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EA201890172A1 - Тау-связывающие антитела - Google Patents

Тау-связывающие антитела

Info

Publication number
EA201890172A1
EA201890172A1 EA201890172A EA201890172A EA201890172A1 EA 201890172 A1 EA201890172 A1 EA 201890172A1 EA 201890172 A EA201890172 A EA 201890172A EA 201890172 A EA201890172 A EA 201890172A EA 201890172 A1 EA201890172 A1 EA 201890172A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
binding fragments
relates
tau
binding
Prior art date
Application number
EA201890172A
Other languages
English (en)
Other versions
EA037092B1 (ru
Inventor
Дэвид Эдвард Ормонд Найт
Теренс Сьюард Бейкер
Дэвид Джеймс Макмиллан
Роберт Энтони Гриффин
Жорж Мере-Коэлло
Партик Дауни
Жан-Филипп Курад
Original Assignee
Юсб Биофарма Спрл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53524640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201890172(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Юсб Биофарма Спрл filed Critical Юсб Биофарма Спрл
Publication of EA201890172A1 publication Critical patent/EA201890172A1/ru
Publication of EA037092B1 publication Critical patent/EA037092B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к выделенным Тау-связывающим антителам или их связывающим фрагментам. Также изобретение относится к выделенным молекулам нуклеиновой кислоты, кодирующим легкую и/или тяжелую цепь указанных антител, к клонирующему или экспрессирующему вектору, к клетке-хозяину, продуцирующей указанные антитела, к способу получения указанных антител и их связывающих фрагментов. Настоящее изобретение, кроме того, относится к применению антител и их связывающих фрагментов в качестве терапевтически активного средства, для использования в лечении таупатии, где таупатиями являются болезнь Альцгеймера или прогрессирующий надъядерный паралич, а также к применению антител и их связывающих фрагментов в качестве диагностического средства диагностирования таупатии.
EA201890172A 2015-07-06 2016-07-05 Тау-связывающие антитела EA037092B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15175522 2015-07-06
PCT/EP2016/065813 WO2017005734A1 (en) 2015-07-06 2016-07-05 Tau-binding antibodies

Publications (2)

Publication Number Publication Date
EA201890172A1 true EA201890172A1 (ru) 2018-10-31
EA037092B1 EA037092B1 (ru) 2021-02-04

Family

ID=53524640

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890172A EA037092B1 (ru) 2015-07-06 2016-07-05 Тау-связывающие антитела

Country Status (27)

Country Link
US (4) US10287343B2 (ru)
EP (1) EP3319983A1 (ru)
JP (3) JP6630426B2 (ru)
KR (2) KR20250027278A (ru)
CN (1) CN107849104B (ru)
AR (1) AR105267A1 (ru)
AU (1) AU2016289755C1 (ru)
BR (1) BR112017028102A2 (ru)
CA (1) CA2991451A1 (ru)
CL (1) CL2018000043A1 (ru)
CO (1) CO2017012971A2 (ru)
EA (1) EA037092B1 (ru)
EC (1) ECSP18000887A (ru)
HK (1) HK1246804A1 (ru)
IL (1) IL256685B (ru)
MA (2) MA42377A (ru)
MX (1) MX2017015817A (ru)
MY (1) MY193677A (ru)
PE (1) PE20180481A1 (ru)
PH (1) PH12017502207B1 (ru)
SG (1) SG10202010735PA (ru)
TN (1) TN2017000539A1 (ru)
TW (1) TWI745295B (ru)
UA (1) UA124616C2 (ru)
UY (1) UY36773A (ru)
WO (1) WO2017005734A1 (ru)
ZA (1) ZA201800027B (ru)

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Also Published As

Publication number Publication date
CL2018000043A1 (es) 2018-05-18
WO2017005734A1 (en) 2017-01-12
AR105267A1 (es) 2017-09-20
UY36773A (es) 2017-01-31
MX2017015817A (es) 2018-04-10
PH12017502207A1 (en) 2018-06-11
PE20180481A1 (es) 2018-03-07
IL256685A (en) 2018-03-29
CO2017012971A2 (es) 2018-03-09
CN107849104A (zh) 2018-03-27
IL256685B (en) 2022-02-01
MY193677A (en) 2022-10-25
AU2016289755A1 (en) 2018-01-04
KR20180025962A (ko) 2018-03-09
TN2017000539A1 (en) 2019-04-12
JP2022141689A (ja) 2022-09-29
KR102770650B1 (ko) 2025-02-19
US10287343B2 (en) 2019-05-14
CN107849104B (zh) 2021-08-27
EA037092B1 (ru) 2021-02-04
AU2016289755C1 (en) 2021-08-19
MA42377A (fr) 2018-05-16
US20190284267A1 (en) 2019-09-19
EP3319983A1 (en) 2018-05-16
US20230416350A1 (en) 2023-12-28
TWI745295B (zh) 2021-11-11
TW201713689A (zh) 2017-04-16
ZA201800027B (en) 2019-06-26
AU2016289755B2 (en) 2020-12-03
JP7100008B2 (ja) 2022-07-12
HK1246804A1 (zh) 2018-09-14
KR20250027278A (ko) 2025-02-25
US10889640B2 (en) 2021-01-12
JP6630426B2 (ja) 2020-01-15
JP2018524001A (ja) 2018-08-30
US20180201666A1 (en) 2018-07-19
JP7413448B2 (ja) 2024-01-15
US20210115121A1 (en) 2021-04-22
US11732034B2 (en) 2023-08-22
ECSP18000887A (es) 2018-03-31
SG10202010735PA (en) 2020-11-27
JP2020055849A (ja) 2020-04-09
NZ738058A (en) 2021-07-30
PH12017502207B1 (en) 2022-08-10
MA41670A1 (fr) 2018-05-31
UA124616C2 (uk) 2021-10-20
BR112017028102A2 (pt) 2018-09-04
CA2991451A1 (en) 2017-01-12

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