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EA201070421A1 - Микрорибонуклеиновые кислоты - Google Patents

Микрорибонуклеиновые кислоты

Info

Publication number
EA201070421A1
EA201070421A1 EA201070421A EA201070421A EA201070421A1 EA 201070421 A1 EA201070421 A1 EA 201070421A1 EA 201070421 A EA201070421 A EA 201070421A EA 201070421 A EA201070421 A EA 201070421A EA 201070421 A1 EA201070421 A1 EA 201070421A1
Authority
EA
Eurasian Patent Office
Prior art keywords
microriponic
acid
mirna
vivo
drugs
Prior art date
Application number
EA201070421A
Other languages
English (en)
Other versions
EA019939B1 (ru
Inventor
Сусанна Обад
Сакари Кауппинен
Йоаким Элмен
Мортен Линдов
Маркус Хейденблад
Original Assignee
Сантарис Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40526747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201070421(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Сантарис Фарма А/С filed Critical Сантарис Фарма А/С
Publication of EA201070421A1 publication Critical patent/EA201070421A1/ru
Publication of EA019939B1 publication Critical patent/EA019939B1/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
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  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

Настоящее изобретение относится к очень коротким глубоко модифицированным олигонуклеотидам, ингибирующим микроРНК in vivo, мишенью для которых является микроРНК, и к их применению в лекарственных средствах и фармацевтических композициях.
EA201070421A 2007-10-04 2008-10-03 МОДИФИЦИРОВАННЫЙ ОЛИГОМЕР ДЛЯ УМЕНЬШЕНИЯ КОЛИЧЕСТВА микроРНК В КЛЕТКЕ EA019939B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97749707P 2007-10-04 2007-10-04
US97921707P 2007-10-11 2007-10-11
US2806208P 2008-02-12 2008-02-12
EP08104780 2008-07-17
PCT/DK2008/000344 WO2009043353A2 (en) 2007-10-04 2008-10-03 Micromirs

Publications (2)

Publication Number Publication Date
EA201070421A1 true EA201070421A1 (ru) 2010-10-29
EA019939B1 EA019939B1 (ru) 2014-07-30

Family

ID=40526747

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070421A EA019939B1 (ru) 2007-10-04 2008-10-03 МОДИФИЦИРОВАННЫЙ ОЛИГОМЕР ДЛЯ УМЕНЬШЕНИЯ КОЛИЧЕСТВА микроРНК В КЛЕТКЕ

Country Status (17)

Country Link
US (5) US8906871B2 (ru)
EP (5) EP2203559B1 (ru)
JP (2) JP6035010B2 (ru)
KR (1) KR101889518B1 (ru)
CN (1) CN101821391B (ru)
AU (1) AU2008306327B2 (ru)
CA (1) CA2701547C (ru)
DK (2) DK2623599T3 (ru)
EA (1) EA019939B1 (ru)
ES (3) ES2406686T3 (ru)
IL (2) IL204254A (ru)
MX (1) MX2010003299A (ru)
MY (1) MY156951A (ru)
NZ (1) NZ583677A (ru)
PL (1) PL2623598T3 (ru)
WO (2) WO2009043354A2 (ru)
ZA (1) ZA201002040B (ru)

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KR20110128838A (ko) 2009-02-04 2011-11-30 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 심장 질환 치료에서 ｍｉｒ－208 및 ｍｉｒ－499의 이중 표적화
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DK2205737T3 (da) 2013-05-21
JP2015130862A (ja) 2015-07-23
JP2010539959A (ja) 2010-12-24
US20090143326A1 (en) 2009-06-04
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AU2008306327B2 (en) 2014-05-15
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KR101889518B1 (ko) 2018-08-17
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US20150299699A1 (en) 2015-10-22
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