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EA202192093A1 - Пиразолопиридины и триазолопиридины в качестве ингибиторов a2а/a2b - Google Patents

Пиразолопиридины и триазолопиридины в качестве ингибиторов a2а/a2b

Info

Publication number
EA202192093A1
EA202192093A1 EA202192093A EA202192093A EA202192093A1 EA 202192093 A1 EA202192093 A1 EA 202192093A1 EA 202192093 A EA202192093 A EA 202192093A EA 202192093 A EA202192093 A EA 202192093A EA 202192093 A1 EA202192093 A1 EA 202192093A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diseases
triazolopyridines
pyrazolopyridines
inhibitors
activity
Prior art date
Application number
EA202192093A
Other languages
English (en)
Inventor
Тайшэн Хуан
Сяочжао Ван
Original Assignee
Инсайт Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Инсайт Корпорейшн filed Critical Инсайт Корпорейшн
Publication of EA202192093A1 publication Critical patent/EA202192093A1/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Данная заявка относится к соединениям формулы (I)или их фармацевтически приемлемым солям, которые модулируют активность аденозиновых рецепторов, таких как подтипы A2A и A2B рецепторов, и пригодны при лечении заболеваний, связанных с активностью аденозиновых рецепторов, включая, например, рак, воспалительные заболевания, сердечно-сосудистые заболевания и нейродегенеративные заболевания.
EA202192093A 2019-01-29 2020-01-28 Пиразолопиридины и триазолопиридины в качестве ингибиторов a2а/a2b EA202192093A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962798180P 2019-01-29 2019-01-29
PCT/US2020/015294 WO2020159905A1 (en) 2019-01-29 2020-01-28 Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors

Publications (1)

Publication Number Publication Date
EA202192093A1 true EA202192093A1 (ru) 2021-11-16

Family

ID=69771050

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192093A EA202192093A1 (ru) 2019-01-29 2020-01-28 Пиразолопиридины и триазолопиридины в качестве ингибиторов a2а/a2b

Country Status (34)

Country Link
US (2) US11390624B2 (ru)
EP (1) EP3917925B1 (ru)
JP (1) JP7447128B2 (ru)
KR (1) KR20210133224A (ru)
CN (1) CN113906022B (ru)
AR (1) AR117900A1 (ru)
AU (1) AU2020215673A1 (ru)
BR (1) BR112021014865A2 (ru)
CA (1) CA3127939A1 (ru)
CL (1) CL2021001984A1 (ru)
CO (1) CO2021011253A2 (ru)
CR (1) CR20210456A (ru)
DK (1) DK3917925T3 (ru)
EA (1) EA202192093A1 (ru)
EC (1) ECSP21063186A (ru)
ES (1) ES2984519T3 (ru)
FI (1) FI3917925T3 (ru)
HR (1) HRP20240491T1 (ru)
HU (1) HUE066718T2 (ru)
IL (1) IL285127B1 (ru)
LT (1) LT3917925T (ru)
MA (1) MA54870B1 (ru)
MD (1) MD3917925T2 (ru)
MX (1) MX2021009117A (ru)
PE (1) PE20212071A1 (ru)
PH (1) PH12021551817A1 (ru)
PL (1) PL3917925T3 (ru)
PT (1) PT3917925T (ru)
RS (1) RS65495B1 (ru)
SG (1) SG11202108180VA (ru)
SI (1) SI3917925T1 (ru)
SM (1) SMT202400170T1 (ru)
TW (1) TWI829857B (ru)
WO (1) WO2020159905A1 (ru)

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US11168089B2 (en) 2018-05-18 2021-11-09 Incyte Corporation Fused pyrimidine derivatives as A2A / A2B inhibitors
KR20210049090A (ko) 2018-07-05 2021-05-04 인사이트 코포레이션 A2a/a2b 억제제로서 융합된 피라진 유도체
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
WO2021138467A1 (en) 2020-01-03 2021-07-08 Incyte Corporation Anti-cd73 antibodies and uses thereof
JP2023509456A (ja) * 2020-01-03 2023-03-08 インサイト・コーポレイション A2a/a2b及びpd-1/pd-l1阻害剤を含む併用療法
AU2020419293A1 (en) 2020-01-03 2022-07-28 Incyte Corporation CD73 inhibitor and A2A/A2B adenosine receptor inhibitor combination therapy
CN119173276A (zh) 2022-04-13 2024-12-20 吉利德科学公司 用于治疗表达Trop-2的癌症的组合疗法

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