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EP0000256A1 - Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents - Google Patents

Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents Download PDF

Info

Publication number
EP0000256A1
EP0000256A1 EP78300055A EP78300055A EP0000256A1 EP 0000256 A1 EP0000256 A1 EP 0000256A1 EP 78300055 A EP78300055 A EP 78300055A EP 78300055 A EP78300055 A EP 78300055A EP 0000256 A1 EP0000256 A1 EP 0000256A1
Authority
EP
European Patent Office
Prior art keywords
teeth
cation
plaque
composition
lanthanum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP78300055A
Other languages
German (de)
English (en)
Other versions
EP0000256B1 (fr
EP0000256B2 (fr
Inventor
Gunnar Rölla
Michael Roy Carlton Winters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10241609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0000256(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of EP0000256A1 publication Critical patent/EP0000256A1/fr
Publication of EP0000256B1 publication Critical patent/EP0000256B1/fr
Application granted granted Critical
Publication of EP0000256B2 publication Critical patent/EP0000256B2/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients

Definitions

  • This invention relates to dental hygiene, and more particularly it relates to a method of cleaning teeth.
  • tooth enamel may be remineral- ised by sequential application to the teeth of a cationic and an anionic component which react below the tooth surface to form an insoluble salt.
  • a cationic component examples include ions derived from barium, lanthanum, manganese, lead, tin, zinc, indium, zirconium, iron, titanium, vanadium and cadmium (UK Patent Specification No. 1,452,125).
  • deposits such as dental plaque may be removed from the surface of teeth, or may be prevented from adhering thereto, by application of a cation of a selected group of elements.
  • a method of cleaning teeth by applying thereto a cation of one or more elements selected from yttrium, scandium and lanthanum and the lanthanides.
  • the lanthanides include cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium and lutetium. These elements are very closely related chemically since they all fall within Group IIIb of the Periodic Table. Lanthanum and the lanthanides form the first group of Inner Transition Elements within Group IIIb.
  • the method of the invention is particularly useful for cleaning teeth in human beings.
  • the efficent cleaning of teeth is, of course,of immense cosmetic value.
  • One of the substances routinely found on the surface of teeth is bacterial plaque and the method of this invention is particularly useful in removing plaque from teeth or in preventing its adhering thereto.
  • the method of the invention is also useful in removing various types of stain from teeth, for example the stain produced by smoking tobacco.
  • bacterial plaque is generally regarded as a dominant etiological factor in caries and periodontal disease and removal of plaque from teeth or prevention of its accumulation is known to have a beneficial effect in those conditions.
  • the preferred cations for use in the method of the invention are those derived from lanthanum and the lanthanides, and a particularly preferred cation is the lanthanum cation.
  • the cation When used in the method of the invention, the cation may be in the form of a salt, and preferably in the form of a water-soluble salt.
  • water soluble salts are the chloride, bromide, iodide, nitrate, acetate or sulphate.
  • the cation may-also be used in the form of a salt with an antibacterial anion.
  • the preferred compound for use in the method of the invention is lanthanum chloride, LaCl 3 .
  • the amount of cation used in the method of the invention may vary from 0.01 m.moles to 1 m.moles of cation and preferably from 0.1 m.moles to 0.5 m.moles of cation, and it may be applied from once a week to 1 to 10 times per day.
  • a preferred regime is three times per day, after meals, or failing this, twice per day, night and morning.
  • the method of the invention achieves a satisfactory result simply by application of the cation to the teeth, for example in the form of a simple aqueous solution.
  • an improved degree of cleansing can be achieved if the method of the invention is combined with one or more of the normal mechanical methods of cleaning teeth, for example if combined with the use of a toothbrush, toothpick, dental floss, dental probe or rotary dental brush.
  • a particularly preferred adjunct to the method of the invention is the use of a toothbrush.
  • the cation for use in the method of the invention may be presented in the form of a composition such as a simple aqueous solution or suspension or in the form of a more sophisticated composition such as a mouthwash, toothpaste, prophylaxis paste, toothpowder, pastille, chewing gum or oral spray, or it may be incorporated into a beverage, nutritional substance or confection. It may also be incorporated into the public water supply.
  • a composition such as a simple aqueous solution or suspension
  • a more sophisticated composition such as a mouthwash, toothpaste, prophylaxis paste, toothpowder, pastille, chewing gum or oral spray, or it may be incorporated into a beverage, nutritional substance or confection. It may also be incorporated into the public water supply.
  • compositions described above are those which are well known to those skilled in this art. They may incorporate any of the ingredients normally used in such compositions, with the addition of the cation in the form of a salt.
  • a mouthwash or oral spray the cation is incorporated at the desired user concentration.
  • a toothpaste, prophylactic paste, toothpowder, lozenge or chewing gum it may be necessary, depending on the nature of the ingredients in the composition,to increase the concentration of the cation to above the level of the desired user concentration, for example by up to five times the desired user concentration, in order to allow for incomplete availability of the cation in use as a result of specific binding of the cation to one or more of the ingredients.
  • these formulations it is preferable to use ingredients which avoid precipitation of the cation in the form of an insoluble salt.
  • a typical mouthwash has an aqueous base and generally incorporates a thickener and a flavour.
  • a gel has an aqueous base and generally incorporates a gelling agent, a surfactant, a flavour and a preservative.
  • a toothpaste has an aqueous base and generally contains an abrasive, a binder, a thickener, a surfactant, a humectant, a flavouring agent and a sweetening agent.
  • compositions for use in the method of cleaning teeth described above which is in a form for use in a non-sequential manner.
  • a form for use in a non-sequential manner we mean, for example, that the composition is presented as a single pack which is intended to be used on its own, and is not intended to be used immediately before or immediately after a second different composition in a sequential manner. It is not, for example, part of a two-component pack, and it is not a single composition which is designed to release separately two components in a sequential manner.
  • the eomposition of the invention is, for example, a simple aqueous solution or suspension, or a more sophisticated composition such as a mouthwash, toothpaste, prophylaxis paste, toothpowder, lozenge, chewing gum or oral spray which is presented in a single pack for use on its own.
  • the pack may optionally carry instructions on how the composition should be used for cleaning teeth according to the method of the invention, and such instructions may indicate that the composition should be used in a non- sequential manner.
  • the instructions will be appropriate to the nature of the composition.
  • the composition is a toothpaste the instructions may indicate that the user should use the paste as the sole agent for brushing his or her teeth.
  • the control group had a mean Plaque Index of 1.0 whereas the treated group had a mean Plaque Index of zero.
  • the very small amount of deposit which was present in the treated group was very loosely attached to the tooth surface and could be blown off with an air jet.
  • the panel was provided with new toothbrushes and instructed to brush their teeth each morning and evening for 30 seconds over a period of four days, according to each individual's own habits, with a 10 ml. test solution, and then to rinse the teeth with the remainder of the test solution.
  • the test solutions were 20 mM aqueous NaCl, 10 mM aqueous LaCl 3 , 20 mM aqueous LaCl 3 and 20 mM aqueous YC1 3 .
  • the whole experiment was carried out under double blind conditions, each person using one of the test solutions in turn. Each person's Plaque Index was brought to zero before using a new test solution.
  • the results obtained were as follows:-
  • each group brushed their teeth with 20 ml. of either a 20 mM aqueous lanthanum acetate solution or water respectively with a new soft toothbrush dipped in the respective test solution. Rinsing for 1 minute was then carried out with the remainder of the test solution. No after-rinses with water were permitted.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
EP78300055A 1977-06-23 1978-06-20 Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents Expired - Lifetime EP0000256B2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2630877 1977-06-23
GB2630877 1977-06-23

Publications (3)

Publication Number Publication Date
EP0000256A1 true EP0000256A1 (fr) 1979-01-10
EP0000256B1 EP0000256B1 (fr) 1983-04-13
EP0000256B2 EP0000256B2 (fr) 1991-09-25

Family

ID=10241609

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78300055A Expired - Lifetime EP0000256B2 (fr) 1977-06-23 1978-06-20 Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents

Country Status (19)

Country Link
US (1) US4218434A (fr)
EP (1) EP0000256B2 (fr)
JP (1) JPS5417137A (fr)
AT (1) AT376365B (fr)
AU (1) AU517737B2 (fr)
BE (1) BE868250A (fr)
CA (1) CA1226525A (fr)
CH (1) CH646603A5 (fr)
DE (2) DE2862228D1 (fr)
DK (1) DK155775C (fr)
ES (2) ES471084A1 (fr)
FI (1) FI69405C (fr)
FR (1) FR2395022A1 (fr)
IE (1) IE47251B1 (fr)
IL (1) IL54926A0 (fr)
IT (1) IT1098329B (fr)
NO (1) NO146839C (fr)
NZ (1) NZ187498A (fr)
ZA (1) ZA783241B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2493704A1 (fr) * 1980-11-07 1982-05-14 Lemouel Jean Composition pour la prophylaxie et les soins de la carie dentaire

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340566A (en) * 1993-08-09 1994-08-23 Colgate-Palmolive Company Method for preventing the progression of gingivitis
US5875798A (en) * 1997-09-23 1999-03-02 Advanced Medical Instruments, Inc. Therapeutic toothpick for treating oral and systemic diseases
WO2007100541A2 (fr) * 2006-02-23 2007-09-07 Research Foundation Of The State University Of New York Procédé de traitement de la parodontite et de réduction de la sensibilité dentinaire
CA2706250C (fr) * 2007-11-20 2018-07-24 Sasi Kumar Sunkara Formulation et procede pour un traitement dentaire
US11110047B2 (en) * 2017-08-07 2021-09-07 Colgate-Palmolive Company Oral care compositions including cyclic anhydrides
US20230235248A1 (en) * 2022-01-24 2023-07-27 Inter-Med, Inc. Dental material compositions for cleansing and removal of anionic contaminants from substrates & their methods of use

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR997488A (fr) * 1949-09-15 1952-01-07 Produit d'hygiène et de prophylaxie dentaire
US3004897A (en) * 1955-02-09 1961-10-17 Shore Joseph Dental preparation
US3751568A (en) * 1971-06-18 1973-08-07 Eastman Dental Center Method of coating teeth with a durable glaze
FR2202697A1 (fr) * 1972-10-13 1974-05-10 Procter & Gamble
FR2250537A1 (fr) * 1973-11-13 1975-06-06 Procter & Gamble
FR2287234A1 (fr) * 1974-10-10 1976-05-07 Procter & Gamble Compositions de remineralisation de l'email dentaire
FR2297631A1 (fr) * 1975-01-17 1976-08-13 Carter Wallace Composition pour la prophylaxie dentaire

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB654472A (en) * 1947-03-12 1951-06-20 Procter & Gamble Preparations for use in contact with the teeth
US3151027A (en) * 1961-06-07 1964-09-29 Procter & Gamble Abrasive for dentifrice composition
JPS4816170B1 (fr) * 1969-07-02 1973-05-19
US4080440A (en) * 1974-12-13 1978-03-21 The Procter & Gamble Company Method for remineralizing tooth enamel
US4083955A (en) * 1975-04-02 1978-04-11 The Procter & Gamble Company Processes and compositions for remineralization of dental enamel

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR997488A (fr) * 1949-09-15 1952-01-07 Produit d'hygiène et de prophylaxie dentaire
US3004897A (en) * 1955-02-09 1961-10-17 Shore Joseph Dental preparation
US3751568A (en) * 1971-06-18 1973-08-07 Eastman Dental Center Method of coating teeth with a durable glaze
FR2202697A1 (fr) * 1972-10-13 1974-05-10 Procter & Gamble
FR2250537A1 (fr) * 1973-11-13 1975-06-06 Procter & Gamble
FR2287234A1 (fr) * 1974-10-10 1976-05-07 Procter & Gamble Compositions de remineralisation de l'email dentaire
FR2297631A1 (fr) * 1975-01-17 1976-08-13 Carter Wallace Composition pour la prophylaxie dentaire

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2493704A1 (fr) * 1980-11-07 1982-05-14 Lemouel Jean Composition pour la prophylaxie et les soins de la carie dentaire

Also Published As

Publication number Publication date
DE2827666C3 (de) 1993-11-18
NO146839B (no) 1982-09-13
IT7824646A0 (it) 1978-06-16
EP0000256B1 (fr) 1983-04-13
FI782004A7 (fi) 1978-12-24
DE2862228D1 (en) 1983-05-19
DE2827666C2 (fr) 1988-01-28
FI69405B (fi) 1985-10-31
ES488073A0 (es) 1981-02-16
JPS6245841B2 (fr) 1987-09-29
CH646603A5 (de) 1984-12-14
FR2395022A1 (fr) 1979-01-19
DK155775C (da) 1989-10-02
CA1226525A (fr) 1987-09-08
FI69405C (fi) 1986-02-10
IL54926A0 (en) 1978-08-31
IE47251B1 (en) 1984-02-08
DK155775B (da) 1989-05-16
JPS5417137A (en) 1979-02-08
DE2827666A1 (de) 1979-01-11
IT1098329B (it) 1985-09-07
ZA783241B (en) 1979-06-27
NZ187498A (en) 1984-05-31
US4218434A (en) 1980-08-19
NO781972L (no) 1978-12-28
DK274378A (da) 1978-12-24
AT376365B (de) 1984-11-12
ES8103645A1 (es) 1981-02-16
AU3691978A (en) 1979-12-13
FR2395022B1 (fr) 1983-07-29
BE868250A (fr) 1978-12-19
IE781145L (en) 1978-12-23
AU517737B2 (en) 1981-08-20
EP0000256B2 (fr) 1991-09-25
NO146839C (no) 1982-12-22
ES471084A1 (es) 1980-05-16
ATA460178A (de) 1980-10-15

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