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EA200501321A1 - Способ получения глимепирида и соответствующего промежуточного соединения - Google Patents

Способ получения глимепирида и соответствующего промежуточного соединения

Info

Publication number
EA200501321A1
EA200501321A1 EA200501321A EA200501321A EA200501321A1 EA 200501321 A1 EA200501321 A1 EA 200501321A1 EA 200501321 A EA200501321 A EA 200501321A EA 200501321 A EA200501321 A EA 200501321A EA 200501321 A1 EA200501321 A1 EA 200501321A1
Authority
EA
Eurasian Patent Office
Prior art keywords
glimepiride
formula
obtaining
intermediate compound
related intermediate
Prior art date
Application number
EA200501321A
Other languages
English (en)
Other versions
EA008193B1 (ru
Inventor
Станислав Радль
Камаль Ярраг
Original Assignee
Зентива А.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива А.С. filed Critical Зентива А.С.
Publication of EA200501321A1 publication Critical patent/EA200501321A1/ru
Publication of EA008193B1 publication Critical patent/EA008193B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Способ получения глимепирида формулы Iпри котором пивалат транс-4-метилциклогексиламина формулы VIIподвергают взаимодействию либо непосредственно, либо после превращения в транс-4-метилциклогексиламин или его другую соль с алкил[4-(2-{[(3-этил-4-метил-2-оксо-2,5-дигидро-1H-пиррол-1-ил)карбонил]амино}этил)фенил]сульфонилкарбаматом общей формулы IVгде R представляет собой C-Cалкил, с получением глимепирида формулы I. Пивалат транс-4-метилциклогексиламина формулы VII.Отчет о международном поиске был опубликован 2004.10.14.
EA200501321A 2003-02-21 2004-02-20 Способ получения глимепирида и соответствующего промежуточного соединения EA008193B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2003530A CZ293789B6 (cs) 2003-02-21 2003-02-21 Způsob výroby glimepiridu a příslušný meziprodukt
PCT/CZ2004/000009 WO2004073585A2 (en) 2003-02-21 2004-02-20 Methode of manufacturing glimepiride and the respective intermediate

Publications (2)

Publication Number Publication Date
EA200501321A1 true EA200501321A1 (ru) 2006-02-24
EA008193B1 EA008193B1 (ru) 2007-04-27

Family

ID=32602129

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501321A EA008193B1 (ru) 2003-02-21 2004-02-20 Способ получения глимепирида и соответствующего промежуточного соединения

Country Status (9)

Country Link
US (1) US7282517B2 (ru)
EP (1) EP1594839A2 (ru)
JP (1) JP2006522019A (ru)
CA (1) CA2515520A1 (ru)
CZ (1) CZ293789B6 (ru)
EA (1) EA008193B1 (ru)
PL (1) PL378560A1 (ru)
SK (1) SK50692005A3 (ru)
WO (1) WO2004073585A2 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006103690A1 (en) * 2005-04-01 2006-10-05 Usv Limited A novel process for preparation of substantially pure glimepiride
CN103601661B (zh) * 2013-09-22 2015-10-21 江苏德峰药业有限公司 Ⅱ型糖尿病药物格列美脲三光气的合成方法
CN103508932B (zh) * 2013-09-22 2015-06-10 江苏德峰药业有限公司 糖尿病药物格列美脲的合成方法
CN106699631A (zh) * 2017-02-08 2017-05-24 深圳市新阳唯康科技有限公司 一种格列美脲γ晶型及其制备方法
CN106866487A (zh) * 2017-02-08 2017-06-20 深圳市新阳唯康科技有限公司 一种格列美脲ε晶型及其制备方法
CN106883161A (zh) * 2017-02-08 2017-06-23 深圳市新阳唯康科技有限公司 一种格列美脲β晶型及其制备方法
CN106866486A (zh) * 2017-02-08 2017-06-20 深圳市新阳唯康科技有限公司 一种格列美脲α晶型及其制备方法
CN106866485A (zh) * 2017-02-08 2017-06-20 深圳市新阳唯康科技有限公司 一种格列美脲δ晶型及其制备方法
CN112028807A (zh) * 2020-08-07 2020-12-04 重庆康刻尔制药股份有限公司 一种格列美脲原料药的精制方法
CN114264765B (zh) * 2020-09-16 2023-10-03 徐州万邦金桥制药有限公司 一种利用hplc测定格列美脲中间体中有关物质的分析方法
CN114839286B (zh) * 2022-04-26 2023-05-30 北京悦康科创医药科技股份有限公司 一种格列美脲原料药中有关物质的测定方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2951135A1 (de) * 1979-12-19 1981-06-25 Hoechst Ag, 6230 Frankfurt Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung

Also Published As

Publication number Publication date
CA2515520A1 (en) 2004-09-02
US7282517B2 (en) 2007-10-16
CZ2003530A3 (cs) 2004-07-14
WO2004073585A3 (en) 2004-10-14
PL378560A1 (pl) 2006-05-02
SK50692005A3 (sk) 2005-11-03
WO2004073585A2 (en) 2004-09-02
JP2006522019A (ja) 2006-09-28
EA008193B1 (ru) 2007-04-27
EP1594839A2 (en) 2005-11-16
CZ293789B6 (cs) 2004-07-14
US20070054954A1 (en) 2007-03-08

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