EA201390142A1 - 2'-фторзамещенные карбануклеозидные аналоги для противовирусного лечения - Google Patents
2'-фторзамещенные карбануклеозидные аналоги для противовирусного леченияInfo
- Publication number
- EA201390142A1 EA201390142A1 EA201390142A EA201390142A EA201390142A1 EA 201390142 A1 EA201390142 A1 EA 201390142A1 EA 201390142 A EA201390142 A EA 201390142A EA 201390142 A EA201390142 A EA 201390142A EA 201390142 A1 EA201390142 A1 EA 201390142A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbanulosis
- analogs
- fluoro
- substituted
- antiviral treatment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Предоставлены методы для лечения инфекций Orthomyxoviridae вируса путем введения рибозидов, фосфатов рибозидов и пролекарств формулы Iгде Rпредставляет собой галоген. Предоставленные соединения, композиции и способы являются полезными, в частности, для лечения вирусных инфекций гриппа человека.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38214510P | 2010-09-13 | 2010-09-13 | |
PCT/US2011/051249 WO2012037038A1 (en) | 2010-09-13 | 2011-09-12 | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
Publications (1)
Publication Number | Publication Date |
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EA201390142A1 true EA201390142A1 (ru) | 2013-09-30 |
Family
ID=44678052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390142A EA201390142A1 (ru) | 2010-09-13 | 2011-09-12 | 2'-фторзамещенные карбануклеозидные аналоги для противовирусного лечения |
Country Status (14)
Country | Link |
---|---|
US (3) | US20120107274A1 (ru) |
EP (1) | EP2616080A1 (ru) |
JP (1) | JP2013541519A (ru) |
KR (1) | KR20140091459A (ru) |
CN (1) | CN103153314A (ru) |
AR (1) | AR082960A1 (ru) |
AU (1) | AU2011302310A1 (ru) |
BR (1) | BR112013005888A2 (ru) |
CA (1) | CA2807584C (ru) |
EA (1) | EA201390142A1 (ru) |
MX (1) | MX2013002871A (ru) |
TW (1) | TW201305185A (ru) |
UY (1) | UY33600A (ru) |
WO (1) | WO2012037038A1 (ru) |
Cited By (1)
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MD4496C1 (ru) * | 2012-03-13 | 2018-02-28 | Gilead Sciences, Inc. | Аналоги 2'-замещенных карба-нуклеозидов для противовирусного лечения |
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CA2773773C (en) | 2009-09-21 | 2019-04-23 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs |
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-
2011
- 2011-09-09 TW TW100132632A patent/TW201305185A/zh unknown
- 2011-09-12 WO PCT/US2011/051249 patent/WO2012037038A1/en active Application Filing
- 2011-09-12 KR KR1020137009336A patent/KR20140091459A/ko not_active Withdrawn
- 2011-09-12 EP EP11761204.4A patent/EP2616080A1/en not_active Withdrawn
- 2011-09-12 AR ARP110103311A patent/AR082960A1/es not_active Application Discontinuation
- 2011-09-12 AU AU2011302310A patent/AU2011302310A1/en not_active Abandoned
- 2011-09-12 JP JP2013528373A patent/JP2013541519A/ja not_active Withdrawn
- 2011-09-12 MX MX2013002871A patent/MX2013002871A/es unknown
- 2011-09-12 CN CN201180048992XA patent/CN103153314A/zh active Pending
- 2011-09-12 US US13/230,634 patent/US20120107274A1/en not_active Abandoned
- 2011-09-12 EA EA201390142A patent/EA201390142A1/ru unknown
- 2011-09-12 UY UY0001033600A patent/UY33600A/es unknown
- 2011-09-12 CA CA2807584A patent/CA2807584C/en not_active Expired - Fee Related
- 2011-09-12 BR BR112013005888A patent/BR112013005888A2/pt not_active Application Discontinuation
-
2014
- 2014-01-24 US US14/163,251 patent/US20140200188A1/en not_active Abandoned
-
2017
- 2017-01-24 US US15/414,351 patent/US20170226140A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4496C1 (ru) * | 2012-03-13 | 2018-02-28 | Gilead Sciences, Inc. | Аналоги 2'-замещенных карба-нуклеозидов для противовирусного лечения |
Also Published As
Publication number | Publication date |
---|---|
CA2807584C (en) | 2018-10-23 |
KR20140091459A (ko) | 2014-07-21 |
CA2807584A1 (en) | 2012-03-22 |
AR082960A1 (es) | 2013-01-23 |
TW201305185A (zh) | 2013-02-01 |
CN103153314A (zh) | 2013-06-12 |
US20140200188A1 (en) | 2014-07-17 |
EP2616080A1 (en) | 2013-07-24 |
JP2013541519A (ja) | 2013-11-14 |
AU2011302310A1 (en) | 2013-02-28 |
BR112013005888A2 (pt) | 2016-05-10 |
US20120107274A1 (en) | 2012-05-03 |
UY33600A (es) | 2012-04-30 |
US20170226140A1 (en) | 2017-08-10 |
WO2012037038A1 (en) | 2012-03-22 |
MX2013002871A (es) | 2013-06-28 |
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