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EA200500974A1 - Антитело или антигенсвязывающий домен, специфически связывающиеся с полипептидом потенциалзависимого воротного ионного канала - Google Patents

Антитело или антигенсвязывающий домен, специфически связывающиеся с полипептидом потенциалзависимого воротного ионного канала

Info

Publication number
EA200500974A1
EA200500974A1 EA200500974A EA200500974A EA200500974A1 EA 200500974 A1 EA200500974 A1 EA 200500974A1 EA 200500974 A EA200500974 A EA 200500974A EA 200500974 A EA200500974 A EA 200500974A EA 200500974 A1 EA200500974 A1 EA 200500974A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ion channel
polypeptide
antigensorating
antibody
potential
Prior art date
Application number
EA200500974A
Other languages
English (en)
Other versions
EA008252B1 (ru
Inventor
Даниель Коэн
Илья Чумаков
Анн-Мари Симон
Хади Абдеррахим
Original Assignee
Женсет
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Женсет filed Critical Женсет
Publication of EA200500974A1 publication Critical patent/EA200500974A1/ru
Publication of EA008252B1 publication Critical patent/EA008252B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к антителу или антигенсвязывающему домену, специфически связывающимся с полипептидом потенциалзависимого воротного ионного канала, к их применению для диагностики шизофрении или биполярного расстройства, к набору антисмысловых последовательностей, ингибирующих экспрессию ионного канала, к соединению, которое активирует или ингибирует экспрессию или активность ионного канала указанного полипептида, к фармацевтической композиции, содержащей антитело или антигенсвязывающий фрагмент, набор антисмысловых последовательностей или такое соединение и к диагностическому набору для диагностики шизофрении или биполярного расстройства.
EA200500974A 2000-12-05 2001-12-04 Антитело или антигенсвязывающий домен, специфически связывающиеся с полипептидом потенциалзависимого воротного ионного канала EA008252B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25131700P 2000-12-05 2000-12-05

Publications (2)

Publication Number Publication Date
EA200500974A1 true EA200500974A1 (ru) 2006-02-24
EA008252B1 EA008252B1 (ru) 2007-04-27

Family

ID=22951418

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200500974A EA008252B1 (ru) 2000-12-05 2001-12-04 Антитело или антигенсвязывающий домен, специфически связывающиеся с полипептидом потенциалзависимого воротного ионного канала
EA200300642A EA006367B1 (ru) 2000-12-05 2001-12-04 Связанные с шизофренией ген и белок потенциалзависимого воротного ионного канала

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200300642A EA006367B1 (ru) 2000-12-05 2001-12-04 Связанные с шизофренией ген и белок потенциалзависимого воротного ионного канала

Country Status (16)

Country Link
US (2) US20040091497A1 (ru)
EP (1) EP1339840B1 (ru)
JP (1) JP2004525614A (ru)
KR (1) KR20030074643A (ru)
CN (1) CN1777676A (ru)
AT (1) ATE339500T1 (ru)
AU (2) AU2002233573B2 (ru)
BR (1) BR0115937A (ru)
CA (1) CA2430712A1 (ru)
DE (1) DE60123109T2 (ru)
EA (2) EA008252B1 (ru)
ES (1) ES2271092T3 (ru)
IL (1) IL156073A0 (ru)
MX (1) MXPA03005069A (ru)
UA (1) UA79927C2 (ru)
WO (1) WO2002046404A2 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020042100A1 (en) * 2000-07-03 2002-04-11 Chunhua Yan Isolated human ion channel proteins, nucleic acid molecules encoding human ion channel proteins, and uses thereof
JPWO2002101035A1 (ja) * 2001-05-10 2004-09-24 持田製薬株式会社 新規な電位依存性カチオンチャネル蛋白質
US7634363B2 (en) 2005-12-07 2009-12-15 Affymetrix, Inc. Methods for high throughput genotyping
WO2007100913A2 (en) * 2006-02-28 2007-09-07 The Regents Of The University Of California Genes differentially expressed in bipolar disorder and/or schizophrenia
FR2906532B1 (fr) * 2006-09-28 2008-12-12 Biomerieux Sa Nouvel oligonucleotide marque
US20200224214A1 (en) * 2014-10-13 2020-07-16 Dow Agrosciences Llc Copi coatomer alpha subunit nucleic acid molecules that confer resistance to coleopteran and hemipteran pests
KR102807004B1 (ko) * 2020-01-03 2025-05-14 삼성전자주식회사 기판 적층 구조를 포함하는 전자 장치
CN114982679B (zh) * 2022-07-22 2023-08-01 中国水产科学研究院长江水产研究所 一种黄鳝家系建立及优良家系选育方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008001A (en) * 1993-11-05 1999-12-28 Yeda Research And Development Co. Ltd. Diagnosis of the susceptibility of contracting schizophrenia
WO1999066041A1 (en) * 1998-06-16 1999-12-23 Human Genome Sciences, Inc. 94 human secreted proteins
WO1999004825A1 (en) * 1997-07-22 1999-02-04 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
JP2001525161A (ja) * 1997-12-03 2001-12-11 メルク エンド カムパニー インコーポレーテッド 低電位で活性化されるカルシウムチャネル組成物と方法
WO1999057316A1 (en) * 1998-04-30 1999-11-11 Institut Pasteur A highly conserved polynucleotide sequence linked to a genetic predisposition to schizophrenia, a method of diagnosis, and applications thereof
US20020081584A1 (en) * 1998-10-13 2002-06-27 Marta Blumenfeld Genes, proteins and biallelic markers related to central nervous system disease
JP2002539845A (ja) * 1999-03-30 2002-11-26 ジェンセット 精神分裂病関連遺伝子、タンパク質およびバイアレリックマーカー
EP1280902A2 (en) * 2000-04-29 2003-02-05 Millennium Pharmaceuticals, Inc. 23949 and 32391, human ion channels and uses thereof
JP2004513618A (ja) * 2000-07-07 2004-05-13 インサイト・ゲノミックス・インコーポレイテッド 輸送体及びイオンチャネル

Also Published As

Publication number Publication date
WO2002046404A3 (en) 2002-12-12
ATE339500T1 (de) 2006-10-15
DE60123109D1 (de) 2006-10-26
JP2004525614A (ja) 2004-08-26
AU3357302A (en) 2002-06-18
AU2002233573B2 (en) 2007-03-01
CA2430712A1 (en) 2002-06-13
EP1339840A2 (en) 2003-09-03
MXPA03005069A (es) 2003-09-05
EA006367B1 (ru) 2005-12-29
BR0115937A (pt) 2003-09-30
EP1339840B1 (en) 2006-09-13
DE60123109T2 (de) 2007-05-16
UA79927C2 (en) 2007-08-10
KR20030074643A (ko) 2003-09-19
ES2271092T3 (es) 2007-04-16
EA200300642A1 (ru) 2003-12-25
US20040091497A1 (en) 2004-05-13
EA008252B1 (ru) 2007-04-27
IL156073A0 (en) 2003-12-23
WO2002046404A9 (en) 2002-08-15
CN1777676A (zh) 2006-05-24
WO2002046404A2 (en) 2002-06-13
US20080184381A1 (en) 2008-07-31

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU