ECSP17023551A - Inhibidores de histona desmetilasa - Google Patents
Inhibidores de histona desmetilasaInfo
- Publication number
- ECSP17023551A ECSP17023551A ECIEPI201723551A ECPI201723551A ECSP17023551A EC SP17023551 A ECSP17023551 A EC SP17023551A EC IEPI201723551 A ECIEPI201723551 A EC IEPI201723551A EC PI201723551 A ECPI201723551 A EC PI201723551A EC SP17023551 A ECSP17023551 A EC SP17023551A
- Authority
- EC
- Ecuador
- Prior art keywords
- cancer
- compositions
- compounds
- histone
- desmetilase
- Prior art date
Links
- 108010033040 Histones Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- QMOPAFMMLWUTKI-UHFFFAOYSA-N 1h-pyrido[3,4-d]pyrimidin-4-one Chemical class N1=CC=C2C(O)=NC=NC2=C1 QMOPAFMMLWUTKI-UHFFFAOYSA-N 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 102000008157 Histone Demethylases Human genes 0.000 abstract 1
- 108010074870 Histone Demethylases Proteins 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona en general con composiciones y métodos para tratar cáncer y enfermedad neoplásica. Se proporcionan aquí compuestos derivados de pirido[3,4-d]pirimidin-4-ona sustituidos y composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos y composiciones objeto son útiles para inhibición de histona desmetilasa. Adicionalmente, los compuestos y composiciones objeto son útiles para el tratamiento de cáncer, tal como cáncer de próstata, cáncer de mama, cáncer de vejiga, cáncer de pulmón y/o melanoma y similares.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051691P | 2014-09-17 | 2014-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP17023551A true ECSP17023551A (es) | 2017-05-31 |
Family
ID=55525128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201723551A ECSP17023551A (es) | 2014-09-17 | 2017-04-17 | Inhibidores de histona desmetilasa |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US9643965B2 (es) |
| EP (2) | EP3193601B1 (es) |
| JP (1) | JP6552608B2 (es) |
| KR (1) | KR20170048591A (es) |
| CN (1) | CN107205391A (es) |
| AU (1) | AU2015317806A1 (es) |
| BR (1) | BR112017005511A2 (es) |
| CA (1) | CA2961610A1 (es) |
| CL (1) | CL2017000659A1 (es) |
| CO (1) | CO2017003538A2 (es) |
| EA (1) | EA201790603A1 (es) |
| EC (1) | ECSP17023551A (es) |
| ES (1) | ES2910226T3 (es) |
| IL (1) | IL251179A0 (es) |
| MX (1) | MX2017003466A (es) |
| SG (1) | SG11201702147TA (es) |
| WO (1) | WO2016044429A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201700493T1 (it) | 2013-03-15 | 2017-11-15 | Quanticel Pharmaceuticals Inc | Inibitori dell' istone demetilasi |
| US9643965B2 (en) | 2014-09-17 | 2017-05-09 | Celgene Quantical Research, Inc. | Histone demethylase inhibitors |
| JP6970681B2 (ja) * | 2016-03-15 | 2021-11-24 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| PL3546456T3 (pl) | 2016-11-28 | 2022-05-02 | Teijin Pharma Limited | Kryształ pochodnej pirydo[3,4-d]pirymidyny lub jej solwatu |
| EP3600287B1 (en) | 2017-03-29 | 2023-07-05 | Purdue Research Foundation | Inhibitors of kinase networks and uses thereof |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| CN115368252B (zh) * | 2022-09-19 | 2024-01-12 | 西北农林科技大学 | 一种4-胺基酚类衍生物及应用 |
| CN116253712B (zh) * | 2023-03-27 | 2025-05-02 | 昆山市第一人民医院 | 5,6,7-三甲氧基-2,3-二氢喹啉类化合物、药物组合物及用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003033472A1 (fr) * | 2001-10-17 | 2003-04-24 | Kirin Beer Kabushiki Kaisha | Derives de quinoline ou de quinazoline inhibant l'autophosphorylation de recepteurs du facteur de croissance des fibroblastes |
| ATE468336T1 (de) * | 2002-03-15 | 2010-06-15 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
| BRPI0410720A (pt) * | 2003-05-27 | 2006-06-20 | Pfizer Prod Inc | quinazolinas e pirido[3,4-d]pirimidinas como inibidores do receptor de tirosina cinase |
| AU2005290081B2 (en) * | 2004-08-23 | 2010-12-02 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| FR2876103B1 (fr) | 2004-10-01 | 2008-02-22 | Aventis Pharma Sa | Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| JP2010502743A (ja) | 2006-09-11 | 2010-01-28 | キュリス，インコーポレイテッド | 抗増殖薬剤としての多機能性低分子 |
| TW200922590A (en) | 2007-09-10 | 2009-06-01 | Curis Inc | VEGFR inhibitors containing a zinc binding moiety |
| JP5552608B2 (ja) | 2012-04-27 | 2014-07-16 | 株式会社ソフイア | 遊技機 |
| KR102160320B1 (ko) | 2012-10-02 | 2020-09-28 | 에피테라퓨틱스 에이피에스 | 히스톤 탈메틸효소의 저해제 |
| AU2013361255B2 (en) | 2012-12-19 | 2017-01-05 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| ES2718495T3 (es) | 2012-12-21 | 2019-07-02 | Celgene Quanticel Res Inc | Inhibidores de la histona desmetilasa |
| AU2014249050B2 (en) | 2013-03-12 | 2017-10-05 | Celgene Quanticel Research, Inc. | Histone dementhylase inhibitors |
| SMT201700493T1 (it) | 2013-03-15 | 2017-11-15 | Quanticel Pharmaceuticals Inc | Inibitori dell' istone demetilasi |
| HK1214533A1 (zh) | 2013-03-15 | 2016-07-29 | 基因泰克公司 | 治疗癌症和预防癌症耐药性的方法 |
| NZ728120A (en) | 2014-06-25 | 2023-06-30 | Celgene Quanticel Res Inc | Histone demethylase inhibitors |
| US10030017B2 (en) | 2014-09-17 | 2018-07-24 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US9643965B2 (en) | 2014-09-17 | 2017-05-09 | Celgene Quantical Research, Inc. | Histone demethylase inhibitors |
| JP6970681B2 (ja) | 2016-03-15 | 2021-11-24 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
-
2015
- 2015-09-16 US US14/855,950 patent/US9643965B2/en active Active
- 2015-09-16 JP JP2017514615A patent/JP6552608B2/ja not_active Expired - Fee Related
- 2015-09-16 SG SG11201702147TA patent/SG11201702147TA/en unknown
- 2015-09-16 EA EA201790603A patent/EA201790603A1/ru unknown
- 2015-09-16 EP EP15842574.4A patent/EP3193601B1/en active Active
- 2015-09-16 WO PCT/US2015/050432 patent/WO2016044429A1/en active Application Filing
- 2015-09-16 EP EP18181949.1A patent/EP3453710B1/en active Active
- 2015-09-16 ES ES15842574T patent/ES2910226T3/es active Active
- 2015-09-16 CN CN201580061425.6A patent/CN107205391A/zh active Pending
- 2015-09-16 BR BR112017005511A patent/BR112017005511A2/pt not_active Application Discontinuation
- 2015-09-16 AU AU2015317806A patent/AU2015317806A1/en not_active Abandoned
- 2015-09-16 CA CA2961610A patent/CA2961610A1/en not_active Abandoned
- 2015-09-16 MX MX2017003466A patent/MX2017003466A/es unknown
- 2015-09-16 KR KR1020177009917A patent/KR20170048591A/ko not_active Withdrawn
-
2017
- 2017-03-15 IL IL251179A patent/IL251179A0/en unknown
- 2017-03-17 CL CL2017000659A patent/CL2017000659A1/es unknown
- 2017-04-12 CO CONC2017/0003538A patent/CO2017003538A2/es unknown
- 2017-04-17 EC ECIEPI201723551A patent/ECSP17023551A/es unknown
- 2017-05-05 US US15/588,561 patent/US10112940B2/en active Active
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2018
- 2018-09-20 US US16/137,219 patent/US10611763B2/en active Active
-
2020
- 2020-02-14 US US16/790,878 patent/US10815234B2/en active Active
- 2020-09-21 US US17/026,763 patent/US11535616B2/en active Active
-
2022
- 2022-11-03 US US17/980,291 patent/US12172998B2/en active Active
-
2024
- 2024-11-01 US US18/935,237 patent/US20250066355A1/en active Pending
Also Published As
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