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EP0753060A4 - Konservierte t-zellrezeptorsequenzen - Google Patents

Konservierte t-zellrezeptorsequenzen

Info

Publication number
EP0753060A4
EP0753060A4 EP95916452A EP95916452A EP0753060A4 EP 0753060 A4 EP0753060 A4 EP 0753060A4 EP 95916452 A EP95916452 A EP 95916452A EP 95916452 A EP95916452 A EP 95916452A EP 0753060 A4 EP0753060 A4 EP 0753060A4
Authority
EP
European Patent Office
Prior art keywords
conserved
cell receptor
receptor sequences
sequences
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95916452A
Other languages
English (en)
French (fr)
Other versions
EP0753060A1 (de
Inventor
Steven M Friedman
Mary K Crow
Yixin Li
Joseph R Tumang
Guang-Rong Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York Society for Relief of Ruptured and Crippled
Original Assignee
New York Society for Relief of Ruptured and Crippled
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Society for Relief of Ruptured and Crippled filed Critical New York Society for Relief of Ruptured and Crippled
Publication of EP0753060A1 publication Critical patent/EP0753060A1/de
Publication of EP0753060A4 publication Critical patent/EP0753060A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP95916452A 1994-04-18 1995-04-14 Konservierte t-zellrezeptorsequenzen Withdrawn EP0753060A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22928594A 1994-04-18 1994-04-18
PCT/US1995/004803 WO1995028481A1 (en) 1994-04-18 1995-04-14 Conserved t-cell receptor sequences
US229285 2000-08-31

Publications (2)

Publication Number Publication Date
EP0753060A1 EP0753060A1 (de) 1997-01-15
EP0753060A4 true EP0753060A4 (de) 1999-11-24

Family

ID=22860556

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95916452A Withdrawn EP0753060A4 (de) 1994-04-18 1995-04-14 Konservierte t-zellrezeptorsequenzen

Country Status (4)

Country Link
EP (1) EP0753060A4 (de)
JP (1) JPH10504181A (de)
CA (1) CA2188182A1 (de)
WO (1) WO1995028481A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19625191A1 (de) * 1996-06-24 1998-01-02 Boehringer Mannheim Gmbh Nierenkarzinom-spezifische T-Zellen
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
EP3699296A1 (de) 2008-11-07 2020-08-26 Adaptive Biotechnologies Corporation Verfahren zur überwachung von zuständen durch sequenzanalyse
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8691510B2 (en) 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
DK2387627T3 (en) 2009-01-15 2016-07-04 Adaptive Biotechnologies Corp Adaptive immunity profiling and methods for producing monoclonal antibodies
RU2539032C2 (ru) 2009-06-25 2015-01-10 Фред Хатчинсон Кансэр Рисёч Сентер Способ измерения искусственного иммунитета
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
EP3388535B1 (de) 2011-12-09 2021-03-24 Adaptive Biotechnologies Corporation Diagnose von lymphoid-malignomen und nachweis von minimaler resterkrankung
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US10077478B2 (en) 2012-03-05 2018-09-18 Adaptive Biotechnologies Corp. Determining paired immune receptor chains from frequency matched subunits
US9150905B2 (en) 2012-05-08 2015-10-06 Adaptive Biotechnologies Corporation Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions
EP3330384B1 (de) 2012-10-01 2019-09-25 Adaptive Biotechnologies Corporation Immunkompetenzbeurteilung durch adaptive immunrezeptordiversität und klonalitätscharakterisierung
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
CA2941612A1 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
ES2784343T3 (es) 2014-10-29 2020-09-24 Adaptive Biotechnologies Corp Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
EP3591074B1 (de) 2015-02-24 2024-10-23 Adaptive Biotechnologies Corp. Verfahren zur diagnose einer infektionskrankheit und bestimmung des hla-status mittels immunrepertoiresequenzierung
AU2016242967B2 (en) 2015-04-01 2021-07-01 Adaptive Biotechnologies Corp. Method of identifying human compatible T cell receptors specific for an antigenic target
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013949A1 (fr) * 1991-02-08 1992-08-20 Roussel-Uclaf Sequences nucleotidiques codant pour des regions variables de chaines alpha des recepteurs des lymphocytes humains ainsi que leurs applications
WO1993004695A1 (en) * 1991-08-28 1993-03-18 The Wistar Institute T cell receptor-based therapy for rheumatoid arthritis
WO1993006135A1 (en) * 1991-09-23 1993-04-01 Genentech, Inc. Diagnosing and treating autoimmune disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886743A (en) * 1985-04-24 1989-12-12 California Institute Of Technology Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof
US5298396A (en) * 1989-11-15 1994-03-29 National Jewish Center For Immunology And Respiratory Medicine Method for identifying T cells disease involved in autoimmune disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013949A1 (fr) * 1991-02-08 1992-08-20 Roussel-Uclaf Sequences nucleotidiques codant pour des regions variables de chaines alpha des recepteurs des lymphocytes humains ainsi que leurs applications
WO1993004695A1 (en) * 1991-08-28 1993-03-18 The Wistar Institute T cell receptor-based therapy for rheumatoid arthritis
WO1993006135A1 (en) * 1991-09-23 1993-04-01 Genentech, Inc. Diagnosing and treating autoimmune disorders

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
GORONZY J.J. ET AL.: "Restrictions in the repertoire of allospecific T cells.", J. IMMUNOL., vol. 151, no. 2, 15 July 1993 (1993-07-15), pages 825 - 836, XP002115157 *
JENKINS R.N. ET AL.: "T cell receptor Vb gene bias in rheumatoid arthritis", J. CLIN. INVEST., vol. 92, February 1993 (1993-02-01), pages 2688 - 2701, XP002115160 *
LI Y. ET AL: "CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response.", J. CLIN. INVEST., vol. 94, no. 6, December 1994 (1994-12-01), pages 2525 - 2531, XP002115156 *
OLIVE C. ET AL.: "Analysis of T cell receptor Va and Vb gene usage in synovia of patients with rheumatoid arthritis.", IMMUNOLOGY AND CELL BIOL., vol. 69, 1991, pages 349 - 354, XP002115158 *
PLUSCHKE G. ET AL.: "Analysis of T cell receptor Vb regions expressed by rheumatoid synovial T lymphocytes.", IMMUNOBIOL., vol. 188, 1993, pages 330 - 339, XP002115159 *
See also references of WO9528481A1 *
UEMATSU Y ET AL: "THE T-CELL-RECEPTOR REPERTOIRE IN THE SYNOVIAL FLUID OF A PATIENT WITH RHEUMATOID ARTHRITIS IS POLYCLONAL", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 88, no. 19, 1 October 1991 (1991-10-01), pages 8534 - 8538, XP002062861, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO1995028481A1 (en) 1995-10-26
CA2188182A1 (en) 1995-10-26
EP0753060A1 (de) 1997-01-15
JPH10504181A (ja) 1998-04-28

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19961115

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Effective date: 19991008

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