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EA202092456A2 - Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака - Google Patents

Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака

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Publication number
EA202092456A2
EA202092456A2 EA202092456A EA202092456A EA202092456A2 EA 202092456 A2 EA202092456 A2 EA 202092456A2 EA 202092456 A EA202092456 A EA 202092456A EA 202092456 A EA202092456 A EA 202092456A EA 202092456 A2 EA202092456 A2 EA 202092456A2
Authority
EA
Eurasian Patent Office
Prior art keywords
cancer
treatment
various types
active agents
pharmaceutically active
Prior art date
Application number
EA202092456A
Other languages
English (en)
Other versions
EA202092456A3 (ru
Inventor
Шон Кэнпил
Джуд Кэнон
Пол Хьюз
Джонатан Д. Олинер
Ричард Дж. Риклес
Анн Й. Саики
Original Assignee
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA202092456A2 publication Critical patent/EA202092456A2/ru
Publication of EA202092456A3 publication Critical patent/EA202092456A3/ru

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    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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Abstract

В настоящем изобретении предлагается комбинированная терапия, включающая ингибитор MDM2 и один или более дополнительных фармацевтически активных агентов, конкретно для лечения различных видов рака. Кроме того, изобретение относится к фармацевтическим композициям, которые содержат ингибитор MDM2 и один или более дополнительных фармацевтически активных агентов для лечения различных видов рака.
EA202092456A 2013-11-11 2014-11-11 Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака EA202092456A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361902717P 2013-11-11 2013-11-11

Publications (2)

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EA202092456A2 true EA202092456A2 (ru) 2021-05-31
EA202092456A3 EA202092456A3 (ru) 2021-09-30

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Application Number Title Priority Date Filing Date
EA202092456A EA202092456A3 (ru) 2013-11-11 2014-11-11 Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака
EA201690980A EA036942B1 (ru) 2013-11-11 2014-11-11 Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза

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EA201690980A EA036942B1 (ru) 2013-11-11 2014-11-11 Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза

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US (3) US20160287569A1 (ru)
EP (2) EP4039256A1 (ru)
JP (5) JP2016535795A (ru)
KR (3) KR102305351B1 (ru)
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BR (1) BR112016010564A2 (ru)
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CL (1) CL2016001131A1 (ru)
CY (1) CY1125358T1 (ru)
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EA (2) EA202092456A3 (ru)
ES (1) ES2916721T3 (ru)
HR (1) HRP20220718T1 (ru)
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SM (1) SMT202200241T1 (ru)
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UA (1) UA120750C2 (ru)
WO (1) WO2015070224A2 (ru)
ZA (1) ZA201603342B (ru)

Families Citing this family (32)

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