[go: up one dir, main page]

EA202191448A1 - Смешанные связывающие домены - Google Patents

Смешанные связывающие домены

Info

Publication number
EA202191448A1
EA202191448A1 EA202191448A EA202191448A EA202191448A1 EA 202191448 A1 EA202191448 A1 EA 202191448A1 EA 202191448 A EA202191448 A EA 202191448A EA 202191448 A EA202191448 A EA 202191448A EA 202191448 A1 EA202191448 A1 EA 202191448A1
Authority
EA
Eurasian Patent Office
Prior art keywords
variable region
linking domains
mixed
mixed linking
domains
Prior art date
Application number
EA202191448A
Other languages
English (en)
Inventor
Корнелис Адриан Де Крёйф
Original Assignee
Мерус Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерус Н.В. filed Critical Мерус Н.В.
Publication of EA202191448A1 publication Critical patent/EA202191448A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Связывающий домен, или мультимер, или их вариант, который содержит вариабельную область, кодируемую нуклеиновой кислотой, сформированной на основе, происходящей или полученной из животного, филогенетически удаленного от человека, причем вариабельная область объединена с вариабельной областью человека.
EA202191448A 2018-12-31 2019-12-27 Смешанные связывающие домены EA202191448A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18215995 2018-12-31
PCT/NL2019/050877 WO2020141973A1 (en) 2018-12-31 2019-12-27 Mixed binding domains

Publications (1)

Publication Number Publication Date
EA202191448A1 true EA202191448A1 (ru) 2021-11-19

Family

ID=65030899

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202191448A EA202191448A1 (ru) 2018-12-31 2019-12-27 Смешанные связывающие домены

Country Status (16)

Country Link
US (1) US20220073649A1 (ru)
EP (1) EP3906255A1 (ru)
JP (2) JP7443376B2 (ru)
KR (1) KR20210110600A (ru)
CN (2) CN113227132A (ru)
AR (1) AR117741A1 (ru)
AU (2) AU2019418280B2 (ru)
BR (1) BR112021013009A2 (ru)
CA (1) CA3124768A1 (ru)
EA (1) EA202191448A1 (ru)
IL (1) IL284353A (ru)
MX (1) MX2021007949A (ru)
PH (1) PH12021551547A1 (ru)
SG (1) SG11202106705UA (ru)
TW (1) TW202039548A (ru)
WO (1) WO2020141973A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ767923A (en) * 2018-03-30 2024-11-29 Merus Nv Multivalent antibody
EP3772518A1 (en) 2019-08-07 2021-02-10 Merus N.V. Modified human variable domains
CN118496354A (zh) * 2023-02-15 2024-08-16 三优生物医药(上海)有限公司 包含共同轻链的抗体库、其制备方法及其用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680376B2 (en) 2000-12-08 2004-01-20 Good Biotech Corporation Process for selectively isolating avian immunoglobulins
AU784900B2 (en) 2002-06-12 2006-07-20 Good Biotech Corporation Process for selectively isolating IgY antibodies from egg yolk of an anseriform bird and IgY antibodies obtained thereby
ES2368733T3 (es) 2002-07-18 2011-11-21 Merus B.V. Producción recombinante de mezclas de anticuerpos.
JP4452884B2 (ja) * 2005-03-01 2010-04-21 国立大学法人広島大学 抗体およびその利用
JP4487051B2 (ja) 2005-08-29 2010-06-23 独立行政法人科学技術振興機構 ダチョウを用いた抗体、及びその作製方法
DE102007035258B3 (de) 2007-07-27 2008-11-20 Forschungszentrum Karlsruhe Gmbh Einphasiges hydraulisches Bindemittel, Verfahren zu seiner Herstellung und mit diesem Bindemittel hergestellter Baustoff
NZ589086A (en) 2008-04-11 2012-09-28 Merrimack Pharmaceuticals Inc Human serum albumin (HSA) linkers and conjugates thereof
PT3456190T (pt) * 2008-06-27 2022-02-15 Merus Nv Animal murino transgénico produtor de anticorpo
KR20110058861A (ko) * 2008-08-29 2011-06-01 심포젠 에이/에스 조류 유래 항체의 클로닝 방법
MX338953B (es) * 2010-08-16 2016-05-06 Novimmune Sa Metodos para la generacion de anticuerpos multiespecificos y multivalentes.
CA2845597A1 (en) * 2011-09-01 2013-03-07 Synageva Biopharma Corp. Transgenic birds that produce chimeric human immunoglobulins
PL2838917T3 (pl) 2012-04-20 2019-12-31 Merus N.V. Sposoby i środki do wytwarzania heterodimerycznych cząsteczek podobnych do Ig
SI2840892T1 (en) * 2013-02-20 2018-08-31 Regeneron Pharmaceuticals, Inc. Animals other than humans with modified immunoglobulin heavy chain sequences
CN108024523A (zh) * 2015-08-27 2018-05-11 晶体生物科学股份有限公司 用于产生具有共同轻链的抗体的转基因动物
JP7296728B2 (ja) * 2015-10-23 2023-06-23 メルス ナムローゼ フェンノートシャップ 癌の成長を抑制する結合分子
NZ767923A (en) 2018-03-30 2024-11-29 Merus Nv Multivalent antibody

Also Published As

Publication number Publication date
BR112021013009A2 (pt) 2021-09-14
JP7443376B2 (ja) 2024-03-05
MX2021007949A (es) 2021-10-22
PH12021551547A1 (en) 2022-08-15
JP2024014897A (ja) 2024-02-01
CN114249823A (zh) 2022-03-29
WO2020141973A1 (en) 2020-07-09
AU2019418280B2 (en) 2023-01-05
AU2019418280A1 (en) 2021-07-08
JP2022520707A (ja) 2022-04-01
TW202039548A (zh) 2020-11-01
KR20210110600A (ko) 2021-09-08
CA3124768A1 (en) 2020-07-09
CN113227132A (zh) 2021-08-06
EP3906255A1 (en) 2021-11-10
IL284353A (en) 2021-08-31
SG11202106705UA (en) 2021-07-29
AR117741A1 (es) 2021-08-25
US20220073649A1 (en) 2022-03-10
AU2022287551A1 (en) 2023-02-02

Similar Documents

Publication Publication Date Title
PH12020551997A1 (en) Psma binding agents and uses thereof
ZA202102549B (en) Substituted tolyl as fungicides
IL277072A (en) Anti-claudin antibodies 18.2
PH12018502225A1 (en) Anti-il-33 antibodies, compositions, methods and uses thereof
EA201992232A1 (ru) Композиции и способы для иммуноонкологии
MY198059A (en) Anti-ox40 antibodies and their uses
EA201890565A1 (ru) Композиции и способы улучшения специфичности в геномной инженерии с применением рнк-направляемых эндонуклеаз
EA201692568A1 (ru) Составы с полипептидами-рецепторами и связанные с ними способы
EA202191448A1 (ru) Смешанные связывающие домены
CL2019002723S1 (es) Segmento de acoplamiento.
PL3999494T3 (pl) Podstawione pirydazynony jako herbicydy
EA201992315A1 (ru) Композиции и способы для лечения рака легкого
MX2022007960A (es) Nuevos anticuerpos anti-fgfr2b.
MX2021006865A (es) Anticuerpos anti-alfa-sinucleina y usos de estos.
CL2019002726S1 (es) Segmento de acoplamiento.
CL2019002728S1 (es) Segmento de acoplamiento.
MX2020010092A (es) Variantes de anticuerpo c-terminales.
PH12019501977B1 (en) Additive composition for ground improvement
EA201991655A1 (ru) Тиобензоимидазолы в качестве фунгицидов
EP4218817A3 (en) Methods for treating metabolic diseases by inhibiting myostatin activation
MX2020003431A (es) Formas solidas de 3-(5-fluorobenzofuran-3-il)-4-(5-metil-5h-[1,3]d ioxolo[4,5-f]indol-7-il)pirrol- 2,5-diona.
BR112019003834A2 (pt) compostos contendo monoterpenoides / fenilpropanóides e métodos de sua fabricação e uso como herbicidas
IT201700043084A1 (it) Pelle ignifuga.
DK3766684T3 (da) Kompositmateriale til fremstilling af låg, samt låg fremstillet deraf.
EA202090727A1 (ru) Варианты антител