[go: up one dir, main page]

EA201171074A1 - Цитотоксические конъюгаты с соединением, связывающим рецептор нейропептида y - Google Patents

Цитотоксические конъюгаты с соединением, связывающим рецептор нейропептида y

Info

Publication number
EA201171074A1
EA201171074A1 EA201171074A EA201171074A EA201171074A1 EA 201171074 A1 EA201171074 A1 EA 201171074A1 EA 201171074 A EA201171074 A EA 201171074A EA 201171074 A EA201171074 A EA 201171074A EA 201171074 A1 EA201171074 A1 EA 201171074A1
Authority
EA
Eurasian Patent Office
Prior art keywords
neuropeptide
receptor
binding
connection
cytotoxic conjugates
Prior art date
Application number
EA201171074A
Other languages
English (en)
Other versions
EA020613B1 (ru
Inventor
Чжэн Синь Дун
Кевин Л. Чжоу
Дэниел Б. Деоливейра
Original Assignee
Ипсен Фарма С.А.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ипсен Фарма С.А.С. filed Critical Ипсен Фарма С.А.С.
Publication of EA201171074A1 publication Critical patent/EA201171074A1/ru
Publication of EA020613B1 publication Critical patent/EA020613B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к группам новых конъюгатов нейропептида Y и цитотоксических соединений, к содержащим их композициям и способам, относящимся к их терапевтическому применению для лечения заболевания или состояния, ассоциированных с нарушенной или нежелательной пролиферацией клеток, которые экспрессируют рецепторы NPY-Y1.
EA201171074A 2009-02-20 2010-02-19 Цитотоксические конъюгаты с соединением, связывающим рецептор нейропептида y EA020613B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20815409P 2009-02-20 2009-02-20
PCT/US2010/000473 WO2010096175A1 (en) 2009-02-20 2010-02-19 Cytotoxic conjugates having neuropeptide y receptor binding compound

Publications (2)

Publication Number Publication Date
EA201171074A1 true EA201171074A1 (ru) 2012-04-30
EA020613B1 EA020613B1 (ru) 2014-12-30

Family

ID=42634162

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171074A EA020613B1 (ru) 2009-02-20 2010-02-19 Цитотоксические конъюгаты с соединением, связывающим рецептор нейропептида y

Country Status (12)

Country Link
US (1) US8877715B2 (ru)
EP (1) EP2398492A4 (ru)
JP (1) JP5584236B2 (ru)
KR (1) KR101413051B1 (ru)
CN (1) CN102325545A (ru)
AU (1) AU2010216372B2 (ru)
BR (1) BRPI1008039A2 (ru)
CA (1) CA2752608A1 (ru)
EA (1) EA020613B1 (ru)
MX (1) MX2011008774A (ru)
UA (1) UA102432C2 (ru)
WO (1) WO2010096175A1 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101925620B1 (ko) 2010-12-16 2018-12-05 노보 노르디스크 에이/에스 Ｇｌｐ-1 아고니스트 및 ｎ-(8-(2-히드록시벤조일)아미노)카프릴산의 염을 포함하는 고체 조성물
RU2641198C3 (ru) 2012-03-22 2021-12-10 Ново Нордиск А/С Композиции glp-1 пептидов и их получение
EP2708243A1 (en) * 2012-09-17 2014-03-19 OntoChem GmbH Receptor ligand linked cytotoxic molecules
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
WO2014070965A2 (en) * 2012-11-01 2014-05-08 Ipsen Pharma S.A.S Somatostatin analogs and dimers thereof
KR20210086717A (ko) 2013-05-02 2021-07-08 노보 노르디스크 에이/에스 Glp-1 화합물의 경구 투여
EP3068795B1 (en) 2013-11-15 2019-03-06 Novo Nordisk A/S Hpyy(1-36) having a beta-homoarginine substitution at position 35
TWI661835B (zh) 2013-11-15 2019-06-11 丹麥商諾佛 儂迪克股份有限公司 選擇性ｐｙｙ化合物及其用途
MA43205A (fr) 2015-06-12 2018-09-19 Novo Nordisk As Composés pyy sélectifs et leurs utilisations
WO2017156183A1 (en) * 2016-03-08 2017-09-14 Los Gatos Pharmaceuticals, Inc. Camptothecin derivatives and uses thereof
EP3426301A4 (en) 2016-03-08 2019-11-06 Los Gatos Pharmaceuticals, Inc. VERBUNDNANOPARTICLES AND USES THEREOF
CN106279287B (zh) * 2016-08-12 2018-11-30 华中科技大学 一种喜树碱磷酸酯类化合物、其制备方法及应用
AR114353A1 (es) 2018-02-02 2020-08-26 Novo Nordisk As Composiciones sólidas que comprenden un agonista del glp-1 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico
EP3774838B1 (en) * 2018-04-10 2022-08-10 Sanofi-Aventis Deutschland GmbH Lixisenatide synthesis with capping
CN114450299A (zh) * 2019-07-24 2022-05-06 莫尔吉尼有限责任公司 受体靶向肽-药物缀合物
CN118240015B (zh) * 2024-03-21 2025-03-21 中国科学院近代物理研究所 一种针对脑胶质瘤的靶向多肽及放射性示踪剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000161A1 (en) * 1993-06-18 1995-01-05 University Of Cincinnati Neuropeptide y antagonists and agonists
US20030022277A1 (en) * 1995-05-05 2003-01-30 Daniel R. Soppet Human neuropeptide receptor
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
US20030190740A1 (en) * 1998-10-13 2003-10-09 The University Of Georgia Research Foundation, Inc Stabilized bioactive peptides and methods of identification, synthesis, and use
AU4267700A (en) * 2000-01-13 2001-07-19 Academia Sinica Application of somatostatin analogs to specific delivery of anti-tumor drugs into tumor cells
ATE368476T1 (de) * 2000-11-24 2007-08-15 Jean-Claude Reubi Neuropeptid-y1-rezeptor-bindende verbindungen zur behandlung und diagnose von krebserkrankungen
WO2007039318A2 (en) * 2005-10-06 2007-04-12 Bayer Schering Pharma Aktiengesellschaft Neuropeptide y analogs
EP1900742A1 (en) * 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
KR20090074806A (ko) * 2006-10-20 2009-07-07 입센 파마 에스.에이.에스 펩타이드-세포독성 접합체
WO2008098788A2 (en) * 2007-02-16 2008-08-21 Ktb Tumorforschungsgesellschaft Mbh Receptor and antigen targeted prodrug
UA101435C2 (ru) * 2009-02-20 2013-03-25 Ипсен Фарма С.А.С. Аналоги нейропептида y, которые содержат по меньшей мере одну замену на синтетическую аминокислоту

Also Published As

Publication number Publication date
UA102432C2 (ru) 2013-07-10
CA2752608A1 (en) 2010-08-26
US20120010154A1 (en) 2012-01-12
JP2012518636A (ja) 2012-08-16
CN102325545A (zh) 2012-01-18
AU2010216372A1 (en) 2011-09-15
EP2398492A4 (en) 2013-07-17
EP2398492A1 (en) 2011-12-28
WO2010096175A1 (en) 2010-08-26
KR20110125235A (ko) 2011-11-18
EA020613B1 (ru) 2014-12-30
JP5584236B2 (ja) 2014-09-03
AU2010216372B2 (en) 2013-06-20
MX2011008774A (es) 2011-10-24
BRPI1008039A2 (pt) 2016-10-04
KR101413051B1 (ko) 2014-07-31
US8877715B2 (en) 2014-11-04

Similar Documents

Publication Publication Date Title
EA201171074A1 (ru) Цитотоксические конъюгаты с соединением, связывающим рецептор нейропептида y
EA201270815A1 (ru) Модуляторы рецепторов эстрогена и их применение
EA201001639A1 (ru) Композиции и способы их получения и применения
EA201101009A1 (ru) АНТАГОНИСТЫ C5aR
EA201071169A1 (ru) ГИДРОКСИМЕТИЛПИРРОЛИДИНЫ В КАЧЕСТВЕ АГОНИСТОВ АДРЕНЕРГИЧЕСКИХ РЕЦЕПТОРОВ β3
ATE469895T1 (de) Cgrp-rezeptorantagonisten
MX2011008500A (es) Moduladores del receptor tipo toll y tratamiento de enfermedades.
MX2010001378A (es) Uso terapeutico de anticuerpos del receptor anti-tweak.
EA200901157A1 (ru) Конденсированные кольцевые гетероциклические модуляторы киназы
EA201290653A1 (ru) Состав антитела и терапевтические режимы
EA201491607A1 (ru) Модуляторы толлподобных рецепторов
UY32996A (es) Antagonistas del receptor crth2 basados en indol
BR112013017943A2 (pt) benzoazepinas substituídas como moduladores receptores do tipo toll
EA201100133A1 (ru) Антагонисты рецепторов простагландина d
BRPI0808775A2 (pt) compostos e composições como moduladores de atividade de gpr119
EA201270467A1 (ru) Полициклические соединения в качестве антагонистов рецепторов лизофосфатидной кислоты
BR112013008501A2 (pt) métodos para o tratamento de psoríase usando anatgonistas de il-17
EA201001253A1 (ru) N,n-дизамещенные аминоалкилбифенилы в качестве антагонистов рецепторов простагландина d
EP4268814A3 (en) Pharmaceutical composition for the treatment of dry eye
EA201100062A1 (ru) Соединения и способы модулирования рецепторов, связанных с белком g
CR10309A (es) "compuestos y composiciones como inhibidores de la actividad del receptor canabinoide 1"
EA200602243A1 (ru) 3-аминоциклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов
EA201190017A1 (ru) Аминоэфирные производные алкалоидов и их медицинские композиции
UY31622A1 (es) Antagonistas de aminoalquilbifenilo n,n-disubstituidos de receptores de prostaglandina d2
CY1112724T1 (el) Παραγωγα ανθρακικης κουινουκλιδινης και ιατρικη συνθεση αυτων

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU