EE03976B1 - Erütromütsiinid ja nende valmistamise meetod - Google Patents

Erütromütsiinid ja nende valmistamise meetod

Info

Publication number: EE03976B1
Authority: EE; Estonia
Prior art keywords: erythromycins; preparation
Prior art date: 1996-07-05

Application number

EEP199900014A

Other languages

English (en)

Other versions

EE9900014A (et

Inventor

Francis Leadlay Peter

Stephen Pacey Michael

Staunton James

Cortes Jesus

Original Assignee

Biotica Technology Limited

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-05

Filing date

1997-07-04

Publication date

2003-02-17

1996-07-05 Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en

1997-05-28 Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en

1997-07-04 Application filed by Biotica Technology Limited, Pfizer Inc. filed Critical Biotica Technology Limited

1999-08-16 Publication of EE9900014A publication Critical patent/EE9900014A/et

2003-02-17 Publication of EE03976B1 publication Critical patent/EE03976B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Biophysics (AREA)
Oncology (AREA)
Cardiology (AREA)
Plant Pathology (AREA)
Vascular Medicine (AREA)
Physics & Mathematics (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EEP199900014A 1996-07-05 1997-07-04 Erütromütsiinid ja nende valmistamise meetod EE03976B1 (et)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9614189.0A GB9614189D0 (en)	1996-07-05	1996-07-05	Polyketides and their synthesis
US2418896P	1996-08-19	1996-08-19
GBGB9710962.3A GB9710962D0 (en)	1997-05-28	1997-05-28	Polyketides and their synthesis
PCT/GB1997/001810 WO1998001571A2 (en)	1996-07-05	1997-07-04	Erythromycins and process for their preparation

Publications (2)

Publication Number	Publication Date
EE9900014A EE9900014A (et)	1999-08-16
EE03976B1 true EE03976B1 (et)	2003-02-17

Family

ID=27268361

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900014A EE03976B1 (et)	1996-07-05	1997-07-04	Erütromütsiinid ja nende valmistamise meetod

Country Status (28)

Country	Link
EP (3)	EP0910633B1 (et)
JP (2)	JP2000511063A (et)
KR (1)	KR20000023579A (et)
CN (1)	CN1179046C (et)
AP (1)	AP1029A (et)
AT (2)	ATE296893T1 (et)
AU (2)	AU731301B2 (et)
BG (1)	BG103133A (et)
BR (1)	BR9710209A (et)
CA (2)	CA2259463A1 (et)
DE (2)	DE69739688D1 (et)
DK (2)	DK0910633T3 (et)
EA (1)	EA001744B1 (et)
EE (1)	EE03976B1 (et)
ES (2)	ES2337424T3 (et)
GB (1)	GB2331518B (et)
GE (1)	GEP20012348B (et)
IL (1)	IL127916A0 (et)
IS (1)	IS4940A (et)
NO (1)	NO990012L (et)
NZ (1)	NZ333861A (et)
OA (1)	OA10952A (et)
PL (1)	PL331285A1 (et)
PT (1)	PT909327E (et)
SI (1)	SI0910633T1 (et)
SK (1)	SK182498A3 (et)
TR (1)	TR199900006T2 (et)
WO (2)	WO1998001546A2 (et)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
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US6063561A (en) *	1991-01-17	2000-05-16	Abbott Laboratories	Polyketide derivatives and recombinant methods for making same
US6060234A (en) *	1991-01-17	2000-05-09	Abbott Laboratories	Polyketide derivatives and recombinant methods for making same
US6558942B1 (en)	1994-05-06	2003-05-06	The Leland Stanford Junior University	Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US20030170725A1 (en)	1993-09-20	2003-09-11	Chaitan Khosla	Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6927057B2 (en)	1993-09-20	2005-08-09	Kosan Biosciences	Macrolide analogs
US6500960B1 (en)	1995-07-06	2002-12-31	Stanford University (Board Of Trustees Of The Leland Stanford Junior University)	Method to produce novel polyketides
US5712146A (en)	1993-09-20	1998-01-27	The Leland Stanford Junior University	Recombinant combinatorial genetic library for the production of novel polyketides
US6495348B1 (en)	1993-10-07	2002-12-17	Regents Of The University Of Minnesota	Mitomycin biosynthetic gene cluster
DE69634127D1 (de)	1995-07-06	2005-02-03	Univ Leland Stanford Junior	Zellfreie synthese von polyketiden
EP0870053A4 (en)	1995-12-19	2002-09-11	Univ Minnesota	METABOLIC METHOD FOR PRODUCING POLYHYDROXYALKANOATE MONOMER SYNTHASES
US6271255B1 (en)	1996-07-05	2001-08-07	Biotica Technology Limited	Erythromycins and process for their preparation
US6399789B1 (en)	1996-12-18	2002-06-04	Kosan Biosciences, Inc.	Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6117659A (en) *	1997-04-30	2000-09-12	Kosan Biosciences, Inc.	Recombinant narbonolide polyketide synthase
US6503741B1 (en)	1998-05-28	2003-01-07	Kosan Biosciences, Inc.	Polyketide synthase genes from Streptomyces venezuelae
IL132590A0 (en)	1997-04-30	2001-03-19	Kosan Biosciences Inc	Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold
JP2008169226A (ja) *	1997-04-30	2008-07-24	Kosan Biosciences Inc	足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー
US6902913B2 (en)	1997-04-30	2005-06-07	Kosan Biosciences, Inc.	Recombinant narbonolide polyketide synthase
US6262340B1 (en)	1997-07-10	2001-07-17	Kosan Biosciences, Inc.	Production of polyketides in plants
AP1060A (en)	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
EP1045912A1 (en) *	1998-01-14	2000-10-25	Glaxo Group Limited	Polyketides and their synthesis
NZ509006A (en) *	1998-05-28	2003-09-26	Kosan Biosciences Inc	Recombinant narbonolide polyketide synthase
US6265202B1 (en) *	1998-06-26	2001-07-24	Regents Of The University Of Minnesota	DNA encoding methymycin and pikromycin
GB9814006D0 (en)	1998-06-29	1998-08-26	Biotica Tech Ltd	Polyketides and their synthesis
AU765821B2 (en)	1998-07-02	2003-10-02	Board Of Regents Of The Leland Stanford Junior University, The	Methods for making polyketides
GB9814622D0 (en) *	1998-07-06	1998-09-02	Biotica Tech Ltd	Polyketides,their preparation,and materials for use therein
AU1447700A (en)	1998-10-28	2000-05-15	Kosan Biosciences, Inc.	Library of novel "unnatural" natural products
ID28286A (id)	1998-11-03	2001-05-10	Pfizer Prod Inc	Antibiotik-antibiotik makrolida baru
US6358712B1 (en)	1999-01-05	2002-03-19	Trustee Of Boston University	Ordered gene assembly
IL144178A0 (en)	1999-01-27	2002-05-23	Pfizer Prod Inc	Ketolide antibiotics
CA2359801A1 (en)	1999-02-09	2000-08-17	Rajesh S. Gokhale	Methods to mediate polyketide synthase module effectiveness
US7001748B2 (en)	1999-02-09	2006-02-21	The Board Of Trustees Of The Leland Stanford Junior University	Methods of making polyketides using hybrid polyketide synthases
ES2272273T3 (es)	1999-04-16	2007-05-01	Kosan Biosciences, Inc.	Agentes antiinfecciosos macrolidos.
CA2370743A1 (en)	1999-04-16	2000-10-26	Dennis Hlasta	Ketolide antibacterials
US6590083B1 (en)	1999-04-16	2003-07-08	Ortho-Mcneil Pharmaceutical, Inc.	Ketolide antibacterials
US6514944B2 (en)	1999-04-16	2003-02-04	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6939861B2 (en)	1999-04-16	2005-09-06	Kosan Biosciences, Inc.	Amido macrolides
US6451768B1 (en)	1999-04-16	2002-09-17	Kosan Biosciences, Inc.	Macrolide antiinfective agents
CZ20013733A3 (cs)	1999-05-24	2002-11-13	Pfizer Products Inc.	Deriváty 13-methylerythromycinu
GB9912563D0 (en) *	1999-05-28	1999-07-28	Biotica Tech Ltd	Polyketides and their synthesis
WO2001034816A1 (en) *	1999-10-29	2001-05-17	Kosan Biosciences, Inc.	Rapamycin analogs
EP1101769A3 (en)	1999-11-18	2001-10-24	Pfizer Products Inc.	Nitrogen containing erythromycin derivatives
AU2001238476A1 (en)	2000-02-18	2001-08-27	Kosan Biosciences, Inc.	Motocide compounds
EP1146051A3 (en) *	2000-04-10	2001-10-31	Pfizer Products Inc.	Erythromycin A derivatives
DE60140936D1 (de)	2000-04-13	2010-02-11	Biotica Tech Ltd	Glycosylierte hybrid-verbindungen, deren herstellung und verwendung
CN1633237B (zh)	2002-02-19	2010-05-26	道农业科学公司	新的产生spinosyn的聚酮合酶
WO2004007709A2 (en)	2002-07-16	2004-01-22	Biotica Technology Limited	Production of polyketides
DK200201957A (da) *	2002-12-20	2003-01-20	Alpharma Aps	10-substituted erythromycin ketolides and methods of making
GB0230217D0 (en) *	2002-12-27	2003-02-05	Biotica Tech Ltd	Borrelidin-producing polyketide synthase and its uses
EP2529730A1 (en)	2003-06-16	2012-12-05	ANDRX Pharmaceuticals LLC.	Oral sustained-release composition
GB0327720D0 (en)	2003-11-28	2003-12-31	Biotica Tech Ltd	Erythromycins and process for their preparation
GB0417852D0 (en)	2004-08-11	2004-09-15	Biotica Tech Ltd	Production of polyketides and other natural products
US7582611B2 (en) *	2005-05-24	2009-09-01	Pfizer Inc.	Motilide compounds
US8962329B2 (en)	2008-09-24	2015-02-24	Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences	Gene cluster
GB0904540D0 (en)	2009-03-17	2009-04-29	Biotica Tech Ltd	Novel compounds and methods for their production
CN101519637B (zh) *	2009-04-07	2011-06-15	华东理工大学	一种红色糖多孢菌及其发酵生产红霉素的方法
GB0914589D0 (en)	2009-08-20	2009-09-30	Biotica Tech Ltd	Novel compounds and methods for their production
WO2011098805A1 (en)	2010-02-09	2011-08-18	Biotica Technology Limited	Sanglifehrin based compounds
WO2011098808A1 (en)	2010-02-09	2011-08-18	Biotica Technology Limited	Sanglifehrin based compounds
BR112012019866A8 (pt)	2010-02-09	2017-12-26	Biotica Tech Limited	Composto, uso do mesmo, composição farmacêutica, e, processo para preparar um composto
GB201118334D0 (en)	2011-10-24	2011-12-07	Biotica Tech Ltd	Novel dosage form
WO2013172782A1 (en) *	2012-05-16	2013-11-21	Nanyang Technological University	A polyketide synthase construct and its use in the preparation of polyketides
WO2016112295A1 (en)	2015-01-09	2016-07-14	Warp Drive Bio, Inc.	Compounds that participate in cooperative binding and uses thereof
US10907188B2 (en)	2016-04-12	2021-02-02	Ginkgo Bioworks, Inc.	Compositions and methods for the production of compounds
SI3491132T1 (sl)	2016-07-29	2021-11-30	Isomerase Therapeutics Limited	Metode in konstrukti za proizvodnjo hibridnih poliketidov (PKS) modularnih PKS tipa 1 ali hibridnih modularnih ne-ribosomalnih peptidov (NRPS)
US20190264184A1 (en) *	2016-10-28	2019-08-29	Ginkgo Bioworks, Inc.	Compositions and methods for the production of compounds
CN110506120A (zh)	2016-10-28	2019-11-26	银杏生物制品公司	用于生产化合物的组合物和方法
CN110678476A (zh)	2017-02-22	2020-01-10	免疫系统调节控股有限公司	新型免疫刺激大环内酯
CA3053874A1 (en)	2017-02-22	2018-08-30	Immune System Regulation Holding Ab	Novel immune stimulating macrolides
CN112188893A (zh)	2018-03-23	2021-01-05	Isr免疫系统调节控股公共有限公司	大环内酯化合物和免疫检查点抑制剂的组合
WO2020154447A1 (en)	2019-01-22	2020-07-30	Aeovian Pharmaceuticals, Inc.	Mtorc modulators and uses thereof
CR20220240A (es)	2019-11-04	2022-08-03	Revolution Medicines Inc	Inhibidores de ras
CA3160142A1 (en)	2019-11-04	2021-05-14	Revolution Medicines, Inc.	Ras inhibitors
PE20221278A1 (es)	2019-11-04	2022-09-05	Revolution Medicines Inc	Inhibidores de ras
IL301298A (en)	2020-09-15	2023-05-01	Revolution Medicines Inc	Indole derivatives as ras inhibitors in the treatment of cancer
AR127308A1 (es)	2021-10-08	2024-01-10	Revolution Medicines Inc	Inhibidores ras
CN117288869B (zh) *	2023-11-24	2024-02-09	中国医学科学院医药生物技术研究所	一种原料药中对甲苯磺酸酯类杂质的检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6060234A (en) *	1991-01-17	2000-05-09	Abbott Laboratories	Polyketide derivatives and recombinant methods for making same
WO1993013663A1 (en) *	1992-01-17	1993-07-22	Abbott Laboratories	Method of directing biosynthesis of specific polyketides
US5712146A (en) *	1993-09-20	1998-01-27	The Leland Stanford Junior University	Recombinant combinatorial genetic library for the production of novel polyketides
PT725778E (pt) *	1993-09-20	2002-03-28	Univ Leland Stanford Junior	Producao recombinante de novos policetidos

1997
- 1997-07-04 GB GB9900156A patent/GB2331518B/en not_active Expired - Fee Related
- 1997-07-04 TR TR1999/00006T patent/TR199900006T2/xx unknown
- 1997-07-04 CN CNB97197649XA patent/CN1179046C/zh not_active Expired - Fee Related
- 1997-07-04 WO PCT/GB1997/001819 patent/WO1998001546A2/en active Application Filing
- 1997-07-04 ES ES97930631T patent/ES2337424T3/es not_active Expired - Lifetime
- 1997-07-04 AT AT97930626T patent/ATE296893T1/de active
- 1997-07-04 GE GEAP19974661A patent/GEP20012348B/en unknown
- 1997-07-04 EP EP97930631A patent/EP0910633B1/en not_active Expired - Lifetime
- 1997-07-04 EP EP09178121A patent/EP2182067A3/en not_active Withdrawn
- 1997-07-04 CA CA002259463A patent/CA2259463A1/en not_active Abandoned
- 1997-07-04 DK DK97930631.3T patent/DK0910633T3/da active
- 1997-07-04 EA EA199900087A patent/EA001744B1/ru not_active IP Right Cessation
- 1997-07-04 DK DK97930626T patent/DK0909327T3/da active
- 1997-07-04 PL PL97331285A patent/PL331285A1/xx unknown
- 1997-07-04 SK SK1824-98A patent/SK182498A3/sk unknown
- 1997-07-04 AP APAP/P/1999/001444A patent/AP1029A/en active
- 1997-07-04 AT AT97930631T patent/ATE451455T1/de not_active IP Right Cessation
- 1997-07-04 AU AU34509/97A patent/AU731301B2/en not_active Ceased
- 1997-07-04 JP JP10504933A patent/JP2000511063A/ja not_active Withdrawn
- 1997-07-04 CA CA002259420A patent/CA2259420C/en not_active Expired - Fee Related
- 1997-07-04 ES ES97930626T patent/ES2244001T3/es not_active Expired - Lifetime
- 1997-07-04 WO PCT/GB1997/001810 patent/WO1998001571A2/en not_active Application Discontinuation
- 1997-07-04 AU AU34514/97A patent/AU731654B2/en not_active Ceased
- 1997-07-04 SI SI9730793T patent/SI0910633T1/sl unknown
- 1997-07-04 BR BR9710209-1A patent/BR9710209A/pt not_active Application Discontinuation
- 1997-07-04 IL IL12791697A patent/IL127916A0/xx unknown
- 1997-07-04 PT PT97930626T patent/PT909327E/pt unknown
- 1997-07-04 DE DE69739688T patent/DE69739688D1/de not_active Expired - Lifetime
- 1997-07-04 JP JP50492598A patent/JP4173551B2/ja not_active Expired - Fee Related
- 1997-07-04 EP EP97930626A patent/EP0909327B1/en not_active Expired - Lifetime
- 1997-07-04 NZ NZ333861A patent/NZ333861A/xx unknown
- 1997-07-04 EE EEP199900014A patent/EE03976B1/et not_active IP Right Cessation
- 1997-07-04 DE DE69733416T patent/DE69733416T2/de not_active Expired - Lifetime
1999
- 1999-01-04 OA OA9900002A patent/OA10952A/en unknown
- 1999-01-04 NO NO990012A patent/NO990012L/no not_active Application Discontinuation
- 1999-01-04 IS IS4940A patent/IS4940A/is unknown
- 1999-01-05 KR KR1019997000024A patent/KR20000023579A/ko not_active Application Discontinuation
- 1999-01-29 BG BG103133A patent/BG103133A/xx unknown

Also Published As

Publication number	Publication date
IS4940A (is)	1999-01-04
EP2182067A2 (en)	2010-05-05
JP2000516450A (ja)	2000-12-12
EP2182067A3 (en)	2010-07-14
GB2331518A (en)	1999-05-26
CA2259420A1 (en)	1998-01-15
CA2259463A1 (en)	1998-01-15
WO1998001546A3 (en)	1998-04-09
SK182498A3 (en)	2000-05-16
EP0910633B1 (en)	2009-12-09
EP0909327B1 (en)	2005-06-01
DK0910633T3 (da)	2010-03-29
ATE296893T1 (de)	2005-06-15
AU731654B2 (en)	2001-04-05
DE69733416D1 (de)	2005-07-07
GB9900156D0 (en)	1999-02-24
BG103133A (en)	2000-04-28
NZ333861A (en)	2000-08-25
DE69733416T2 (de)	2006-04-27
DE69739688D1 (de)	2010-01-21
ATE451455T1 (de)	2009-12-15
WO1998001546A2 (en)	1998-01-15
AP9901444A0 (en)	1999-03-31
CA2259420C (en)	2007-09-18
IL127916A0 (en)	1999-11-30
WO1998001571A2 (en)	1998-01-15
AU3451497A (en)	1998-02-02
EP0910633A2 (en)	1999-04-28
KR20000023579A (ko)	2000-04-25
AP1029A (en)	2001-12-11
EE9900014A (et)	1999-08-16
JP4173551B2 (ja)	2008-10-29
TR199900006T2 (xx)	1999-04-21
OA10952A (en)	2002-02-25
AU3450997A (en)	1998-02-02
GB2331518B (en)	2001-03-14
PT909327E (pt)	2005-10-31
AU731301B2 (en)	2001-03-29
NO990012L (no)	1999-02-23
DK0909327T3 (da)	2005-09-26
CN1229438A (zh)	1999-09-22
PL331285A1 (en)	1999-07-05
JP2000511063A (ja)	2000-08-29
BR9710209A (pt)	2000-01-11
SI0910633T1 (sl)	2010-04-30
NO990012D0 (no)	1999-01-04
CN1179046C (zh)	2004-12-08
EA199900087A1 (ru)	1999-08-26
ES2337424T3 (es)	2010-04-23
EP0909327A2 (en)	1999-04-21
GEP20012348B (en)	2001-01-25
EA001744B1 (ru)	2001-08-27
ES2244001T3 (es)	2005-12-01
WO1998001571A3 (en)	1998-02-19

Publication	Publication Date	Title
EE03976B1 (et)	2003-02-17	Erütromütsiinid ja nende valmistamise meetod
FI973750A0 (fi)	1997-09-22	2-metyylitienobentsodiatsepiinin valmistus ja kiteiset muodot
EE04540B1 (et)	2005-10-17	Meetod bioloogiliselt sobivate biodegradeeruvate mikroosakeste valmistamiseks ja mikroosakeste kasutamine
FI962544A0 (fi)	1996-06-19	Lattakaapeli ja menetelmä sen valmistamiseksi
FI941137A (fi)	1994-09-12	2-debentsoyyli-2-asyylitaksolijohdannaisia ja menetelmiä niiden valmistamiseksi
FI972165A (fi)	1997-07-21	Aerogeelipitoinen komposiittimateriaali, menetelmä sen valmistamiseksi ja sen käyttö
FI951340A0 (fi)	1995-03-22	SOI-substraatti ja menetelmä sen valmistamiseksi
FI962055A (fi)	1996-11-17	Pariston jatkolaite ja siihen liittyvä menetelmä
FR2744442B1 (fr)	1998-02-27	Preparation du 1,1,1,3,3-pentachlorobutane et du 1,1,1,3,3,-pentafluorobutane
EE9800161A (et)	1998-12-15	Vähivaktsiin ja selle valmistamismeetod
FI980246A0 (fi)	1998-02-04	Menetelmä keittimen käyttämiseksi ja keitin
EE9800234A (et)	1998-12-15	Ravimeetod ja farmatseutiline kompositsioon
KR960007649A (ko)	1996-03-22	공중합 폴리아미드 및 그의 제조방법
EE9900141A (et)	1999-12-15	Keerdotstega suletav pakend ja meetod pakendamiseks
FI108157B (fi)	2001-11-30	Kytkentämenetelmä ja laite
FI971138A (fi)	1997-03-18	Keraamisia eristeitä ja menetelmiä niiden muodostamiseksi
DE69524527D1 (de)	2002-01-24	AIDS-hemmende Arzneizubereitung und Verfahren
DE19749117B4 (de)	2005-10-20	Pleuelstange und Herstellungsverfahren dafür
FI953391A0 (fi)	1995-07-11	Komposiittimateriaali, menetelmä sen valmistamiseksi ja sen käyttö
FI940403A (fi)	1994-07-30	Elliptisiinijohdannainen ja menetelmä sen valmistamiseksi
EE9700139A (et)	1997-12-15	Diaminoeetri diklavulanaatsool ja selle valmistamismeetod
IL130510A0 (en)	2000-06-01	Novel erythromycin derivatives method of preparation and application as medicines
FI99277B (fi)	1997-12-31	Ilmanjakolaite ja menetelmä ilmanjakolaitteen säädössä
FI974086A (fi)	1999-04-30	Säätömenetelmä ja säätöjärjestely
FR2750425B1 (fr)	1998-08-28	Preparation de derives de 3-amino-isoxazole et nouveaux 3-amino-isoxazoles intermediaires

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2005-04-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20040704