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ECSP045156A - Derivados de indolilalquilamina como ligandos 5-hidroxitriptamina-6 - Google Patents

Derivados de indolilalquilamina como ligandos 5-hidroxitriptamina-6

Info

Publication number
ECSP045156A
ECSP045156A EC2004005156A ECSP045156A ECSP045156A EC SP045156 A ECSP045156 A EC SP045156A EC 2004005156 A EC2004005156 A EC 2004005156A EC SP045156 A ECSP045156 A EC SP045156A EC SP045156 A ECSP045156 A EC SP045156A
Authority
EC
Ecuador
Prior art keywords
indolilalquilamine
hidroxitriptamina
ligandos
derivatives
receptor
Prior art date
Application number
EC2004005156A
Other languages
English (en)
Inventor
Derek Cecil Cole
Joseph Raymond Stock
William Joseph Lennox
Ping Zhou
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP045156A publication Critical patent/ECSP045156A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención proporciona un compuesto de la fórmula (I) y su uso para el tratamiento terapéutico de desórdenes relacionados o afectados por el receptor 5-HT6.
EC2004005156A 2001-12-20 2004-06-16 Derivados de indolilalquilamina como ligandos 5-hidroxitriptamina-6 ECSP045156A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34290701P 2001-12-20 2001-12-20

Publications (1)

Publication Number Publication Date
ECSP045156A true ECSP045156A (es) 2004-07-23

Family

ID=23343804

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005156A ECSP045156A (es) 2001-12-20 2004-06-16 Derivados de indolilalquilamina como ligandos 5-hidroxitriptamina-6

Country Status (29)

Country Link
US (2) US6770642B2 (es)
EP (1) EP1455779B1 (es)
JP (1) JP4335684B2 (es)
KR (1) KR100985140B1 (es)
CN (1) CN1309385C (es)
AR (1) AR037906A1 (es)
AT (1) ATE335477T1 (es)
AU (1) AU2002357270B2 (es)
BR (1) BR0215222A (es)
CA (1) CA2470863C (es)
CO (1) CO5590924A2 (es)
CY (1) CY1105705T1 (es)
DE (1) DE60213856T2 (es)
DK (1) DK1455779T3 (es)
EC (1) ECSP045156A (es)
ES (1) ES2269827T3 (es)
HU (1) HUP0402640A3 (es)
IL (1) IL162243A0 (es)
MX (1) MXPA04005889A (es)
NO (1) NO330338B1 (es)
NZ (1) NZ533666A (es)
PL (1) PL210413B1 (es)
PT (1) PT1455779E (es)
RU (1) RU2309157C2 (es)
SI (1) SI1455779T1 (es)
TW (1) TWI254705B (es)
UA (1) UA78536C2 (es)
WO (1) WO2003053433A1 (es)
ZA (1) ZA200405731B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038532A1 (en) * 2000-11-09 2002-05-16 Mitsui Chemicals, Inc. Optically active amine derivative and method of synthesis
TW200301251A (en) * 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
EP1654258A1 (en) * 2003-07-23 2006-05-10 Wyeth Sulfonyldihydro- benzimidazolone compounds as 5-hydroxytryptamine-6 ligands
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
AU2004261606A1 (en) * 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-Hydroxytryptamine-6 ligands
TW200517381A (en) * 2003-08-01 2005-06-01 Genelabs Tech Inc Bicyclic heteroaryl derivatives
KR101049868B1 (ko) 2004-01-02 2011-07-19 수벤 라이프 사이언시스 리미티드 신규한 인데노[2,1ａ]인덴 및 이소인돌[2,1-ａ]인돌
PE20060303A1 (es) * 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
BRPI0519036A2 (pt) * 2004-12-14 2008-12-23 Wyeth Corp mÉtodo para o tratamento de um paciente acometido por uma doenÇa neuro-degenerativa; composiÇço farmacÊutica para tratar uma doenÇa neuro-degenerativa; e uso de um agonista 5-ht6 ou de um agonista 5-ht6
RU2007130896A (ru) * 2005-01-14 2009-02-20 Дженелэбс Текнолоджиз, Инк. (Us) Индольные производные для лечения вирусных инфекций
EP1953153A1 (en) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
BRPI0811225A2 (pt) * 2007-05-24 2014-10-29 Memory Pharm Corp Composto 4'-substituídos tendo afinidade pelo receptor 5-ht6.
DE602007012683D1 (de) * 2007-07-19 2011-04-07 Esteve Labor Dr Substituierte Tetrahydro-Chinolinsulfonamidverbindungen, ihre Herstellung und ihre Verwendung als Medikamente
EP2053052A1 (en) 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide
EP2231160B1 (en) * 2007-12-04 2013-08-14 Merck Sharp & Dohme Corp. Tryptamine sulfonamides as 5-ht6 antagonists
WO2009082268A2 (ru) 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) * 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
WO2015090233A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
MX380810B (es) 2014-08-29 2025-03-12 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
US10907197B2 (en) 2014-08-29 2021-02-02 Chdi Foundation, Inc. Probes for imaging huntingtin protein
CA3230779A1 (en) 2021-09-03 2023-03-09 Paul Daley Asymmetric allyl tryptamines

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
RU2101283C1 (ru) * 1992-04-07 1998-01-10 Пфайзер Инк. Производные индола или их фармацевтически приемлемые соли
US6194410B1 (en) 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
US6133287A (en) * 1998-03-24 2000-10-17 Allelix Biopharmaceuticals Inc. Piperidine-indole compounds having 5-HT6 affinity
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
US6403808B1 (en) * 1999-12-10 2002-06-11 Virginia Commonwealth University Selective 5-HT6 receptor ligands
DE60011269T2 (de) * 1999-08-12 2005-06-23 Nps Allelix Corp., Mississauga Azaidole mit serotonin rezeptor affinität
AU1542201A (en) * 1999-11-05 2001-05-14 Nps Allelix Corp. Compounds having 5-HT6 receptor antagonist activity
WO2001034146A1 (en) * 1999-11-08 2001-05-17 Smithkline Beecham Corporation Novel anti-infectives

Also Published As

Publication number Publication date
KR100985140B1 (ko) 2010-10-05
US7022701B2 (en) 2006-04-04
SI1455779T1 (sl) 2006-12-31
RU2309157C2 (ru) 2007-10-27
HUP0402640A2 (hu) 2005-04-28
TW200301252A (en) 2003-07-01
DE60213856T2 (de) 2007-09-13
JP2005517661A (ja) 2005-06-16
RU2004122129A (ru) 2005-05-10
IL162243A0 (en) 2005-11-20
US20040209867A1 (en) 2004-10-21
US6770642B2 (en) 2004-08-03
CO5590924A2 (es) 2005-12-30
CA2470863C (en) 2012-05-15
TWI254705B (en) 2006-05-11
PL370711A1 (en) 2005-05-30
AU2002357270B2 (en) 2007-06-14
ZA200405731B (en) 2007-02-28
HUP0402640A3 (en) 2012-09-28
BR0215222A (pt) 2005-05-24
US20030171353A1 (en) 2003-09-11
NZ533666A (en) 2006-03-31
PL210413B1 (pl) 2012-01-31
ES2269827T3 (es) 2007-04-01
KR20040075892A (ko) 2004-08-30
UA78536C2 (en) 2007-04-10
DE60213856D1 (de) 2006-09-21
NO20043100L (no) 2004-08-26
JP4335684B2 (ja) 2009-09-30
CY1105705T1 (el) 2010-12-22
EP1455779A1 (en) 2004-09-15
MXPA04005889A (es) 2004-11-01
DK1455779T3 (da) 2006-10-30
WO2003053433A1 (en) 2003-07-03
AU2002357270A1 (en) 2003-07-09
AR037906A1 (es) 2004-12-22
CA2470863A1 (en) 2003-07-03
EP1455779B1 (en) 2006-08-09
PT1455779E (pt) 2006-11-30
HK1065949A1 (en) 2005-03-11
ATE335477T1 (de) 2006-09-15
CN1309385C (zh) 2007-04-11
CN1620290A (zh) 2005-05-25
NO330338B1 (no) 2011-03-28

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