ECSP11011150A - Derivados de arilciclopropilacetamida útiles como activadores de glucoquinasa - Google Patents
Derivados de arilciclopropilacetamida útiles como activadores de glucoquinasaInfo
- Publication number
- ECSP11011150A ECSP11011150A EC2011011150A ECSP11011150A ECSP11011150A EC SP11011150 A ECSP11011150 A EC SP11011150A EC 2011011150 A EC2011011150 A EC 2011011150A EC SP11011150 A ECSP11011150 A EC SP11011150A EC SP11011150 A ECSP11011150 A EC SP11011150A
- Authority
- EC
- Ecuador
- Prior art keywords
- glucoquinase
- arilciclopropilacetamide
- activators
- derivatives
- useful
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la fórmula:y composiciones farmacéuticas para el tratamiento de diabetes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08380341 | 2008-12-19 | ||
| US15378109P | 2009-02-19 | 2009-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11011150A true ECSP11011150A (es) | 2011-07-29 |
Family
ID=40545955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011011150A ECSP11011150A (es) | 2008-12-19 | 2011-06-17 | Derivados de arilciclopropilacetamida útiles como activadores de glucoquinasa |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US8063079B2 (es) |
| EP (1) | EP2379517B1 (es) |
| JP (1) | JP5497064B2 (es) |
| KR (1) | KR101290437B1 (es) |
| CN (1) | CN102256952B (es) |
| AR (1) | AR074470A1 (es) |
| AU (1) | AU2009335931B2 (es) |
| BR (1) | BRPI0923183B1 (es) |
| CA (1) | CA2746746C (es) |
| CO (1) | CO6382120A2 (es) |
| CR (1) | CR20110342A (es) |
| DK (1) | DK2379517T3 (es) |
| DO (1) | DOP2011000197A (es) |
| EA (1) | EA019055B1 (es) |
| EC (1) | ECSP11011150A (es) |
| ES (1) | ES2435242T3 (es) |
| HR (1) | HRP20130983T1 (es) |
| IL (1) | IL213210A (es) |
| JO (1) | JO2979B1 (es) |
| MA (1) | MA32902B1 (es) |
| MX (1) | MX2011006434A (es) |
| MY (1) | MY180567A (es) |
| NZ (1) | NZ592930A (es) |
| PA (1) | PA8851901A1 (es) |
| PE (1) | PE20120339A1 (es) |
| PL (1) | PL2379517T3 (es) |
| PT (1) | PT2379517E (es) |
| SG (1) | SG172256A1 (es) |
| SI (1) | SI2379517T1 (es) |
| TN (1) | TN2011000294A1 (es) |
| TW (1) | TWI395748B (es) |
| UA (1) | UA104742C2 (es) |
| WO (1) | WO2010080333A1 (es) |
| ZA (1) | ZA201103944B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011123572A1 (en) | 2010-03-31 | 2011-10-06 | The Scripps Research Institute | Reprogramming cells |
| WO2015075942A1 (ja) | 2013-11-22 | 2015-05-28 | 国立大学法人 東京大学 | 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60108108T2 (de) | 2000-05-03 | 2005-12-08 | F. Hoffmann-La Roche Ag | Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren |
| DE60106599T2 (de) | 2000-05-08 | 2006-02-09 | F. Hoffmann-La Roche Ag | Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren |
| ES2307623T3 (es) | 2000-05-08 | 2008-12-01 | F. Hoffmann-La Roche Ag | Activadores de fenilamida glucokinasa para-amina sustituida. |
| MY141521A (en) * | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
| EP1585739B1 (en) | 2003-01-06 | 2011-04-20 | Eli Lilly And Company | Substituted arylcyclopropylacetamides as glucokinase activators |
| JP4621198B2 (ja) | 2003-02-11 | 2011-01-26 | プロシディオン・リミテッド | トリ（シクロ）置換アミドグルコキナーゼ活性化化合物 |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| NZ541824A (en) * | 2003-02-26 | 2010-04-30 | Banyu Pharma Co Ltd | Heteroarylcarbamoylbenzene derivatives as glucokinase activators |
| CA2563192A1 (en) | 2004-04-21 | 2005-11-03 | Prosidion Limited | Tri(cyclo) substituted amide compounds |
| CA2576407A1 (en) | 2004-08-12 | 2006-02-16 | Prosidion Limited | Substituted phenylacetamides and their use as glucokinase activators |
| AU2005311269B2 (en) * | 2004-12-03 | 2011-11-10 | Transtech Pharma, Inc. | Heteroaromatic glucokinase activators |
| WO2007005763A2 (en) * | 2005-07-01 | 2007-01-11 | Novartis Ag | Combination of a renin inhibitor and an insulin secretion enhancer or an insulin sensitizer |
| JP4033409B1 (ja) | 2005-07-11 | 2008-01-16 | 田辺三菱製薬株式会社 | オキシム誘導体及びその製法 |
| JP2009504621A (ja) * | 2005-08-09 | 2009-02-05 | アストラゼネカ アクチボラグ | 糖尿病の処置のためのヘテロアリールカルバモイルベンゼン誘導体 |
| BRPI0618067A2 (pt) | 2005-11-03 | 2011-08-16 | Prosidion Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso e processo para a preparação de um composto ou um sal farmaceuticamente aceitável do mesmo |
| AU2006310474A1 (en) | 2005-11-03 | 2007-05-10 | Prosidion Ltd | Tricyclo substituted amides |
| US20080293741A1 (en) * | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
| WO2008012227A2 (en) * | 2006-07-24 | 2008-01-31 | F. Hoffmann-La Roche Ag | Pyrazoles as glucokinase activators |
| JP5207981B2 (ja) * | 2007-01-10 | 2013-06-12 | 田辺三菱製薬株式会社 | ヒドラゾン誘導体 |
| ME02198B (me) | 2008-04-28 | 2016-02-20 | Kyorin Seiyaku Kk | Derivati ciklopentilakrilamida |
-
2009
- 2009-11-12 UA UAA201107562A patent/UA104742C2/uk unknown
- 2009-12-03 PA PA20098851901A patent/PA8851901A1/es unknown
- 2009-12-03 AR ARP090104672A patent/AR074470A1/es active IP Right Grant
- 2009-12-04 TW TW098141556A patent/TWI395748B/zh active
- 2009-12-06 JO JO2009467A patent/JO2979B1/en active
- 2009-12-11 SG SG2011044823A patent/SG172256A1/en unknown
- 2009-12-11 CA CA2746746A patent/CA2746746C/en active Active
- 2009-12-11 WO PCT/US2009/067603 patent/WO2010080333A1/en active Application Filing
- 2009-12-11 EA EA201170845A patent/EA019055B1/ru not_active IP Right Cessation
- 2009-12-11 EP EP09768316.3A patent/EP2379517B1/en active Active
- 2009-12-11 PT PT97683163T patent/PT2379517E/pt unknown
- 2009-12-11 CN CN200980150686XA patent/CN102256952B/zh active Active
- 2009-12-11 BR BRPI0923183-8A patent/BRPI0923183B1/pt not_active IP Right Cessation
- 2009-12-11 AU AU2009335931A patent/AU2009335931B2/en not_active Ceased
- 2009-12-11 HR HRP20130983AT patent/HRP20130983T1/hr unknown
- 2009-12-11 SI SI200930713T patent/SI2379517T1/sl unknown
- 2009-12-11 US US12/635,758 patent/US8063079B2/en active Active
- 2009-12-11 MY MYPI2011002765A patent/MY180567A/en unknown
- 2009-12-11 NZ NZ592930A patent/NZ592930A/xx not_active IP Right Cessation
- 2009-12-11 KR KR1020117014073A patent/KR101290437B1/ko not_active Expired - Fee Related
- 2009-12-11 JP JP2011542276A patent/JP5497064B2/ja active Active
- 2009-12-11 PL PL09768316T patent/PL2379517T3/pl unknown
- 2009-12-11 DK DK09768316.3T patent/DK2379517T3/da active
- 2009-12-11 ES ES09768316T patent/ES2435242T3/es active Active
- 2009-12-11 PE PE2011001220A patent/PE20120339A1/es active IP Right Grant
- 2009-12-11 MX MX2011006434A patent/MX2011006434A/es active IP Right Grant
-
2011
- 2011-05-27 ZA ZA2011/03944A patent/ZA201103944B/en unknown
- 2011-05-30 IL IL213210A patent/IL213210A/en active IP Right Grant
- 2011-06-09 TN TN2011000294A patent/TN2011000294A1/fr unknown
- 2011-06-14 MA MA33945A patent/MA32902B1/fr unknown
- 2011-06-17 DO DO2011000197A patent/DOP2011000197A/es unknown
- 2011-06-17 EC EC2011011150A patent/ECSP11011150A/es unknown
- 2011-06-17 CR CR20110342A patent/CR20110342A/es unknown
- 2011-06-23 CO CO11079303A patent/CO6382120A2/es active IP Right Grant
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