[go: up one dir, main page]

EA200901459A1 - Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства - Google Patents

Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства

Info

Publication number
EA200901459A1
EA200901459A1 EA200901459A EA200901459A EA200901459A1 EA 200901459 A1 EA200901459 A1 EA 200901459A1 EA 200901459 A EA200901459 A EA 200901459A EA 200901459 A EA200901459 A EA 200901459A EA 200901459 A1 EA200901459 A1 EA 200901459A1
Authority
EA
Eurasian Patent Office
Prior art keywords
active substances
improved properties
reconstructed surface
directed
amino acid
Prior art date
Application number
EA200901459A
Other languages
English (en)
Other versions
EA017697B1 (ru
Inventor
Ян Йоханссон
Торе Курстедт
Бенгт Робертсон
Original Assignee
Кьези Фармачеутичи С. П. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кьези Фармачеутичи С. П. А. filed Critical Кьези Фармачеутичи С. П. А.
Publication of EA200901459A1 publication Critical patent/EA200901459A1/ru
Publication of EA017697B1 publication Critical patent/EA017697B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

Настоящее изобретение относится к реконструированному поверхностно-активному веществу, содержащему липидный носитель, полипептидный аналог природного поверхностно-активного белка SP-C и полипептид, содержащий последовательность повторяющихся единиц, состоящих из ряда гидрофобных аминокислотных остатков в количестве от 3 до 8 и одного основного аминокислотного остатка. Изобретение также относится к содержащим его фармацевтическим композициям и его применению для профилактики и/или лечения RDS (респираторного дистресс-сидрома) и других респираторных расстройств.
EA200901459A 2007-06-01 2008-05-22 Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства EA017697B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07010857A EP1997502A1 (en) 2007-06-01 2007-06-01 Reconstituted surfactants having improved properties
PCT/EP2008/004097 WO2008145298A1 (en) 2007-06-01 2008-05-22 Reconstituted surfactants having improved properties

Publications (2)

Publication Number Publication Date
EA200901459A1 true EA200901459A1 (ru) 2010-06-30
EA017697B1 EA017697B1 (ru) 2013-02-28

Family

ID=38421186

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901459A EA017697B1 (ru) 2007-06-01 2008-05-22 Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства

Country Status (13)

Country Link
US (1) US7897577B2 (ru)
EP (2) EP1997502A1 (ru)
JP (1) JP5575639B2 (ru)
KR (1) KR101516443B1 (ru)
CN (1) CN101687006B (ru)
AT (1) ATE544461T1 (ru)
AU (1) AU2008256449B2 (ru)
BR (1) BRPI0811320A2 (ru)
CA (1) CA2689066C (ru)
EA (1) EA017697B1 (ru)
MX (1) MX2009012675A (ru)
WO (1) WO2008145298A1 (ru)
ZA (1) ZA200908445B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20021058A1 (it) 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
UA94477C2 (ru) 2006-10-13 2011-05-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Воспроизведенные сурфактанты, которые имеют улучшенные свойства
EP2022798A1 (en) 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides
WO2009049159A1 (en) 2007-10-10 2009-04-16 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
US8399406B2 (en) * 2009-06-05 2013-03-19 Chiesi Farmaceutici S.P.A. Reconstituted surfactant composition containing analogs of surfactant protein B (SP-B) and surfactant protein C (SP-C)
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
US8778383B2 (en) 2011-06-07 2014-07-15 Parion Sciences, Inc. Methods of treatment
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
SG11201405944PA (en) 2012-03-28 2014-10-30 Discovery Lab Inc Lyophilization of synthetic liposomal pulmonary surfactant
WO2013181232A2 (en) 2012-05-29 2013-12-05 Michael Ross Johnson Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
WO2014099673A1 (en) 2012-12-17 2014-06-26 Parion Sciences, Inc. 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
BR112015014349A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por hidratação mucosa insuficiente
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
AU2015325013B2 (en) 2014-10-01 2021-01-28 Plant Health Care, Inc. Hypersensitive response elicitor peptides and use thereof
CA2962945A1 (en) 2014-10-01 2016-04-07 Plant Health Care, Inc. Elicitor peptides having disrupted hypersensitive response box and use thereof
WO2017176588A1 (en) 2016-04-06 2017-10-12 Plant Health Care, Inc. Beneficial microbes for delivery of effector peptides or proteins and use thereof
MX389549B (es) 2016-04-06 2025-03-20 Plant Health Care Inc Peptidos derivados de inductores de respuesta de hipersensibilidad y su uso.
CA3043792A1 (en) 2016-12-22 2018-06-28 Chiesi Farmaceutici S.P.A. A therapeutic combination comprising a pulmonary surfactant and a steroid for the treatment of evolving bpd
KR102781186B1 (ko) 2018-04-23 2025-03-17 키에시 파르마슈티시 엣스. 피. 에이. Bpd의 예방을 위한 폐 계면활성제 및 스테로이드를 포함하는 치료학적 조합물
US20230097886A1 (en) * 2021-07-30 2023-03-30 Ayuvis Research, Inc. Compositions and methods for the treatment of bronchopulmonary dysplasia (bpd) and bpd-associated pulmonary hypertension

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
IT1308180B1 (it) 1999-02-12 2001-12-07 Chiesi Farma Spa Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante
EP1189625A1 (en) * 1999-06-11 2002-03-27 Byk Gulden Lomberg Chemische Fabrik GmbH Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
IL164795A0 (en) * 2002-04-25 2005-12-18 Scripps Research Inst Treatment and prevention of pulmonary conditions
ITMI20021058A1 (it) 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
EP1481665A1 (en) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Novel lipid mixtures for synthetic surfactants
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
UA94477C2 (ru) * 2006-10-13 2011-05-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Воспроизведенные сурфактанты, которые имеют улучшенные свойства
EP2022798A1 (en) 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides

Also Published As

Publication number Publication date
ZA200908445B (en) 2011-02-23
JP5575639B2 (ja) 2014-08-20
EP2152288A1 (en) 2010-02-17
EA017697B1 (ru) 2013-02-28
US7897577B2 (en) 2011-03-01
CA2689066A1 (en) 2008-12-04
ATE544461T1 (de) 2012-02-15
MX2009012675A (es) 2009-12-14
CN101687006A (zh) 2010-03-31
EP2152288B1 (en) 2012-02-08
AU2008256449A1 (en) 2008-12-04
KR101516443B1 (ko) 2015-05-07
US20090088379A1 (en) 2009-04-02
KR20100015802A (ko) 2010-02-12
HK1140420A1 (en) 2010-10-15
AU2008256449B2 (en) 2012-09-13
CN101687006B (zh) 2013-10-16
EP1997502A1 (en) 2008-12-03
JP2010528997A (ja) 2010-08-26
WO2008145298A1 (en) 2008-12-04
BRPI0811320A2 (pt) 2014-10-21
CA2689066C (en) 2016-03-29

Similar Documents

Publication Publication Date Title
EA200901459A1 (ru) Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства
TN2009000099A1 (en) Reconstituted surfactants having improved properties
BRPI1010120A2 (pt) composição de surfactante reconstituído melhorada contendo análogos de proteína b do surfactante (sp-b) e proteína c do surfactante ( sp-c)
IL210668A (en) Glucagon-like peptide-2 (2-glp) analogues and their pharmaceutical preparations
CY1113094T1 (el) Ανοσοσφαιρινες κατευθυνομενες εναντι nogo
WO2009010968A3 (en) Disease treatment via antimicrobial peptides or their inhibitors
EA202192925A1 (ru) Твердые формы ингибитора glyt1
EA202190310A1 (ru) Белок для лечения воспалительных заболеваний
ATE503768T1 (de) Synthetische lungensurfactant peptide
EA201590601A1 (ru) Применение pedf-производных полипептидов для лечения остеоартрита
MY147920A (en) Antibacterial and antiviral peptides from actinomadura namibiensis
BR112022005782A2 (pt) Proteína galectina 9 estabilizada recombinante, vetor recombinante, transformante, composição farmacêutica para prevenção ou tratamento de uma doença óssea, alimento funcional de saúde para prevenção ou melhora de uma doença óssea, e, uso de uma proteína galectina 9 estabilizada recombinante
RS20170169A1 (sr) Poboljšana rekonstituisana kompozicija sufraktanta koja sadrži analoge sufraktanta proteina b (sp-b) i surfaktanta proteina c (sp-c)
TH135738A (th) องค์ประกอบสารลดแรงตึงผิวที่ถูกสร้างใหม่ (reconstituted surfactant composition) ซึ่งถูกปรับปรุง ที่ประกอบด้วยแอนะล็อกส์ของโปรตีนของสารลดแรงตึงผิว b(sp-b) และโปรตีนของสารลดแรงตึงผิว c (sp-c)
UA93432C2 (ru) Модифицированный генно-инженерный рекомбинантный белок, который имитирует свойства поверхностного антигена cd34 человека

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM