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EA200500958A1 - Дейтерированные производные катехоламина, а также лекарственные средства, содержащие эти соединения - Google Patents

Дейтерированные производные катехоламина, а также лекарственные средства, содержащие эти соединения

Info

Publication number
EA200500958A1
EA200500958A1 EA200500958A EA200500958A EA200500958A1 EA 200500958 A1 EA200500958 A1 EA 200500958A1 EA 200500958 A EA200500958 A EA 200500958A EA 200500958 A EA200500958 A EA 200500958A EA 200500958 A1 EA200500958 A1 EA 200500958A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
well
catecholamine
medicines containing
deuterated derivatives
Prior art date
Application number
EA200500958A
Other languages
English (en)
Other versions
EA009258B1 (ru
Inventor
Рудольф-Гизберт Алкен
Original Assignee
Бдд Беролина Драг Девелопмент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бдд Беролина Драг Девелопмент Гмбх filed Critical Бдд Беролина Драг Девелопмент Гмбх
Publication of EA200500958A1 publication Critical patent/EA200500958A1/ru
Publication of EA009258B1 publication Critical patent/EA009258B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к дейтерированным производным катехоламина, а также лекарственным средствам, содержащим эти соединения. Кроме того изобретение относится к применению дейтерированных производных катехоламина, а также их физиологически переносимых солей, а также к фармацевтическим составам, содержащим эти соединения, также в сочетании с ферментными угнетателями активности для лечения заболеваний, связанных с недостатком допамина, или заболеваний, вызванных нарушением переноса тирозина или разрушением тирозиндекарбоксилазы, а также других заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500958A 2002-12-19 2003-12-18 Дейтерированные производные катехоламина, а также лекарственные средства, содержащие эти соединения EA009258B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10261807A DE10261807A1 (de) 2002-12-19 2002-12-19 Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
PCT/DE2003/004203 WO2004056724A1 (de) 2002-12-19 2003-12-18 Deuterierte catecholaminderivate sowie diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
EA200500958A1 true EA200500958A1 (ru) 2006-02-24
EA009258B1 EA009258B1 (ru) 2007-12-28

Family

ID=32404400

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500958A EA009258B1 (ru) 2002-12-19 2003-12-18 Дейтерированные производные катехоламина, а также лекарственные средства, содержащие эти соединения

Country Status (17)

Country Link
US (2) US8168820B2 (ru)
EP (1) EP1613571B1 (ru)
JP (5) JP2006510686A (ru)
CN (1) CN100584807C (ru)
AT (1) ATE451340T1 (ru)
AU (1) AU2003289841B2 (ru)
CA (1) CA2513088C (ru)
DE (2) DE10261807A1 (ru)
DK (1) DK1613571T3 (ru)
EA (1) EA009258B1 (ru)
ES (1) ES2337046T3 (ru)
IL (1) IL169203A (ru)
MX (1) MXPA05006408A (ru)
NZ (1) NZ541047A (ru)
PL (1) PL219269B1 (ru)
PT (1) PT1613571E (ru)
WO (1) WO2004056724A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100360109B1 (ko) * 2000-12-19 2002-11-07 주식회사 포스코 미분을 재활용하는 분철광석의 유동층식 용융환원장치 및이를 이용한 용융환원방법
DE10261807A1 (de) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
PT1991522T (pt) * 2006-02-17 2016-08-23 Imphar Ag Derivados de catecolamina deuterada e medicamentos compreendendo os referidos compostos
US8822498B2 (en) * 2007-09-13 2014-09-02 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
US9763904B2 (en) 2013-02-05 2017-09-19 Teva Pharmaceuticals International Gmbh Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds
EP2953926B1 (en) 2013-02-05 2021-10-20 Teva Pharmaceuticals International GmbH Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds
CA2917159C (en) 2013-07-08 2022-08-23 Auspex Pharmaceuticals, Inc. Dihydroxyphenyl neurotransmitter compounds, compositions and methods
EP2918266A1 (en) 2014-03-11 2015-09-16 CDRD Berolina AB Composition comprising a dopamine agonist and an L-DOPA derivative for treating Parkinson's disease
TW201720443A (zh) 2015-10-09 2017-06-16 梯瓦製藥國際有限責任公司 用以治療帕金森氏症之經氘化左旋多巴、碳度巴、以及奧匹卡朋的組合
WO2020051648A1 (en) 2018-09-13 2020-03-19 University Of Canberra Methods of inhibition

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3699158A (en) * 1969-08-25 1972-10-17 Merck & Co Inc Selective deuteration of tyrosine, aspartic and glutamic acids
US3769424A (en) 1970-10-01 1973-10-30 Merck & Co Inc Composition and method of treating dopamine deficiency in brain tissue
DE2049115C3 (de) 1970-10-06 1981-07-30 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo Verwendung von Calcium-5-butylpicolinat und/oder Calcium-5-pentylpicolinat bei der Bekämpfung des Parkinsonismus mit 3-(3,4-Dihydroxyphenyl)-L-alanin (L-Dopa)
US4663349A (en) 1985-12-30 1987-05-05 Merck & Co., Inc. Rectally absorbable form of L-dopa
DE3779500T2 (de) 1986-06-10 1993-01-21 Chiesi Farma Spa Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.
JP2718504B2 (ja) * 1988-02-22 1998-02-25 アローンサクル シャオバニー 中枢神経系疾患治療法及びアルツハイマー病診断法
IT1226902B (it) 1988-07-12 1991-02-21 Mini Ricerca Scient Tecnolog Processo per la sintesi del levodopa
US5354885A (en) 1992-12-24 1994-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Process for preparing ethyl ester of L-DOPA
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
IL119417A (en) * 1996-10-13 2003-02-12 Moshe Kushnir Pharmaceutical composition for transdermal administration of levodopa for parkinson's disease
ATE314388T1 (de) 1997-10-08 2006-01-15 Isotechnika Inc Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien
US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
NO309305B1 (no) 1999-02-19 2001-01-15 Norsk Hydro As Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
DE60001623T2 (de) * 1999-12-03 2003-12-18 Pfizer Products Inc., Groton Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel
JP2001203263A (ja) 2000-01-20 2001-07-27 Hitachi Ltd 半導体集積回路装置の製造方法および半導体集積回路装置
JP2002097137A (ja) 2000-07-19 2002-04-02 Junichi Sudo パーキンソン病の予防および／または治療剤
DE10123129A1 (de) 2001-05-02 2002-11-14 Berolina Drug Dev Ab Svedala Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel
DE10261807A1 (de) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
NZ541047A (en) 2008-09-26
ES2337046T3 (es) 2010-04-20
DE50312224D1 (de) 2010-01-21
EP1613571B1 (de) 2009-12-09
US20060135615A1 (en) 2006-06-22
PL219269B1 (pl) 2015-04-30
WO2004056724A1 (de) 2004-07-08
CN100584807C (zh) 2010-01-27
IL169203A (en) 2012-05-31
US8168820B2 (en) 2012-05-01
JP2012087124A (ja) 2012-05-10
ATE451340T1 (de) 2009-12-15
DE10261807A1 (de) 2004-07-01
JP2018193356A (ja) 2018-12-06
PL377584A1 (pl) 2006-02-06
USRE46629E1 (en) 2017-12-12
JP2006510686A (ja) 2006-03-30
HK1086548A1 (zh) 2006-09-22
JP2015178537A (ja) 2015-10-08
JP2015212287A (ja) 2015-11-26
PT1613571E (pt) 2010-02-10
AU2003289841A1 (en) 2004-07-14
CA2513088A1 (en) 2004-07-08
AU2003289841B2 (en) 2010-01-28
CA2513088C (en) 2012-03-06
EP1613571A1 (de) 2006-01-11
CN1738782A (zh) 2006-02-22
EA009258B1 (ru) 2007-12-28
MXPA05006408A (es) 2006-03-08
DK1613571T3 (da) 2010-04-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU