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EA200401533A1 - Способ получения росувастатина - Google Patents

Способ получения росувастатина

Info

Publication number
EA200401533A1
EA200401533A1 EA200401533A EA200401533A EA200401533A1 EA 200401533 A1 EA200401533 A1 EA 200401533A1 EA 200401533 A EA200401533 A EA 200401533A EA 200401533 A EA200401533 A EA 200401533A EA 200401533 A1 EA200401533 A1 EA 200401533A1
Authority
EA
Eurasian Patent Office
Prior art keywords
rosuvastatin
obtaining
obtaining rosuvastatin
pyrimidinaldehyde
pyrimidinecarboxaldehyde
Prior art date
Application number
EA200401533A
Other languages
English (en)
Inventor
Ятендра Кумар
Шантану Де
Мохаммад Рафеек
Хашим Низар Поованатхил Нагоор Мееран
Сваргам Сатхянараяна
Original Assignee
Ранбакси Лабораторис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ранбакси Лабораторис Лимитед filed Critical Ранбакси Лабораторис Лимитед
Publication of EA200401533A1 publication Critical patent/EA200401533A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к экономически эффективному и промышленно выгодному способу получения 4-4(фторфенил)-6-изопропил-2-(N-метил-N-метилсульфониламино)-5-пиримидинкарбоксальдегида, называемого здесь пиримидинальдегидом структурной формулы I, и к применению этого соединения в качестве промежуточного продукта при получении росувастатина.Отчет о международном поиске был опубликован 2004.05.21.
EA200401533A 2002-05-21 2003-05-21 Способ получения росувастатина EA200401533A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN575DE2002 2002-05-21
PCT/IB2003/001946 WO2003097614A2 (en) 2002-05-21 2003-05-21 Process for the preparation of rosuvastatin

Publications (1)

Publication Number Publication Date
EA200401533A1 true EA200401533A1 (ru) 2005-06-30

Family

ID=29434392

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401533A EA200401533A1 (ru) 2002-05-21 2003-05-21 Способ получения росувастатина

Country Status (7)

Country Link
US (1) US20050222415A1 (ru)
EP (1) EP1585736A2 (ru)
AR (1) AR039836A1 (ru)
AU (1) AU2003228010A1 (ru)
BR (1) BR0311195A (ru)
EA (1) EA200401533A1 (ru)
WO (1) WO2003097614A2 (ru)

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CN1763015B (zh) * 2004-10-22 2011-06-22 四川抗菌素工业研究所有限公司 一种罗舒伐他汀及其药用盐的制备方法及中间体
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US20070167625A1 (en) * 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
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US20090124803A1 (en) * 2005-03-22 2009-05-14 Pandurang Balwant Deshpande Process for preparation of rosuvastatin
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EP1893585A1 (en) * 2005-06-01 2008-03-05 Fermion Oy Process for the preparation of n-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-pyrimidin-2-yl]-n-methylmethanesulfonamide
JP5146965B2 (ja) * 2005-06-24 2013-02-20 レツク・フアーマシユーテイカルズ・デー・デー 不純物を含まない非晶質ロスバスタチンカルシウムの調製方法
KR20090108671A (ko) * 2005-08-16 2009-10-15 테바 파마슈티컬 인더스트리즈 리미티드 저염 함량의 로수바스타틴 칼슘
US7868169B2 (en) * 2005-08-16 2011-01-11 Teva Pharmaceutical Industries, Ltd. Crystalline rosuvastatin intermediate
CN100436428C (zh) * 2005-08-22 2008-11-26 鲁南制药集团股份有限公司 瑞舒伐他汀及其盐的制备方法
JP2008526897A (ja) * 2005-10-03 2008-07-24 テバ ファーマシューティカル インダストリーズ リミティド ロスバスタチンのジアステレオマー精製
WO2007074391A2 (en) * 2005-12-28 2007-07-05 Bakulesh Mafatlal Khamar Preparation of a key intermediate in the synthesis of rosuvastatin
ES2564250T3 (es) 2006-05-03 2016-03-21 Msn Laboratories Private Limited Nuevo proceso para estatinas y sus sales farmacéuticamente aceptables de las mismas
EP1948618A1 (en) * 2006-09-18 2008-07-30 Teva Pharmaceutical Industries Ltd. Crystalline rosuvastatin calcium
EP2086945B1 (en) 2006-10-09 2016-01-06 MSN Laboratories Private Limited Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
US8318933B2 (en) 2006-10-31 2012-11-27 Aurobindo Pharma Ltd Process for preparing rosuvastatin calcium
US8212034B2 (en) 2006-12-13 2012-07-03 Aurobindo Pharma Ltd. Process for preparing rosuvastatin calcium
WO2008093205A2 (en) * 2007-01-31 2008-08-07 Orchid Chemicals & Pharmaceuticals Limited A method for the purification of rosuvastatin intermediate
ES2385623T3 (es) 2007-02-08 2012-07-27 Aurobindo Pharma Limited Un procedimiento mejorado para la preparación de rosuvastatina cálcica
JP2009538831A (ja) 2007-04-18 2009-11-12 テバ ファーマシューティカル インダストリーズ リミティド ロスバスタチン中間体及びロスバスタチンの調製方法。
CN101323597B (zh) * 2007-06-11 2012-09-05 安徽省庆云医药化工有限公司 4-(4-氟苯基)-6-异丙基-2-(n-甲基-n-甲磺酰氨基)嘧啶-5-甲醛的制备方法
US20090069563A1 (en) 2007-07-12 2009-03-12 Valerie Niddam-Hildesheim Rosuvastatin intermediates and their preparation
EP2022784A1 (en) * 2007-08-08 2009-02-11 LEK Pharmaceuticals D.D. Process for the preparation of methyl ester of rosuvastatin
WO2009027081A2 (en) 2007-08-28 2009-03-05 Ratiopharm Gmbh Process for preparing pentanoic diacid derivatives
EP2298745B1 (en) 2008-05-27 2014-09-03 Changzhou Pharmaceutical Factory Preparation method of rosuvastatin calcium and its intermediates
US8394956B2 (en) * 2008-09-30 2013-03-12 Aurobindo Pharma Ltd. Process for preparing pyrimidine propenaldehyde
EP2752407B1 (en) 2009-01-14 2015-09-23 Krka Tovarna Zdravil, D.D., Novo Mesto Crystalline rosuvastatin calcium trihydrate
AU2010205464A1 (en) 2009-01-15 2011-08-18 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Process for the preparation of rosuvastatin salts
EP2387561A4 (en) 2009-01-19 2012-07-25 Msn Lab Ltd IMPROVED PROCESS FOR THE PREPARATION OF HIGH-PURITY (3R, 5S) -7-β-CYCLOPROPYL-4- (4-FLUOROPHENYL) QUINOLIN-3-YL-3,5-DIHYDROXY-6 (E) -HEPTENOIC ACID, INCLUDING ITS PHARMACEUTICALLY ACCEPTABLE SALTS
KR101160152B1 (ko) * 2009-02-24 2012-06-27 한미사이언스 주식회사 스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물
EP2526099B1 (en) 2010-01-18 2016-03-30 MSN Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
WO2011141934A1 (en) 2010-05-13 2011-11-17 Matrix Laboratories Ltd. An improved process for the preparation of an intermediate of hmg-coa reductase inhibitors
WO2012011129A2 (en) * 2010-07-22 2012-01-26 Msn Laboratories Limited Novel polymorph of bis[(e)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid] calcium salt
CN101955463B (zh) * 2010-08-04 2012-01-04 重庆博腾制药科技股份有限公司 瑞舒伐他汀钙中间体的制备方法
HU230987B1 (hu) 2010-11-29 2019-08-28 Egis Gyógyszergyár Nyrt. Eljárás nagy tisztaságú gyógyszeripari intermedierek előállítására
AU2012345473B2 (en) 2011-11-28 2017-05-25 Mylan Laboratories Ltd Process for producing chiral statin side chain intermediates employing candida|antarctica lipase B
CN103134893B (zh) * 2013-01-25 2014-12-03 峨眉山天梁星制药有限公司 一种3-叔丁基二甲硅氧基戊二酸酐的高效液相色谱分析法
CN111548312A (zh) * 2020-06-01 2020-08-18 雅本化学股份有限公司 一种瑞舒伐他汀钙片及其制备工艺
CN113754590B (zh) * 2021-09-06 2023-06-13 浙江乐普药业股份有限公司 一种瑞舒伐他汀钙中间体的制备方法

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Also Published As

Publication number Publication date
BR0311195A (pt) 2005-02-22
WO2003097614A2 (en) 2003-11-27
WO2003097614A3 (en) 2004-05-21
EP1585736A2 (en) 2005-10-19
US20050222415A1 (en) 2005-10-06
AR039836A1 (es) 2005-03-02
AU2003228010A1 (en) 2003-12-02

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