EG18335A - Use of pyridoxine derivatives in the prevention and treatment of hyperlipidaemia and antherosclerosis - Google Patents
Use of pyridoxine derivatives in the prevention and treatment of hyperlipidaemia and antherosclerosisInfo
- Publication number
- EG18335A EG18335A EG53/88A EG5388A EG18335A EG 18335 A EG18335 A EG 18335A EG 53/88 A EG53/88 A EG 53/88A EG 5388 A EG5388 A EG 5388A EG 18335 A EG18335 A EG 18335A
- Authority
- EG
- Egypt
- Prior art keywords
- hyperlipidaemia
- treatment
- pyridoxine
- antherosclerosis
- prevention
- Prior art date
Links
- 208000031226 Hyperlipidaemia Diseases 0.000 title abstract 2
- 150000003227 pyridoxines Chemical class 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 abstract 2
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 abstract 2
- NHZMQXZHNVQTQA-UHFFFAOYSA-N pyridoxamine Chemical compound CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 229940009098 aspartate Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 238000011866 long-term treatment Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 235000008164 pyridoxal Nutrition 0.000 abstract 1
- 239000011674 pyridoxal Substances 0.000 abstract 1
- 229960003581 pyridoxal Drugs 0.000 abstract 1
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 abstract 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 abstract 1
- 229960001327 pyridoxal phosphate Drugs 0.000 abstract 1
- 235000008151 pyridoxamine Nutrition 0.000 abstract 1
- 239000011699 pyridoxamine Substances 0.000 abstract 1
- ZMJGSOSNSPKHNH-UHFFFAOYSA-N pyridoxamine 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(CN)=C1O ZMJGSOSNSPKHNH-UHFFFAOYSA-N 0.000 abstract 1
- WHOMFKWHIQZTHY-UHFFFAOYSA-N pyridoxine 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(CO)=C1O WHOMFKWHIQZTHY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873705549 DE3705549A1 (de) | 1987-02-18 | 1987-02-18 | Verwendung von pyridoxin-derivaten bei der prophylaxe und therapie von hyperlipidaemien und atherosklerose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EG18335A true EG18335A (en) | 1992-09-30 |
Family
ID=6321453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EG53/88A EG18335A (en) | 1987-02-18 | 1988-02-01 | Use of pyridoxine derivatives in the prevention and treatment of hyperlipidaemia and antherosclerosis |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0282696B1 (xx) |
| JP (2) | JPH0710777B2 (xx) |
| KR (1) | KR950009094B1 (xx) |
| AT (1) | ATE82125T1 (xx) |
| CA (1) | CA1340246C (xx) |
| DE (2) | DE3705549A1 (xx) |
| DK (1) | DK55888A (xx) |
| EG (1) | EG18335A (xx) |
| ES (1) | ES2052609T3 (xx) |
| GR (1) | GR3006693T3 (xx) |
| HU (1) | HUT47850A (xx) |
| ZA (1) | ZA88577B (xx) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6228858B1 (en) | 1995-09-12 | 2001-05-08 | University Of Kansas Medical Center | Advanced glycation end-product intermediaries and post-amadori inhibition |
| US6740668B1 (en) | 1995-08-28 | 2004-05-25 | Kansas University Medical Center | Methods for inhibiting diabetic complications |
| US6716858B1 (en) | 1995-08-28 | 2004-04-06 | Kansas University Medical Center | Methods for inhibiting diabetic complications |
| US5744451A (en) | 1995-09-12 | 1998-04-28 | Warner-Lambert Company | N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity |
| US6730686B1 (en) | 1995-09-12 | 2004-05-04 | Kansas University Medical Center | Methods for inhibiting oxidative modification of proteins |
| US6750209B1 (en) | 1995-09-12 | 2004-06-15 | Kansas University Medical Center | Advanced glycation end-product intermediaries and post-amadori inhibition |
| US7030146B2 (en) | 1996-09-10 | 2006-04-18 | University Of South Carolina | Methods for treating diabetic neuropathy |
| US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
| WO2000022094A2 (en) * | 1998-10-09 | 2000-04-20 | Kansas University Medical Center | Methods for inhibiting oxidative modification of proteins |
| EP1169322B8 (en) | 1999-03-08 | 2006-09-13 | Medicure Inc. | Pyridoxal analogues for the treatment of disorders caused by a deficiency in vitamin b6 |
| US6489345B1 (en) | 1999-07-13 | 2002-12-03 | Medicure, Inc. | Treatment of diabetes and related pathologies |
| WO2001013900A2 (en) | 1999-08-24 | 2001-03-01 | Medicure International Inc. | Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds |
| US7442689B2 (en) | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| US6605612B2 (en) | 2000-02-29 | 2003-08-12 | Medicure International Inc. | Cardioprotective phosohonates and malonates |
| JP2003528146A (ja) | 2000-03-28 | 2003-09-24 | メディキュア インターナショナル インコーポレイテッド | 脳血管疾患の治療 |
| US6897228B2 (en) | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
| AU7226301A (en) | 2000-07-07 | 2002-01-21 | Medicure Int Inc | Pyridoxine and pyridoxal analogues: cardiovascular therapeutics |
| US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
| JP2006523206A (ja) * | 2003-03-27 | 2006-10-12 | メディキュア インコーポレーテッド | 細胞死の調節 |
| JP2008517956A (ja) | 2004-10-28 | 2008-05-29 | メディキュア・インターナショナル・インコーポレーテッド | 二重の抗血小板性／抗凝固性ピリドキシン類似体 |
| US7375112B2 (en) * | 2005-01-05 | 2008-05-20 | Medicure International Inc. | Compounds and methods for regulating triglyceride levels |
| FR3038227B1 (fr) * | 2015-06-30 | 2018-08-17 | Assistance Publique - Hopitaux De Paris | Formulation effervescente a base de pyridoxal-5-phosphate |
| JP7244024B2 (ja) * | 2018-06-25 | 2023-03-22 | 学校法人近畿大学 | ニコチン摂取の影響による血管壁のコラーゲン分解防止剤 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR6707M (xx) * | 1966-04-29 | 1969-02-17 | ||
| GB1070120A (en) * | 1966-05-06 | 1967-05-24 | Tanabe Seiyaku Co | Pyridoxine derivative and the preparation thereof |
| FR7238M (xx) * | 1968-03-27 | 1969-09-01 | ||
| FR2035765A1 (en) * | 1969-03-06 | 1970-12-24 | Inst Rech Scient | Medicaments contg pyridoxine heparinates or - other vitamin b6 heparinates |
| FR2176509A2 (en) * | 1972-03-21 | 1973-11-02 | Inst Rech Scient | Pyridoxine p-chlorophenoxyisobutyrate prodn - giving very pure product from corresp acid and pyridoxine |
| JPS5018470A (xx) * | 1973-05-31 | 1975-02-26 | ||
| CH607773A5 (en) | 1974-12-24 | 1978-10-31 | Steigerwald Arzneimittelwerk | Process for the preparation of novel pyridoxine derivatives |
| DE2461742C2 (de) * | 1974-12-28 | 1983-01-27 | Steigerwald Arzneimittelwerk Gmbh, 6100 Darmstadt | Pyridoxin-5'-phosphorsäureester-Derivate sowie deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| FR2349330A1 (fr) * | 1976-04-29 | 1977-11-25 | Savini Emile | Composition destinee au traitement des hyperlipidemies |
| JPS5347110A (en) * | 1976-10-12 | 1978-04-27 | Osaka Bosui Kensetsusha Kk | Impermeable wall forming method |
| US6152775A (en) | 1998-12-07 | 2000-11-28 | Framatome Connectors Interlock, Inc. | Filtered electrical connector with multiple ferrite members |
-
1987
- 1987-02-18 DE DE19873705549 patent/DE3705549A1/de not_active Withdrawn
-
1988
- 1988-01-20 DE DE8888100747T patent/DE3875760D1/de not_active Expired - Fee Related
- 1988-01-20 EP EP88100747A patent/EP0282696B1/de not_active Expired - Lifetime
- 1988-01-20 ES ES88100747T patent/ES2052609T3/es not_active Expired - Lifetime
- 1988-01-20 AT AT88100747T patent/ATE82125T1/de not_active IP Right Cessation
- 1988-01-28 ZA ZA880577A patent/ZA88577B/xx unknown
- 1988-02-01 EG EG53/88A patent/EG18335A/xx active
- 1988-02-03 DK DK055888A patent/DK55888A/da not_active Application Discontinuation
- 1988-02-16 HU HU88723A patent/HUT47850A/hu unknown
- 1988-02-17 JP JP63032943A patent/JPH0710777B2/ja not_active Expired - Lifetime
- 1988-02-17 KR KR1019880001692A patent/KR950009094B1/ko not_active Expired - Fee Related
- 1988-02-18 CA CA000559285A patent/CA1340246C/en not_active Expired - Fee Related
-
1992
- 1992-12-28 GR GR920403159T patent/GR3006693T3/el unknown
-
1994
- 1994-09-02 JP JP6209830A patent/JP2588686B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK55888A (da) | 1988-08-19 |
| EP0282696A2 (de) | 1988-09-21 |
| JPH0710777B2 (ja) | 1995-02-08 |
| JPH07238020A (ja) | 1995-09-12 |
| ATE82125T1 (de) | 1992-11-15 |
| EP0282696B1 (de) | 1992-11-11 |
| DK55888D0 (da) | 1988-02-03 |
| ZA88577B (en) | 1988-07-28 |
| DE3875760D1 (de) | 1992-12-17 |
| CA1340246C (en) | 1998-12-15 |
| EP0282696A3 (en) | 1989-06-14 |
| GR3006693T3 (xx) | 1993-06-30 |
| HUT47850A (en) | 1989-04-28 |
| JP2588686B2 (ja) | 1997-03-05 |
| ES2052609T3 (es) | 1994-07-16 |
| DE3705549A1 (de) | 1988-09-01 |
| JPS63203621A (ja) | 1988-08-23 |
| KR880009649A (ko) | 1988-10-04 |
| KR950009094B1 (ko) | 1995-08-14 |
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