EA201490516A1 - Бифенилкарбоксиамиды в качестве ингибиторов rock-киназ - Google Patents
Бифенилкарбоксиамиды в качестве ингибиторов rock-киназInfo
- Publication number
- EA201490516A1 EA201490516A1 EA201490516A EA201490516A EA201490516A1 EA 201490516 A1 EA201490516 A1 EA 201490516A1 EA 201490516 A EA201490516 A EA 201490516A EA 201490516 A EA201490516 A EA 201490516A EA 201490516 A1 EA201490516 A1 EA 201490516A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitors
- diseases
- rock
- relates
- present
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 7
- 230000006806 disease prevention Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 239000011435 rock Substances 0.000 abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
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- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
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- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Psychiatry (AREA)
- Pregnancy & Childbirth (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
Настоящее изобретение относится к новым ингибиторам киназ, а именно к ингибиторам ROCK, к композициям, в частности фармацевтическим препаратам, содержащим такие ингибиторы, и к применениям таких ингибиторов в лечении и профилактике заболеваний. В частности, настоящее изобретение относится к новым ингибиторам ROCK, к композициям, в частности фармацевтическим препаратам, содержащим такие ингибиторы, и к применениям таких ингибиторов в лечении и профилактике заболеваний. Помимо этого, настоящее изобретение относится к способам лечения и использованию указанных соединений в производстве лекарственного препарата для применения при ряде терапевтических показаний, включая сексуальную дисфункцию, воспалительные заболевания, глазные заболевания, желудочно-кишечные заболевания и респираторные заболевания.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11179491 | 2011-08-31 | ||
PCT/EP2012/067018 WO2013030367A1 (en) | 2011-08-31 | 2012-08-31 | Biphenylcarboxamides as rock kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
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EA201490516A1 true EA201490516A1 (ru) | 2014-07-30 |
Family
ID=46796597
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490495A EA024232B1 (ru) | 2011-08-31 | 2012-08-31 | Новые легкоразрушающиеся ингибиторы rock |
EA201490516A EA201490516A1 (ru) | 2011-08-31 | 2012-08-31 | Бифенилкарбоксиамиды в качестве ингибиторов rock-киназ |
EA201490515A EA201490515A1 (ru) | 2011-08-31 | 2012-08-31 | Новые ингибиторы rock-киназ |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490495A EA024232B1 (ru) | 2011-08-31 | 2012-08-31 | Новые легкоразрушающиеся ингибиторы rock |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490515A EA201490515A1 (ru) | 2011-08-31 | 2012-08-31 | Новые ингибиторы rock-киназ |
Country Status (16)
Country | Link |
---|---|
US (3) | US9079858B2 (ru) |
EP (3) | EP2751078A1 (ru) |
JP (3) | JP2014525427A (ru) |
KR (2) | KR20140072879A (ru) |
CN (3) | CN103874683A (ru) |
AU (3) | AU2012300833B2 (ru) |
BR (3) | BR112014004447A2 (ru) |
CA (3) | CA2846695A1 (ru) |
EA (3) | EA024232B1 (ru) |
ES (1) | ES2560830T3 (ru) |
IL (2) | IL231123A0 (ru) |
MX (3) | MX2014002395A (ru) |
PT (1) | PT2751080E (ru) |
SG (2) | SG11201400058PA (ru) |
WO (3) | WO2013030367A1 (ru) |
ZA (3) | ZA201401417B (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10842669B2 (en) * | 2008-11-13 | 2020-11-24 | Gholam A. Peyman | Ophthalmic drug delivery method |
JP2014525427A (ja) * | 2011-08-31 | 2014-09-29 | アマケン エンヴェー | Rockキナーゼ阻害剤としてのビフェニルカルボキサミド |
CA3151343A1 (en) | 2012-10-05 | 2014-04-10 | Kadmon Corporation, Llc | Rho kinase inhibitors |
PT2951172T (pt) | 2013-01-29 | 2017-07-12 | Redx Pharma Plc | Derivados de piridina como inibidores de rock leves |
JP5840324B2 (ja) * | 2013-04-15 | 2016-01-06 | 株式会社レナサイエンス | Pai−1阻害剤の新規用途 |
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