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EP0409901A4 - Lak cell cytotoxin - Google Patents

Lak cell cytotoxin

Info

Publication number
EP0409901A4
EP0409901A4 EP19890905571 EP89905571A EP0409901A4 EP 0409901 A4 EP0409901 A4 EP 0409901A4 EP 19890905571 EP19890905571 EP 19890905571 EP 89905571 A EP89905571 A EP 89905571A EP 0409901 A4 EP0409901 A4 EP 0409901A4
Authority
EP
European Patent Office
Prior art keywords
lak cell
cell cytotoxin
cytotoxin
lak
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890905571
Other versions
EP0409901A1 (en
Inventor
Evan M. Hersh
Philip Scuderi, Jr.
William Grimes
Sydney E. Salmon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Publication of EP0409901A1 publication Critical patent/EP0409901A1/en
Publication of EP0409901A4 publication Critical patent/EP0409901A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19890905571 1988-04-15 1989-04-05 Lak cell cytotoxin Withdrawn EP0409901A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18187088A 1988-04-15 1988-04-15
US181870 1988-04-15

Publications (2)

Publication Number Publication Date
EP0409901A1 EP0409901A1 (en) 1991-01-30
EP0409901A4 true EP0409901A4 (en) 1991-10-30

Family

ID=22666155

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890905571 Withdrawn EP0409901A4 (en) 1988-04-15 1989-04-05 Lak cell cytotoxin

Country Status (3)

Country Link
EP (1) EP0409901A4 (en)
JP (1) JPH03503844A (en)
WO (1) WO1989009831A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2955314B2 (en) * 1988-10-27 1999-10-04 リージェンツ・オブ・ザ・ユニバーシティー・オブ・ミネソタ IL-2 containing liposome immunoadjuvant
JPH06506465A (en) * 1991-04-05 1994-07-21 リージエンツ・オブ・ザ・ユニバーシテイ・オブ・ミネソタ Methods for enhancing immunotherapeutic activity of immune cells through deletion/positive selection of cell subsets
US5725855A (en) * 1991-04-05 1998-03-10 The United States Of America As Represented By The Department Of Health And Human Services Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations
IE922233A1 (en) * 1991-07-10 1993-01-13 Augusto C Ochoa Short-term anti-cd3 stimulation of lymphocytes to increase¹their in vivo activity
JPH07502734A (en) * 1991-12-31 1995-03-23 ザイモジェネティクス,インコーポレイティド Methods and compositions for reducing blood loss

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186833B1 (en) * 1984-12-20 1992-08-19 Yeda Research And Development Company Limited A monoclonal antibody recognizing a cytotoxin, a hybridoma cell line expressing same and a process for the preparation of a purified cytotoxin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186833B1 (en) * 1984-12-20 1992-08-19 Yeda Research And Development Company Limited A monoclonal antibody recognizing a cytotoxin, a hybridoma cell line expressing same and a process for the preparation of a purified cytotoxin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANCER RESEARCH, vol. 48, no. 16, 15th August 1988, pages 4687-4688, Philadelphia, USA; D.M. LOWREY et al.: "Isolation and characterization of cytotoxic granules from human lymphokine (interleukin 2) activated killer cells" *
PROC. AM. ASSOC. CANCER. RES. 79TH ANNU. MEET., vol. 29, March 1988, page 399, abstract no. 1588; E.M. HERSH et al.: "A soluble antitumor factor produced during interleukin-2 (IL-2) induced generation of lymphokine activated killer (LAK) cells. Evidence for a dual mechanism of lak-cell action" *
See also references of WO8909831A1 *

Also Published As

Publication number Publication date
JPH03503844A (en) 1991-08-29
EP0409901A1 (en) 1991-01-30
WO1989009831A1 (en) 1989-10-19

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19901015

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19910912

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19931015

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: RESEARCH CORPORATION TECHNOLOGIES, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19940918