EP0841910A4 - INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS - Google Patents

INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS

Info

Publication number: EP0841910A4
Authority: EP; European Patent Office
Prior art keywords: coa; apoptosis; inhibition; independent transacylase; transacylase
Prior art date: 1995-07-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP96925501A

Other languages

German (de)

French (fr)

Other versions

EP0841910A1 (en

Inventor

James David Winkler

Floyd Chilton Iii

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-25

Filing date

1996-07-24

Publication date

2006-09-13

1996-07-24 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

1998-05-20 Publication of EP0841910A1 publication Critical patent/EP0841910A1/en

2006-09-13 Publication of EP0841910A4 publication Critical patent/EP0841910A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Compositions Of Macromolecular Compounds (AREA)

EP96925501A 1995-07-25 1996-07-24 INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS Withdrawn EP0841910A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US223995P	1995-07-25	1995-07-25
US2239P		1995-07-25
PCT/US1996/012257 WO1997004765A1 (en)	1995-07-25	1996-07-24	INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS

Publications (2)

Publication Number	Publication Date
EP0841910A1 EP0841910A1 (en)	1998-05-20
EP0841910A4 true EP0841910A4 (en)	2006-09-13

Family

ID=21699854

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP96925501A Withdrawn EP0841910A4 (en)	1995-07-25	1996-07-24	INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS

Country Status (3)

Country	Link
EP (1)	EP0841910A4 (en)
JP (1)	JPH11511130A (en)
WO (1)	WO1997004765A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19829448A1 (en) *	1998-07-01	2000-10-12	Medmark Pharma Gmbh	1-Octadecyl-2-methyl-sn-glycero-3-phosphocholine (ET180CH3) for the treatment of human breast cancer
GB9904895D0 (en) *	1999-03-03	1999-04-28	Scarista Limited	Regulators of coenzyme-A-independent transacylase as psychotropic drugs
ES2351612T3 (en)	2005-03-07	2011-02-08	Bayer Schering Pharma Aktiengesellschaft	PHARMACEUTICAL COMPOSITION THAT INCLUDES A DIFFENILUREA REPLACED WITH OMEGA-CARBOXIARIL FOR THE TREATMENT OF CANCER.
WO2008074572A1 (en) *	2006-12-20	2008-06-26	Universitätsklinikum Hamburg-Eppendorf	Use of tri-substituted glycerol compounds for the treatment of hematological malignancies

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991009590A1 (en) *	1990-01-03	1991-07-11	Medmark Pharma Gmbh	Pharmaceutical preparation of et18-och3 for intravenous administration
WO1992004331A1 (en) *	1990-09-11	1992-03-19	Smith Kline & French Laboratories Limited	Substituted 2 imidazolone derivatives, their preparation and pharmaceutical compositions
WO1993016674A1 (en) *	1992-02-11	1993-09-02	Smithkline Beecham Corporation	CoA-IT AND PAF INHIBITORS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5545669A (en) *	1994-06-02	1996-08-13	Adams; Jerry L.	Anti-inflammatory compounds
US5447957A (en) *	1994-06-02	1995-09-05	Smithkline Beecham Corp.	Anti-inflammatory compounds
US5470882A (en) *	1994-06-02	1995-11-28	Smithkline Beecham Corp.	Anti-inflammatory compounds

1996
- 1996-07-24 WO PCT/US1996/012257 patent/WO1997004765A1/en not_active Application Discontinuation
- 1996-07-24 EP EP96925501A patent/EP0841910A4/en not_active Withdrawn
- 1996-07-24 JP JP9507752A patent/JPH11511130A/en active Pending

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991009590A1 (en) *	1990-01-03	1991-07-11	Medmark Pharma Gmbh	Pharmaceutical preparation of et18-och3 for intravenous administration
WO1992004331A1 (en) *	1990-09-11	1992-03-19	Smith Kline & French Laboratories Limited	Substituted 2 imidazolone derivatives, their preparation and pharmaceutical compositions
WO1993016674A1 (en) *	1992-02-11	1993-09-02	Smithkline Beecham Corporation	CoA-IT AND PAF INHIBITORS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9704765A1 *

Also Published As

Publication number	Publication date
WO1997004765A1 (en)	1997-02-13
EP0841910A1 (en)	1998-05-20
JPH11511130A (en)	1999-09-28

Publication	Publication Date	Title
PL327569A1 (en)	1998-12-21	Promedications of thrombosin inhibitors
IL118101A0 (en)	1996-09-12	Inhibitors of farnesyltransferase
GB9514437D0 (en)	1995-09-13	Inhibition of gene expression
ZA961600B (en)	1996-09-05	Inhibition of hair growth
PL322549A1 (en)	1998-02-02	Inhibitors of proteinous farnesiltransferase
SI1445259T1 (en)	2006-10-31	Use of crystal forms of 2-methyl-thieno-benzodiazepine
GB9526560D0 (en)	1996-02-28	Use of 2-Amino-Heterocycles
GB9514435D0 (en)	1995-09-13	Inhibition of gene expression
ZA9610901B (en)	1997-06-27	Treatment and prophylaxis of osteoporosis
GB9512290D0 (en)	1995-08-16	Uses of polyhexanide
AU6692996A (en)	1997-03-05	Inhibitors of apoptosis
EP0711168A4 (en)	1998-04-01	Methods of treating apoptosis and associated conditions
ZA96725B (en)	1996-08-20	Use of phenyclyclohexylcarboxamides
IL123320A0 (en)	1998-09-24	Detection of hypoprathyroidism
HUP9603529A3 (en)	1999-03-29	Femoral part of hip-joint-prothesis
EP0830375A4 (en)	2001-11-21	Human inhibitor of apoptosis gene 1
IL118574A0 (en)	1996-10-16	Methods of inhibiting melanoma
GB9621852D0 (en)	1996-12-11	Inhibition of scale
PL320114A1 (en)	1997-09-15	Phenyl-substituted fluoroderivatives of 4-azasteroides
EP0841910A4 (en)	2006-09-13	INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS
IL114831A0 (en)	1995-12-08	Determination of chromium
ZA969429B (en)	1997-06-02	Amidinohydrazones of ketones
GB9526691D0 (en)	1996-02-28	Medical use of proteases
EP0800396A4 (en)	2000-06-28	Treatment of hyperandrogenic conditions
GB9602162D0 (en)	1996-04-03	Treatment of waste

Legal Events

Date	Code	Title	Description
1998-04-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1998-05-20	17P	Request for examination filed	Effective date: 19980202
1998-05-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): BE CH DE ES FR GB IT LI NL
2006-09-13	A4	Supplementary search report drawn up and despatched	Effective date: 20060817
2007-04-27	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2007-05-30	18D	Application deemed to be withdrawn	Effective date: 20061117