[go: up one dir, main page]

EP0311863B1 - Dispositif de distribution de fluide - Google Patents

Dispositif de distribution de fluide Download PDF

Info

Publication number
EP0311863B1
EP0311863B1 EP88116290A EP88116290A EP0311863B1 EP 0311863 B1 EP0311863 B1 EP 0311863B1 EP 88116290 A EP88116290 A EP 88116290A EP 88116290 A EP88116290 A EP 88116290A EP 0311863 B1 EP0311863 B1 EP 0311863B1
Authority
EP
European Patent Office
Prior art keywords
pump
stop
piston
stroke
pump cylinder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP88116290A
Other languages
German (de)
English (en)
Other versions
EP0311863A3 (en
EP0311863A2 (fr
Inventor
Karl-Heinz Fuchs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptar Radolfzell GmbH
Original Assignee
Ing Erich Pfeiffer GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ing Erich Pfeiffer GmbH filed Critical Ing Erich Pfeiffer GmbH
Priority to AT88116290T priority Critical patent/ATE84229T1/de
Publication of EP0311863A2 publication Critical patent/EP0311863A2/fr
Publication of EP0311863A3 publication Critical patent/EP0311863A3/de
Application granted granted Critical
Publication of EP0311863B1 publication Critical patent/EP0311863B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons

Definitions

  • the invention relates to a discharge device according to the preamble of claim 1.
  • Such discharge devices are generally used for the metered discharge of the flowable medium in metering volume units, so that they are particularly suitable for pharmaceutical, cosmetic and similar products.
  • the thrust piston pump of the discharge device can be arranged on a storage container, on which it draws into the pump chamber at the respective return stroke in the upright normal position and / or in the reverse head position, if necessary via an inlet valve closing during the pump stroke.
  • the discharge device can also be designed as a disposable applicator, the stored media supply of which is exhausted after a full pump stroke, so that the pump chamber is not repeatedly filled.
  • EP-B-0 021 123 is a discharge device become known, which has stops protruding in the form of stops to limit the stroke over the piston raceway, on which the pump piston including its sealing surface is deformed both during the stop-limited run-up and when overflowing, so that the sealing engagement in the region of the piston raceway is impaired because the stops in the region the piston raceway.
  • the invention has for its object to provide a discharge device of the type mentioned, with which a metered amount of the flowable medium can be applied in a simple manner, which is smaller compared to the effective working volume of the metering chamber or compared to the metered amount applied during a full pump stroke.
  • the features of claim 1 are suitable for achieving this object.
  • the respective stop is expediently associated with a limiting device which at most extends as far as the piston raceway in order to reduce the discharge volume to at least one partial volume.
  • This limitation device can effectively prevent a quantity of media corresponding to the full pump stroke from being applied, the quantity applied also representing a precisely metered quantity or a quantity precisely determined by the limitation means and not merely representing an arbitrary or arbitrary quantity, as is the case It would be the case if the pump piston was not pushed all the way to its pump stroke end position in a conventional push piston pump.
  • the limiting device does not protrude inward beyond the piston raceway or opposite the Envelope surface of the piston raceway is offset axially outwards or with respect to the piston raceway, it cannot lead to impairments of the piston guidance or the tight contact of the pump piston with the piston raceway.
  • a particularly precise metering is achieved if the pump chamber is designed in the form of a metering chamber which determines the discharge volume per pump stroke.
  • the limiting device could e.g. be an opening in the pump cylinder which is to be made with a tool or which already exists and which is closed on the part of the pump stroke corresponding to the partial volume and then opened so that the pressure in the pump chamber drops and therefore no further discharge takes place.
  • a particularly advantageous embodiment results, however, if the limiting device has at least one stop assigned to a counterstop, in particular a stroke stop that limits the pump stroke to at least one partial stroke, this stop or the counterstop expediently reaching at most as far as the piston raceway or essentially outside of the piston stroke Piston raceway, in particular on an outside of the pump cylinder.
  • the limiting device could be designed such that the associated partial volume can no longer be changed once the limiting device has been defined.
  • the limiting device is expediently designed to be detachable in the sense of removing the limitation. This can be achieved in a very simple manner in that the stop is designed as a latch that can be overcome under a predetermined pump actuation force.
  • the limiting device acts due to a noticeable resistance which is higher than the normal pump actuating force and opposes this actuating force and which can be overcome by increasing the actuating force by the user immediately after the preceding partial stroke, so that it is also possible to have two or more Apply partial volumes immediately after each other.
  • the stop or counterstop can be provided on components of the discharge device that are not formed directly by the pump cylinder or the pump piston or are arranged separately from them or at a distance from them.
  • the stop is expediently provided on a component that can be moved relative to the pump cylinder, in particular with the pump piston, wherein preferably the counterstop can be formed by the pump cylinder, so that no separate components are required or even the counterstop can be formed directly by an outside of the pump cylinder without separate shaping.
  • the stop is designed to be resilient, in particular provided on a spring arm approximately parallel to the pump axis, the stop preferably has a run-up slope for the counterstop, so that the stop can be moved resiliently from the stop position by the pressure of the counterstop or the counterstop surface if the actuating force exerted on the thrust piston pump is increased accordingly.
  • the stop could also lie within the pump cylinder, but at a distance from the piston raceway, for example, in such a way that it protrudes beyond the inner end of the pump piston and runs onto a bottom surface of the pump cylinder as a counter-stop, the stop then being able to be moved in relation to the pump piston by the partial strokes .
  • the stop lies outside the pump cylinder and is in particular assigned to an end face of the pump cylinder which is provided as a counterstop, the stop preferably projecting freely in a particularly cap-shaped actuating handle for the push piston pump, so that it is protected outside of the cylinder despite being arranged lies.
  • the stop extends like a collar around the pump axis and is formed, for example, by at least one inner ring collar, which is preferably subdivided in the circumferential direction, then on the one hand there is very high strength with small dimensions and on the other hand the stop can be used for additional mutual guidance of pump pistons and Pump cylinders are used on at least one partial stroke. In addition, relatively high spring forces of the stop can be achieved through this design.
  • the stop is designed in the manner of a resiliently expandable clamp, which is formed in particular by at least two partially sleeve-shaped spring arms, so that a very precise mutual alignment of the stop and the pump cylinder is possible.
  • the stop is formed by a component separate from the pump piston and fastened in a holder, since different components are then used to achieve this Partial volumes different stops can be attached to one and the same discharge device.
  • the stop can be formed by a sleeve-shaped stop body, which in particular has an end wall and the spring arms projecting therefrom, the stop body preferably being fastened by being blown into a retaining clip that engages around the outer circumference.
  • the mutual alignment of the pump cylinder and the pump piston, at least in the area of the respective stop position, can be significantly improved in that a centering guide is provided in front of the stop surface of the stop, which is preferably formed by at least one conical inner surface of the stop body on which the pump cylinder is expedient runs with a peripheral edge that is sharp angled in cross section.
  • the media store is expediently formed directly by the pump cylinder, which in this case is cup-shaped and can be closed at the bottom by a bottom wall formed in one piece with its jacket.
  • This pump cylinder is advantageously designed as a separate vessel from the rest of the discharge device, which is closed at its open end with a suitable closure, for example with a zipper designed in the manner of a crimp closure. After opening this cap, the container filled with medium can be placed on the pump piston. The medium to be discharged is thus transported in a vessel forming the pump chamber, stored and kept ready for consumption and then discharged with the discharge device directly out of this vessel via the outlet channel through the discharge opening.
  • the training can be provided in this way be that the vessel is drawn off from the pump piston after being pumped empty and replaced by a new, still filled vessel.
  • the base body is formed by the actuating handle, which preferably receives the stop in a discharge nozzle projecting over an end wall, a piston shaft forming the pump piston lying within the handle and on the inside of the end wall carrying the discharge nozzle, so that in addition only three separate components for the discharge device are required for the vessel. If the stop is formed in one piece with the base body, only two such components are required.
  • the example in the manner of a freewheel which releases the respective continuation of the pump stroke, but which prevents pull-back movements, can be formed in a very simple manner directly by the stop, which is preferably an annular shoulder of the Pump cylinder engages like a barb when the pump piston has been moved in the direction of the pump stroke while overcoming the stop detent beyond the associated stop position.
  • the design according to the invention is particularly suitable for discharge devices in which the discharge opening is designed as a spray nozzle.
  • the discharge opening is designed as a spray nozzle.
  • two limited partial volumes or two stroke-limited partial strokes can be provided, each partial volume being intended for use in one of the two nostrils of the user and only the first stop position being designed to be overcome.
  • the discharge device shown in FIGS. 1 to 3 is designed for the discharge of relatively small amounts of media in the order of less than one ml and can, for example, have a length in the order of only about 5 cm.
  • the discharge device 1 consists exclusively of plastic parts, which are expediently produced by injection molding and are only connected to one another by plugging them together.
  • the discharge device 1 has a base body 2 designed in the manner of a housing, which carries a media reservoir 3 which can be moved relative to it and a thrust piston pump 4.
  • the thrust piston pump 4 has a pump cylinder 5 which is formed directly by the media reservoir 3 and which lies essentially within the base body 2 and is formed by a vessel which is cylindrical over most of its length.
  • the base body 2 carries a pump piston 6 rigidly connected to it, to which the inner surface of the pump cylinder 5 is assigned as piston raceway 7.
  • a pump chamber 8, which is at the same time the storage space of the media store 3, is delimited at one end by the pump piston 6 in the pump cylinder 5.
  • An outlet channel 9 extends from the inner end face of the pump piston 6, the valve-free is guided up to a discharge opening 10 leading into the open, which is formed by an atomizing nozzle.
  • the pump piston 6 can be moved relative to the pump cylinder 5 only by means of a single full pump stroke 11, through which the pump cylinder 5 or the media store 3 is essentially completely emptied and which by means of a limiting device to be described, in two partial strokes 12 of approximately the same length, 13 is divided.
  • the base body 2 forms an actuating handle 14, which is essentially formed by the outer end face of an oval end wall 15.
  • a discharge nozzle 16 which is in the axis of the thrust piston pump 4 and which is formed in one piece with the base body 2 and has the discharge opening 10 in its end face, projects beyond the outside thereof.
  • a cap jacket 17 which is oval in view of the end wall 15 and has an axial extent of the order of that of the discharge port 16, preferably slightly larger in comparison to the discharge port 16.
  • the pump cylinder 5 or the media store 3 projects with part of its length beyond the open end of the cap jacket 17, while after the pump stroke 11 or the first partial stroke 12 has been carried out, it extends completely within the Cap jacket 17 lies.
  • the cap jacket 17 is provided with two opposing finger openings 18, which are designed so that they can hold the thumb of the hand of a user who puts the index finger and the middle finger of this hand on both sides of the discharge nozzle 16 on the outside of the end wall 15 or on the actuating handle 14 formed by this.
  • the pump cylinder 5 is displaced with respect to the pump piston 6 or the base body 2 and medium is displaced from the pump chamber 8 through the discharge channel 9 and sprayed out through the discharge opening 10.
  • the substantially hollow or tubular discharge nozzle 16 has a piston sleeve 19 formed in one piece with it and lying within it at a radial distance, which projects beyond the end wall 15 both outwardly and inwardly into the cap jacket 17 and which the piston inserted into it 6 wears.
  • the rear end of the piston 6 is extended to a piston shaft 20 which is formed in one piece with it and has approximately the same outer cross-sections, which only protrudes by the length of the discharge nozzle relative to the end face of the discharge nozzle 16 and with its associated end surface on an inner shoulder of the discharge nozzle 16 bears in such a way that a swirl device for the medium is formed between this end face and the discharge nozzle 16.
  • the outlet channel is formed by a central longitudinal bore which passes directly behind the end of the piston sleeve 19 at the pump piston 6 via a transverse bore into a main section of the outlet channel 9, which extends between the outer circumference of the piston skirt 20 and the inner circumference of the piston sleeve 19 is limited and can be formed, for example, by at least one longitudinal groove on the outer circumference of the piston skirt 20.
  • the pumping piston 6 has at least one, in particular two, ring-shaped piston lips 21, one behind the other, which are formed in one piece with it, the front of which is provided directly after the front end face of the pumping piston 6, while the rear, small distance from the associated end of the piston sleeve 19 Has.
  • the pump cylinder 5 or the media reservoir 3 is closed at its end opposite the pump piston 6 with a cylinder base 22 which is formed in one piece with the rest of the pump cylinder 5 and is curved inward in the manner of a spherical cap such that it has a thumb cavity on the outside for engaging the Thumb tip of the user's hand and on the inside forms a correspondingly curved elevation.
  • the front end surface of the pump piston 6 is provided with a recess which is adapted to this elevation and has the same shape, the bottom surface of which strikes the cylinder base 22 at the end of the full pump stroke 11, so that virtually no residual amount of the medium to be discharged remains in the pump cylinder 5.
  • the open end of the pump cylinder 5 facing away from the cylinder base 22 is approximately at the level of the end wall 15.
  • the pump cylinder 5 has a substantially cylindrical annular collar 23 which is formed in one piece with it and projects beyond its other outer circumference and which can serve as a fastening collar for receiving a tear-open closure of the media store 3.
  • the outer diameter of the piston sleeve 19 is at least in its end region engaging in the pump cylinder 5 approximately as large as the inner diameter of the piston raceway 7 or the outer diameter of the piston lips 21 or, on the other hand, only slightly smaller, this freely projecting end of the piston sleeve 19 practically in every functional position Thrust piston pump 4 engages in the pump cylinder 5.
  • the pump cylinder 5 can be guided very securely even with a relatively thin-walled design with a wall thickness of the order of magnitude of, for example, only one millimeter and at the same time stiffened by the piston rod formed by the piston sleeve 19 and the piston skirt 20.
  • a limiting device 24 is provided, for which, in addition to the previously mentioned components of the discharge device 1, only a single additional component is required, so that by omitting this Component same discharge device can also be used for an undivided pump stroke.
  • This component has a number of stops one behind the other in the stroke direction, which can be smaller than or equal to the number of partial strokes by one stop, so that such a stop 25 is provided at least for all partial strokes before the last partial stroke.
  • the stop 25 or the stops lying one behind the other is assigned a counter stop 26 formed directly by the pump cylinder 5, the stop 25 having two stop surfaces 27, which are opposite one another on both sides of the pump axis 30 and are designed in the manner of inner shoulders and are curved around the pump axis 30, which as Counter abutment surface 28 is associated with the open end or end surface of the pump cylinder 5 or the annular collar 23, specifically in its radially outer region.
  • the stop surface 27 and / or the counter stop surface 28 has one Raised bevel 29 extending at least over part of its width, it also being possible for the entire stop surface 27 to be designed as a bevel.
  • the stop 25 is formed by a circumferentially divided, radially inwardly projecting ring collar 31, the ring sections of which are each provided on a spring arm 32 which projects freely approximately parallel to the pump axis 30 in the direction of the pump stroke of the pump piston 6 or is formed in one piece therewith.
  • two sections of the annular collar 31 or spring arms 32 lying opposite one another in the direction of the longer extension of the end wall 15 are provided, which according to FIG. Fig. 3 formed ring segment-shaped and the ends of which are slightly set back relative to the flat, curved longitudinal sides of the cap jacket 17 and are thus contact-free with respect to the base body 2.
  • the spring arms 32 are also each curved over an arc angle of approximately 90 ° about the pump axis 30, so that they form shell-shaped and also relatively hard resilient spring elements with a relatively small wall thickness.
  • the stop 25 or the spring arms 32 form part of a one-piece, sleeve-shaped stop body 33 which, at its end remote from the free ends of the spring arms 32, has an annular disk-shaped end wall 34 which is at a distance from the stop 25 and which is in the region of the connection of the discharge nozzle 16 rests with its outside against an annular shoulder of the base body 2 formed by the inside of the end wall 15.
  • the stop body 33 is fastened by being blasted into a holding clamp 35, which is formed in one piece with the base body 2 and is preferably formed by two ring segment-shaped clamp jaws 39, which extend from the inside of the end wall 15 stand out.
  • clamp jaws 39 which grip the stop body 33 only in the area of the spring arms 32 and also only over a small part of its length on the outside, each have an annular groove or the like on their inner sides for the engagement of a locking bead 38, which is approximately in the Level of the inside of the end wall 34 is provided on the outer circumference of the stop body 33 and is used for resilient, axially secured insertion of the stop body 33 into the retaining clip 35.
  • the stop 25 lies at a distance from the free ends of the spring arms 32 or, in the case of two partial strokes 12, 13 provided, approximately in the middle of their length.
  • the spring arms 32 form centering guides 36 for the pump cylinder 5 on their mutually facing inner surfaces, these centering guides 36 being practically formed by an inner cone tapering at an acute angle to the stop surface 27 the outer peripheral edge 37 of the open end of the pump cylinder 5 or the collar 23 is assigned as the counter surface.
  • the pump cylinder 5 is still completely outside the stop body 33 or the centering guide 36.
  • the open end of the pump cylinder 5 is immersed in the centering guide 36, so that the pump cylinder 5 except over the pump piston 6 is also guided and centered directly with respect to the stop body 33 or with respect to the base body 2.
  • the counter abutment surface 28 abuts the abutment surface 27, as a result of which considerable or at least significant resistance is opposed to the further actuation of the discharge device 1.
  • the spring arms 32 are pressed outwards as a result of the run-up slope 29 until they slide with the inner peripheral surfaces of the annular collars 31 adjoining the run-up coulters 29 on the outer circumference of the pump cylinder 5 or the annular collar 23.
  • the second partial stroke 13 begins.
  • the counter-stop surface 28 can strike another stop surface 27 'of the stop body 33, this stop surface 27' being expediently formed by the inside of the end wall 34 and so arranged that at the same time the front end surface of the pump piston 6 strikes the cylinder base 22.
  • the end wall 34 is penetrated by the piston sleeve 19 or the piston rod, so that it can help stabilize its position.
  • a pull-off protection 40 is provided.
  • this has at least one locking shoulder 41 which is essentially fixed in the lifting direction with respect to the base body 2 and to which a counter shoulder 42 is assigned on the pump cylinder 5 such that this counter shoulder 42 is engaged by the locking shoulder 41 in the locked position.
  • the resiliently expandable locking shoulder 41 in the manner of locking pliers can be formed in a simple manner by the shoulder surface of the annular collar 31 which faces away from the stop surface 27 or the stop surface 27 'and which is at a distance from the stop surface 27', which is essentially the same as is the axial extent of the collar 23 of the pump cylinder 5.
  • this handle 14a in the embodiment according to FIGS. Fig. 4 concave hollowed finger depressions formed, which rise from the narrow ends of the end wall in each case over an arc angle of about 90 ° to the discharge nozzle 16a.
  • the discharge device 1a lies very securely in the hand.

Landscapes

  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Reciprocating Pumps (AREA)
  • Lubricants (AREA)
  • Coating Apparatus (AREA)

Claims (11)

  1. Dispositif d'évacuation (1) pour fluides, avec un corps de base (2) pour le logement d'un réservoir de fluide (3) et une pompe à piston plongeur de poussée (4) qui présente un piston plongeur (6) guidé pouvant se déplacer sur la voie de glissement du piston plongeur (7) d'un cylindre de pompe (5) entre une position de sortie (fig. 2) et une position de fin de course ainsi qu'une chambre de pompe (8) délimitée par le cylindre de la pompe (5) et le piston plongeur (6) et reliée à un orifice d'évacuation (10) du dispositif (1) par un canal de sortie (9), le piston plongeur (6) et le cylindre de la pompe (5) étant disposés de manière à pouvoir se déplacer réciproquement d'une course partielle limitée par au moins une butée (25), caractérisé en ce que la butée prévue au minimum (25) est séparée de la voie de glissement du piston plongeur (7).
  2. Dispositif d'évacuation selon la revendication 1 caractérisé en ce que la butée prévue au minimum (25) s'étend au maximum jusqu'à la voie de glissement du piston plongeur (7) et est prévue pour la formation d'un limiteur de course (24) destiné à réduire le volume à évacuer à au moins un volume partiel, la chambre de la pompe (8) étant de préférence conçue comme la chambre de dosage déterminant le volume évacué à chaque course de la pompe (11).
  3. Dispositif d'évacuation selon la revendication 1 ou 2 caractérisé en ce que la butée (25) prévue au minimum se trouva essentiellement à l'extérieur de la voie de glissement du piston plongeur (7), en particulier contre la face externe du cylindre de la pompe (5).
  4. Dispositif d'évacuation selon une des revendications précédentes caractérisé en ce qu'une contre-butée (26) est affectée à la butée prévue au minimum (25), comme butée de limitation de la course limitant la course du piston plongeur (11) à au moins une course partielle (12,13) et en ce que la butée (25) est de préférence prévue sur une composante mobile avec le piston plongeur (6) par rapport au cylindre de la pompe (5) tandis que la contre-butée (26) est en particulier formée par le cylindre de la pompe (5).
  5. Dispositif d'évacuation selon une des revendications précédentes caractérisé en ce qu'une position de limitation déterminée par la butée (25) prévue au minimum: pour l'évacuation d'un volume partiel (13) est conçue de manière à pouvoir être déclenchée, en particulier comme taquet qui peut être franchi avec une force d'actionnement de la pompe prédéterminée, la butée (25) étant de préférence à ressort, en particulier disposée sur un bras à ressort (32) presque parallèle à l'axe de la pompe (30) et/ou présentant un plan incliné de contact (29) pour la contre-butée (28).
  6. Dispositif d'évacuation selon une des revendications précédentes caractérisé en ce que la butée (25) prévue au minimum se trouve à l'extérieur du cylindre de la pompe (5) ou est affectée à une surface extrême du cylindre de la pompe (5) conçue comme surface de contre-butée (28) et en ce que la butée (25) se trouve en particulier dans une pièce de prise destinée à l'actionnement (14) en cuvette pour la pompe à piston plongeur de poussée (4), la butée (25) s'étendent de préférence autour de l'axe de la pompe (30) ou étant formé par au moins un collet annulaire interne (31) qui est divisé dans le sens de sa circonférence.
  7. Dispositif d'évacuation selon une des revendications précédentes caractérisé en ce que la butée (25) prévue au minimum est conçue comme une bride pouvant être écartée par ressort, en particulier est formée de deux bras à ressort (32) en forme de douille partielle, la butée (25) se composant de préférence d'un élément d'arrêt (33) en forme de manchon qui comporte en particulier une paroi externe (34) ainsi que les bras à ressort (32) écartés de celui-ci et/ou est fixée par pénétration dans une bride de retenue (35) entourant sa périphérie externe.
  8. Dispositif d'évacuation selon une des revendications précédentes caractérisé en ce qu'une glissière de centrage (36) est prévue pour l'orientation réciproque du cylindre de la pompe (5) et du piston plongeur (6) ou du corps de base (2) avant la butée (25) prévue au minimum ou sa surface de butée (27) et est de préférence formée par au moins une surface interne conique de l'élément d'arrêt (33).
  9. Dispositif d'évacuation selon une des revendications précédentes caractérisé en ce que le réservoir de fluide (3) est formé par le cylindre de la pompe (5), en particulier en cuvette, fermée à hauteur du fond du cylindre (22) qui est de préférence conçu comme un récipient séparé à placer sur le piston plongeur (6) après ouverture d'un couvercle.
  10. Dispositif d'évacuation selon une des revendications précédentes caractérisé en ce que le corps de base (2) est formé par la pièce de prise destinée à l'actionnement (14) qui loge de préférence dans un embout d'expulsion (16) en saillie une tige de piston (20) formant le piston plongeur (6) situé à l'intérieur de la pièce de prise (14) et la butée (25) sur sa face interne d'une paroi frontale (15) portant l'embout d'expulsion (16).
  11. Dispositif d'évacuation selon une des revendications précédentes caractérisé par une sécurité contre une course de retour ou l'extraction (40) pour le cylindre de la pompe (5) situé à l'extrémité d'au moins une course partielle (13) ou de la course de la pompe (11), la sécurité contre l'extraction (40), étant en particulier formée par la butée (25) qui saisit de préférence par l'arrière un contre-épaulement (32) du cylindre de la pompe (5) à la manière d'un barbelé.
EP88116290A 1987-10-10 1988-10-01 Dispositif de distribution de fluide Expired - Lifetime EP0311863B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT88116290T ATE84229T1 (de) 1987-10-10 1988-10-01 Austragvorrichtung fuer fliessfaehige medien.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873734306 DE3734306A1 (de) 1987-10-10 1987-10-10 Austragvorrichtung fuer fliessfaehige medien
DE3734306 1987-10-10

Publications (3)

Publication Number Publication Date
EP0311863A2 EP0311863A2 (fr) 1989-04-19
EP0311863A3 EP0311863A3 (en) 1990-01-24
EP0311863B1 true EP0311863B1 (fr) 1993-01-07

Family

ID=6338050

Family Applications (1)

Application Number Title Priority Date Filing Date
EP88116290A Expired - Lifetime EP0311863B1 (fr) 1987-10-10 1988-10-01 Dispositif de distribution de fluide

Country Status (5)

Country Link
US (1) US4946069A (fr)
EP (1) EP0311863B1 (fr)
JP (1) JP2660561B2 (fr)
AT (1) ATE84229T1 (fr)
DE (2) DE3734306A1 (fr)

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0443192A2 (fr) * 1990-02-22 1991-08-28 Ing. Erich Pfeiffer GmbH & Co. KG Tête de distribution pour fluides
WO1992000812A1 (fr) * 1990-07-04 1992-01-23 Ing. Erich Pfeiffer Gmbh & Co. Kg Applicateurs de milieux
EP0477563A2 (fr) * 1990-09-27 1992-04-01 Ing. Erich Pfeiffer GmbH Distributeur de fluide
FR2668082A1 (fr) * 1990-10-18 1992-04-24 Step Soc Tech Pulverisation Dispositif de distribution ou de pulverisation sans reprise d'air d'un produit fluide, et son procede de montage.
US5171219A (en) * 1989-06-08 1992-12-15 Sumitomo Pharmaceuticals Co., Ltd. Pharmaceutical preparation administrator
WO1993000172A1 (fr) * 1991-06-26 1993-01-07 Valois (Societe Anonyme) Dispositif pour projeter une dose predeterminee d'un produit fluide, et son procede de remplissage
FR2678906A1 (fr) * 1991-07-10 1993-01-15 Valois Dispositif pour projeter une dose predeterminee d'un produit fluide, et son procede de remplissage.
EP0580897A1 (fr) * 1992-06-03 1994-02-02 ELETTRO PLASTICA S.p.A. Pulvérisateur nasal d'une dose unique de médicament liquide
US5307953A (en) * 1991-12-03 1994-05-03 Glaxo Group Limited Single dose dispenser having a piercing member
US5427280A (en) * 1990-03-14 1995-06-27 Ing. Erich Pfeiffer Gmbh & Co. Kg Media dispenser with dosing stroke limiter
US5431155A (en) * 1992-06-03 1995-07-11 Elettro Plastica S.P.A. Single-dose nasal dispenser for atomized liquid drugs
WO1998030335A1 (fr) 1997-01-09 1998-07-16 Ing. Erich Pfeiffer Gmbh Dispositif pour decharger des substances coulantes a l'aide d'une pompe a piston de poussee
US5893484A (en) * 1995-07-14 1999-04-13 Ing. Erich Pfeiffer Gmbh Discharge device for fluid media, particularly for single-stroke only discharge
EP1078694A2 (fr) 1999-08-25 2001-02-28 Ing. Erich Pfeiffer GmbH Distributeur à actionnement manuel
US6257457B1 (en) 1997-03-26 2001-07-10 Valois S.A. Device for spraying a fluid product, such as a double dose dispenser
WO2002074336A2 (fr) 2001-02-23 2002-09-26 Glaxosmithkline Biologicals S.A. Vaccin
WO2007068907A2 (fr) 2005-12-13 2007-06-21 Glaxosmithkline Biologicals Sa Nouvelle composition
DE19700437B4 (de) * 1996-01-23 2008-01-03 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für fließfähige Medien mittels einer Schubkolbenpumpe
WO2011051445A1 (fr) 2009-10-30 2011-05-05 Glaxosmithkline Biologicals S.A. Procédé de préparation d'un virus de semence de la grippe pour la fabrication de vaccins
EP2397153A1 (fr) 2005-03-23 2011-12-21 GlaxoSmithKline Biologicals S.A. Nouvelle Composition
EP2422810A1 (fr) 2006-07-17 2012-02-29 GlaxoSmithKline Biologicals s.a. Vaccin anti-grippal
WO2012055951A2 (fr) 2010-10-27 2012-05-03 Glaxosmithkline Biologicals S.A. Composition immunogène
EP2455101A2 (fr) 2007-04-20 2012-05-23 GlaxoSmithKline Biologicals S.A. Vaccin contre la grippe avec adjuvant d'huile-en-eau
WO2013139655A1 (fr) 2012-03-23 2013-09-26 Glaxosmithkline Biologicals S.A. Vaccins antigrippe
WO2017149054A1 (fr) 2016-03-02 2017-09-08 Glaxosmithkline Biologicals S.A. Nouveaux antigènes de la grippe
WO2017167768A1 (fr) 2016-03-28 2017-10-05 Glaxosmithkline Biologicals S.A. Nouvelle composition vaccinale
US10940274B2 (en) 2015-12-01 2021-03-09 Cipla Limited Nasal spray assembly
WO2023274860A1 (fr) 2021-06-28 2023-01-05 Glaxosmithkline Biologicals Sa Nouveaux antigènes de la grippe
WO2024133065A2 (fr) 2022-12-20 2024-06-27 Glaxosmithkline Biologicals Sa Nouveaux antigènes de la grippe

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5257726A (en) * 1985-08-14 1993-11-02 Ing. Erich Pfeiffer Gmbh & Co. Kg Dispenser for flowable media
DE4005527C2 (de) * 1990-02-22 2003-04-30 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien mit einer handbetätigten Pumpe
US5395032A (en) * 1989-02-22 1995-03-07 Ing. Erich Pfeiffer Gmbh & Co. Kg Dispenser for media
DE4005528C2 (de) * 1990-02-22 1998-01-15 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
DE4027672A1 (de) * 1990-08-31 1992-03-05 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer medien
IT1244803B (it) * 1990-11-21 1994-09-05 Promo Pack S A Erogatore-spruzzatore monodose per la somministrazione endonasale di medicamenti liquidi.
IT1253173B (it) * 1991-08-02 1995-07-10 Rosaria Galli Contenitore-nebulizzatore endonasale avente incorporato un dispositivodi servoerogazione atto ad assicurare la efficace somministrazione in due tempi.
ES2118226T3 (es) * 1992-02-07 1998-09-16 Procter & Gamble Envase con bomba de pulverizacion que emplea multiples orificios para distribuir liquido con distintas configuraciones de pulverizacion con carrera de bombeo optimizada ajustada automaticamente para cada configuracion.
US5433343A (en) * 1993-07-30 1995-07-18 Meshberg; Philip Delivery system for measured quantities of liquids, especially medications
US5516006A (en) * 1993-07-30 1996-05-14 Meshberg; Philip Nasal dispenser
US5385303A (en) * 1993-10-12 1995-01-31 The Procter & Gamble Company Adjustable aerosol spray package
DE19502725B4 (de) * 1995-01-28 2004-03-04 Ing. Erich Pfeiffer Gmbh & Co Kg Austragvorrichtung für Medien
DE19642976A1 (de) * 1996-10-18 1998-04-23 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
DE19749514A1 (de) 1997-11-08 1999-05-12 Pfeiffer Erich Gmbh & Co Kg Verfahren zum Ausbringen von wenigstens zwei verschiedenen Medien und Spender dafür
DE19807922A1 (de) * 1998-02-25 1999-08-26 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
DE29811242U1 (de) * 1998-06-24 1999-11-04 Fritz Albert Riegler GmbH & Co. KG, 64367 Mühltal Applikations-Vorrichtung für keimfreie Fluide
ES2214204T3 (es) * 1999-10-14 2004-09-16 Becton, Dickinson And Company Dispositivo de administracion nasal que incluye una boquilla de pulverizacion.
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
US20060083691A1 (en) * 2000-05-10 2006-04-20 Wermeling Daniel P Intranasal opioid compositions, delivery devices and methods of using same
US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
AU2001286518A1 (en) * 2000-08-15 2002-02-25 University Of Kentucky Research Foundation Programmable multi-dose intranasal drug delivery device
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
IL159154A0 (en) * 2001-06-15 2004-06-01 Akzo Nobel Nv Dispenser for administration of a pharmaceutical fluid
US7021561B2 (en) 2001-12-18 2006-04-04 Becton, Dickinson And Company Spray device and method
GB0204829D0 (en) * 2002-03-01 2002-04-17 Glaxo Group Ltd A fluid dispensing device
AU2003224153B8 (en) * 2002-05-09 2009-06-18 Glaxo Group Limited A fluid dispensing device
US20080220107A1 (en) * 2002-09-03 2008-09-11 Pharmacure Health Care Ab Nasal spray apparatus
AU2002333785A1 (en) * 2002-09-03 2004-03-29 Pharmacure Health Care Ab Nasal sprays
GB0302536D0 (en) * 2003-02-04 2003-03-12 Bespak Plc Container
GB0305583D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd A fluid dispensing device
GB0309354D0 (en) * 2003-04-24 2003-06-04 Glaxo Group Ltd Nozzle for a nasal inhaler
GB2403153A (en) * 2003-06-26 2004-12-29 Bespak Plc Hand held nasal dispensing device
GB0405477D0 (en) * 2004-03-11 2004-04-21 Glaxo Group Ltd A fluid dispensing device
PL1699512T3 (pl) 2003-11-03 2012-11-30 Glaxo Group Ltd Urządzenie do dozowania płynów
GB0400804D0 (en) 2004-01-14 2004-02-18 Innoscience Technology Bv Pharmaceutical compositions
DE102005009295A1 (de) * 2004-07-13 2006-02-16 Ing. Erich Pfeiffer Gmbh Dosiervorrichtung für Medien
GB0507224D0 (en) * 2005-04-09 2005-05-18 Glaxo Group Ltd A fluid dispensing device
GB0515592D0 (en) 2005-07-28 2005-09-07 Glaxo Group Ltd Nozzle for a nasal inhaler
US20070212307A1 (en) * 2006-02-10 2007-09-13 Daniel Wermeling Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same
GB2441129B (en) 2006-08-26 2008-11-26 Norwich Pharma Technologies Ltd Dosage Dispensing Canister
JP5877939B2 (ja) 2007-01-19 2016-03-08 ハナンヤ イーエイチエフ 治療薬を送達するための方法および組成物
US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
US9180261B2 (en) 2010-01-12 2015-11-10 Dance Biopharm Inc. Preservative free insulin formulations and systems and methods for aerosolizing
US20130269684A1 (en) 2012-04-16 2013-10-17 Dance Pharmaceuticals, Inc. Methods and systems for supplying aerosolization devices with liquid medicaments
DE102011005820A1 (de) * 2011-03-18 2012-09-20 Ing. Erich Pfeiffer Gmbh Austragvorrichtung
CN103533953A (zh) 2011-05-17 2014-01-22 葛兰素史密丝克莱恩生物有限公司 针对肺炎链球菌的疫苗
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
FR3052690B1 (fr) * 2016-06-20 2018-06-22 Aptar France Sas Dispositif de distribution de produit fluide.
USD828543S1 (en) * 2017-08-01 2018-09-11 Khanquer Pharma, Inc. Dual nostril nasal spray device
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
GB2570319B (en) 2018-01-19 2021-01-06 Consort Medical Plc A medicament delivery device
WO2021142238A1 (fr) 2020-01-10 2021-07-15 First Wave Bio, Inc. Niclosamide deutéré
US10980756B1 (en) 2020-03-16 2021-04-20 First Wave Bio, Inc. Methods of treatment
US20230190684A1 (en) 2020-03-16 2023-06-22 First Wave Bio, Inc. Methods of treating covid-19 with a niclosamide compound
FR3108536B1 (fr) 2020-03-30 2022-06-17 Aptar France Sas Dispositif de distribution de produit fluide, en particulier pour un nombre limité de doses
US12102445B2 (en) 2020-05-06 2024-10-01 Janssen Pharmaceuticals, Inc. Monitoring and communicating information using drug administration devices
US12051495B2 (en) 2020-05-06 2024-07-30 Janssen Pharmaceuticals, Inc. Patient monitoring using drug administration devices
US11607216B2 (en) 2020-05-06 2023-03-21 Janssen Pharmaceuticals, Inc. Adaptive responses from smart packaging of drug delivery absorbable adjuncts
US12062423B2 (en) 2020-05-06 2024-08-13 Janssen Pharmaceuticals, Inc. Drug administration devices that communicate with surgical hubs
US12239460B2 (en) 2020-05-06 2025-03-04 Janssen Pharmaceuticals, Inc. Controlling operation of drug administration devices using surgical hubs
USD993389S1 (en) * 2020-07-08 2023-07-25 Aptar France Sas Nasal spray device
USD993390S1 (en) * 2020-07-08 2023-07-25 Aptar France Sas Nasal spray device
USD989280S1 (en) * 2020-08-05 2023-06-13 Aptar France Sas Nasal spray device
USD994115S1 (en) * 2020-08-05 2023-08-01 Aptar France Sas Nasal spray device
USD994114S1 (en) * 2020-08-05 2023-08-01 Aptar France Sas Nasal spray device
WO2022049086A1 (fr) 2020-09-01 2022-03-10 Janssen Pharmaceutica Nv Dispositifs d'administration de médicament à tête de distribution multiple
US20230321366A1 (en) 2020-09-01 2023-10-12 Janssen Pharmaceutica Nv Drug delivery devices with a mechanical stop
WO2022049102A1 (fr) 2020-09-01 2022-03-10 Janssen Pharmaceutica Nv Dispositifs d'administration de médicament avec destruction de médicament embarquée
WO2022049076A1 (fr) 2020-09-01 2022-03-10 Janssen Pharmaceutica Nv Dispositif d'administration de médicament multidose rechargeable
WO2022049136A1 (fr) 2020-09-01 2022-03-10 Janssen Pharmaceutica Nv Systèmes et procédés d'administration de médicament et médicaments
USD990660S1 (en) * 2021-01-19 2023-06-27 Aptar France Sas Nasal spray device
WO2022212365A1 (fr) 2021-03-29 2022-10-06 Chimerix, Inc. Nucléosides de pyrrolopyrimidine pour le traitement ou la prévention d'une infection par sras-cov-2
USD981553S1 (en) * 2021-06-10 2023-03-21 Lindal France Sas Nasal diffuser
USD974543S1 (en) * 2021-11-10 2023-01-03 Nemera La Verpilliere Nasal spray device
CN116650774B (zh) * 2023-07-31 2023-09-26 成都普什医药塑料包装有限公司 一种医用雾化器

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1670570A (en) * 1926-03-19 1928-05-22 George N Hein Inverted hypodermic syringe
US1926367A (en) * 1931-06-05 1933-09-12 Booth John Bertram Liquid and semiliquid container
FR805024A (fr) * 1935-07-29 1936-11-09 Pompe pour le lavage de cavités anatomiques telles que les fosses nasales
US2474496A (en) * 1947-06-26 1949-06-28 Rayman Lawrence Syringe
FR949453A (fr) * 1947-07-08 1949-08-31 Dispositif d'emmagasinage et de pulvérisation pour produits liquides
US2578812A (en) * 1947-12-20 1951-12-18 Kollsman Paul Injection syringe
US2856925A (en) * 1956-01-13 1958-10-21 Easton Syringe structure
FR1577954A (fr) * 1968-04-09 1969-08-14
US3923059A (en) * 1971-07-01 1975-12-02 Ims Ltd Medicament injector
US3934586A (en) * 1975-01-22 1976-01-27 Easton Fred H Non-refillable multiple dosage syringe
SE7502318L (sv) * 1975-03-03 1976-09-06 Af Ekenstam Thuresson Bo Emballage for flytande till halvfasta material, passande for smerre kvantiteter
US4175704A (en) * 1976-02-17 1979-11-27 Cohen Milton J Non-aerosol continuous spray dispenser
JPH024074Y2 (fr) * 1979-03-24 1990-01-30
DE7916475U1 (de) * 1979-06-08 1979-10-18 Hoechst Ag, 6000 Frankfurt Spriihapplikator
DE3315334A1 (de) * 1983-04-28 1984-10-31 Pfeiffer Erich Gmbh & Co Kg Zerstaeuber- oder dosierpumpe
DE3445562A1 (de) * 1984-12-14 1986-06-19 Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell Schubkolben-pumpe fuer wirkstoff-spender
DE8526339U1 (de) * 1985-09-14 1987-05-07 Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell Austragvorrichtung für fließfähige Medien
US4820272A (en) * 1987-09-02 1989-04-11 Palmer Michele M Non-reusable hypodermic syringe
US4758232A (en) * 1987-09-08 1988-07-19 Chak Choi K Suction syringe with an automatic locking means

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171219A (en) * 1989-06-08 1992-12-15 Sumitomo Pharmaceuticals Co., Ltd. Pharmaceutical preparation administrator
EP0443192A3 (en) * 1990-02-22 1991-12-04 Ing. Erich Pfeiffer Gmbh & Co. Kg Discharge head for fluids
EP0443192A2 (fr) * 1990-02-22 1991-08-28 Ing. Erich Pfeiffer GmbH & Co. KG Tête de distribution pour fluides
US5427280A (en) * 1990-03-14 1995-06-27 Ing. Erich Pfeiffer Gmbh & Co. Kg Media dispenser with dosing stroke limiter
WO1992000812A1 (fr) * 1990-07-04 1992-01-23 Ing. Erich Pfeiffer Gmbh & Co. Kg Applicateurs de milieux
EP0827782A2 (fr) * 1990-07-04 1998-03-11 Ing. Erich Pfeiffer GmbH Distributeur de fluides
US5437397A (en) * 1990-09-27 1995-08-01 Ing. Erich Pfeifer Gmbh & Co. Kg Media dispenser with loadable medium reservoir
EP0477563A2 (fr) * 1990-09-27 1992-04-01 Ing. Erich Pfeiffer GmbH Distributeur de fluide
EP0477563A3 (en) * 1990-09-27 1992-05-20 Ing. Erich Pfeiffer Gmbh & Co. Kg Fluid dispenser
FR2668082A1 (fr) * 1990-10-18 1992-04-24 Step Soc Tech Pulverisation Dispositif de distribution ou de pulverisation sans reprise d'air d'un produit fluide, et son procede de montage.
WO1993000172A1 (fr) * 1991-06-26 1993-01-07 Valois (Societe Anonyme) Dispositif pour projeter une dose predeterminee d'un produit fluide, et son procede de remplissage
FR2678906A1 (fr) * 1991-07-10 1993-01-15 Valois Dispositif pour projeter une dose predeterminee d'un produit fluide, et son procede de remplissage.
US5307953A (en) * 1991-12-03 1994-05-03 Glaxo Group Limited Single dose dispenser having a piercing member
US5431155A (en) * 1992-06-03 1995-07-11 Elettro Plastica S.P.A. Single-dose nasal dispenser for atomized liquid drugs
EP0580897A1 (fr) * 1992-06-03 1994-02-02 ELETTRO PLASTICA S.p.A. Pulvérisateur nasal d'une dose unique de médicament liquide
US5893484A (en) * 1995-07-14 1999-04-13 Ing. Erich Pfeiffer Gmbh Discharge device for fluid media, particularly for single-stroke only discharge
DE19700437B4 (de) * 1996-01-23 2008-01-03 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für fließfähige Medien mittels einer Schubkolbenpumpe
WO1998030335A1 (fr) 1997-01-09 1998-07-16 Ing. Erich Pfeiffer Gmbh Dispositif pour decharger des substances coulantes a l'aide d'une pompe a piston de poussee
EP1219356A2 (fr) 1997-01-09 2002-07-03 Ing. Erich Pfeiffer GmbH Dispositif de décharge de fluides utilisant une pompe à piston
US6257457B1 (en) 1997-03-26 2001-07-10 Valois S.A. Device for spraying a fluid product, such as a double dose dispenser
EP1078694A2 (fr) 1999-08-25 2001-02-28 Ing. Erich Pfeiffer GmbH Distributeur à actionnement manuel
DE19940236A1 (de) * 1999-08-25 2001-03-08 Pfeiffer Erich Gmbh & Co Kg Spender mit manuell betätigbarer Ausbringeinrichtung
US6446839B1 (en) 1999-08-25 2002-09-10 Ing. Erich Pfeiffer Gmbh Dispenser with manually operable discharge device
WO2002074336A2 (fr) 2001-02-23 2002-09-26 Glaxosmithkline Biologicals S.A. Vaccin
EP2269639A2 (fr) 2001-02-23 2011-01-05 GlaxoSmithKline Biologicals s.a. Formulations de vaccins contre la grippe dispositif pour administration intradermique
EP2281573A2 (fr) 2001-02-23 2011-02-09 GlaxoSmithKline Biologicals s.a. Formulations de vaccins contre la grippe dispositif pour administration intradermique
EP2397153A1 (fr) 2005-03-23 2011-12-21 GlaxoSmithKline Biologicals S.A. Nouvelle Composition
WO2007068907A2 (fr) 2005-12-13 2007-06-21 Glaxosmithkline Biologicals Sa Nouvelle composition
EP2364721A1 (fr) 2005-12-13 2011-09-14 GlaxoSmithKline Biologicals S.A. Compositions vaccinales contenant un adjuvant de saponine
EP2364724A1 (fr) 2005-12-13 2011-09-14 GlaxoSmithKline Biologicals S.A. Compositions vaccinales contenant un adjuvant de saponine
EP2364723A1 (fr) 2005-12-13 2011-09-14 GlaxoSmithKline Biologicals S.A. Compositions vaccinales contenant un adjuvant de saponine
EP2364722A1 (fr) 2005-12-13 2011-09-14 GlaxoSmithKline Biologicals S.A. Compositions vaccinales contenant un adjuvant de saponine
EP2364720A1 (fr) 2005-12-13 2011-09-14 GlaxoSmithKline Biologicals S.A. Compositions vaccinales contenant un adjuvant de saponine
EP2422810A1 (fr) 2006-07-17 2012-02-29 GlaxoSmithKline Biologicals s.a. Vaccin anti-grippal
EP2455101A2 (fr) 2007-04-20 2012-05-23 GlaxoSmithKline Biologicals S.A. Vaccin contre la grippe avec adjuvant d'huile-en-eau
WO2011051445A1 (fr) 2009-10-30 2011-05-05 Glaxosmithkline Biologicals S.A. Procédé de préparation d'un virus de semence de la grippe pour la fabrication de vaccins
WO2012055951A2 (fr) 2010-10-27 2012-05-03 Glaxosmithkline Biologicals S.A. Composition immunogène
EP3560511A2 (fr) 2010-10-27 2019-10-30 GlaxoSmithKline Biologicals S.A. Composition immunogène
WO2013139655A1 (fr) 2012-03-23 2013-09-26 Glaxosmithkline Biologicals S.A. Vaccins antigrippe
US10940274B2 (en) 2015-12-01 2021-03-09 Cipla Limited Nasal spray assembly
WO2017149054A1 (fr) 2016-03-02 2017-09-08 Glaxosmithkline Biologicals S.A. Nouveaux antigènes de la grippe
WO2017167768A1 (fr) 2016-03-28 2017-10-05 Glaxosmithkline Biologicals S.A. Nouvelle composition vaccinale
WO2023274860A1 (fr) 2021-06-28 2023-01-05 Glaxosmithkline Biologicals Sa Nouveaux antigènes de la grippe
WO2024133065A2 (fr) 2022-12-20 2024-06-27 Glaxosmithkline Biologicals Sa Nouveaux antigènes de la grippe

Also Published As

Publication number Publication date
EP0311863A3 (en) 1990-01-24
DE3877309D1 (de) 1993-02-18
ATE84229T1 (de) 1993-01-15
DE3734306A1 (de) 1989-04-27
JP2660561B2 (ja) 1997-10-08
JPH01139376A (ja) 1989-05-31
US4946069A (en) 1990-08-07
EP0311863A2 (fr) 1989-04-19

Similar Documents

Publication Publication Date Title
EP0311863B1 (fr) Dispositif de distribution de fluide
DE3631341C2 (de) Zerstäuber für fließfähige Medien
DE69106486T2 (de) Sprayspender für eine Endonasendosis von flüssigen Medikamenten.
EP1637233B1 (fr) Dispositif pour délivrer, notamment pour pulvériser un fluide
DE19522451C2 (de) Vorrichtung zur Abgabe eines fließfähigen Stoffes aus einem Behälter
DE3339180C2 (de) Austragvorrichtung für Medien
EP0775530B1 (fr) Distributeur avec deux unitées à débiter
EP0516636B1 (fr) Distributeur pour milieux
DE69001223T2 (de) Wegwerfduesenadapter fuer intranasale spruehbehaelter.
EP0591182B1 (fr) Applicateurs de milieux
EP0521022B1 (fr) Applicateur pour milieux
DE4332307C1 (de) Spritze zum dosierten Abgeben von viskosen Werkstoffen, insbesondere von dentalen Werkstoffen
EP1479450A2 (fr) Dispositif de dosage avec une pompe à course unique
DE19840723A1 (de) Spender für Medien
DE4412041A1 (de) Austragvorrichtung für fließfähige Medien, insbesondere für den Austrag in nur einem Hub
DE3407648A1 (de) Behaelter zum ausbringen von dentalmassen
DE3315334A1 (de) Zerstaeuber- oder dosierpumpe
DE19944209A1 (de) Spender zum ggf. zerstäubten Ausbringen eines insbesondere flüssigen Mediums aus einem Behältnis
DE3243581C2 (de) Auftragegerät für kosmetische Präparate
EP0516635B1 (fr) Distributeur de milieux
EP1116522B1 (fr) Distributeur de fluide
EP0692313B1 (fr) Distributeur de fluide
DE19502725A1 (de) Austragvorrichtung für Medien
EP0388651B1 (fr) Dispositif pour décharger un fluide
DE3538001C2 (fr)

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT LI NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ING. ERICH PFEIFFER GMBH & CO. KG

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LI NL SE

RHK1 Main classification (correction)

Ipc: A61M 11/00

17P Request for examination filed

Effective date: 19900322

17Q First examination report despatched

Effective date: 19910625

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE FR GB IT LI NL SE

REF Corresponds to:

Ref document number: 84229

Country of ref document: AT

Date of ref document: 19930115

Kind code of ref document: T

ET Fr: translation filed
REF Corresponds to:

Ref document number: 3877309

Country of ref document: DE

Date of ref document: 19930218

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 19930129

ITF It: translation for a ep patent filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
EAL Se: european patent in force in sweden

Ref document number: 88116290.3

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20021022

Year of fee payment: 15

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20031001

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20041019

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20041025

Year of fee payment: 17

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20051002

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20060501

EUG Se: european patent has lapsed
NLV4 Nl: lapsed or anulled due to non-payment of the annual fee

Effective date: 20060501

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20061023

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20061024

Year of fee payment: 19

Ref country code: GB

Payment date: 20061024

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20061031

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20061208

Year of fee payment: 19

BERE Be: lapsed

Owner name: ERICH *PFEIFFER G.M.B.H. & CO. K.G.

Effective date: 20071031

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20071001

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20071031

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20071031

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20080501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20071031

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20080630

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20061020

Year of fee payment: 19

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20071001

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20071031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20071001