EA200702601A1 - Производные тиазола и их применение - Google Patents
Производные тиазола и их применениеInfo
- Publication number
- EA200702601A1 EA200702601A1 EA200702601A EA200702601A EA200702601A1 EA 200702601 A1 EA200702601 A1 EA 200702601A1 EA 200702601 A EA200702601 A EA 200702601A EA 200702601 A EA200702601 A EA 200702601A EA 200702601 A1 EA200702601 A1 EA 200702601A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diseases
- application
- tiazole
- derivatives
- tiazole derivatives
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 231100000516 lung damage Toxicity 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 150000007979 thiazole derivatives Chemical class 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
Abstract
Настоящее изобретение относится к производным тиазола формулы (I), в частности, для лечения и/или профилактики аутоиммунных нарушений и/или воспалительных заболеваний, сердечно-сосудистых заболеваний, нейродегенеративных заболеваний, бактериальных или вирусных инфекций, заболеваний почек, агрегации тромбоцитов, злокачественной опухоли, трансплантации, отторжения трансплантата или повреждений легких.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05104418 | 2005-05-24 | ||
| US68626605P | 2005-06-01 | 2005-06-01 | |
| PCT/EP2006/062602 WO2006125807A1 (en) | 2005-05-24 | 2006-05-24 | Thiazole derivatives and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200702601A1 true EA200702601A1 (ru) | 2008-06-30 |
| EA017166B1 EA017166B1 (ru) | 2012-10-30 |
Family
ID=35134467
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200702601A EA017166B1 (ru) | 2005-05-24 | 2006-05-24 | Производные тиазола и их применение |
| EA200702599A EA014350B1 (ru) | 2005-05-24 | 2006-05-24 | Производные тиазола и их применение |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200702599A EA014350B1 (ru) | 2005-05-24 | 2006-05-24 | Производные тиазола и их применение |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US7879888B2 (ru) |
| EP (2) | EP1888573A1 (ru) |
| JP (2) | JP2008542240A (ru) |
| KR (2) | KR20080031190A (ru) |
| CN (2) | CN101304995B (ru) |
| AU (2) | AU2006251161B2 (ru) |
| BR (2) | BRPI0611176A2 (ru) |
| CA (2) | CA2608143A1 (ru) |
| DK (1) | DK1885716T3 (ru) |
| EA (2) | EA017166B1 (ru) |
| ES (1) | ES2399101T3 (ru) |
| IL (2) | IL187391A (ru) |
| MX (2) | MX2007014884A (ru) |
| NO (2) | NO20076558L (ru) |
| PT (1) | PT1885716E (ru) |
| UA (2) | UA93374C2 (ru) |
| WO (2) | WO2006125803A1 (ru) |
| ZA (2) | ZA200710105B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| UA93374C2 (en) * | 2005-05-24 | 2011-02-10 | Лаборатуар Cepoho C.A. | Thiazole derivatives and use thereof |
| UA96735C2 (en) | 2005-05-24 | 2011-12-12 | Мерк Сероно Са | Thiazole derivatives and use thereof |
| US8455658B2 (en) | 2006-01-25 | 2013-06-04 | Synta Pharmaceuticals Corp. | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
| BRPI0820722A2 (pt) | 2007-12-20 | 2015-06-16 | Novartis Ag | Derivados de tiazol usados como inibidores de pi 3 cinases |
| UA104147C2 (ru) | 2008-09-10 | 2014-01-10 | Новартис Аг | Производная пирролидиндикарбоновой кислоты и ее применение в лечении пролиферативных заболеваний |
| EP2440556A1 (en) * | 2009-06-10 | 2012-04-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of phosphatidylinositol 3-kinase |
| US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| US8637557B2 (en) | 2009-10-19 | 2014-01-28 | Taisho Pharmaceutical Co., Ltd | Aminothiazole derivative |
| JP6236481B2 (ja) * | 2016-02-17 | 2017-11-22 | 東京エレクトロン株式会社 | パターン形成方法 |
| RU2618622C1 (ru) * | 2016-03-22 | 2017-05-04 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный университет" | Способ фармакологической коррекции экспериментальной ишемии скелетной мышцы варденафилом и пентоксифиллином в условиях комбинированной терапии |
| RU2618621C1 (ru) * | 2016-03-22 | 2017-05-04 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный университет" | Способ фармакологической коррекции экспериментальной ишемии скелетной мышцы силденафилом и пентоксифиллином в условиях комбинированной терапии |
| RU2717104C1 (ru) * | 2019-06-26 | 2020-03-18 | Общество с ограниченной ответственностью "Иван-поле" | Способ получения алкил- и ацил-замещенных тиазолов |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2009A (en) * | 1841-03-18 | Improvement in machines for boring war-rockets | ||
| US2008A (en) * | 1841-03-18 | Gas-lamp eok conducting gas pkom ah elevated buhner to one below it | ||
| US2003A (en) * | 1841-03-12 | Improvement in horizontal windivhlls | ||
| US4649146A (en) | 1983-01-31 | 1987-03-10 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives and pharmaceutical composition comprising the same |
| UA71971C2 (en) | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
| AU779908B2 (en) * | 1999-09-10 | 2005-02-17 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| AU2002349705A1 (en) * | 2001-12-03 | 2003-06-17 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
| US20030158199A1 (en) * | 2002-01-25 | 2003-08-21 | Kylix, B.V. | Novel compounds for inhibition of Tie-2 |
| PE20030968A1 (es) | 2002-02-28 | 2004-01-12 | Novartis Ag | Derivados de 5-feniltiazol como inhibidores de cinasas |
| OA12937A (en) * | 2002-10-09 | 2006-10-13 | Pfizer Prod Inc | Thiazole compounds for the treatment of neurodegenerative disorders. |
| WO2004052286A2 (en) | 2002-12-11 | 2004-06-24 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| GB0305152D0 (en) * | 2003-03-06 | 2003-04-09 | Novartis Ag | Organic compounds |
| AR044519A1 (es) * | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| GB0320197D0 (en) | 2003-08-28 | 2003-10-01 | Novartis Ag | Organic compounds |
| GB0326601D0 (en) | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
| CN1926121B (zh) * | 2004-01-12 | 2012-06-13 | 默克雪兰诺有限公司 | 噻唑衍生物及其应用 |
| SE0402735D0 (sv) | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
| UA93374C2 (en) * | 2005-05-24 | 2011-02-10 | Лаборатуар Cepoho C.A. | Thiazole derivatives and use thereof |
| UA96735C2 (en) | 2005-05-24 | 2011-12-12 | Мерк Сероно Са | Thiazole derivatives and use thereof |
| WO2007082956A1 (en) | 2006-01-23 | 2007-07-26 | Laboratoires Serono S.A. | Thiazole derivatives and use thereof |
-
2006
- 2006-05-24 UA UAA200712866A patent/UA93374C2/ru unknown
- 2006-05-24 KR KR1020077029795A patent/KR20080031190A/ko not_active Ceased
- 2006-05-24 CA CA002608143A patent/CA2608143A1/en not_active Abandoned
- 2006-05-24 EA EA200702601A patent/EA017166B1/ru not_active IP Right Cessation
- 2006-05-24 US US11/915,521 patent/US7879888B2/en active Active
- 2006-05-24 CN CN2006800270292A patent/CN101304995B/zh not_active Expired - Fee Related
- 2006-05-24 ZA ZA200710105A patent/ZA200710105B/xx unknown
- 2006-05-24 BR BRPI0611176-9A patent/BRPI0611176A2/pt not_active IP Right Cessation
- 2006-05-24 US US11/915,508 patent/US7888379B2/en not_active Expired - Fee Related
- 2006-05-24 ZA ZA200710104A patent/ZA200710104B/xx unknown
- 2006-05-24 EP EP06755297A patent/EP1888573A1/en not_active Withdrawn
- 2006-05-24 EA EA200702599A patent/EA014350B1/ru not_active IP Right Cessation
- 2006-05-24 JP JP2008512840A patent/JP2008542240A/ja active Pending
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