EE03688B1 - N-[4-(heteroarüülmetüül)fenüül]-heteroarüülamiinid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja meetod selle valmistamiseks - Google Patents
N-[4-(heteroarüülmetüül)fenüül]-heteroarüülamiinid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja meetod selle valmistamiseksInfo
- Publication number
- EE03688B1 EE03688B1 EE9800437A EE9800437A EE03688B1 EE 03688 B1 EE03688 B1 EE 03688B1 EE 9800437 A EE9800437 A EE 9800437A EE 9800437 A EE9800437 A EE 9800437A EE 03688 B1 EE03688 B1 EE 03688B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- heteroarylamines
- heteroarylmethyl
- phenyl
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96201781 | 1996-06-27 | ||
| PCT/EP1997/003248 WO1997049704A1 (en) | 1996-06-27 | 1997-06-19 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9800437A EE9800437A (et) | 1999-06-15 |
| EE03688B1 true EE03688B1 (et) | 2002-04-15 |
Family
ID=8224119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9800437A EE03688B1 (et) | 1996-06-27 | 1997-06-19 | N-[4-(heteroarüülmetüül)fenüül]-heteroarüülamiinid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja meetod selle valmistamiseks |
Country Status (33)
| Country | Link |
|---|---|
| US (5) | US6124330A (hu) |
| EP (1) | EP0907650B1 (hu) |
| JP (1) | JP3404749B2 (hu) |
| KR (1) | KR100365312B1 (hu) |
| CN (1) | CN1102593C (hu) |
| AR (1) | AR007626A1 (hu) |
| AT (1) | ATE229019T1 (hu) |
| AU (1) | AU711575B2 (hu) |
| BG (1) | BG63545B1 (hu) |
| BR (1) | BR9710002A (hu) |
| CA (1) | CA2258165C (hu) |
| CZ (1) | CZ297769B6 (hu) |
| DE (1) | DE69717627T2 (hu) |
| DK (1) | DK0907650T3 (hu) |
| EE (1) | EE03688B1 (hu) |
| ES (1) | ES2188957T3 (hu) |
| HK (1) | HK1018458A1 (hu) |
| HU (1) | HU223093B1 (hu) |
| ID (1) | ID17275A (hu) |
| IL (1) | IL127740A (hu) |
| MY (1) | MY116917A (hu) |
| NO (1) | NO312102B1 (hu) |
| NZ (1) | NZ333382A (hu) |
| PL (1) | PL201704B1 (hu) |
| PT (1) | PT907650E (hu) |
| RU (1) | RU2190611C2 (hu) |
| SI (1) | SI0907650T1 (hu) |
| SK (1) | SK282769B6 (hu) |
| TR (1) | TR199802709T2 (hu) |
| TW (1) | TW490464B (hu) |
| UA (1) | UA53649C2 (hu) |
| WO (1) | WO1997049704A1 (hu) |
| ZA (1) | ZA975698B (hu) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0907650T3 (da) * | 1996-06-27 | 2003-03-10 | Janssen Pharmaceutica Nv | N-4-(heteroarylmethyl)phenyl]-heteroaryl aminer |
| DK1037880T3 (da) | 1997-12-11 | 2004-11-15 | Janssen Pharmaceutica Nv | Anilider som retinsyremimetika |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| DE19951701A1 (de) | 1999-10-27 | 2001-05-03 | Aventis Pharma Gmbh | Verwendung von 2-Imidazolyl-substituierten Carbinolen zur Herstellung eines Medikaments zur Behandlung oder Prophylaxe von durch ischämischen Zuständen bewirkten Krankheiten |
| AU2003223672A1 (en) * | 2002-04-17 | 2003-11-03 | Tyco Healthcare Group Lp | Method and apparatus for anastomosis including an expandable anchor |
| AU2003284981B2 (en) | 2002-10-30 | 2009-05-28 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| CA2522430A1 (en) | 2003-04-24 | 2004-11-11 | Merck & Co., Inc. | Inhibitors of akt activity |
| US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| WO2005003100A2 (en) | 2003-07-03 | 2005-01-13 | Myriad Genetics, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
| DE10337942A1 (de) * | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Aminobenzimidazolderivate |
| WO2006036507A1 (en) | 2004-09-24 | 2006-04-06 | Allergan, Inc. | 4-(heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists |
| AU2005289998A1 (en) * | 2004-09-24 | 2006-04-06 | Allergan, Inc. | 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists |
| AU2005290075A1 (en) | 2004-09-24 | 2006-04-06 | Allergan, Inc. | 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists |
| BRPI0516217A (pt) * | 2004-09-28 | 2008-08-26 | Allergan Inc | compostos de 4-benzil-1,3-diidro-imidazol-2-tionas não-substituìdos e substituìdos que atuam como agonistas especìficos ou seletivos alfa2-adrenérgicos e métodos de utilização dos mesmos |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| US7547782B2 (en) | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| EP1981343B8 (en) * | 2006-01-17 | 2015-06-24 | Stiefel Laboratories, Inc. | Treatment of inflammatory disorders with triazole compounds |
| US8188124B2 (en) | 2006-10-17 | 2012-05-29 | Stiefel Laboratories, Inc. | Talarazole metabolites |
| CA2702307C (en) * | 2007-10-18 | 2016-04-05 | Dompe S.P.A. | (r)-4-(heteroaryl) phenylethyl derivatives and pharmaceutical compositions containing them |
| GB0811091D0 (en) * | 2008-06-17 | 2008-07-23 | Cancer Rec Tech Ltd | CYP26 Inhibitors |
| US10414760B2 (en) | 2016-11-29 | 2019-09-17 | Angion Biomedica Corp. | Cytochrome P450 inhibitors and uses thereof |
| EP2576544A4 (en) | 2010-06-01 | 2013-09-11 | Angion Biomedica Corp | INHIBITORS OF CYTOCHROMES P450 AND USES THEREOF |
| KR101108577B1 (ko) * | 2010-07-28 | 2012-01-30 | 국제엘렉트릭코리아 주식회사 | 테이프 히터 |
| RU2017135541A (ru) | 2010-11-19 | 2019-02-08 | Лиганд Фармасьютикалс Инкорпорейтед | Гетероциклические амины и их применения |
| US9248120B2 (en) | 2011-08-23 | 2016-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Reversing intestinal inflammation by inhibiting retinoic acid metabolism |
| AU2015301891B2 (en) | 2014-08-11 | 2019-12-05 | Angion Biomedica Corporation | Cytochrome P450 inhibitors and uses thereof |
| JP2018501279A (ja) | 2014-12-31 | 2018-01-18 | アンギオン バイオメディカ コーポレイション | 疾患を治療するための方法及び薬剤 |
| US10807983B2 (en) | 2015-03-16 | 2020-10-20 | Ligand Pharmaceuticals, Inc. | Imidazo-fused heterocycles and uses thereof |
| CN106632051A (zh) * | 2016-12-15 | 2017-05-10 | 青岛辰达生物科技有限公司 | 一种盐酸右美托咪定中间体的合成方法 |
| CN106588780A (zh) * | 2016-12-15 | 2017-04-26 | 青岛辰达生物科技有限公司 | 一种盐酸右美托咪定中间体的制备工艺 |
| CN106588779A (zh) * | 2016-12-15 | 2017-04-26 | 青岛辰达生物科技有限公司 | 一种合成盐酸右美托咪定中间体的方法 |
| KR20210055340A (ko) | 2019-11-07 | 2021-05-17 | 정화종 | 화물 커버 |
| CN115462347B (zh) * | 2021-08-13 | 2024-07-16 | 广州市妇女儿童医疗中心 | 视黄酸代谢通路在先天性巨结肠疾病中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ221729A (en) * | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
| CA2002859C (en) * | 1988-11-29 | 1998-12-29 | Jean P. F. Van Wauwe | Method of treating epithelial disorders |
| DE69132329T2 (de) | 1990-04-25 | 2000-11-30 | Nissan Chemical Industries, Ltd. | Pyridazinonderivat |
| TW321649B (hu) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| US5582832A (en) * | 1995-06-06 | 1996-12-10 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Compositions for topical application to skin |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| HUP9901155A3 (en) | 1996-02-13 | 2003-04-28 | Astrazeneca Ab | Quinazoline derivatives as vegf inhibitors |
| US5731342A (en) * | 1996-02-22 | 1998-03-24 | Eli Lilly And Company | Benzothiophenes, formulations containing same, and methods |
| DK0907650T3 (da) * | 1996-06-27 | 2003-03-10 | Janssen Pharmaceutica Nv | N-4-(heteroarylmethyl)phenyl]-heteroaryl aminer |
-
1997
- 1997-06-19 DK DK97930378T patent/DK0907650T3/da active
- 1997-06-19 PL PL330816A patent/PL201704B1/pl unknown
- 1997-06-19 BR BR9710002A patent/BR9710002A/pt not_active IP Right Cessation
- 1997-06-19 CN CN97195865A patent/CN1102593C/zh not_active Expired - Lifetime
- 1997-06-19 DE DE69717627T patent/DE69717627T2/de not_active Expired - Lifetime
- 1997-06-19 UA UA98116146A patent/UA53649C2/uk unknown
- 1997-06-19 HU HU9902138A patent/HU223093B1/hu active IP Right Grant
- 1997-06-19 WO PCT/EP1997/003248 patent/WO1997049704A1/en active IP Right Grant
- 1997-06-19 SK SK1781-98A patent/SK282769B6/sk not_active IP Right Cessation
- 1997-06-19 NZ NZ333382A patent/NZ333382A/xx not_active IP Right Cessation
- 1997-06-19 CA CA002258165A patent/CA2258165C/en not_active Expired - Lifetime
- 1997-06-19 IL IL12774097A patent/IL127740A/en not_active IP Right Cessation
- 1997-06-19 TR TR1998/02709T patent/TR199802709T2/xx unknown
- 1997-06-19 PT PT97930378T patent/PT907650E/pt unknown
- 1997-06-19 AT AT97930378T patent/ATE229019T1/de active
- 1997-06-19 AU AU34356/97A patent/AU711575B2/en not_active Expired
- 1997-06-19 ES ES97930378T patent/ES2188957T3/es not_active Expired - Lifetime
- 1997-06-19 US US09/214,080 patent/US6124330A/en not_active Expired - Lifetime
- 1997-06-19 SI SI9730478T patent/SI0907650T1/xx unknown
- 1997-06-19 KR KR10-1998-0709764A patent/KR100365312B1/ko not_active IP Right Cessation
- 1997-06-19 RU RU99101902/04A patent/RU2190611C2/ru active
- 1997-06-19 EP EP97930378A patent/EP0907650B1/en not_active Expired - Lifetime
- 1997-06-19 JP JP50232198A patent/JP3404749B2/ja not_active Expired - Lifetime
- 1997-06-19 EE EE9800437A patent/EE03688B1/xx unknown
- 1997-06-19 CZ CZ0423198A patent/CZ297769B6/cs not_active IP Right Cessation
- 1997-06-23 TW TW086108726A patent/TW490464B/zh not_active IP Right Cessation
- 1997-06-25 MY MYPI97002859A patent/MY116917A/en unknown
- 1997-06-26 AR ARP970102822A patent/AR007626A1/es active IP Right Grant
- 1997-06-26 ID IDP972217A patent/ID17275A/id unknown
- 1997-06-26 ZA ZA975698A patent/ZA975698B/xx unknown
-
1998
- 1998-12-14 BG BG103013A patent/BG63545B1/bg unknown
- 1998-12-21 NO NO19986017A patent/NO312102B1/no not_active IP Right Cessation
-
1999
- 1999-08-16 HK HK99103546A patent/HK1018458A1/xx not_active IP Right Cessation
-
2000
- 2000-07-25 US US09/624,966 patent/US6486187B1/en not_active Expired - Lifetime
-
2002
- 2002-09-10 US US10/238,686 patent/US6833375B2/en not_active Expired - Lifetime
-
2004
- 2004-11-02 US US10/979,362 patent/US7205312B2/en not_active Expired - Fee Related
-
2006
- 2006-12-13 US US11/639,043 patent/US7378433B2/en not_active Expired - Fee Related
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