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EA200602254A1 - Способ стабилизации белков - Google Patents

Способ стабилизации белков

Info

Publication number
EA200602254A1
EA200602254A1 EA200602254A EA200602254A EA200602254A1 EA 200602254 A1 EA200602254 A1 EA 200602254A1 EA 200602254 A EA200602254 A EA 200602254A EA 200602254 A EA200602254 A EA 200602254A EA 200602254 A1 EA200602254 A1 EA 200602254A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bulk
monomeric protein
excipient
stabilization
proteins
Prior art date
Application number
EA200602254A
Other languages
English (en)
Other versions
EA012281B1 (ru
Inventor
Амер Джабер
Original Assignee
Арес Трейдинг С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Арес Трейдинг С.А. filed Critical Арес Трейдинг С.А.
Publication of EA200602254A1 publication Critical patent/EA200602254A1/ru
Publication of EA012281B1 publication Critical patent/EA012281B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Описывают способ получения стабилизированного исходного раствора мономерного белка, который включает в себя приготовление исходного материала мономерного белка в буферном растворе и добавление наполнителя к исходному препарату, при этом наполнитель выбирают из группы, состоящей из бактериостатических средств, поверхностно-активных веществ, изотонических средств, аминокислот, антиоксидантов и их комбинаций. Предпочтительно мономерный белок представляет собой IFN-бета.
EA200602254A 2004-06-01 2005-05-27 Способ стабилизации белков EA012281B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04076627 2004-06-01
PCT/EP2005/052413 WO2005117948A1 (en) 2004-06-01 2005-05-27 Method of stabilizing proteins

Publications (2)

Publication Number Publication Date
EA200602254A1 true EA200602254A1 (ru) 2007-06-29
EA012281B1 EA012281B1 (ru) 2009-08-28

Family

ID=34928262

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200602254A EA012281B1 (ru) 2004-06-01 2005-05-27 Способ стабилизации белков

Country Status (16)

Country Link
US (1) US7858082B2 (ru)
EP (1) EP1750750B1 (ru)
JP (1) JP2008500995A (ru)
CN (1) CN1993138B (ru)
AT (1) ATE543506T1 (ru)
AU (1) AU2005249232B2 (ru)
BR (1) BRPI0510527A (ru)
CA (1) CA2567309A1 (ru)
EA (1) EA012281B1 (ru)
ES (1) ES2381674T3 (ru)
IL (1) IL179617A0 (ru)
MX (1) MXPA06014079A (ru)
NO (1) NO20065861L (ru)
UA (1) UA93349C2 (ru)
WO (1) WO2005117948A1 (ru)
ZA (1) ZA200610041B (ru)

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Also Published As

Publication number Publication date
CN1993138A (zh) 2007-07-04
EP1750750A1 (en) 2007-02-14
ES2381674T3 (es) 2012-05-30
HK1102561A1 (en) 2007-11-30
EP1750750B1 (en) 2012-02-01
UA93349C2 (ru) 2011-02-10
MXPA06014079A (es) 2007-02-15
BRPI0510527A (pt) 2007-10-30
ZA200610041B (en) 2008-07-30
AU2005249232B2 (en) 2010-08-05
US7858082B2 (en) 2010-12-28
EA012281B1 (ru) 2009-08-28
US20070244299A1 (en) 2007-10-18
JP2008500995A (ja) 2008-01-17
CN1993138B (zh) 2010-12-15
NO20065861L (no) 2007-03-01
ATE543506T1 (de) 2012-02-15
AU2005249232A1 (en) 2005-12-15
IL179617A0 (en) 2007-05-15
WO2005117948A1 (en) 2005-12-15
CA2567309A1 (en) 2005-12-15

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU