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EA201992490A1 - Р-этокси нуклеиновые кислоты для ингибирования bcl2 - Google Patents

Р-этокси нуклеиновые кислоты для ингибирования bcl2

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Publication number
EA201992490A1
EA201992490A1 EA201992490A EA201992490A EA201992490A1 EA 201992490 A1 EA201992490 A1 EA 201992490A1 EA 201992490 A EA201992490 A EA 201992490A EA 201992490 A EA201992490 A EA 201992490A EA 201992490 A1 EA201992490 A1 EA 201992490A1
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EA
Eurasian Patent Office
Prior art keywords
bcl2
etoxy
inhibition
nucleic acids
delivery systems
Prior art date
Application number
EA201992490A
Other languages
English (en)
Inventor
Ана Тари Асидзава
Питер Нильсен
Original Assignee
Байо-Пат Холдингз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байо-Пат Холдингз, Инк. filed Critical Байо-Пат Холдингз, Инк.
Publication of EA201992490A1 publication Critical patent/EA201992490A1/ru

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/34—Spatial arrangement of the modifications
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Abstract

В данном документе предложены улучшенные системы доставки олигонуклеотидов, причем указанная система доставки содержит липосому, которая содержит нейтральные фосфолипиды и Р-этокси олигонуклеотид, который нацелен на полинуклеотид, кодируемый BCL2. Также предложены способы лечения пациентов с помощью указанных систем доставки.
EA201992490A 2017-04-19 2018-04-19 Р-этокси нуклеиновые кислоты для ингибирования bcl2 EA201992490A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762487302P 2017-04-19 2017-04-19
PCT/US2018/028267 WO2018195253A1 (en) 2017-04-19 2018-04-19 P-ethoxy nucleic acids for bcl2 inhibition

Publications (1)

Publication Number Publication Date
EA201992490A1 true EA201992490A1 (ru) 2020-03-03

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Country Link
US (1) US12234457B2 (ru)
EP (1) EP3612160A4 (ru)
JP (2) JP7284709B2 (ru)
KR (1) KR102775924B1 (ru)
CN (1) CN110636835A (ru)
AU (1) AU2018254468B2 (ru)
BR (1) BR112019021775A2 (ru)
CA (1) CA3058486A1 (ru)
EA (1) EA201992490A1 (ru)
IL (1) IL269616A (ru)
SG (1) SG11201909649SA (ru)
WO (1) WO2018195253A1 (ru)

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SG11201909649SA (en) 2017-04-19 2019-11-28 Bio Path Holdings Inc P-ethoxy nucleic acids for bcl2 inhibition
CN110636836B (zh) 2017-04-19 2022-12-16 拜奥-帕斯控股股份有限公司 用于stat3抑制的p-乙氧基核酸

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JP2020517646A (ja) 2020-06-18
KR20190141196A (ko) 2019-12-23
EP3612160A4 (en) 2021-01-20
SG11201909649SA (en) 2019-11-28
EP3612160A1 (en) 2020-02-26
BR112019021775A2 (pt) 2020-05-05
CN110636835A (zh) 2019-12-31
US20210123058A1 (en) 2021-04-29
AU2018254468B2 (en) 2023-11-16
CA3058486A1 (en) 2018-10-25
JP2023052819A (ja) 2023-04-12
AU2018254468A1 (en) 2019-11-14
US12234457B2 (en) 2025-02-25
WO2018195253A1 (en) 2018-10-25
KR102775924B1 (ko) 2025-03-07
JP7284709B2 (ja) 2023-05-31
IL269616A (en) 2019-11-28

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