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EA201000211A1 - Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения - Google Patents

Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения

Info

Publication number
EA201000211A1
EA201000211A1 EA201000211A EA201000211A EA201000211A1 EA 201000211 A1 EA201000211 A1 EA 201000211A1 EA 201000211 A EA201000211 A EA 201000211A EA 201000211 A EA201000211 A EA 201000211A EA 201000211 A1 EA201000211 A1 EA 201000211A1
Authority
EA
Eurasian Patent Office
Prior art keywords
protein
modeling
connection
gpr119 receptor
formula
Prior art date
Application number
EA201000211A
Other languages
English (en)
Other versions
EA016595B1 (ru
Inventor
Дин А. Уокер
Карен А. Росси
Инг Ванг
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201000211A1 publication Critical patent/EA201000211A1/ru
Publication of EA016595B1 publication Critical patent/EA016595B1/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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Abstract

Способ модулирования активности рецептора GPR119, сопряженного с G-белком, включающий введение млекопитающему, нуждающемуся в этом, терапевтически эффективного количества по меньшей мере одного соединения формулы (I) или формулы (IA) и, возможно, дополнительного терапевтического агента.
EA201000211A 2007-07-17 2008-07-16 Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения EA016595B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95016207P 2007-07-17 2007-07-17
PCT/US2008/070103 WO2009012277A1 (en) 2007-07-17 2008-07-16 Method for modulating gpr119 g protein-coupled receptor and selected compounds

Publications (2)

Publication Number Publication Date
EA201000211A1 true EA201000211A1 (ru) 2010-06-30
EA016595B1 EA016595B1 (ru) 2012-06-29

Family

ID=39864683

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201000211A EA016595B1 (ru) 2007-07-17 2008-07-16 Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения
EA201000210A EA018709B1 (ru) 2007-07-17 2008-07-16 Пиридоновые агонисты сопряженного с g-белком рецептора gpr119

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201000210A EA018709B1 (ru) 2007-07-17 2008-07-16 Пиридоновые агонисты сопряженного с g-белком рецептора gpr119

Country Status (26)

Country Link
US (6) US7928230B2 (ru)
EP (2) EP2173737B1 (ru)
JP (3) JP5301539B2 (ru)
KR (2) KR20100045471A (ru)
CN (3) CN101801956B (ru)
AR (2) AR067568A1 (ru)
AT (2) ATE540945T1 (ru)
AU (2) AU2008276057B2 (ru)
BR (2) BRPI0815097A2 (ru)
CA (2) CA2693444A1 (ru)
CL (2) CL2008002111A1 (ru)
CO (1) CO6160315A2 (ru)
CY (2) CY1112151T1 (ru)
DK (2) DK2170864T3 (ru)
EA (2) EA016595B1 (ru)
ES (2) ES2371515T3 (ru)
HR (2) HRP20110806T1 (ru)
IL (1) IL228120A0 (ru)
NZ (2) NZ582664A (ru)
PE (2) PE20090449A1 (ru)
PL (2) PL2173737T3 (ru)
PT (2) PT2173737E (ru)
SI (2) SI2170864T1 (ru)
TW (2) TW200904439A (ru)
WO (2) WO2009012275A1 (ru)
ZA (2) ZA201000151B (ru)

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