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EA201071144A1 - Гетероциклические производные - Google Patents

Гетероциклические производные

Info

Publication number
EA201071144A1
EA201071144A1 EA201071144A EA201071144A EA201071144A1 EA 201071144 A1 EA201071144 A1 EA 201071144A1 EA 201071144 A EA201071144 A EA 201071144A EA 201071144 A EA201071144 A EA 201071144A EA 201071144 A1 EA201071144 A1 EA 201071144A1
Authority
EA
Eurasian Patent Office
Prior art keywords
heterocyclic derivatives
medicaments
manufacture
treatment
specifically
Prior art date
Application number
EA201071144A
Other languages
English (en)
Other versions
EA018521B1 (ru
Inventor
Сунг Ох Ахн
Чан Хее Парк
Дзунг Хван Им
Соон Ок Ли
Киоунг Дзун Ли
Сеонг Воок Чо
Кванг Сеок Ко
Сун Янг Хан
Вон Ил Ли
Original Assignee
Си Энд Си Рисерч Лэборетериз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Си Энд Си Рисерч Лэборетериз filed Critical Си Энд Си Рисерч Лэборетериз
Publication of EA201071144A1 publication Critical patent/EA201071144A1/ru
Publication of EA018521B1 publication Critical patent/EA018521B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к гетероциклическим производным и, более конкретно, к новым гетероциклическим производным, полезным для получения лекарственных средств для лечения заболевания, связанного с мочевой кислотой.
EA201071144A 2008-03-31 2009-03-31 Гетероциклические производные EA018521B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080030067 2008-03-31
PCT/KR2009/001659 WO2009145456A2 (ko) 2008-03-31 2009-03-31 헤테로사이클 유도체

Publications (2)

Publication Number Publication Date
EA201071144A1 true EA201071144A1 (ru) 2011-06-30
EA018521B1 EA018521B1 (ru) 2013-08-30

Family

ID=41377713

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071144A EA018521B1 (ru) 2008-03-31 2009-03-31 Гетероциклические производные

Country Status (23)

Country Link
US (1) US8394792B2 (ru)
EP (1) EP2266989B1 (ru)
JP (1) JP5314123B2 (ru)
KR (1) KR101250297B1 (ru)
CN (1) CN102015726B (ru)
AU (1) AU2009252166B9 (ru)
BR (1) BRPI0909691B1 (ru)
CA (1) CA2718709C (ru)
DK (1) DK2266989T3 (ru)
EA (1) EA018521B1 (ru)
ES (1) ES2552311T3 (ru)
HR (1) HRP20151098T1 (ru)
HU (1) HUE026261T2 (ru)
IL (1) IL208203A (ru)
MX (1) MX2010010366A (ru)
MY (1) MY155517A (ru)
NZ (1) NZ587880A (ru)
PL (1) PL2266989T3 (ru)
PT (1) PT2266989E (ru)
SI (1) SI2266989T1 (ru)
TW (2) TWI613203B (ru)
WO (1) WO2009145456A2 (ru)
ZA (1) ZA201006475B (ru)

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* Cited by examiner, † Cited by third party
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GB201106814D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compounds
US20130090334A1 (en) * 2011-10-05 2013-04-11 Hoffmann-La Roche Inc Azabenzoxazine derivatives as crac modulators
WO2013111870A1 (ja) * 2012-01-27 2013-08-01 帝人ファーマ株式会社 糖尿病の治療薬
WO2013152308A2 (en) * 2012-04-06 2013-10-10 Deka Products Limited Partnership Water vapor distillation apparatus, method and system
JP5805613B2 (ja) * 2012-11-16 2015-11-04 株式会社神戸製鋼所 改質石炭の製造方法及び改質石炭製造装置
CN103936762B (zh) * 2013-01-17 2016-02-24 上海汇伦生命科技有限公司 吗啉并喹啉类化合物，其制备方法和用途
CN103664764A (zh) * 2013-12-06 2014-03-26 常熟市联创化学有限公司 一种3-氨基-2-羟基吡啶的制备方法
EP3091984B1 (en) 2014-01-09 2020-04-22 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Substituted benzoxazine and related compounds
RU2016148736A (ru) * 2014-05-13 2018-06-14 Тейдзин Фарма Лимитед Новые кристаллические полиморфы производного пиридина и способ их получения
CA2971125C (en) 2014-12-29 2024-05-21 Nippon Chemiphar Co., Ltd. Urat1 inhibitor
US10029995B2 (en) 2015-09-03 2018-07-24 Forma Therapeutics, Inc. [6,6] fused bicyclic HDAC8 inhibitors
EP3397627B1 (en) 2015-12-28 2022-01-26 Shanghai Fochon Pharmaceutical Co., Ltd. Indolizine derivatives, composition and methods of use
CN108084186B (zh) 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
WO2018090921A1 (zh) 2016-11-16 2018-05-24 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
CA3061301C (en) * 2017-05-25 2022-05-31 Jw Pharmaceutical Corporation Method for preparing heterocyclic derivative compound, composition containing same compound, and hydrate of same compound
CN109111464B (zh) 2017-06-23 2021-02-26 爱科诺生物医药股份有限公司 一种具有细胞坏死抑制活性的杂环化合物
WO2018237370A1 (en) 2017-06-23 2018-12-27 Accro Bioscience Inc. HETEROARYL COMPOUNDS AS INHIBITORS OF THE NECROSIS, COMPOSITION AND METHOD OF USE THEREOF
US11453674B2 (en) 2018-01-19 2022-09-27 Evopoint Biosciences Co., Ltd. Heterocyclic compound, preparation method and use thereof in medicine
CN108558906A (zh) * 2018-05-21 2018-09-21 日照市普达医药科技有限公司 一种治疗白内障药物苯并吩噁嗪类化合物及其制备方法
JP7637049B2 (ja) 2018-08-13 2025-02-27 エフ． ホフマン－ラ ロシュ アーゲー モノアシルグリセロールリパーゼ阻害剤としての新規の複素環化合物
KR20220021912A (ko) * 2019-06-17 2022-02-22 포천 파마슈티컬즈, 엘티디. 헤테로사이클릭 유도체 및 이의 용도
JP7652794B2 (ja) 2020-06-04 2025-03-27 ベイジーン リミテッド ＩＡＰアンタゴニストとしてのピリド［２，３－ｂ］［１，４］オキサジンまたはテトラヒドロピリド［２，３－ｂ］［１，４］オキサゼピン
CN111841896B (zh) * 2020-08-06 2022-10-18 武汉工程大学 一种苯并杂环羟肟酸类捕收剂及其制备方法和应用
WO2022169974A1 (en) 2021-02-05 2022-08-11 Nexys Therapeutics, Inc. Inhibitors of urat1 and pharmaceutical uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002220389A (ja) * 2001-01-26 2002-08-09 Hokko Chem Ind Co Ltd ピリジルベンズオキサジン誘導体、除草剤および中間体
AR051780A1 (es) 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
JP3988832B2 (ja) 2004-11-29 2007-10-10 日本たばこ産業株式会社 窒素含有縮合環化合物及びその用途
US20060177646A1 (en) * 2005-02-09 2006-08-10 Detlef Burgard Method for producing shatterproof glass panels and casting resin molding
US20070197512A1 (en) * 2006-01-27 2007-08-23 Japan Tobacco Inc. Carboxylic Acid Compounds and Use Thereof
TWI385161B (zh) * 2006-02-02 2013-02-11 Mitsubishi Tanabe Pharma Corp 含氮雜雙環化合物
RU2407740C2 (ru) * 2006-02-13 2010-12-27 Ф.Хоффманн-Ля Рош Аг Гетеробициклические сульфонамидные производные для лечения диабета
US20080064871A1 (en) * 2006-05-26 2008-03-13 Japan Tobacco Inc. Production Method of Nitrogen-Containing Fused Ring Compounds
WO2009120660A2 (en) * 2008-03-28 2009-10-01 Cara Therapeutics, Inc. Substituted pyridoxazines

Also Published As

Publication number Publication date
TW201000488A (en) 2010-01-01
PL2266989T3 (pl) 2016-04-29
DK2266989T3 (en) 2015-11-23
EP2266989A2 (en) 2010-12-29
IL208203A (en) 2016-06-30
EA018521B1 (ru) 2013-08-30
ES2552311T3 (es) 2015-11-27
SI2266989T1 (sl) 2015-12-31
WO2009145456A2 (ko) 2009-12-03
CN102015726A (zh) 2011-04-13
JP2011516468A (ja) 2011-05-26
BRPI0909691A8 (pt) 2018-01-02
CA2718709A1 (en) 2009-12-03
WO2009145456A3 (ko) 2010-01-21
TWI613203B (zh) 2018-02-01
IL208203A0 (en) 2010-12-30
NZ587880A (en) 2012-06-29
JP5314123B2 (ja) 2013-10-16
AU2009252166B2 (en) 2013-10-10
PT2266989E (pt) 2015-11-23
EP2266989B1 (en) 2015-09-02
AU2009252166A1 (en) 2009-12-03
TW201522347A (zh) 2015-06-16
BRPI0909691A2 (pt) 2015-08-04
HRP20151098T1 (hr) 2016-01-01
BRPI0909691B1 (pt) 2021-07-20
CA2718709C (en) 2016-08-09
MY155517A (en) 2015-10-30
US8394792B2 (en) 2013-03-12
TWI500622B (zh) 2015-09-21
ZA201006475B (en) 2011-10-26
AU2009252166B9 (en) 2014-02-13
HK1148283A1 (en) 2011-09-02
KR20110005688A (ko) 2011-01-18
MX2010010366A (es) 2010-11-30
CN102015726B (zh) 2014-07-23
KR101250297B1 (ko) 2013-04-03
US20110028467A1 (en) 2011-02-03
HUE026261T2 (en) 2016-06-28
EP2266989A4 (en) 2011-10-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM