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EA200970401A1 - 2-[1-ФЕНИЛ-5-ГИДРОКСИ ИЛИ МЕТОКСИ-4-АЛЬФА-МЕТИЛГЕКСАГИДРОЦИКЛОПЕНТА[f]ИНДАЗОЛ-5-ИЛ] ЭТИЛФЕНИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ЛИГАНДОВ ГЛЮКОКОРТИКОИДНОГО РЕЦЕПТОРА - Google Patents

2-[1-ФЕНИЛ-5-ГИДРОКСИ ИЛИ МЕТОКСИ-4-АЛЬФА-МЕТИЛГЕКСАГИДРОЦИКЛОПЕНТА[f]ИНДАЗОЛ-5-ИЛ] ЭТИЛФЕНИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ЛИГАНДОВ ГЛЮКОКОРТИКОИДНОГО РЕЦЕПТОРА

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Publication number
EA200970401A1
EA200970401A1 EA200970401A EA200970401A EA200970401A1 EA 200970401 A1 EA200970401 A1 EA 200970401A1 EA 200970401 A EA200970401 A EA 200970401A EA 200970401 A EA200970401 A EA 200970401A EA 200970401 A1 EA200970401 A1 EA 200970401A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenyl
indazol
hydroxy
derivatives
methylhexhydrocyclopent
Prior art date
Application number
EA200970401A
Other languages
English (en)
Inventor
Кристофер Дж. Бунгард
Джесс Дж. Маниковски
Джеймс Дж. Перкинс
Роберт Мейсснер
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200970401A1 publication Critical patent/EA200970401A1/ru

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Abstract

Настоящее изобретение относится к 2-[1-фенил-5-гидрокси-4-альфа-метилгексагидроциклопента[f]индазол-5-ил]этилфенильным производным в качестве лигандов глюкокортикоидного рецептора, которые полезны при лечении ряда аутоиммунных и воспалительных заболеваний или состояний. Также рассмотрены фармацевтические композиции и способы применения.
EA200970401A 2006-10-23 2007-10-23 2-[1-ФЕНИЛ-5-ГИДРОКСИ ИЛИ МЕТОКСИ-4-АЛЬФА-МЕТИЛГЕКСАГИДРОЦИКЛОПЕНТА[f]ИНДАЗОЛ-5-ИЛ] ЭТИЛФЕНИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ЛИГАНДОВ ГЛЮКОКОРТИКОИДНОГО РЕЦЕПТОРА EA200970401A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85365506P 2006-10-23 2006-10-23
US92333707P 2007-04-13 2007-04-13
PCT/US2007/022449 WO2008060391A2 (en) 2006-10-23 2007-10-23 2- [l-phenyl-5-hydr0xy-4alpha-methyl-hexahydr0cycl0penta[f] indaz0l-5-yl] ethyl phenyl derivatives as glucocorticoid receptor ligands

Publications (1)

Publication Number Publication Date
EA200970401A1 true EA200970401A1 (ru) 2009-10-30

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EA200970401A EA200970401A1 (ru) 2006-10-23 2007-10-23 2-[1-ФЕНИЛ-5-ГИДРОКСИ ИЛИ МЕТОКСИ-4-АЛЬФА-МЕТИЛГЕКСАГИДРОЦИКЛОПЕНТА[f]ИНДАЗОЛ-5-ИЛ] ЭТИЛФЕНИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ЛИГАНДОВ ГЛЮКОКОРТИКОИДНОГО РЕЦЕПТОРА

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Country Link
US (1) US8119681B2 (ru)
EP (2) EP2091922B1 (ru)
JP (1) JP5271911B2 (ru)
KR (1) KR20090068345A (ru)
CN (1) CN101528707B (ru)
AT (1) ATE538099T1 (ru)
AU (1) AU2007309507A1 (ru)
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