EP0655448A4 - - Google Patents
Info
- Publication number
- EP0655448A4 EP0655448A4 EP94908117A EP94908117A EP0655448A4 EP 0655448 A4 EP0655448 A4 EP 0655448A4 EP 94908117 A EP94908117 A EP 94908117A EP 94908117 A EP94908117 A EP 94908117A EP 0655448 A4 EP0655448 A4 EP 0655448A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- represent
- lower haloalkyl
- hydrogen
- benzopyran
- epilepsy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000005130 benzoxazines Chemical class 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP217975/92 | 1992-08-17 | ||
| JP21797592 | 1992-08-17 | ||
| JP21797592 | 1992-08-17 | ||
| JP8846293 | 1993-04-15 | ||
| JP8846293 | 1993-04-15 | ||
| JP88462/93 | 1993-04-15 | ||
| PCT/JP1993/001150 WO1994004521A1 (en) | 1992-08-17 | 1993-08-17 | Benzopyran and benzoxazine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP0655448A1 EP0655448A1 (de) | 1995-05-31 |
| EP0655448A4 true EP0655448A4 (de) | 1995-06-07 |
| EP0655448B1 EP0655448B1 (de) | 2000-04-12 |
Family
ID=26429828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP94908117A Expired - Lifetime EP0655448B1 (de) | 1992-08-17 | 1993-08-17 | Benzopyran und benzoxazin-derivate |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US5614633A (de) |
| EP (1) | EP0655448B1 (de) |
| KR (1) | KR100231634B1 (de) |
| CN (1) | CN1044605C (de) |
| AT (1) | ATE191716T1 (de) |
| AU (1) | AU4761693A (de) |
| CA (1) | CA2142471A1 (de) |
| DE (1) | DE69328366T2 (de) |
| ES (1) | ES2145129T3 (de) |
| TW (1) | TW258735B (de) |
| WO (1) | WO1994004521A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9309716D0 (en) * | 1993-05-12 | 1993-06-23 | Zeneca Ltd | Heterocyclic derivatives |
| WO1995013272A1 (fr) * | 1993-11-10 | 1995-05-18 | Japan Tobacco Inc. | Derive de chromanne et utilisation therapeutique de ce dernier |
| NZ329200A (en) * | 1996-12-16 | 1999-05-28 | Hoechst Ag | Sulphonamide substituted quinazoline, isoquinoline, quinoline or benzo[1,3-]oxazine derivatives and medicaments |
| TW533073B (en) * | 1997-03-03 | 2003-05-21 | Chugai Pharmaceutical Co Ltd | Therapeutic agents for peripheral vascular disease |
| EP1283829B1 (de) * | 2000-05-23 | 2007-06-27 | Syngenta Participations AG | Verfahren zur herstellung von acylamiden durch synthesierung und acylierung von benzoxazinen |
| US7161001B2 (en) * | 2000-05-23 | 2007-01-09 | Syngenta Crop Protection, Inc. | Method for making acylamides by synthesizing and acylating benzoxazines |
| JP2005505586A (ja) * | 2001-10-04 | 2005-02-24 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体 |
| NZ550441A (en) * | 2004-05-05 | 2009-07-31 | Hoffmann La Roche | Arylsulfonyl benzodioxanes useful for modulating the 5-HT6 receptor, the 5-HT2A receptor or both |
| WO2006002470A1 (en) * | 2004-06-30 | 2006-01-12 | Monash University | Chiral ligands for asymmetric catalysis |
| WO2006066745A1 (en) * | 2004-12-21 | 2006-06-29 | F.Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
| KR100889185B1 (ko) * | 2004-12-21 | 2009-03-16 | 에프. 호프만-라 로슈 아게 | 테트랄린 및 인단 유도체 및 5-ｈｔ 길항제로서의 이의용도 |
| AU2005318550B2 (en) * | 2004-12-21 | 2011-04-07 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
| BRPI0516381A (pt) * | 2004-12-21 | 2008-09-02 | Hoffmann La Roche | derivados de cromano e seu uso como ligandos de receptor de 5-ht |
| CA2591810A1 (en) | 2004-12-21 | 2006-06-29 | F.Hoffmann-La Roche Ag | Chroman derivatives and uses thereof in the treatment of cns disorders |
| US7812183B2 (en) | 2005-09-01 | 2010-10-12 | Janssen Pharmaceutica Nv | Benzopyran derivatives as potassium channel openers |
| ES2359735T3 (es) * | 2005-11-03 | 2011-05-26 | F. Hoffmann-La Roche Ag | Arilsulfonilcromanos como inhibidores de 5-ht6. |
| AU2007263076A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonyl naphthalene derivatives and uses thereof |
| WO2007147771A2 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
| CN101472883A (zh) * | 2006-06-20 | 2009-07-01 | 弗·哈夫曼-拉罗切有限公司 | 芳基磺酰氨基四氢萘衍生物以及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3046300A (en) * | 1960-10-21 | 1962-07-24 | Merck & Co Inc | alpha-trifluoromethyloxyphenylalanines |
| FR2615191B1 (fr) * | 1987-05-16 | 1991-01-11 | Sandoz Sa | Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments |
| IL86798A (en) * | 1987-06-23 | 1992-12-01 | Sanofi Sa | 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them |
| US4971982A (en) * | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
| IL88035A0 (en) * | 1987-10-27 | 1989-06-30 | American Home Prod | Benzopyran derivatives,their preparation and pharmaceutical compositions containing them |
| US5021432A (en) * | 1988-04-26 | 1991-06-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzopyran compound and its pharmaceutical use |
| DE68921972T2 (de) * | 1988-12-13 | 1995-11-16 | Beecham Group Plc | Benzopyran und verwandte Verbindungen. |
| FR2657872B2 (fr) * | 1989-11-06 | 1992-06-12 | Sanofi Sa | Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant. |
| DE4018552A1 (de) * | 1990-06-09 | 1991-12-12 | Sandoz Ag | Asthma-prophylaktische verwendung von k(pfeil hoch)+(pfeil hoch) kanal-activatoren |
| CN1060467A (zh) * | 1990-09-25 | 1992-04-22 | 武田药品工业株式会社 | 1，3-苯并嗪衍生物、其生产方法和用途 |
-
1993
- 1993-08-17 EP EP94908117A patent/EP0655448B1/de not_active Expired - Lifetime
- 1993-08-17 TW TW082106610A patent/TW258735B/zh active
- 1993-08-17 CN CN93109297A patent/CN1044605C/zh not_active Expired - Fee Related
- 1993-08-17 WO PCT/JP1993/001150 patent/WO1994004521A1/ja active IP Right Grant
- 1993-08-17 KR KR1019950700620A patent/KR100231634B1/ko not_active IP Right Cessation
- 1993-08-17 ES ES94908117T patent/ES2145129T3/es not_active Expired - Lifetime
- 1993-08-17 AU AU47616/93A patent/AU4761693A/en not_active Abandoned
- 1993-08-17 AT AT94908117T patent/ATE191716T1/de not_active IP Right Cessation
- 1993-08-17 DE DE69328366T patent/DE69328366T2/de not_active Expired - Fee Related
- 1993-08-17 CA CA002142471A patent/CA2142471A1/en not_active Abandoned
-
1995
- 1995-03-15 US US08/387,745 patent/US5614633A/en not_active Expired - Fee Related
-
1996
- 1996-06-27 US US08/673,207 patent/US5874446A/en not_active Expired - Fee Related
-
1998
- 1998-02-19 US US09/026,127 patent/US5977167A/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0655448B1 (de) | 2000-04-12 |
| US5977167A (en) | 1999-11-02 |
| ATE191716T1 (de) | 2000-04-15 |
| KR950702976A (ko) | 1995-08-23 |
| CA2142471A1 (en) | 1994-03-03 |
| DE69328366D1 (de) | 2000-05-18 |
| AU4761693A (en) | 1994-03-15 |
| TW258735B (de) | 1995-10-01 |
| ES2145129T3 (es) | 2000-07-01 |
| EP0655448A1 (de) | 1995-05-31 |
| US5874446A (en) | 1999-02-23 |
| WO1994004521A1 (en) | 1994-03-03 |
| KR100231634B1 (ko) | 1999-11-15 |
| CN1086817A (zh) | 1994-05-18 |
| DE69328366T2 (de) | 2000-08-10 |
| US5614633A (en) | 1997-03-25 |
| CN1044605C (zh) | 1999-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: NABATA, HIROYUKI Inventor name: ISHIZAWA, TAKENORI Inventor name: SATO, HARUHIKO Inventor name: KOGA, HIROSHI |
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