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EA201891799A1 - Замещенные 1,2,3-триазолы в качестве nr2b-селективных модуляторов nmda - Google Patents

Замещенные 1,2,3-триазолы в качестве nr2b-селективных модуляторов nmda

Info

Publication number
EA201891799A1
EA201891799A1 EA201891799A EA201891799A EA201891799A1 EA 201891799 A1 EA201891799 A1 EA 201891799A1 EA 201891799 A EA201891799 A EA 201891799A EA 201891799 A EA201891799 A EA 201891799A EA 201891799 A1 EA201891799 A1 EA 201891799A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nr2b
triazoles
substituted
selective nmda
nmda modulators
Prior art date
Application number
EA201891799A
Other languages
English (en)
Inventor
Ган Чэнь
Криста К. Кровиан
Хитер Р. Коут
Курт А. Дворак
Кристин Ф. Желен
Афтон Хискокс
Майкл А. Летавич
Джейсон К. Рех
Акинола Сойод-Джонсон
Брис Стенн
Джессика Л. Уолл
Вэй Чжан
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201891799A1 publication Critical patent/EA201891799A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
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    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Замещенные 1,2,3-триазолы в качестве лигандов рецепторов NR2B. Такие соединения можно использовать для модуляции рецептора NR2B, а также в фармацевтических композициях и способах лечения заболеваний, расстройств и состояний, опосредованных активностью рецептора NR2B.
EA201891799A 2016-02-10 2017-02-09 Замещенные 1,2,3-триазолы в качестве nr2b-селективных модуляторов nmda EA201891799A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662293680P 2016-02-10 2016-02-10
PCT/US2017/017093 WO2017139428A1 (en) 2016-02-10 2017-02-09 Substituted 1,2,3-triazoles as nr2b-selective nmda modulators

Publications (1)

Publication Number Publication Date
EA201891799A1 true EA201891799A1 (ru) 2019-02-28

Family

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EA201891799A EA201891799A1 (ru) 2016-02-10 2017-02-09 Замещенные 1,2,3-триазолы в качестве nr2b-селективных модуляторов nmda

Country Status (14)

Country Link
US (3) US10071988B2 (ru)
EP (1) EP3414233A1 (ru)
JP (1) JP6923543B2 (ru)
KR (1) KR20180108822A (ru)
CN (1) CN109071488B (ru)
AU (1) AU2017217542B2 (ru)
BR (1) BR112018016329A2 (ru)
CA (1) CA3014314A1 (ru)
EA (1) EA201891799A1 (ru)
IL (1) IL261046B (ru)
MA (1) MA44008A (ru)
MX (1) MX2018009752A (ru)
SG (1) SG11201806750WA (ru)
WO (1) WO2017139428A1 (ru)

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EA201891799A1 (ru) 2016-02-10 2019-02-28 Янссен Фармацевтика Нв Замещенные 1,2,3-триазолы в качестве nr2b-селективных модуляторов nmda
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AU2017217542B2 (en) 2021-06-03
US10071988B2 (en) 2018-09-11
US20190135791A1 (en) 2019-05-09
CA3014314A1 (en) 2017-08-17
US20170226089A1 (en) 2017-08-10
WO2017139428A1 (en) 2017-08-17
US20180334451A1 (en) 2018-11-22
US10233173B2 (en) 2019-03-19
KR20180108822A (ko) 2018-10-04
CN109071488A (zh) 2018-12-21
US10766880B2 (en) 2020-09-08
IL261046B (en) 2021-09-30
AU2017217542A1 (en) 2018-08-23
JP2019504854A (ja) 2019-02-21
SG11201806750WA (en) 2018-09-27
MX2018009752A (es) 2019-02-07
EP3414233A1 (en) 2018-12-19
JP6923543B2 (ja) 2021-08-18
CN109071488B (zh) 2021-08-13
MA44008A (fr) 2018-12-19
IL261046A (en) 2019-02-28
BR112018016329A2 (pt) 2018-12-18

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