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EA201391421A1 - Пролекарства d-гамма-глутамил-d-триптофана и d-гамма-глутамил-l-триптофана - Google Patents

Пролекарства d-гамма-глутамил-d-триптофана и d-гамма-глутамил-l-триптофана

Info

Publication number
EA201391421A1
EA201391421A1 EA201391421A EA201391421A EA201391421A1 EA 201391421 A1 EA201391421 A1 EA 201391421A1 EA 201391421 A EA201391421 A EA 201391421A EA 201391421 A EA201391421 A EA 201391421A EA 201391421 A1 EA201391421 A1 EA 201391421A1
Authority
EA
Eurasian Patent Office
Prior art keywords
glutamyl
gamma
triptophana
compounds
methods
Prior art date
Application number
EA201391421A
Other languages
English (en)
Inventor
Тим Фэт Тэм
Реджис Леунг-Тоунг
Иншэн Ван
Яньцин Чжао
Тао Синь
Вэнрен Ли
Йоланта Мария Водзинска
Враджлал С. Рабадия
Биренкумар Шах
Кристофер Джон Фини
Original Assignee
Апотекс Текнолоджиз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Апотекс Текнолоджиз Инк. filed Critical Апотекс Текнолоджиз Инк.
Publication of EA201391421A1 publication Critical patent/EA201391421A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Предоставлены соединения, которые представляют собой пролекарства D-гамма-глутамил-[D/L]-триптофана, способы получения соединений и способы использования соединений.
EA201391421A 2011-03-31 2012-03-30 Пролекарства d-гамма-глутамил-d-триптофана и d-гамма-глутамил-l-триптофана EA201391421A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161470470P 2011-03-31 2011-03-31
PCT/CA2012/000327 WO2012129680A1 (en) 2011-03-31 2012-03-30 Prodrugs of d-gamma-glutamyl-d-tryptophan and d-gamma- glutamyl-l-tryptophan

Publications (1)

Publication Number Publication Date
EA201391421A1 true EA201391421A1 (ru) 2014-02-28

Family

ID=46929263

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391421A EA201391421A1 (ru) 2011-03-31 2012-03-30 Пролекарства d-гамма-глутамил-d-триптофана и d-гамма-глутамил-l-триптофана

Country Status (9)

Country Link
US (1) US20150011484A1 (ru)
EP (1) EP2691370A4 (ru)
JP (1) JP2014510734A (ru)
CN (1) CN103502215A (ru)
AU (1) AU2012234689A1 (ru)
CA (1) CA2831429A1 (ru)
EA (1) EA201391421A1 (ru)
WO (1) WO2012129680A1 (ru)
ZA (1) ZA201307230B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014287044B2 (en) * 2013-07-12 2020-02-06 Genentech, Inc. Elucidation of ion exchange chromatography input optimization
EP4514344A1 (en) * 2022-04-25 2025-03-05 The Regents of The University of Michigan Lipids, formulations, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2107692C1 (ru) * 1995-06-07 1998-03-27 Дейгин Владислав Исакович Пептид и способ его получения
US5744452A (en) * 1995-11-28 1998-04-28 Edward T. Wei γ-L-glutamyl containing immunomodulator compounds and methods therewith
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
CA2528383A1 (en) * 2003-06-05 2005-01-27 University Of Maryland, Baltimore County Inactivators and bivalent inhibitors of glyoxalase i and methods of inhibiting tumor growth
CA2569204A1 (en) * 2006-11-28 2008-05-28 Apotex Technologies Inc. Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium salt of d-isoglutamyl-d-tryptophan
WO2009065217A1 (en) * 2007-11-20 2009-05-28 Immunotech Developments Inc. Novel immunoregulatory peptides, compositions and uses thereof

Also Published As

Publication number Publication date
WO2012129680A1 (en) 2012-10-04
US20150011484A1 (en) 2015-01-08
EP2691370A4 (en) 2014-08-20
ZA201307230B (en) 2015-04-29
JP2014510734A (ja) 2014-05-01
CA2831429A1 (en) 2012-10-04
EP2691370A1 (en) 2014-02-05
AU2012234689A1 (en) 2013-10-17
CN103502215A (zh) 2014-01-08
NZ615882A (en) 2015-05-29

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