EE04178B1 - 3- või 4-asendatud 4-(aminometüül)piperidiini bitsüklilised bensamiidid, vaheühend ja farmatseutiline kompositsioon ning nende valmistamismeetodid - Google Patents

3- või 4-asendatud 4-(aminometüül)piperidiini bitsüklilised bensamiidid, vaheühend ja farmatseutiline kompositsioon ning nende valmistamismeetodid

Info

Publication number: EE04178B1
Authority: EE; Estonia
Prior art keywords: aminomethyl; piperidine; substituted; preparation; methods
Prior art date: 1997-07-11

Application number

EEP200000015A

Other languages

English (en)

Inventor

Ren Marie Andr Bosmans Jean-Paul

Anna Jozef De Cleyn Michel

Surkyn Michel

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-11

Filing date

1998-07-07

Publication date

2003-12-15

1998-07-07 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2000-10-16 Publication of EE200000015A publication Critical patent/EE200000015A/et

2003-12-15 Publication of EE04178B1 publication Critical patent/EE04178B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/12—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/16—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

EEP200000015A 1997-07-11 1998-07-07 3- või 4-asendatud 4-(aminometüül)piperidiini bitsüklilised bensamiidid, vaheühend ja farmatseutiline kompositsioon ning nende valmistamismeetodid EE04178B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP97202180		1997-07-11
EP98200624		1998-02-27
PCT/EP1998/004190 WO1999002156A1 (en)	1997-07-11	1998-07-07	Gastrokinetic bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivates

Publications (2)

Publication Number	Publication Date
EE200000015A EE200000015A (et)	2000-10-16
EE04178B1 true EE04178B1 (et)	2003-12-15

Family

ID=26146699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000015A EE04178B1 (et)	1997-07-11	1998-07-07	3- või 4-asendatud 4-(aminometüül)piperidiini bitsüklilised bensamiidid, vaheühend ja farmatseutiline kompositsioon ning nende valmistamismeetodid

Country Status (34)

Country	Link
US (10)	US6452013B1 (et)
EP (3)	EP1206938A1 (et)
JP (2)	JP4530530B2 (et)
KR (2)	KR100885658B1 (et)
CN (2)	CN1117568C (et)
AR (2)	AR016324A1 (et)
AT (2)	ATE255092T1 (et)
AU (2)	AU734475B2 (et)
BG (2)	BG63709B1 (et)
BR (2)	BRPI9811688B8 (et)
CA (2)	CA2295088C (et)
CZ (2)	CZ297298B6 (et)
DE (2)	DE69820065T2 (et)
DK (2)	DK0991410T3 (et)
EA (1)	EA002619B1 (et)
EE (1)	EE04178B1 (et)
ES (2)	ES2212330T3 (et)
HK (2)	HK1025047A1 (et)
HR (2)	HRP20000006B1 (et)
HU (2)	HUP0004564A3 (et)
ID (2)	ID24481A (et)
IL (2)	IL133918A (et)
MY (2)	MY123199A (et)
NO (2)	NO314662B1 (et)
NZ (2)	NZ502209A (et)
PL (2)	PL190310B1 (et)
PT (2)	PT1000028E (et)
RU (1)	RU2213089C2 (et)
SI (2)	SI0991410T1 (et)
SK (2)	SK284942B6 (et)
TR (2)	TR200000022T2 (et)
TW (2)	TW402591B (et)
UA (1)	UA67745C2 (et)
WO (2)	WO1999002156A1 (et)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW402591B (en) *	1997-07-11	2000-08-21	Janssen Pharmaceutica Nv	Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
TW570920B (en) *	1998-12-22	2004-01-11	Janssen Pharmaceutica Nv	4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
US20040253179A1 (en) *	2003-02-26	2004-12-16	Acm Medical Technologies, Inc.	Measuring gastrointestinal parameters
US20080219928A1 (en) *	2003-02-26	2008-09-11	Becker Jane A	Measuring Gastrointestinal Parameters
PL1641783T3 (pl)	2003-06-19	2012-08-31	Janssen Pharmaceutica Nv	4-(aminometylo)-piperydyno-benzamidy podstawione aminosulfonylem jako antagoniści 5HT₄
JO2478B1 (en) *	2003-06-19	2009-01-20	جانسين فارماسوتيكا ان. في.	(Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
JP4767844B2 (ja) *	2003-06-19	2011-09-07	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	５ｈｔ４−アンタゴニストとしての複素環式置換４−（アミノメチル）−ピペリジンベンズアミド
PL1638959T3 (pl) *	2003-06-19	2008-02-29	Janssen Pharmaceutica Nv	4-(Aminometylo)piperydynobenzamidy antagonistyczne względem 5HT4
CA2555258C (en) *	2004-01-29	2009-04-28	Pfizer Inc.	1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-ht4 receptor agonistic activity
TW200533348A (en) *	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
WO2005092882A1 (en) *	2004-03-01	2005-10-06	Pfizer Japan, Inc.	4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders
US7728006B2 (en) *	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en)	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US9641902B2 (en)	2007-06-26	2017-05-02	Broadband Itv, Inc.	Dynamic adjustment of electronic program guide displays based on viewer preferences for minimizing navigation in VOD program selection
EP1807422B1 (en) *	2004-11-05	2009-09-02	Theravance, Inc.	5-ht4 receptor agonist compounds
EP1807423B1 (en) *	2004-11-05	2009-05-20	Theravance, Inc.	Quinolinone-carboxamide compounds
PL2377557T3 (pl)	2004-11-24	2017-05-31	Meda Pharmaceuticals Inc.	Kompozycje zawierające azelastynę i sposoby ich zastosowania
US20070020330A1 (en)	2004-11-24	2007-01-25	Medpointe Healthcare Inc.	Compositions comprising azelastine and methods of use thereof
RU2404179C2 (ru) *	2004-12-22	2010-11-20	Тереванс, Инк.	Индазол-карбоксамидные соединения
WO2006094063A1 (en) *	2005-03-02	2006-09-08	Theravance, Inc.	Quinolinone compounds as 5-ht4 receptor agonists
TWI377206B (en) *	2005-04-06	2012-11-21	Theravance Inc	Crystalline form of a quinolinone-carboxamide compound
GB0603550D0 (en) *	2006-02-22	2006-04-05	Glaxo Group Ltd	Novel compounds
US8642772B2 (en)	2008-10-14	2014-02-04	Sk Biopharmaceuticals Co., Ltd.	Piperidine compounds, pharmaceutical composition comprising the same and its use
US20110313319A1 (en) *	2008-11-07	2011-12-22	SAND COUNTY BIOTECHNOLOGY, Inc.	Measuring method for the concentration of intragastric contents
US8232315B2 (en)	2009-06-26	2012-07-31	Sk Biopharmaceuticals Co., Ltd.	Methods for treating drug addiction and improving addiction-related behavior
CA2779442A1 (en)	2009-11-06	2011-05-12	Sk Biopharmaceuticals Co., Ltd.	Methods for treating fibromyalgia syndrome
ES2447295T3 (es)	2009-11-06	2014-03-11	Sk Biopharmaceuticals Co., Ltd.	Métodos para el tratamiento del trastorno de déficit de atención/hiperactividad
KR101180174B1 (ko) *	2010-04-23	2012-09-05	동아제약주식회사	신규한 벤즈아미드 유도체
US8623913B2 (en)	2010-06-30	2014-01-07	Sk Biopharmaceuticals Co., Ltd.	Methods for treating restless legs syndrome
US9610274B2 (en)	2010-06-30	2017-04-04	Sk Biopharmaceuticals Co., Ltd.	Methods for treating bipolar disorder
JP6182989B2 (ja)	2012-06-28	2017-08-23	セントラル硝子株式会社	１，３，３，３−テトラフルオロプロペンの製造方法
WO2014083003A1 (en)	2012-11-27	2014-06-05	Shire International Gmbh	Pro-cognitive compound
KR101595183B1 (ko) *	2013-07-25	2016-02-17	동아에스티 주식회사	벤즈아미드 유도체의 제조방법, 그의 제조에 사용되는 새로운 중간체 및 상기 중간체의 제조방법
CN115515933A (zh) *	2020-05-04	2022-12-23	武田药品工业株式会社	经管腔作用的n-(哌啶-4-基)苯甲酰胺衍生物
EP4393470A1 (en)	2022-12-30	2024-07-03	SkyLab AG	Plant-mineral composition based on aloe barbadensis extract and trimethylglycine for ph-dependent regulation of type 3 aquaporins and transepidermal water flow in deep epidermal layers

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1046052B (it)	1973-10-12	1980-06-30	Sigurta Farmaceutici Spa	Processo per la preparazione di i aralchil 4 aminometil piperidin 4 oli
US4348763A (en) *	1980-08-07	1982-09-07	Hewlett-Packard Company	Multiple stripe leaky mode laser
US4711703A (en)	1982-02-03	1987-12-08	Orbisphere Corporation Wilmington, Succursale De Collonge-Bellerive	Thermal protection method for electroanalytical cell
DE3416224C2 (de)	1983-05-06	1994-05-05	Mitsubishi Chem Ind	Verfahren zur Herstellung eines Kohleverflüssigungsöls
US4772630A (en)	1984-11-23	1988-09-20	Ciba-Geigy Corp.	Benzamides and their salts
US4722630A (en)	1985-09-20	1988-02-02	The Garrett Corporation	Ceramic-metal braze joint
GB8527052D0 (en)	1985-11-02	1985-12-04	Beecham Group Plc	Compounds
US4910312A (en)	1985-11-08	1990-03-20	Warner-Lambert Company	Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
US4910193A (en)	1985-12-16	1990-03-20	Sandoz Ltd.	Treatment of gastrointestinal disorders
US4746655A (en) *	1987-06-10	1988-05-24	A. H. Robins Company, Incorporated	Fused aromatic-spiropiperidine oxazepinones(and thiones)
BE1000689A6 (fr)	1987-07-14	1989-03-14	Donnay Donnay S A Ets	Raquette de tennis, de squash ou sport analogue.
US5130312A (en)	1987-07-17	1992-07-14	Janssen Pharmaceutica N.V.	Substituted N-(3-hydroxy-4-piperidinyl)benzamides
US4906643A (en)	1987-07-17	1990-03-06	Janssen Pharmaceutica N.V.	Substituted N-(3-hydroxy-4-piperidinyl)benzamides as gastrointestinal agents
NZ225152A (en) *	1987-07-17	1990-04-26	Janssen Pharmaceutica Nv	Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
JPH0719937B2 (ja) *	1987-09-24	1995-03-06	三井石油化学工業株式会社	高周波用積層板およびその製造方法
US5041454A (en)	1987-09-25	1991-08-20	Janssen Pharmaceutica N.V.	Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
CA1317940C (en) *	1987-09-25	1993-05-18	Georges H. P. Van Daele	Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US4975439A (en)	1987-09-25	1990-12-04	Janssen Pharmaceutical N.V.	Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
JP2573017B2 (ja)	1988-03-08	1997-01-16	三洋電機株式会社	ディスクプレーヤ
US5053412A (en)	1990-04-10	1991-10-01	Israel Institute For Biological Research	Spiro nitrogen-bridged heterocyclic compounds
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en)	1990-03-06	1990-05-02	Janssen Pharmaceutica Nv	N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5103141A (en)	1990-03-08	1992-04-07	U.S. Philips Corporation	Switching arrangement for increasing the white life of a high pressure sodium lamp
US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
US5407938A (en)	1990-04-10	1995-04-18	Israel Institute For Biological Research	Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
TW243449B (et) *	1991-02-15	1995-03-21	Hokuriku Pharmaceutical
AU2435092A (en)	1991-08-20	1993-03-16	Smithkline Beecham Plc	5-ht4 receptor antagonists
SG49153A1 (en)	1991-09-12	1998-05-18	Smithkline Beecham Plc	5-HT4 receptor antagonists
IT1252567B (it) *	1991-12-20	1995-06-19	Italfarmaco Spa	Derivati di 5-isochinolinsolfonammidi inibitori delle protein-chinasi
WO1993013101A1 (en)	1991-12-27	1993-07-08	Yoshitomi Pharmaceutical Industries, Ltd.	Pyridonecarboxylate compound, pharmaceutical use thereof, and spiro compound
WO1993016072A1 (en)	1992-02-06	1993-08-19	Smithkline Beecham Plc	Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
JPH05236345A (ja)	1992-02-21	1993-09-10	Nec Ic Microcomput Syst Ltd	画像用垂直フィルタ回路
MX9306311A (es)	1992-10-13	1994-04-29	Smithkline Beecham Plc	Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
NZ257545A (en)	1992-11-05	1997-01-29	Smithkline Beecham Plc	Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
US6127379A (en) *	1993-02-01	2000-10-03	Smithkline Beecham P.L.C.	Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
US5864039A (en) *	1994-03-30	1999-01-26	Yoshitomi Pharmaceutical Industries, Ltd.	Benzoic acid compounds and use thereof as medicaments
CA2186623A1 (en) *	1994-03-30	1995-10-21	Takeshi Kawakita	Benzoic acid compound and use thereof as medicine
TW490465B (en) *	1994-11-24	2002-06-11	Janssen Pharmaceutica Nv	Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
GB9507882D0 (en) *	1995-04-18	1995-05-31	Pharmacia Spa	Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
EP0873990A1 (en) *	1995-09-22	1998-10-28	Yoshitomi Pharmaceutical Industries, Ltd.	Benzoic acid compounds and medicinal use thereof
KR100469029B1 (ko) *	1996-02-15	2005-05-27	얀센 파마슈티카 엔.브이.	세로토닌재흡수억제제의위장효과를극복하기위한5ht4수용체길항제의용도
US6096761A (en) *	1996-02-15	2000-08-01	Janssen Pharmaceutica N.V.	Esters of 3-hydroxy-piperidinemethanol derivatives
TW402591B (en)	1997-07-11	2000-08-21	Janssen Pharmaceutica Nv	Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
WO1999023654A1 (en)	1997-10-31	1999-05-14	Daewoo Electronics Co., Ltd.	Cd changer with a driving mechanism operated by a single driving source
KR100413150B1 (ko) *	1998-09-10	2003-12-31	에프. 호프만-라 로슈 아게	5-에이치티4 수용체 길항제로서의 디하이드로벤조디옥신 카복스아미드 및 케톤 유도체

1998
- 1998-06-12 TW TW087109332A patent/TW402591B/zh not_active IP Right Cessation
- 1998-06-12 TW TW087109331A patent/TW548103B/zh not_active IP Right Cessation
- 1998-07-07 HU HU0004564A patent/HUP0004564A3/hu unknown
- 1998-07-07 PL PL98338005A patent/PL190310B1/pl not_active IP Right Cessation
- 1998-07-07 JP JP2000502022A patent/JP4530530B2/ja not_active Expired - Lifetime
- 1998-07-07 KR KR1019997012486A patent/KR100885658B1/ko not_active IP Right Cessation
- 1998-07-07 NZ NZ502209A patent/NZ502209A/xx not_active IP Right Cessation
- 1998-07-07 IL IL13391898A patent/IL133918A/en not_active IP Right Cessation
- 1998-07-07 EE EEP200000015A patent/EE04178B1/et unknown
- 1998-07-07 PT PT98939620T patent/PT1000028E/pt unknown
- 1998-07-07 TR TR2000/00022T patent/TR200000022T2/xx unknown
- 1998-07-07 ID IDW20000036D patent/ID24481A/id unknown
- 1998-07-07 EP EP02075710A patent/EP1206938A1/en not_active Ceased
- 1998-07-07 WO PCT/EP1998/004190 patent/WO1999002156A1/en active IP Right Grant
- 1998-07-07 BR BRPI9811688 patent/BRPI9811688B8/pt not_active IP Right Cessation
- 1998-07-07 EP EP98939620A patent/EP1000028B1/en not_active Expired - Lifetime
- 1998-07-07 NZ NZ502208A patent/NZ502208A/en unknown
- 1998-07-07 WO PCT/EP1998/004189 patent/WO1999002494A1/en active IP Right Grant
- 1998-07-07 SI SI9830311T patent/SI0991410T1/xx unknown
- 1998-07-07 ES ES98939620T patent/ES2212330T3/es not_active Expired - Lifetime
- 1998-07-07 SK SK1840-99A patent/SK284942B6/sk not_active IP Right Cessation
- 1998-07-07 ES ES98940158T patent/ES2187051T3/es not_active Expired - Lifetime
- 1998-07-07 CA CA002295088A patent/CA2295088C/en not_active Expired - Lifetime
- 1998-07-07 CZ CZ0463899A patent/CZ297298B6/cs not_active IP Right Cessation
- 1998-07-07 TR TR2000/00023T patent/TR200000023T2/xx unknown
- 1998-07-07 EA EA200000110A patent/EA002619B1/ru not_active IP Right Cessation
- 1998-07-07 DE DE69820065T patent/DE69820065T2/de not_active Expired - Lifetime
- 1998-07-07 AU AU88574/98A patent/AU734475B2/en not_active Expired
- 1998-07-07 US US09/462,287 patent/US6452013B1/en not_active Expired - Lifetime
- 1998-07-07 EP EP98940158A patent/EP0991410B1/en not_active Expired - Lifetime
- 1998-07-07 AU AU88063/98A patent/AU747199B2/en not_active Expired
- 1998-07-07 PL PL98338008A patent/PL190611B1/pl unknown
- 1998-07-07 KR KR10-1999-7012492A patent/KR100500372B1/ko not_active IP Right Cessation
- 1998-07-07 CN CN98806950A patent/CN1117568C/zh not_active Expired - Lifetime
- 1998-07-07 PT PT98940158T patent/PT991410E/pt unknown
- 1998-07-07 CN CNB988069571A patent/CN1195736C/zh not_active Expired - Lifetime
- 1998-07-07 RU RU2000103212/04A patent/RU2213089C2/ru active
- 1998-07-07 DE DE69809050T patent/DE69809050T2/de not_active Expired - Lifetime
- 1998-07-07 IL IL13391798A patent/IL133917A/xx not_active IP Right Cessation
- 1998-07-07 SI SI9830579T patent/SI1000028T1/xx unknown
- 1998-07-07 AT AT98939620T patent/ATE255092T1/de not_active IP Right Cessation
- 1998-07-07 DK DK98940158T patent/DK0991410T3/da active
- 1998-07-07 BR BR9811687-8A patent/BR9811687A/pt active Search and Examination
- 1998-07-07 DK DK98939620T patent/DK1000028T3/da active
- 1998-07-07 AT AT98940158T patent/ATE226820T1/de active
- 1998-07-07 SK SK1734-99A patent/SK284632B6/sk not_active IP Right Cessation
- 1998-07-07 UA UA2000010195A patent/UA67745C2/uk unknown
- 1998-07-07 CZ CZ19994587A patent/CZ295506B6/cs not_active IP Right Cessation
- 1998-07-07 HU HU0002539A patent/HU227424B1/hu unknown
- 1998-07-07 ID IDW2000030A patent/ID24161A/id unknown
- 1998-07-07 CA CA002295087A patent/CA2295087C/en not_active Expired - Lifetime
- 1998-07-07 JP JP50812599A patent/JP2002508000A/ja active Pending
- 1998-07-08 MY MYPI98003106A patent/MY123199A/en unknown
- 1998-07-08 MY MYPI98003107A patent/MY117803A/en unknown
- 1998-07-10 AR ARP980103373A patent/AR016324A1/es active IP Right Grant
- 1998-07-10 AR ARP980103374A patent/AR013361A1/es active IP Right Grant
1999
- 1999-12-10 BG BG103983A patent/BG63709B1/bg unknown
- 1999-12-10 BG BG103984A patent/BG64230B1/bg unknown
2000
- 2000-01-05 HR HR20000006A patent/HRP20000006B1/xx not_active IP Right Cessation
- 2000-01-05 HR HR20000005A patent/HRP20000005B1/xx not_active IP Right Cessation
- 2000-01-10 NO NO20000115A patent/NO314662B1/no not_active IP Right Cessation
- 2000-01-10 NO NO20000116A patent/NO317467B1/no not_active IP Right Cessation
- 2000-07-08 HK HK00104203A patent/HK1025047A1/xx not_active IP Right Cessation
- 2000-07-08 HK HK00104201A patent/HK1025093A1/xx not_active IP Right Cessation
2001
- 2001-02-22 US US09/791,227 patent/US6635643B2/en not_active Ceased
2002
- 2002-06-05 US US10/162,802 patent/US6750349B2/en not_active Expired - Lifetime
2003
- 2003-08-19 US US10/643,506 patent/US20040058958A1/en not_active Abandoned
2005
- 2005-10-26 US US11/259,719 patent/USRE40793E1/en not_active Expired - Lifetime
2006
- 2006-02-16 US US11/355,326 patent/US20060142341A1/en not_active Abandoned
- 2006-02-17 US US11/357,884 patent/US20060142342A1/en not_active Abandoned
- 2006-10-20 US US11/584,732 patent/US7790750B2/en not_active Expired - Fee Related
2010
- 2010-05-04 US US12/773,183 patent/US8063070B2/en not_active Expired - Fee Related
2011
- 2011-09-20 US US13/237,330 patent/US8318742B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
TR200000023T2 (tr)	2000-09-21
HRP20000006B1 (en)	2009-06-30
PT991410E (pt)	2003-03-31
HUP0004564A3 (en)	2001-08-28
US8318742B2 (en)	2012-11-27
PL338005A1 (en)	2000-09-25
RU2213089C2 (ru)	2003-09-27
DK0991410T3 (da)	2003-02-24
BG103984A (en)	2000-09-29
DE69820065T2 (de)	2004-08-26
PL338008A1 (en)	2000-09-25
NO20000116L (no)	2000-03-07
CN1262674A (zh)	2000-08-09
EE200000015A (et)	2000-10-16
JP4530530B2 (ja)	2010-08-25
BG63709B1 (bg)	2002-10-31
HK1025093A1 (en)	2000-11-03
CZ458799A3 (cs)	2000-05-17
AU8857498A (en)	1999-02-08
BG103983A (en)	2000-09-29
US7790750B2 (en)	2010-09-07
NO20000115L (no)	2000-03-13
BG64230B1 (bg)	2004-06-30
HRP20000005A2 (en)	2000-12-31
US20020086879A1 (en)	2002-07-04
ATE226820T1 (de)	2002-11-15
AR013361A1 (es)	2000-12-27
DE69809050D1 (de)	2002-12-05
US6635643B2 (en)	2003-10-21
HRP20000005B1 (en)	2008-12-31
MY117803A (en)	2004-08-30
ES2187051T3 (es)	2003-05-16
AU747199B2 (en)	2002-05-09
TW548103B (en)	2003-08-21
US20060142341A1 (en)	2006-06-29
PL190611B1 (pl)	2005-12-30
US20120028987A1 (en)	2012-02-02
SK173499A3 (en)	2000-06-12
NZ502209A (en)	2001-01-26
HK1025047A1 (en)	2000-11-03
AU734475B2 (en)	2001-06-14
HRP20000006A2 (en)	2000-12-31
US20040058958A1 (en)	2004-03-25
IL133918A (en)	2004-06-20
ID24481A (id)	2000-07-20
HUP0002539A3 (en)	2002-03-28
USRE40793E1 (en)	2009-06-23
JP2002508000A (ja)	2002-03-12
WO1999002156A1 (en)	1999-01-21
CA2295088A1 (en)	1999-01-21
BRPI9811688B1 (pt)	2011-10-18
SK184099A3 (en)	2000-09-12
US20100210657A1 (en)	2010-08-19
MY123199A (en)	2006-05-31
US20070037850A1 (en)	2007-02-15
BRPI9811688A (pt)	2000-09-26
EP1000028A1 (en)	2000-05-17
US6750349B2 (en)	2004-06-15
ATE255092T1 (de)	2003-12-15
UA67745C2 (uk)	2004-07-15
EP0991410B1 (en)	2002-10-30
US20030078427A1 (en)	2003-04-24
US8063070B2 (en)	2011-11-22
NO20000116D0 (no)	2000-01-10
HUP0002539A2 (hu)	2000-12-28
BRPI9811688B8 (pt)	2021-07-06
KR100500372B1 (ko)	2005-07-11
NO314662B1 (no)	2003-04-28
HU227424B1 (en)	2011-05-30
IL133917A (en)	2005-05-17
EP1206938A1 (en)	2002-05-22
SK284942B6 (sk)	2006-02-02
HUP0004564A2 (hu)	2001-07-30
BR9811687A (pt)	2000-09-26
CN1195736C (zh)	2005-04-06
JP2001509503A (ja)	2001-07-24
TW402591B (en)	2000-08-21
NZ502208A (en)	2001-04-27
CA2295087C (en)	2007-05-15
DK1000028T3 (da)	2004-04-05
ID24161A (id)	2000-07-13
CZ295506B6 (cs)	2005-08-17
DE69809050T2 (de)	2003-07-24
SI0991410T1 (en)	2003-04-30
US6452013B1 (en)	2002-09-17
PL190310B1 (pl)	2005-11-30
CA2295088C (en)	2007-10-23
SI1000028T1 (en)	2004-04-30
CN1262621A (zh)	2000-08-09
CZ297298B6 (cs)	2006-11-15
AR016324A1 (es)	2001-07-04
ES2212330T3 (es)	2004-07-16
US20060142342A1 (en)	2006-06-29
DE69820065D1 (de)	2004-01-08
PT1000028E (pt)	2004-04-30
KR100885658B1 (ko)	2009-02-25
KR20010014341A (ko)	2001-02-26
EA002619B1 (ru)	2002-06-27
AU8806398A (en)	1999-02-08
CN1117568C (zh)	2003-08-13
EP0991410A1 (en)	2000-04-12
KR20010014336A (ko)	2001-02-26
CZ463899A3 (cs)	2000-04-12
TR200000022T2 (tr)	2000-06-21
WO1999002494A1 (en)	1999-01-21
SK284632B6 (sk)	2005-08-04
NO317467B1 (no)	2004-11-01
CA2295087A1 (en)	1999-01-21
EA200000110A1 (ru)	2000-08-28
EP1000028B1 (en)	2003-11-26
IL133918A0 (en)	2001-04-30
NO20000115D0 (no)	2000-01-10
IL133917A0 (en)	2001-04-30

Publication	Publication Date	Title
EE200000015A (et)	2000-10-16	3- või 4-asendatud 4-(aminometüül)piperidiini bitsüklilised bensamiidid, vaheühend ja farmatseutiline kompositsioon ning nende valmistamismeetodid
EE200100335A (et)	2002-08-15	4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid
EE9900018A (et)	1999-08-16	Asendatud püridiinid, nende kasutamine ja farmatseutilised kompositsioonid
EE05104B1 (et)	2008-12-15	Asetidiini derivaadid, nende valmistamise meetodid ja farmatseutiline kompositsioon
EE200100252A (et)	2002-10-15	Pürimidiinderivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja sellevalmistamismeetod, kombinatsioon ning saadus
BR0016396A (pt)	2002-08-20	Novos antagonistas do receptor p2x7 para uso no tratamento de doenças inflamatórias, imunes ou cardiovasculares
EE9500064A (et)	1996-06-17	Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
EE05001B1 (et)	2008-04-15	Heterotsüklilised ühendid, meetod nende valmistamiseks, neid sisaldav ravimkoostis ning nende kasutamine ravis
HUP0203528A3 (en)	2003-11-28	Piperidine derivatives useful as ccr5 antagonists, pharmaceutical compositions containing them and their use
CA2424664A1 (en)	2002-04-25	Novel non-imidazole compounds
DK199900554A (da)	2000-01-03	Paroxetinsalte, fremgangsmåde til fremstilling deraf, farmaceutiske præparater omfattende disse og anvendelser deraf
ATE345133T1 (de)	2006-12-15	Laktose-freie, nicht-hygroskopische und wasserfreie pharmazeutische zusammensetzungen von descarboethoxyloratadin
HUP0203836A3 (en)	2005-03-29	1,3-disubstituted pyrrololidines as alpha-2-adrenoceptor antagonists, process for their preparation and pharmaceutical compositions containing them and their use
EE200000620A (et)	2002-04-15	3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon
HUP0402019A3 (en)	2009-07-28	Piperidine derivatives useful as ccr5 antagonists and pharmaceutical compositions containing them
EE200100328A (et)	2002-08-15	Antihistamiinsed spiroühendid, vaheühendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid
EE200200281A (et)	2003-06-16	Pikornaviirusevastased ühendid ja kompositsioonid, nende farmatseutilised kasutusalad ning ained nende sünteesiks
DK0888292T3 (da)	2002-02-18	Tricykliske forbindelser med virkning over for integriner, især alphavbeta3 integriner, fremgangsmåde til deres fremstilling, mellemprodukter deraf, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf
EE03996B1 (et)	2003-04-15	Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
EE200300553A (et)	2004-02-16	Piperidiinkarboksamiidi derivaadid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
DK0815126T3 (da)	2001-05-07	Bicykliske tachykinin-antagonister, fremstilling deraf og deres anvendelse i farmaceutiske præparater
EE200100544A (et)	2003-02-17	15-lülilised 8a- ja 9a-laktaamid, nende valmistamismeetod ja farmatseutiline kompositsioon
EE200000752A (et)	2002-04-15	Alfa-D-ksüloosiühendid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon
PL340381A1 (en)	2001-01-29	Novel 19-norsteroids substituted at position 11beta, method of obtaining them, intermediate compounds used in that method, their application as drugs and pharmacological compositions containing them
HUP0104588A3 (en)	2002-05-28	Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators pharmaceutical compositions comprising thereof, method for their preparation and their use

Legal Events

Date	Code	Title	Description
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231