GB2403153A - Hand held nasal dispensing device - Google Patents
Hand held nasal dispensing device Download PDFInfo
- Publication number
- GB2403153A GB2403153A GB0315010A GB0315010A GB2403153A GB 2403153 A GB2403153 A GB 2403153A GB 0315010 A GB0315010 A GB 0315010A GB 0315010 A GB0315010 A GB 0315010A GB 2403153 A GB2403153 A GB 2403153A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hand held
- dispenser according
- stopper
- container
- annular collar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 39
- 229940127557 pharmaceutical product Drugs 0.000 claims abstract description 39
- 238000007789 sealing Methods 0.000 claims abstract description 27
- 239000000463 material Substances 0.000 claims description 8
- 239000004033 plastic Substances 0.000 claims description 5
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 5
- 229920001971 elastomer Polymers 0.000 claims description 4
- 239000000806 elastomer Substances 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 16
- 238000007599 discharging Methods 0.000 abstract description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920002614 Polyether block amide Polymers 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000012633 leachable Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229920003031 santoprene Polymers 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1001—Piston pumps
- B05B11/1023—Piston pumps having an outlet valve opened by deformation or displacement of the piston relative to its actuating stem
- B05B11/1025—Piston pumps having an outlet valve opened by deformation or displacement of the piston relative to its actuating stem a spring urging the outlet valve in its closed position
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Otolaryngology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Abstract
A hand held pharmaceutical dispenser for discharging a pharmaceutical product in liquid form as may be used in a nasal inhaler. The dispenser comprises first (70) and second (10) portions movable relative to each other with the first portion (70) being arranged to receive a pharmaceutical product to be dispensed and the second portion (10) having a stopper (33) to releasably engage a sealing surface (41) associated with the first portion (70) to seal a pharmaceutical product within the first portion (70). The first (70) and second (10) portions are arranged such that when they are at first relative positions the stopper (33) is arranged to engage the sealing surface (41) to seal a pharmaceutical product in the first portion (70) and when the first (70) and second (10) portions are moved to second relative positions the stopper (33) is disengaged from the sealing surface (41) such that, in use, pharmaceutical product may be dispensed from the dispenser.
Description
Dispenser This invention relates to a dispenser. In particular, this
invention relates to a hand held pharmaceutical dispenser for discharging a single dose of a pharmaceutical product in liquid form as may be used in a nasal inhaler.
S US 4,946,069 discloses a single use dispenser for discharging small quantities of liquid. This dispenser comprises a body which has a pump cylinder including a liquid reservoir containing a dose of a liquid to be dispensed and a piston arranged within the pump cylinder. The piston has an outlet channel along its length to connect the liquid reservoir with an outlet nozzle. In use the pump cylinder is displaced with respect to the piston so that liquid from the reservoir is discharged from the reservoir, through the outlet channel and out of the outlet nozzle. A disadvantage of this type of device is that since the outlet channel communicates with the outside environment, the liquid in the reservoir is not entirely closed off from the outside. There is therefore a possibility of permeation into or out of the device.
EP 0 546 607 discloses another single use dispenser. In this dispenser a container of the substance to be discharged is mounted on a piston member and a seal is arranged across the container to seal in the substance to be discharged. The dispenser has a hollow stainless steel needle which extends towards the seal such that in use the needle is arranged to penetrate through the seal and the substance to be discharged is then expelled from the container and through the hollow stainless steel needle to an outlet. A disadvantage of this type of device is that it can generate particulates when piercing. There is also the possibility of contamination of the substance to be discharged from the needle, both from the difficulty of cleaning the narrow channel within the needle and the possible presence of oils etc on the needle surface from the production of the stainless steel. Moreover, the precompression system used by this device which includes a snap ring produces a variation in the actuation force, mainly due to the manufacturing process, materials properties and tolerance stack up such that it may be difficult to force the needle through the seal resulting in awkward activation of the dispenser. Furthermore, once used there are possible safety implications from the disposal of dispensers containing sharp needles.
It is an object of the present invention to overcome the disadvantages discussed above.
According to a first aspect of the present invention there is provided a hand held pharmaceutical nasal dispenser comprising first and second portions movable relative to each other; the first portion being arranged to receive a pharmaceutical product to be dispensed and the second portion having a stopper to releasably engage a sealing surface associated with the first portion to seal a pharmaceutical product within the first 1 0 portion; the first and second portions being arranged such that when they are at first relative positions the stopper is arranged to engage the sealing surface to seal a pharmaceutical product in the first portion and when the first and second portions are moved to second relative positions the stopper is disengaged from the sealing surface such that, in use, pharmaceutical product may be dispensed from the dispenser.
The releasably engageable stopper provides a means of sealing a pharmaceutical product when the first and second portions are at first relative positions and of enabling a pharmaceutical product to be discharged when the first and second portions are moved to second relative positions, overcoming the disadvantages associated with a needle discussed above whilst still sealing the pharmaceutical product from permeation into or out of the device.
The stopper, or at least a portion of its outside surface, is preferably made from an elastomer, a plastic or a combination of the two such as a thermoplastic elastomer.
The sealing surface is preferably provided as an annular collar to receive the stopper and to form a seal with the stopper when the first and second portions are in the first relative positions.
The movement of the first and second portions from the first relative positions to the second relative positions preferably involves moving them towards each other such that, in use, the stopper is moved towards a reservoir of pharmaceutical product.
This movement assists in discharging pharmaceutical product from the first portion of the dispenser.
Embodiments of the present invention will now be described, by way of example only, with reference to the accompanying drawings, in which Figure 1 is an exploded view of a dispenser according to the present invention; Figure 2 is a cross-sectional view of the assembled dispenser before actuation; Figure 3 is a cross-sectional view of the dispenser being actuated and Figure 4 is a cross-sectional view of the dispenser after actuation.
Figure 1 shows the components of a dispenser illustrating the present invention. An actuator 10 has an outlet 11 through which a pharmaceutical product may be dispensed. The outlet 11 is provided at the end portion of a generally frusto conical shaped nozzle portion 12, which in this example has a shape and size to enable it to be easily inserted into a user's nostril. A body portion 13 connects the nozzle portion 12 to a skirt 14 which is shaped and sized to engage and be movable relative to a base portion 70. The skirt 14 has two external shoulders 15 with a shape and size to enable a user's fingers to engage them. The underside of the skirt 14 is provided with two sets of recesses (not shown in this figure) arranged to engage corresponding protrusions 72 in the base portion 70 to maintain the actuator 10 and the base portion in predetermined relative positions before and after use.
A member 20 is provided having a first end portion 21 and a second end portion 22. The first end portion 21 is arranged to be received and fixed in the actuator 10 and has a channel 23 formed along its length through which pharmaceutical product may pass to the outlet 11 of the actuator 10. The second end portion 22 is arranged to receive a sleeve 30 which in use slides over the second end portion 22 of the member 20. The second end portion 22 and the sleeve 30 are arranged such that a gap is provided between the outer surface of the second end portion 22 of the member 20 and the inner surface of the sleeve 30 through which pharmaceutical product may pass to the channel 23 and the outlet 11. A first end 31 of the sleeve 30 is arranged to engage the actuator 10. A second end 32 of the sleeve 30 supports a stopper 33. The stopper 33 provides a seal when in contact with an annular collar 40 which in use is assembled over the sleeve 30. The annular collar 40 seals with the stopper 33 when the actuator 10 and base 60 are in first relative positions.
The stopper 33, or at least a portion of its outside surface which engages a sealing surface, is made from a material which has low leachable and extractable characteristics and good resistance to gas and liquid permeability. The stopper 33 could undergo a barrier process to provide these qualities to the surface of the stopper 33. To provide these properties the stopper 33 or at least a portion of its outside surface, could be made from an elastomer, a plastic or a combination of the two such S as a thermoplastic elastomer. Examples of suitable thermoplastic elastomers include Santoprene, Pebax, Vitaprene, Hytrel or the like. The annular collar 40, or at least a portion of its outside surface which engages the stopper 33, is made from a material with similar properties to the stopper 33 and is preferably made from the same material as the stopper 33.
A resilient member, in this embodiment a spring 50, is provided on the outside surface of the sleeve 30. When the dispenser is assembled, one end of the spring SO engages the actuator 10 and the other end of the spring SO engages the annular collar as shown in figures 2, 3 and 4.
The annular collar 40 is arranged to be provided inside a container 60. The outside surface of the annular collar 40 is sized to engage and seal against the inside surface of the container 60. The container 60 may be made from any suitable material such as stainless steel, plastic or glass and contains a single dose of pharmaceutical product.
The base portion 70 has a suitably sized periphery to be received within the skirt 14 of the actuator 10 and has a support 71 to support the container 60. If desired, the container 60 and base portion 70 could be provided as a single part to reduce the number of components. Protrusions 72 are provided to be received in either of two sets of corresponding recesses on the inside of the skirt 14 of the actuator 10 to maintain the base portion 70 and actuator 10 in predetermined relative positions before and after use. The underside 73 of the base portion 70 is concave so that during use a user may conveniently grip the dispenser by placing a finger on each of the shoulders and a thumb on the concave underside 73 of the base portion 70 and dispense pharmaceutical product from the outlet 11 by squeezing the actuator 10 and base portion 70 towards each other.
Figure 2 shows a cross-sectional view of the assembled dispenser prior to actuation. The actuator 10 and base 70 are maintained in their preactuated relative positions by the protrusions 72 of the base being engaged within a first set of recesses s on the underside of the skirt 14 (not shown). If desired a tamper evident seal may be provided on the outside of the dispenser to indicate to a user that the dispenser has not been accidentally actuated prior to use. When the dispenser is actuated by the base 70 and actuator 10 being moved towards each other, the protrusions 72 of the base are forced or 'snapped' out of the first set of recesses to engage a second set of recesses 16 nearer to the shoulders 1 S on the underside of the skirt to maintain the actuator 10 and base 70 in second post-actuation relative positions preventing re-use.
Prior to use, the container 60 is provided with a single dose of pharmaceutical product, usually in liquid form. The first end portion 21 of the member 20 is inserted into the inside of the nozzle portion 12 of the actuator 10 and the sleeve 30 with the spring 50 and annular collar 40 on its outside surface is fitted over the second end portion 22 of the member 20. One end 51 of the spring 50 engages an annular surface 17 on the inside of the actuator 10 and the other end 52 of the spring 50 engages the annular collar 40. The annular collar 40 is inserted into the container 60 to form a seal between its outside surface and the inside surface of the container 60. Prior to actuation as shown in Figure 2, the stopper 33is engaged with a sealing surface 41 on a lower side of the neck of the annular collar 40 to seal the pharmaceutical product within the container 60.
Manually depressing the base portion 70 and actuator 10 of the nasal single dose dispenser together causes the member 20 and stopper 33 to move towards the bottom of the container 60. This movement causes the annular collar 40 to be driven down into the container 60, with a periphery of the annular collar 40 still maintaining a seal with the inside surface of the container 60. When the pressure within the container overcomes the force generated by the spring 50 acting on the annular collar 40, the stopper 33 unseats relative to the annular collar 40 and when openings 34 between the sleeve 30 and the stopper 33 are exposed as shown in Figure 3, liquid is forced up through a fluid flow path through openings 34, between the sleeve 30 and member 20 and out through outlet 11. The spring force therefore provides a pre compression mechanism to generate the pressure required to break up particles of pharmaceutical liquid in the container plus also provides a very smooth and repeatable operation. The action of forcing or 'snapping' the protusions 72 out of the first set of pre-actuation recesses on the skirt of the actuator 10 also generates pressure to break up particles of pharmaceutical liquid in the container and provides a very smooth and repeatable operation.
As liquid is forced out of the container 60, the force generated by the spring 50 pushes the annular collar 40 into the base of the container as shown in Figure 4.
As explained earlier, when actuated, the protrusions 72 on the base portion 70 are received in the second set of recesses 16 on the actuator 10 to maintain the actuator and the base portion 70 in predetermined postactuation relative positions preventing further use.
Many variations may be made to the example described above whilst still falling within the scope of the invention. For example the stopper 33 and annular collar 40 may be made from any suitable materials able to seal a pharmaceutical product in the container 60. Any number of the components which are shown in the above example as being separate may if desired be incorporated into a single component, such as for example the spring 50 and annular collar 40 or the actuator 10 and spring 50.
The pharmaceutical product could be any suitable fluid including, for example, a pure drug or a drug with a liquid and/or a pharmaceutical acceptable excipient.
The example described above is for a single dose liquid device. However the device could also be used as a bi-dose device, for example by including a twist action that would have a two position actuation, or a clip/button that can be used as a stop for the first actuation then removed or pushed to allow for the second actuation. Another variant could be to have a two stage button and base actuation in which the button is depressed for the first actuation, then the base is depressed for the second actuation.
Claims (14)
1. A hand held pharmaceutical nasal dispenser comprising first and second portions movable relative to each other; the first portion being arranged to receive a pharmaceutical product to be dispensed and the second portion having a stopper to releasably engage a sealing surface associated with the first portion to seal a pharmaceutical product within the first portion; the first and second portions being arranged such that when they are at first relative positions the stopper is arranged to engage the sealing surface to seal a pharmaceutical product in the first portion and when the first and second portions are moved to second relative positions the stopper is disengaged from the sealing surface such that, in use, pharmaceutical product may be dispensed from the dispenser.
2. A hand held pharmaceutical nasal dispenser according to claim 1, wherein the first portion has or is arranged to receive a container to contain a pharmaceutical product.
3. A hand held pharmaceutical nasal dispenser according to claim 2, wherein the sealing surface is provided in or on the container.
4. A hand held pharmaceutical nasal dispenser according to claim 3, wherein the sealing surface is an annular collar provided in the container.
5. A hand held pharmaceutical nasal dispenser according to claim 4, wherein a neck of the annular collar provides the sealing surface and a periphery of the annular collar forms a seal with the inside surface of the container and is movable within the container whilst still maintaining a seal with the inside surface of the container.
6. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims, wherein the dispenser is actuated by pushing the first and second portions towards each other.
7. A hand held pharmaceutical nasal dispenser according to claim 6 when dependent upon claim 5, wherein the sealing surface engageable by the stopper is provided on a side of the annular collar closest to a base of the container such that when the dispenser is actuated the stopper disengages the sealing surface and moves towards the base of the container.
8. A hand held pharmaceutical nasal dispenser according to claim 7, wherein a resilient means is provided between the annular collar and the second portion such that when the first and second portions are pushed towards each other the resilient means forces the annular collar towards the base of the container with the periphery of the annular collar maintaining a seal with the inside surface of the container as it moves within the container.
9. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims wherein the first and second portions are provided with one or more inter-engageable protrusions and recesses to maintain them in predetermined relative positions before and after actuation.
10. A hand held pharmaceutical nasal dispenser according to claim 9, wherein the first portion is provided with one or more protrusions and the second portion is provided with two sets of one or more recesses, the one or more protrusions being arranged to engage a first set of one or more recesses before actuation and the one or more protrusions being arranged to engage a second set of one or more recesses after actuation.
11. A hand held pharmaceutical nasal dispenser according to claim 9, wherein the first portion is provided with two sets of one or more recesses and the second portion is provided with one or more protrusions, the one or more protrusions being arranged to engage a first set of one or more recesses before actuation and the one or more protrusions being arranged to engage a second set of one or more recesses after actuation.
12. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims, wherein the stopper, or at least the portion of its outside surface which releasably engages the sealing surface, is made from an elastomer.
13. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims, wherein the stopper, or at least the portion of its outside surface which releasably engages the sealing surface, is made from a plastic.
14. A hand held pharmaceutical nasal dispenser substantially as hereinbefore described with reference to the accompanying drawings.
14. A hand held pharmaceutical nasal dispenser according to claim 12 and claim 13, wherein the stopper, or at least the portion of its outside surface which releasably engages the sealing surface, is made from a thermoplastic elastomer.
15. A hand held pharmaceutical nasal dispenser according to any one of claims 12, 13 or 14 wherein the sealing surface is made from the same material as the portion of the stopper with which it is releasably engageable.
16. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims, wherein the second portion has an outlet portion through which a pharmaceutical product is arranged to be dispensed and which is shaped and sized to be insertable into a user's nostril.
17. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims, arranged to dispense a single dose of pharmaceutical product.
18. A hand held pharmaceutical nasal dispenser according to any one of claims 1 to 16, arranged to dispense a bi-dose of pharmaceutical product.
19. A hand held pharmaceutical nasal dispenser substantially as hereinbefore described with reference to the accompanying drawings.
Amendments to the claims have been filed as follows
1. A hand held pharmaceutical dispenser comprising first and second portions movable relative to each other; the first portion having or being arranged to receive a container to contain a pharmaceutical product to be dispensed and having an annular collar provided in the container with a resilient means provided between the annular collar and the second portion; and the second portion having a stopper to releasably engage the annular collar to l o seal a pharmaceutical product within the container; the first and second portions being arranged such that when they are at first relative positions the stopper is arranged to engage the annular collar to seal a pharmaceutical product in the container and when the first and second portions are pushed towards each other the annular collar is driven down into the container, with a periphery of the annular collar still maintaining a seal with the inside surface of the container until the pressure within the container overcomes the force generated by the resilient member acting on the annular collar so that the stopper is disengaged from the annular collar such that, in use, pharmaceutical product may be dispensed from the dispenser.
2. A hand held pharmaceutical dispenser according to claim 1, wherein a neck of the annular collar is releasably engaged by the stopper.
3. A hand held pharmaceutical nasal dispenser according to claim 1 or claim 2, wherein the portion of the annular collar engageable by the stopper is provided on a side of the annular collar closest to a base of the container such that when the dispenser is actuated the stopper disengages the annular collar and moves towards the base of the container.
4. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims wherein the first and second portions are provided with one or more 12' inter-engageable protrusions and recesses to maintain them in predetermined relative positions before and after actuation.
5. A hand held pharmaceutical nasal dispenser according to claim 4, wherein the first portion is provided with one or more protrusions and the second portion is provided with two sets of one or more recesses, the one or more protrusions being arranged to engage a first set of the one or more recesses before actuation and the one or more protrusions being arranged to engage the second set of one or more recesses after actuation.
6. A hand held pharmaceutical nasal dispenser according to claim 4, wherein the first portion is provided with two sets of one or more recesses and the second portion is provided with one or more protrusions, the one or more protrusions being arranged to engage the first set of one or more recesses before actuation and the one or more protrusions being arranged to engage the second set of one or more recesses after actuation.
7. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims, wherein the stopper, or at least the portion of its outside surface which releasably engages the sealing surface, is made from an elastomer.
8. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims, wherein the stopper, or at least the portion of its outside surface which releasably engages the sealing surface, is made from a plastic.
9. A hand held pharmaceutical nasal dispenser according to claim 7 and claim 8, wherein the stopper, or at least the portion of its outside surface which releasably engages the sealing surface, is made from a thermoplastic elastomer.
so 10 A hand held pharmaceutical nasal dispenser according to any one of claims 7 to 9, wherein the sealing surface is made from the same material as the portion of the l stopper with which it is releasably engageable.
11. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims, wherein the second portion has an outlet portion through which a pharmaceutical product is arranged to be dispensed and which is shaped and sized to be insertable into a user's nostril.
12. A hand held pharmaceutical nasal dispenser according to any one of the preceding claims, arranged to dispense a single dose of pharmaceutical product.
13 A hand held pharmaceutical nasal dispenser according to any one of claims 1 to 1 1, arranged to dispense a bi-dose of pharmaceutical product.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0315010A GB2403153A (en) | 2003-06-26 | 2003-06-26 | Hand held nasal dispensing device |
| PCT/GB2004/002580 WO2005000477A1 (en) | 2003-06-26 | 2004-06-17 | Dispenser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0315010A GB2403153A (en) | 2003-06-26 | 2003-06-26 | Hand held nasal dispensing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB0315010D0 GB0315010D0 (en) | 2003-07-30 |
| GB2403153A true GB2403153A (en) | 2004-12-29 |
Family
ID=27637461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0315010A Withdrawn GB2403153A (en) | 2003-06-26 | 2003-06-26 | Hand held nasal dispensing device |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB2403153A (en) |
| WO (1) | WO2005000477A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2392373A1 (en) * | 2010-06-04 | 2011-12-07 | Cheng-Yuan Su | Nasal spray device |
| EP2484454A1 (en) * | 2011-02-02 | 2012-08-08 | Dispensys AG | Discharge device for flowable material |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8827946B2 (en) | 2009-07-31 | 2014-09-09 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| US9061096B2 (en) | 2009-12-16 | 2015-06-23 | Water Pik, Inc. | Powered irrigator for sinus cavity rinse |
| US8888752B2 (en) | 2009-12-16 | 2014-11-18 | Water Pik, Inc. | Bottle for sinus cavity rinse |
| US8486029B2 (en) | 2009-12-16 | 2013-07-16 | Water Pik, Inc. | Pot for sinus cavity rinse |
| US8991660B2 (en) | 2009-12-16 | 2015-03-31 | Water Pik, Inc. | Squeeze bottle for sinus cavity rinse |
| US8409152B2 (en) | 2010-06-25 | 2013-04-02 | Water Pik, Inc. | Faceted nasal seal |
| CA2806669C (en) * | 2010-07-30 | 2015-07-21 | Water Pik, Inc. | Faceted nasal seal |
| USD670373S1 (en) | 2010-12-16 | 2012-11-06 | Water Pik, Inc. | Powered irrigator for sinus cavity rinse |
| RU2594244C2 (en) | 2011-01-31 | 2016-08-10 | Син Ниппон Байомедикал Лэборэтэриз, Лтд. | Device for intranasal delivery |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2000232A (en) * | 1977-06-20 | 1979-01-04 | Foam Schaumtechnik | Dispensing valves |
| WO1982004203A1 (en) * | 1981-06-04 | 1982-12-09 | Kalat Edwin F | Pressurized container with dispensing pump |
| US5421492A (en) * | 1993-11-02 | 1995-06-06 | Glaxo Inc. | Metered aerosol dispensing apparatus and method of use thereof |
| US5450983A (en) * | 1993-03-12 | 1995-09-19 | Djs&T, Limited Partnership | Aerosol spray texture apparatus and method for a particulate containing material |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3734306A1 (en) * | 1987-10-10 | 1989-04-27 | Pfeiffer Erich Gmbh & Co Kg | DISCHARGE DEVICE FOR FLOWABLE MEDIA |
| FR2667050B1 (en) * | 1990-09-25 | 1994-05-27 | Valois | DEVICE FOR PROJECTING IN A SPRAYED OR PULSED FORM A DEFINED DOSE OF LIQUID OR VISCOUS PRODUCT, AND IN PARTICULAR A MEDICAMENT, AND METHOD FOR MAINTAINING THIS WATERPROOF DEVICE. |
| JPH06508549A (en) * | 1991-06-26 | 1994-09-29 | バロワ （ソシエテ アノニム） | Device for spraying a predetermined amount of fluid and method for filling the device |
| GB9125699D0 (en) * | 1991-12-03 | 1992-01-29 | Glaxo Group Ltd | Device |
| FR2793708B1 (en) * | 1999-05-21 | 2001-08-03 | Valois Sa | FLUID PRODUCT DISPENSING DEVICE |
| FR2793707B1 (en) * | 1999-05-21 | 2002-02-15 | Valois Sa | IMPROVED FLUID PRODUCT DISPENSING DEVICE |
-
2003
- 2003-06-26 GB GB0315010A patent/GB2403153A/en not_active Withdrawn
-
2004
- 2004-06-17 WO PCT/GB2004/002580 patent/WO2005000477A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2000232A (en) * | 1977-06-20 | 1979-01-04 | Foam Schaumtechnik | Dispensing valves |
| WO1982004203A1 (en) * | 1981-06-04 | 1982-12-09 | Kalat Edwin F | Pressurized container with dispensing pump |
| US5450983A (en) * | 1993-03-12 | 1995-09-19 | Djs&T, Limited Partnership | Aerosol spray texture apparatus and method for a particulate containing material |
| US5421492A (en) * | 1993-11-02 | 1995-06-06 | Glaxo Inc. | Metered aerosol dispensing apparatus and method of use thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2392373A1 (en) * | 2010-06-04 | 2011-12-07 | Cheng-Yuan Su | Nasal spray device |
| EP2484454A1 (en) * | 2011-02-02 | 2012-08-08 | Dispensys AG | Discharge device for flowable material |
| WO2012104199A1 (en) * | 2011-02-02 | 2012-08-09 | Dispensys Ag | Discharge device for flowable material |
| CN103561873A (en) * | 2011-02-02 | 2014-02-05 | 迪斯朋有限公司 | Discharge device for flowable material |
| US20140060523A1 (en) * | 2011-02-02 | 2014-03-06 | Alberto C. Sogaro | Discharge device for a flowable substance |
| CN103561873B (en) * | 2011-02-02 | 2016-03-16 | 苏尔寿米克斯帕有限公司 | For the discharger of flowable mass |
| US9694148B2 (en) | 2011-02-02 | 2017-07-04 | Dispensys Ag | Discharge device for a flowable substance |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0315010D0 (en) | 2003-07-30 |
| WO2005000477A1 (en) | 2005-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |