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EP1083951A4 - Methods of delivering aerosolized polynucleotides to the respiratory tract - Google Patents

Methods of delivering aerosolized polynucleotides to the respiratory tract

Info

Publication number
EP1083951A4
EP1083951A4 EP99930226A EP99930226A EP1083951A4 EP 1083951 A4 EP1083951 A4 EP 1083951A4 EP 99930226 A EP99930226 A EP 99930226A EP 99930226 A EP99930226 A EP 99930226A EP 1083951 A4 EP1083951 A4 EP 1083951A4
Authority
EP
European Patent Office
Prior art keywords
polynucleotides
methods
respiratory tract
delivering aerosolized
aerosolized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99930226A
Other languages
German (de)
French (fr)
Other versions
EP1083951A1 (en
Inventor
Igor Gonda
Hans Schreier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aradigm Corp
Original Assignee
Aradigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aradigm Corp filed Critical Aradigm Corp
Publication of EP1083951A1 publication Critical patent/EP1083951A1/en
Publication of EP1083951A4 publication Critical patent/EP1083951A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99930226A 1998-06-12 1999-06-11 Methods of delivering aerosolized polynucleotides to the respiratory tract Withdrawn EP1083951A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8914698P 1998-06-12 1998-06-12
US89146P 1998-06-12
PCT/US1999/013306 WO1999064094A1 (en) 1998-06-12 1999-06-11 Methods of delivering aerosolized polynucleotides to the respiratory tract

Publications (2)

Publication Number Publication Date
EP1083951A1 EP1083951A1 (en) 2001-03-21
EP1083951A4 true EP1083951A4 (en) 2004-07-07

Family

ID=22215942

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99930226A Withdrawn EP1083951A4 (en) 1998-06-12 1999-06-11 Methods of delivering aerosolized polynucleotides to the respiratory tract

Country Status (3)

Country Link
EP (1) EP1083951A4 (en)
AU (1) AU4680699A (en)
WO (1) WO1999064094A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759029B2 (en) 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
CA2447519C (en) 2001-05-24 2008-09-16 Alexza Molecular Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US6737042B2 (en) 2001-05-24 2004-05-18 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US6805853B2 (en) 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
EP1446102A1 (en) 2001-11-21 2004-08-18 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
AU2003300401A1 (en) * 2002-12-27 2004-07-29 Introgen Therapeutics, Inc. p53 treatment of papillomavirus and carcinogen-transformed cells in hyperplastic lesions
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (en) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heating unit
ES2594867T3 (en) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
EP2338520A1 (en) 2009-12-21 2011-06-29 Ludwig Maximilians Universität Conjugate with targeting ligand and use of same
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
CA2873274C (en) * 2012-06-08 2021-06-01 Ethris Gmbh Pulmonary delivery of messenger rna
DK3268072T3 (en) 2015-03-11 2024-01-22 Alexza Pharmaceuticals Inc USE OF ANTISTATIC MATERIALS IN THE AIRWAY FOR THERMAL AEROSOL CONDENSATION PROCESS
SG11201808314QA (en) 2016-04-08 2018-10-30 Krystal Biotech Inc Compositions and methods for the treatment of wounds, disorders, and diseases of the skin
KR102852740B1 (en) 2018-02-02 2025-08-29 알렉스자 파마스티칼즈, 인크. Electrical Condensation Aerosol Device
EP3775236A1 (en) 2018-04-12 2021-02-17 Krystal Biotech, LLC Compositions and methods for the treatment of autosomal recessive congenital ichthyosis
JP7602999B2 (en) 2018-04-27 2024-12-19 クリスタル バイオテック インコーポレイテッド Recombinant Nucleic Acids Encoding Cosmetic Proteins for Aesthetic Uses - Patent application
JP7562515B2 (en) 2018-09-24 2024-10-07 クリスタル バイオテック インコーポレイテッド Compositions and methods for the treatment of Netherton syndrome
KR20210124277A (en) 2019-02-08 2021-10-14 크리스탈 바이오테크, 인크. Compositions and methods for delivering CFTR polypeptides
CA3213789A1 (en) 2021-04-02 2022-10-06 Krystal Biotech, Inc. Viral vectors for cancer therapy

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027653A2 (en) * 1993-05-21 1994-12-08 Aradigm Corporation The intrapulmonary delivery of aerosolized aqueous formulations
WO1996013161A1 (en) * 1994-10-28 1996-05-09 Aradigm Corporation Creating an aerosolized formulation of insulin
WO1996040963A1 (en) * 1995-06-07 1996-12-19 Megabios Corporation Cationic lipid:dna complexes for gene targeting
WO1996041873A1 (en) * 1995-06-09 1996-12-27 The Regents Of The University Of California Dry powder formulations of polynucleotide complexes
US5724957A (en) * 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5743250A (en) * 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5579758A (en) * 1994-07-13 1996-12-03 Century; Theodore J. Sub-miniature aerosolizer with helical flow path formed by threaded insert
US5906202A (en) * 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5724957A (en) * 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
WO1994027653A2 (en) * 1993-05-21 1994-12-08 Aradigm Corporation The intrapulmonary delivery of aerosolized aqueous formulations
WO1996013161A1 (en) * 1994-10-28 1996-05-09 Aradigm Corporation Creating an aerosolized formulation of insulin
WO1996040963A1 (en) * 1995-06-07 1996-12-19 Megabios Corporation Cationic lipid:dna complexes for gene targeting
WO1996041873A1 (en) * 1995-06-09 1996-12-27 The Regents Of The University Of California Dry powder formulations of polynucleotide complexes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9964094A1 *

Also Published As

Publication number Publication date
WO1999064094A1 (en) 1999-12-16
EP1083951A1 (en) 2001-03-21
AU4680699A (en) 1999-12-30

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20001221

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): DE ES FR GB IT

A4 Supplementary search report drawn up and despatched

Effective date: 20040525

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61M 11/00 B

Ipc: 7A 61M 15/00 A

17Q First examination report despatched

Effective date: 20050218

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050629