[go: up one dir, main page]

EA201400001A1 - Новые производные фталазинонпирролопиримидинкарбоксамида - Google Patents

Новые производные фталазинонпирролопиримидинкарбоксамида

Info

Publication number
EA201400001A1
EA201400001A1 EA201400001A EA201400001A EA201400001A1 EA 201400001 A1 EA201400001 A1 EA 201400001A1 EA 201400001 A EA201400001 A EA 201400001A EA 201400001 A EA201400001 A EA 201400001A EA 201400001 A1 EA201400001 A1 EA 201400001A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phthalasinonpyrropopyrimidinkarboxamide
new derivatives
formula
types
description
Prior art date
Application number
EA201400001A
Other languages
English (en)
Other versions
EA023713B1 (ru
Inventor
Томас Штенгель
Томас Майер
Александер Манн
Йозеф Штадльвизер
Дитер Флоккерци
Андреас Паль
Эвальд Бенедиктус
Мануэла Хессманн
Тобиас Канахер
Рагна Хуссонг
Кристоф Цитт
Ханс Кристоф Хольст
Рольф-Петер Хуммель
Мартин Фиртельхаус
Германн Тенор
Торстен Дункерн
Армин Хатцельманн
Кристиан Хесслингер
Original Assignee
Такеда Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44764312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201400001(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Такеда Гмбх filed Critical Такеда Гмбх
Publication of EA201400001A1 publication Critical patent/EA201400001A1/ru
Publication of EA023713B1 publication Critical patent/EA023713B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявке описаны соединения формулы (1)в которой R1, R7, R8, R9, R10, R17, R18, R19, R20 и m обладают значениями, приведенными в описании, которые являются новыми эффективными ингибиторами фосфодиэстеразы типа 4 и 5.
EA201400001A 2011-06-17 2012-06-12 Производные фталазинонпирролопиримидинкарбоксамида EA023713B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11170440 2011-06-17
PCT/EP2012/061084 WO2012171900A1 (en) 2011-06-17 2012-06-12 Novel phthalazinone-pyrrolopyrimidinecarboxamide derivatives

Publications (2)

Publication Number Publication Date
EA201400001A1 true EA201400001A1 (ru) 2014-05-30
EA023713B1 EA023713B1 (ru) 2016-07-29

Family

ID=44764312

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400001A EA023713B1 (ru) 2011-06-17 2012-06-12 Производные фталазинонпирролопиримидинкарбоксамида

Country Status (22)

Country Link
US (2) US20140112945A1 (ru)
EP (1) EP2721030B1 (ru)
JP (1) JP5980318B2 (ru)
KR (1) KR20140037195A (ru)
CN (1) CN103582644B (ru)
AR (1) AR086915A1 (ru)
AU (1) AU2012269133A1 (ru)
BR (1) BR112013031791A2 (ru)
CA (1) CA2837248A1 (ru)
CL (1) CL2013003556A1 (ru)
CO (1) CO6852074A2 (ru)
CR (1) CR20130656A (ru)
DO (1) DOP2013000298A (ru)
EA (1) EA023713B1 (ru)
EC (1) ECSP13013076A (ru)
ES (1) ES2564882T3 (ru)
MA (1) MA35269B1 (ru)
MX (1) MX2013014888A (ru)
PE (1) PE20140648A1 (ru)
PH (1) PH12013502546A1 (ru)
TN (1) TN2013000439A1 (ru)
WO (1) WO2012171900A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2981624A1 (en) 2015-04-09 2016-10-13 Galderma Sa An extract from indigo naturalis and a process for preparing the same
EP3280428A1 (en) 2015-04-09 2018-02-14 Galderma S.A. Antibacterial indigo naturalis or indigo-producing plant extract and use thereof
BR112017021190B1 (pt) 2015-04-09 2021-12-21 Galderma Sa. Uso de uma composição farmacêutica que compreende um extrato de indigo naturalis

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8828477D0 (en) 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
DE407028T1 (de) 1989-05-31 1994-03-17 Fisons Plc Medikament und Inhalationsvorrichtung dafür.
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
IL97065A (en) 1990-02-02 1994-01-25 Fisons Plc Repellent preparations for aerosol
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
EP0636362B1 (en) 1990-03-23 1999-12-22 Minnesota Mining And Manufacturing Company The use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
AU658854B2 (en) 1990-10-18 1995-05-04 Minnesota Mining And Manufacturing Company Aerosol formulation comprising beclomethasone 17,21 dipropionate
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
IL104068A (en) 1991-12-12 1998-10-30 Glaxo Group Ltd Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
GB9306703D0 (en) 1993-03-31 1993-05-26 Fisons Plc Inhalation device
IL111194A (en) 1993-10-08 1998-02-08 Fisons Plc Process for the production of medicament formulations
SK283270B6 (sk) * 1997-01-15 2003-04-01 Altana Pharma Ag Ftalazinóny, farmaceutické prostriedky s ich obsahom a ich použitie
CA2323771A1 (en) * 1998-03-14 1999-09-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone pde iii/iv inhibitors
WO2000007567A1 (de) 1998-08-04 2000-02-17 Jago Research Ag Medizinische aerosolformulierungen
US6397838B1 (en) 1998-12-23 2002-06-04 Battelle Pulmonary Therapeutics, Inc. Pulmonary aerosol delivery device and method
DE60030103T2 (de) 1999-04-23 2007-02-08 Ventaira Pharmaceuticals, Inc., Columbus Elektrostatisches versprühen mit transfer- hoher masse
US6302331B1 (en) 1999-04-23 2001-10-16 Battelle Pulmonary Therapeutics, Inc. Directionally controlled EHD aerosol sprayer
PL358057A1 (en) * 2000-06-05 2004-08-09 Altana Pharma Ag Compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors
EP1324749B1 (en) 2000-10-09 2006-03-15 3M Innovative Properties Company Medicinal aerosol formulations
CZ20032491A3 (cs) 2001-02-15 2004-01-14 Altana Pharma Ag Ftalazinonpiperidinové deriváty
CA2445233A1 (en) * 2001-04-25 2002-10-31 Altana Pharma Ag Phthalazinones derivatives useful as pde4/7 inhibitors
AU2003255376A1 (en) 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
CA2494650A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
BR0313330A (pt) 2002-08-10 2005-06-14 Altana Pharma Ag Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4
WO2004062671A2 (en) * 2003-01-14 2004-07-29 Altana Pharma Ag Pde4 inhibitors for the treatment of neoplasms of lymphoid cells
EP1720854A1 (en) * 2004-02-04 2006-11-15 Altana Pharma AG Phthalzinone derivatives as pde4 inhibitors
US7494990B2 (en) 2004-02-04 2009-02-24 Nycomed Gmbh 2-(piperidin-4-yl)-4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
AR070454A1 (es) * 2008-02-27 2010-04-07 Nycomed Gmbh Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden
AR077898A1 (es) * 2009-08-26 2011-09-28 Nycomed Gmbh Metilpirrolopirimidincarboxamidas

Also Published As

Publication number Publication date
US20140112945A1 (en) 2014-04-24
CA2837248A1 (en) 2012-12-20
WO2012171900A1 (en) 2012-12-20
JP5980318B2 (ja) 2016-08-31
CN103582644B (zh) 2016-07-20
AR086915A1 (es) 2014-01-29
ECSP13013076A (es) 2014-01-31
CR20130656A (es) 2014-02-18
ES2564882T3 (es) 2016-03-29
EP2721030B1 (en) 2015-12-16
MX2013014888A (es) 2014-02-27
KR20140037195A (ko) 2014-03-26
AU2012269133A1 (en) 2014-01-30
BR112013031791A2 (pt) 2017-01-31
CN103582644A (zh) 2014-02-12
PH12013502546A1 (en) 2014-01-27
CL2013003556A1 (es) 2014-06-13
DOP2013000298A (es) 2014-03-31
PE20140648A1 (es) 2014-05-30
EA023713B1 (ru) 2016-07-29
MA35269B1 (fr) 2014-07-03
US20160108049A1 (en) 2016-04-21
TN2013000439A1 (en) 2015-03-30
CO6852074A2 (es) 2014-01-30
EP2721030A1 (en) 2014-04-23
JP2014517021A (ja) 2014-07-17

Similar Documents

Publication Publication Date Title
CY1122266T1 (el) Ενωσεις 3-αμινοκυκλοαλκυλιου ως ror-gamma-t αναστολεις και χρησεις αυτων
JO3515B1 (ar) مثبطات fgfr4 بيريميدين
UA112428C2 (uk) Пестицидні композиції і пов'язані з ними способи
CR20140135A (es) Nuevos derivados de aril-quinolina
EA201400333A1 (ru) Бензонитрильные производные в качестве ингибиторов киназ
UY34156A (es) Compuestos inhibidores de metaloenzimas
CO6480927A2 (es) Derivados de imidazolin-2-ona 1,3-disustituida como inhibidores de cyp17.
EA201100875A1 (ru) Новые пиразол-4-n-алкоксикарбоксамиды в качестве микробиоцидов
EA201390877A1 (ru) Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение
EA201401054A1 (ru) N-циклиламиды в качестве нематоцидов
MX385616B (es) Inhibidores de cdk
EA201490596A1 (ru) Новые производные дигидрохинолин-2-она
EA201301301A1 (ru) Производные тиазола
CR20140468A (es) Inhibidores de diacilglicerol aciltransferasa 2
UA111744C2 (uk) ЗАМІЩЕНІ ПІРИДОПІРАЗИНИ ЯК ІНГІБІТОРИ Syk
EA201101060A1 (ru) Новые гербициды
UA106880C2 (uk) Нові гербіциди
UA114417C2 (uk) Інгібітори iap
PH12016500347A1 (en) Triazolopyridine compounds, compositions and methods of use thereof
EA201590787A1 (ru) Замещенные пиридопиразины в качестве ингибиторов syk
EA201101097A1 (ru) Новые микробиоциды
MX2015016332A (es) Inhibidores de alk biciclicos fusionados.
EA201491227A1 (ru) Новые производные морфолинила, подходящие для применения в качестве ингибиторов mogat-2
EA201590347A1 (ru) Азагетероциклы в качестве ингибиторов bir2 и/или bir3
EA200901504A1 (ru) Производные пиразолона, как ингибиторы pde4

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU