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EA200601795A1 - Синтез эфиров бороновой кислоты и кислотных соединений - Google Patents

Синтез эфиров бороновой кислоты и кислотных соединений

Info

Publication number
EA200601795A1
EA200601795A1 EA200601795A EA200601795A EA200601795A1 EA 200601795 A1 EA200601795 A1 EA 200601795A1 EA 200601795 A EA200601795 A EA 200601795A EA 200601795 A EA200601795 A EA 200601795A EA 200601795 A1 EA200601795 A1 EA 200601795A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
boronic acid
acid
ethers
compounds
Prior art date
Application number
EA200601795A
Other languages
English (en)
Other versions
EA012927B1 (ru
Inventor
И. Фразер Пикерсгилл
Джон Бишоп
Кристоф Кёльнер
Жан-Марк Гомез
Ахим Гайзер
Роберт Хетт
Винс Аммоскато
Стефен Мунк
Янг Ло
Фанг-Тинг Чуй
Витхалананд Р. Кулкарни
Original Assignee
Миллениум Фармасьютикалз, Инк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34968044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200601795(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Миллениум Фармасьютикалз, Инк filed Critical Миллениум Фармасьютикалз, Инк
Publication of EA200601795A1 publication Critical patent/EA200601795A1/ru
Publication of EA012927B1 publication Critical patent/EA012927B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

Изобретение относится к синтезу эфиров бороновой кислоты и кислотных соединений. Более конкретно, изобретение касается усовершенствованных способов синтеза для крупномасштабного производства эфиров бороновой кислоты и кислотных соединений, включая ингибитор протеазомы на основе пептидной бороновой кислоты - бортезомиб.
EA200601795A 2004-03-30 2005-03-24 Синтез эфиров бороновой кислоты и кислотных соединений EA012927B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55753504P 2004-03-30 2004-03-30
PCT/US2005/009774 WO2005097809A2 (en) 2004-03-30 2005-03-24 Synthesis of boronic ester and acid compounds

Publications (2)

Publication Number Publication Date
EA200601795A1 true EA200601795A1 (ru) 2007-04-27
EA012927B1 EA012927B1 (ru) 2010-02-26

Family

ID=34968044

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601795A EA012927B1 (ru) 2004-03-30 2005-03-24 Синтез эфиров бороновой кислоты и кислотных соединений

Country Status (41)

Country Link
US (14) US7714159B2 (ru)
EP (5) EP3385267B1 (ru)
JP (4) JP4558039B2 (ru)
KR (1) KR100939598B1 (ru)
CN (5) CN107474062A (ru)
AR (3) AR049374A1 (ru)
AT (1) ATE521612T1 (ru)
AU (1) AU2005230930B2 (ru)
BR (1) BRPI0509587A (ru)
CA (4) CA2853272A1 (ru)
CL (2) CL2010000350A1 (ru)
CR (1) CR8653A (ru)
CY (3) CY1112053T1 (ru)
DK (4) DK1756121T3 (ru)
DO (1) DOP2011000293A (ru)
EA (1) EA012927B1 (ru)
EC (1) ECSP066960A (ru)
ES (4) ES2974758T3 (ru)
FI (1) FI4008721T3 (ru)
HK (1) HK1246300A1 (ru)
HR (4) HRP20110846T1 (ru)
HU (2) HUE056859T2 (ru)
IL (3) IL178250A (ru)
LT (2) LT3385267T (ru)
ME (1) ME01975B (ru)
MX (1) MX367324B (ru)
MY (1) MY145427A (ru)
NL (3) NL1028639C2 (ru)
NO (4) NO338905B1 (ru)
NZ (3) NZ550522A (ru)
PE (3) PE20060162A1 (ru)
PL (4) PL4008721T3 (ru)
PT (4) PT1756121E (ru)
RS (4) RS65253B1 (ru)
SG (5) SG151322A1 (ru)
SI (4) SI1756121T1 (ru)
TW (1) TWI386212B (ru)
UA (1) UA90108C2 (ru)
UY (3) UY28830A1 (ru)
WO (1) WO2005097809A2 (ru)
ZA (1) ZA200608689B (ru)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA030685B1 (ru) * 2008-06-17 2018-09-28 Милленниум Фармасьютикалз, Инк. Способ получения соединения боронатного эфира
EA034601B1 (ru) * 2007-08-06 2020-02-25 Милленниум Фармасьютикалз, Инк. Способ получения бороновых кислот

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA034601B1 (ru) * 2007-08-06 2020-02-25 Милленниум Фармасьютикалз, Инк. Способ получения бороновых кислот
EA030685B1 (ru) * 2008-06-17 2018-09-28 Милленниум Фармасьютикалз, Инк. Способ получения соединения боронатного эфира

Also Published As

Publication number Publication date
CA2560886C (en) 2014-08-12
EA012927B1 (ru) 2010-02-26
CA2853272A1 (en) 2005-10-20
ES2457593T3 (es) 2014-04-28
JP2007530687A (ja) 2007-11-01
SI4008721T1 (sl) 2024-05-31
EP4008721B1 (en) 2024-01-03
HRP20110846T1 (hr) 2011-12-31
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