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EP1080358A2 - Procede permettant d'amener un prelevement ou une lame dans un plan de coupe d'un microtome - Google Patents

Procede permettant d'amener un prelevement ou une lame dans un plan de coupe d'un microtome

Info

Publication number
EP1080358A2
EP1080358A2 EP00929207A EP00929207A EP1080358A2 EP 1080358 A2 EP1080358 A2 EP 1080358A2 EP 00929207 A EP00929207 A EP 00929207A EP 00929207 A EP00929207 A EP 00929207A EP 1080358 A2 EP1080358 A2 EP 1080358A2
Authority
EP
European Patent Office
Prior art keywords
sample
cutting plane
motor drive
cutting
carriage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00929207A
Other languages
German (de)
English (en)
Inventor
Bernd Günther
Siegbert Holtermüller
Andreas Laudat
Rolf Metzner
Roland Walter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leica Microsystems CMS GmbH
Leica Biosystems Nussloch GmbH
Original Assignee
Leica Microsystems Nussloch GmbH
Leica Microsystems CMS GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leica Microsystems Nussloch GmbH, Leica Microsystems CMS GmbH filed Critical Leica Microsystems Nussloch GmbH
Publication of EP1080358A2 publication Critical patent/EP1080358A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G01N2001/065—Drive details
    • G01N2001/066—Drive details electric
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/04—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/04—Processes
    • Y10T83/05—With reorientation of tool between cuts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/04—Processes
    • Y10T83/0505—With reorientation of work between cuts
    • Y10T83/051—Relative to same tool
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/141—With means to monitor and control operation [e.g., self-regulating means]
    • Y10T83/148—Including means to correct the sensed operation
    • Y10T83/152—And modify another operation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/162—With control means responsive to replaceable or selectable information program
    • Y10T83/173—Arithmetically determined program
    • Y10T83/175—With condition sensor
    • Y10T83/178—Responsive to work
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/525—Operation controlled by detector means responsive to work
    • Y10T83/538—Positioning of tool controlled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/525—Operation controlled by detector means responsive to work
    • Y10T83/541—Actuation of tool controlled in response to work-sensing means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/647—With means to convey work relative to tool station
    • Y10T83/6492—Plural passes of diminishing work piece through tool station
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/647—With means to convey work relative to tool station
    • Y10T83/6667—Work carrier rotates about axis fixed relative to tool station

Definitions

  • the invention relates to a method for delivering a sample or a cutting knife via a delivery carriage into a cutting plane of a microtome, in particular into the cutting plane of a disk microtome, in which the delivery carriage is moved by a motor drive.
  • a disk microtome is known from WO 98 04 898 A1.
  • the disk microtome described here has a motor drive for the cut to generate a relative movement between the object and the cutting knife.
  • the disc microtome is equipped with a motorized feed device for setting the section thickness.
  • Both one-part motors can be designed as stepper motors and are connected to a control circuit. The motors are controlled via the control circuit.
  • An angle encoder is provided in the disk microtome to detect the object position.
  • the method for delivering a sample or a cutting knife via a delivery carriage into a cutting plane of a microtome is characterized in that the delivery carriage is moved by a motor drive and the delivery carriage is first advanced to a surface sensor. Stepper motors or linear motors with incremental encoders can be used as drives. When the sample surface comes into contact with the surface sensor, the position of the motor drive is determined and compared with a stored position of the cutting plane. Control signals for the motor drive are calculated from the two values and the feed carriage is fed into the cutting plane with the motor drive taking these control signals into account.
  • the feed carriage is first fed manually into the cutting plane using the motor drive. This position of the motor drive is determined when there is contact between the sample surface and the cutting knife. Then the infeed carriage is moved to the surface sensor with the motor drive and when the sample surface comes into contact with the
  • the position of the motor drive is determined.
  • the difference between the determined position of the motor drive during the infeed into the cutting plane and the determined position of the infeed carriage during the infeed on the surface sensor is formed and stored as the position value of the cutting plane.
  • the distance between the stored position of the cutting plane and the position of the motorized drive is continuously determined during the delivery of the sample with the motor drive into the cutting plane.
  • the speed of the motor drive is also regulated as a function of the determined distance between the stored position of the cutting plane and the position of the motor drive. This ensures that the speed of the drive is slowed down as the distances between the sample and the sensor or the cutting plane become smaller. This can be done continuously or in stages. This ensures that the drive is braked safely in good time before reaching the respective position, thus preventing overrun and an associated uncontrolled collision.
  • the continuously determined positions of the motor drive are compared with stored positions and if discrete positions match, the speed of the motor drive is slowed down and / or the force of the motor-adjustable parameter is increased.
  • the position of the surface of the sample to be cut upon contact with the surface of the sensor is determined and the difference is formed with a stored value for the position of the cutting plane.
  • an automatic alignment preferably an already cut sample or a sample with a smooth surface, can be achieved. This prevents a sample from being positioned and cut diagonally in the cutting plane.
  • the sample surface is aligned with the surface sensor using a motor-adjustable object holder and that contact is made with the sensor in succession with three corners of the sample and the position of the sample in space is calculated from the three positions.
  • the sample is therefore brought into contact with the surface sensor with its three corner points one after the other and the respective position of the motorized feed carriage drive and the positions of the motor-adjustable object holder are determined. From these positions, a parallel position for the sample surface to the cutting plane or the sensor surface can then be calculated and set.
  • the difference between the position of the object in space and a stored position is calculated and the motor-adjustable object holder is controlled as a function of the determined difference.
  • the figure shows a disc microtome 1 with a basic bed 2 and a base part 18 of a feed carriage 14 arranged thereon for a knife holder 3.
  • the knife holder 3 carries a cutting knife 4.
  • the feed carriage 5 is designed to be movable on the base part 18 in the direction of the double arrow and is provided by a feeder.
  • Stepper motor 15 driven. Together with the knife 3, the cutting plane 13 is defined by the feed carriage. In this plane 13, the knife edge contacts the object or the sample 5.
  • the stepper motor 15 is electrically connected to a control circuit 8 via a control line 23.
  • a pressure-sensitive area sensor 9 is additionally arranged on the knife holder 3. The sensor 9 is connected to the control circuit 8 via a control line 22.
  • a rotatable arm 7 with an object holder 6 which can be aligned in the double arrow direction X and Y and which has a sample 5 to be cut arranged thereon.
  • the rotatable arm 7 of the disk microtome is mounted in a rotary bearing 19 and is moved by a drive motor 16.
  • the motor 16 is connected to the control circuit 8 via a control line 27.
  • the rotatable arm 7 is also assigned an angular step encoder 17, which outputs the actual value of the position of the rotatable arm 7 to the control device 8 via a control line 26.
  • a stepper motor 20 is provided for the object holder 6, which can be aligned in space
  • An external control panel 10 is connected to the control circuit 8 via a control line 24 and a handwheel 11 with an associated encoder 12 is connected via a control line 25.
  • the cut is made in the disk microtome by the movement of the rotatable arm 7.
  • the sample 5 is guided in the cutting plane 13 over the cutting knife 4.
  • the feed carriage 14 is moved forward by the control circuit 8 by the amount of the cut thickness specified via the control panel 10.
  • the positions of the stepper motors 15, 20, 21 and the angle stepper 17 are continuously queried and compared with stored values in the control circuit 8.
  • a sample 5 is first cut manually controlled. This is always necessary if, for example, a knife change or a change in the cutting angle has been carried out and the position of the cutting plane 13 changes has changed.
  • the motorized feed motor 15 is fed to the sample 5 via switching means of the control panel 10. After contact between the knife edge 4 and the object surface, the position of the feed carriage 14 is stored as a value in the control circuit 8.
  • the object head 6 is then positioned in front of the pressure-sensitive sensor 9 and a contact is established between the sample surface and the sensor 9 via the feed slide 14.
  • This position of the motorized feed carriage 14 is also stored as a value in the control circuit 8. From the difference between the two values, the exact distance between the
  • Samples 5 that have already been cut or samples with a smooth surface can be automatically oriented to the cutting plane 13. This takes place in that the object holder 6 is first brought into a stop position via the stepper motors 20 and 21. Thereafter, a contact is made between the surface of the sample 5 and the sensor 9 via the motorized feed slide 14 and passed on to the control circuit 8 as a value. Then the stepper motors 20, 21 and the Motorized feed carriage 14 is controlled step by step until sensor 9 no longer emits a signal.
  • the orientation of the sample 5 can also be achieved by first bringing the two stepper motors 20 and 21 into one of their end positions via the control circuit 8 in order then to make contact with the sensor 9. These and two other corner positions of the surface of sample 5 are approached and stored as values.
  • the orientation of the sample 15 to the cutting plane 13 can be calculated and set by simultaneously recording the distances covered when approaching the respective corner positions.
  • the sensor 9 is designed as a location-sensitive area sensor or 2D potentiometer pad.
  • Values for the speed and force of the drive motor 16 are entered via the control panel 10 and stored in the control device 8.
  • the speed and position of the rotatable arm 7 can be detected as a value and compared with the stored value via the connected angle step encoder 17.
  • the speed is increased and the power of the motor 8 is reduced by a current limitation.
  • the speed is reduced and the power of the motor 16 is increased again.
  • the speed of the motor 8 can also be regulated additionally via a manually operated handwheel 11.
  • the signals generated during the rotation of the handwheel 11 via the encoder 12 are stored as values in the control circuit 8 and compared with the values of the angle stepper 17.
  • a signal for controlling the speed of the motor 16 is obtained from the difference.
  • a foot switch 30 is provided, which is connected to the control circuit 8 via a control line 31.
  • the foot switch can also be equipped with a potentiometer, the position of which is a value for the Cutting speed or the speed of the motor 16 is specified via the control circuit 8.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un procédé permettant d'amener un prélèvement ou une lame dans un plan de coupe d'un microtome, notamment dans le plan de coupe d'un microtome à disques, à l'aide d'un chariot d'avancement. Selon ce procédé, le chariot d'avancement est déplacé et amené jusqu'à un capteur surfacique par un mécanisme motorisé. La position du mécanisme motorisé est déterminée et comparée à une position mémorisée du plan de coupe lorsque la surface du prélèvement est en contact avec le détecteur surfacique. Des signaux de commande sont calculés à partir de ces deux valeurs de position pour le mécanisme motorisé. Ensuite, le chariot d'avancement est amené jusqu'au plan de coupe sur la base de ces signaux de commande et à l'aide du mécanisme motorisé.
EP00929207A 1999-03-12 2000-03-08 Procede permettant d'amener un prelevement ou une lame dans un plan de coupe d'un microtome Withdrawn EP1080358A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19911005A DE19911005A1 (de) 1999-03-12 1999-03-12 Verfahren zur Steuerung eines Scheibenmikrotoms
DE19911005 1999-03-12
PCT/DE2000/000727 WO2000054020A2 (fr) 1999-03-12 2000-03-08 Procede permettant d'amener un prelevement ou une lame dans un plan de coupe d'un microtome

Publications (1)

Publication Number Publication Date
EP1080358A2 true EP1080358A2 (fr) 2001-03-07

Family

ID=7900702

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00929207A Withdrawn EP1080358A2 (fr) 1999-03-12 2000-03-08 Procede permettant d'amener un prelevement ou une lame dans un plan de coupe d'un microtome

Country Status (7)

Country Link
US (1) US6634268B1 (fr)
EP (1) EP1080358A2 (fr)
JP (1) JP2002539424A (fr)
CN (1) CN1302374A (fr)
CA (1) CA2331520A1 (fr)
DE (1) DE19911005A1 (fr)
WO (1) WO2000054020A2 (fr)

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Also Published As

Publication number Publication date
CN1302374A (zh) 2001-07-04
DE19911005A1 (de) 2000-09-28
CA2331520A1 (fr) 2000-09-14
JP2002539424A (ja) 2002-11-19
US6634268B1 (en) 2003-10-21
WO2000054020A2 (fr) 2000-09-14
WO2000054020A3 (fr) 2000-12-28

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