- 1999-07-08 EP EP99932362A patent/EP1094788B1/fr not_active Expired - Lifetime
- 1999-07-08 CA CA002336570A patent/CA2336570C/fr not_active Expired - Fee Related
- 1999-07-08 DK DK99932362T patent/DK1094788T3/da active
- 1999-07-08 ES ES99932362T patent/ES2217774T3/es not_active Expired - Lifetime
- 1999-07-08 WO PCT/US1999/015510 patent/WO2000002536A1/fr active IP Right Grant
- 1999-07-08 AT AT99932362T patent/ATE261299T1/de not_active IP Right Cessation
- 1999-07-08 PT PT99932362T patent/PT1094788E/pt unknown
- 1999-07-08 DE DE1999615478 patent/DE69915478T2/de not_active Expired - Lifetime

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5320848A (en) *	1991-05-28	1994-06-14	Affinity Biotech, Inc.	Chewable drug-delivery composition
US5681590A (en) *	1992-12-02	1997-10-28	Merck & Co., Inc.	Dry mix formulation for bisphosphonic acids
WO1995025521A1 (fr) *	1994-03-24	1995-09-28	The Procter & Gamble Company	Formes galeniques solides renfermant du bismuth
WO1999044581A2 (fr) *	1998-03-04	1999-09-10	Ortho-Mcneil Pharmaceutical, Inc.	Composition pharmaceutique de topiramate

Also Published As

Publication number	Publication date
CA2336570C (fr)	2009-04-14
DE69915478T2 (de)	2005-01-13
EP1094788A1 (fr)	2001-05-02
ATE261299T1 (de)	2004-03-15
EP1094788B1 (fr)	2004-03-10
WO2000002536A1 (fr)	2000-01-20
ES2217774T3 (es)	2004-11-01
CA2336570A1 (fr)	2000-01-20
PT1094788E (pt)	2004-07-30
DK1094788T3 (da)	2004-08-16
US6099865A (en)	2000-08-08
DE69915478D1 (de)	2004-04-15

Publication	Publication Date	Title
EP1094788A4 (fr)	2003-04-02	Croscarmellose comme masquant de saveur
CA2360236A1 (fr)	2000-07-20	Formulations pharmaceutiques solides a liberation prolongee a base d'ether sulfoalkyle de cyclodextrine
AU6294501A (en)	2002-04-02	Spray drying process and compositions of fenofibrate
NO331256B1 (no)	2011-11-07	Fremgangsmate for fremstilling av granuler med maskert smak og umiddelbar frigjoring av det aktive prinsipp
DE69728857D1 (de)	2004-06-03	Feste arzneimittel enthaltend trehalose
WO2002047607A3 (fr)	2003-03-20	Procede de preparation d'une forme posologique rapidement soluble
HUP0200309A2 (en)	2002-06-29	Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression, process for their preparation and pharmaceutical compositions containing them
EP0664701A1 (fr)	1995-08-02	Compositions a base de ranitidine masquant le gout de celle-ci.
HUP0101608A2 (hu)	2002-03-28	Aeroszol formájú gyógyszerkészítmény és eljárás előállítására
IL141532A0 (en)	2002-03-10	Multiple unit controlled food effect-independent release pharmaceutical preparations and method for preparing the same
GR3030256T3 (en)	1999-08-31	Pellets
CA2307101A1 (fr)	2000-10-30	Fabrication d'articles pharmaceutiques comprenant des inhibiteurs selectifs de phosphodiesterase pour traiter les dysfonction sexuelles
AP1595A (en)	2006-04-12	Pharmaceutical formulation having a masked taste and method for the production thereof.
JPH10504295A (ja)	1998-04-28	医薬処方
CA2079934A1 (fr)	1993-04-16	Enrobages permettant de masquer le gout de comprimes pharmaceutiques machables
UA89349C2 (uk)	2010-01-25	Таблетка без покриття, яка містить оланзапін, та спосіб її одержання
AU761750B2 (en)	2003-06-12	Method for producing medicaments from plant extracts, in a solid form of administration
CA2433812C (fr)	2008-12-02	Procede de production de comprimes a partir d'extraits vegetaux
HUP0100398A2 (hu)	2001-08-28	Eljárás gyógyászati készítmény előállítására
JP2005185918A (ja)	2005-07-14	高分子被覆粒子の製造方法、高分子被覆粒子、並びにこれを用いた圧縮成形品
HUP0402283A3 (en)	2009-07-28	Substituted 2-pyrrolidine-2-yl-1h-indole derivatives for the treatment of migraine, process for their preparation and pharmaceutical compositions containing them
HUP9601057A3 (en)	1997-05-28	Process for inhibiting photodecomposition of 3-substituted 2-oxindoles and pharmaceutical tablet, capsule and composition
HU0100122D0 (en)	2001-03-28	Use of tiludronic acid and derivatives thereof in poultry for preparation of a medicinal product for preventing and treating osteoporosis

Legal Events

Date	Code	Title	Description
2001-03-17	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
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2002-08-07	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: R.P. SCHERER TECHNOLOGIES, INC.
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2003-04-02	A4	Supplementary search report drawn up and despatched	Effective date: 20030220
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