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EA200401405A1 - Модифицированный осповакцинный вирус анкара для вакцинации новорожденных - Google Patents

Модифицированный осповакцинный вирус анкара для вакцинации новорожденных

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Publication number
EA200401405A1
EA200401405A1 EA200401405A EA200401405A EA200401405A1 EA 200401405 A1 EA200401405 A1 EA 200401405A1 EA 200401405 A EA200401405 A EA 200401405A EA 200401405 A EA200401405 A EA 200401405A EA 200401405 A1 EA200401405 A1 EA 200401405A1
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EA
Eurasian Patent Office
Prior art keywords
virus
vaccination
relates
antigens
neonatal
Prior art date
Application number
EA200401405A
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English (en)
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EA011233B1 (ru
Inventor
Пол Чаплин
Марк Сутер
Матиас Акерманн
Марко Франкини
Сабине Волльстедт
Ханс Петер Хефти
Original Assignee
Бавариан Нордик А/С
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Application filed by Бавариан Нордик А/С filed Critical Бавариан Нордик А/С
Publication of EA200401405A1 publication Critical patent/EA200401405A1/ru
Publication of EA011233B1 publication Critical patent/EA011233B1/ru

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Abstract

Изобретение относится к применению вируса для получения лекарственного препарата для вакцинации или лечения животного, включая человека, в неонатальном или пренатальном периоде, где вирус способен инфицировать клетки животного, включая человека, в неонатальном или пренатальном периоде, но не способен реплицироваться в инфекционное потомство вируса у животного, включая человека, в неонатальном или пренатальном периоде. Вирус предпочтительно представляет собой модифицированный осповакцинный вирус Анкара. В частности, изобретение относится к вакцинации новорожденных против инфекций, вызываемых вирусами, относящимися к той же группе вирусов, что и вирус, используемый для вакцинации. Кроме того, изобретение относится к вакцинации новорожденных против антигенов, выбранных из чужеродных антигенов и опухолевых антигенов, где опухолевый антиген и/или чужеродный антиген отличаются от антигенов, связанных с вирусом. Изобретение дополнительно относится к применению вирусов, определенных выше, для увеличения концентрации факторов, которые активируют дендритные клетки или их клетки-предшественники, и/или увеличения количества дендритных клеток или их клеток-предшественников, и/или повышения продукции и/или клеточного содержания интерферона (IFN) или IL-12.Отчет о международном поиске был опубликован 2004.02.19.
EA200401405A 2002-04-19 2003-04-16 Применение модифицированного вируса осповакцины анкара для вакцинации новорожденных EA011233B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200200590 2002-04-19
PCT/EP2003/003994 WO2003088994A2 (en) 2002-04-19 2003-04-16 Modified vaccinia virus ankara for the vaccination of neonates

Publications (2)

Publication Number Publication Date
EA200401405A1 true EA200401405A1 (ru) 2005-04-28
EA011233B1 EA011233B1 (ru) 2009-02-27

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ID=29225556

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Application Number Title Priority Date Filing Date
EA200401405A EA011233B1 (ru) 2002-04-19 2003-04-16 Применение модифицированного вируса осповакцины анкара для вакцинации новорожденных

Country Status (23)

Country Link
US (3) US7897156B2 (ru)
EP (4) EP2204180A3 (ru)
JP (4) JP4801880B2 (ru)
KR (2) KR20110017904A (ru)
CN (1) CN100540051C (ru)
AT (1) ATE366586T2 (ru)
AU (1) AU2003239805B2 (ru)
BR (1) BR0309339A (ru)
CA (1) CA2478009C (ru)
CY (1) CY1106848T1 (ru)
DE (1) DE60314823T3 (ru)
DK (1) DK1420822T4 (ru)
EA (1) EA011233B1 (ru)
ES (1) ES2288609T5 (ru)
IL (1) IL163701A0 (ru)
MX (1) MXPA04010353A (ru)
NO (1) NO336348B1 (ru)
NZ (2) NZ547776A (ru)
PL (1) PL220781B1 (ru)
PT (1) PT1420822E (ru)
SG (1) SG173216A1 (ru)
UA (1) UA85371C2 (ru)
WO (1) WO2003088994A2 (ru)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3163902A (en) * 2000-11-23 2002-06-03 Bavarian Nordic Res Inst As Modified vaccinia ankara virus variant
US7628980B2 (en) * 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
JP4801880B2 (ja) * 2002-04-19 2011-10-26 バヴァリアン・ノルディック・アクティーゼルスカブ 新生仔予防接種用変異ワクシニアウイルスアンカラ
WO2004043490A1 (en) * 2002-11-07 2004-05-27 Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health Smallpox vaccine regimen
WO2006089690A1 (en) * 2005-02-23 2006-08-31 Bavarian Nordic A/S Use of a modified poxvirus for the rapid induction of immunity against a poxvirus or other infectious agents
EP1835031A1 (en) * 2006-03-14 2007-09-19 Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe Use of a recombinant modified vaccinia virus Ankara (MVA) for the treatment of type I hypersensitivity in a living animal including humans
US8268327B2 (en) * 2007-04-27 2012-09-18 Bavarian Nordic A/S Immediate protection against pathogens via MVA
US20110052627A1 (en) * 2008-06-20 2011-03-03 Paul Chaplin Recombinant modified vaccinia virus measles vaccine
US8883168B2 (en) 2010-11-05 2014-11-11 Bavarian Nordic A/S Modulation of immune responses by the poxviral K4 protein
US9821054B2 (en) 2011-03-11 2017-11-21 Turnstone Limited Partnership Method of vaccination comprising a histone deacetylase inhibitor
EP3639851A1 (en) * 2012-09-04 2020-04-22 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
MY175269A (en) * 2013-03-15 2020-06-17 Bavarian Nordic As Single high dose of mva induces a protective immune response in neonates and infants
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
AU2014368898B2 (en) 2013-12-20 2020-06-11 Dana-Farber Cancer Institute, Inc. Combination therapy with neoantigen vaccine
EP3757211A1 (en) 2014-12-19 2020-12-30 The Broad Institute, Inc. Methods for profiling the t-cell-receptor repertoire
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
UA113442C2 (xx) 2015-01-27 2017-01-25 Ентеросорбент
AU2016229408A1 (en) * 2015-02-25 2017-09-14 Memorial Sloan-Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva) as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
AU2016264623B2 (en) 2015-05-20 2022-06-30 Dana-Farber Cancer Institute, Inc. Shared neoantigens
TWI750122B (zh) 2015-06-09 2021-12-21 美商博德研究所有限公司 用於贅瘤疫苗之調配物及其製備方法
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
CA3015650A1 (en) 2016-02-25 2017-08-31 Memorial Sloan Kettering Cancer Center Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy
CN109152827B (zh) 2016-02-25 2023-07-21 纪念斯隆凯特琳癌症中心 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途
AU2017254477A1 (en) 2016-04-18 2018-11-01 Jennifer G. ABELIN Improved HLA epitope prediction
WO2018140391A1 (en) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
EP3621646A4 (en) 2017-05-12 2021-06-02 Memorial Sloan Kettering Cancer Center USEFUL VACCINE VIRUS MUTANTS FOR ANTI-CANCER IMMUNOTHERAPY
US12252702B2 (en) 2018-09-15 2025-03-18 Memorial Sloan Kettering Cancer Center Recombinant poxviruses for cancer immunotherapy
WO2020072700A1 (en) 2018-10-02 2020-04-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
BR112022009598A2 (pt) 2019-11-18 2022-08-16 Janssen Biotech Inc Vacinas baseadas em calr e jak2 mutantes e uso dos mesmos
WO2022009052A2 (en) 2020-07-06 2022-01-13 Janssen Biotech, Inc. Prostate neoantigens and their uses
EP4452305A1 (en) * 2021-12-23 2024-10-30 Bavarian Nordic A/S Recombinant mva viruses for intraperitoneal administration for treating cancer
WO2024015892A1 (en) 2022-07-13 2024-01-18 The Broad Institute, Inc. Hla-ii immunopeptidome methods and systems for antigen discovery

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914408A (en) * 1973-10-12 1975-10-21 Univ Nebraska Vaccine for neonatal calf diarrhea
DE2714665A1 (de) * 1977-04-01 1978-10-05 Mayr Anton Praeparat zur behandlung von herpes zoster und anderen herpes-infektionen, sowie verfahren zu seiner herstellung
US5338683A (en) 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
JPS6035647A (ja) 1983-08-09 1985-02-23 Nippon Denso Co Ltd アンチスキツド制御装置
US6248333B1 (en) * 1990-04-04 2001-06-19 Health Research Inc. Isolated nucleic acid sequence of equine herpesvirus type 1 glycoprotein D (EHV-1 gD)
US5843456A (en) * 1991-03-07 1998-12-01 Virogenetics Corporation Alvac poxvirus-rabies compositions and combination compositions and uses
US5403582A (en) * 1993-01-21 1995-04-04 Nippon Zeon Co., Ltd. Vaccine comprising fowlpox virus recombinants expressing the envelope glycoprotein of an avian reticuloendotheliosis retrovirus
US5405772A (en) * 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
US6190655B1 (en) * 1993-12-03 2001-02-20 Immunex Corporation Methods of using Flt-3 ligand for exogenous gene transfer
DE4405841C1 (de) * 1994-02-23 1995-01-05 Mayr Anton Prof Dr Med Vet Dr Multipotente Paramunitätsinducer auf der Basis von Kombinationen von Pockenviruskomponenten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ATE298370T1 (de) * 1994-04-29 2005-07-15 Baxter Healthcare Sa Rekombinante poxviren mit fremdenpolynukleotiden in wichtigen regionen
US5753489A (en) * 1994-11-10 1998-05-19 Immuno Ag Method for producing viruses and vaccines in serum-free culture
US5756341A (en) * 1994-11-10 1998-05-26 Immuno Ag Method for controlling the infectivity of viruses
UA68327C2 (en) 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
WO1997031119A1 (en) 1996-02-21 1997-08-28 Res Inst For Genetic And Human Methods and compositions for protective and therapeutic genetic immunization
WO1998013500A2 (en) 1996-09-24 1998-04-02 Bavarian Nordic Research Institute A/S Recombinant mva virus expressing dengue virus antigens, and the use thereof in vaccines
AU5091898A (en) * 1996-10-25 1998-05-15 Wistar Institute Of Anatomy And Biology, The Method of vaccinating infants against infections
US6204250B1 (en) * 1996-11-22 2001-03-20 The Mount Sinai Medical Center Of The City Of New York Immunization of infants
GB0023203D0 (en) * 2000-09-21 2000-11-01 Isis Innovation Vaccination method
GB9711957D0 (en) 1997-06-09 1997-08-06 Isis Innovation Methods and reagents for vaccination
WO1999007869A1 (en) 1997-08-05 1999-02-18 University Of Florida Live recombinant vaccine comprising inefficiently or non-replicating virus
AU766954B2 (en) 1998-11-18 2003-10-30 Oxford Biomedica (Uk) Limited Polypeptide
GB2370571B (en) 1998-11-18 2003-05-07 Oxford Biomedica Ltd A modified 5t4 antigen
KR100880765B1 (ko) 2000-03-14 2009-02-02 버베리안 노딕 에이/에스 변형된 백시니아 바이러스 안카라(mva)의 변형 균주
KR20030036194A (ko) 2000-05-24 2003-05-09 메리알 돼지 생식기 호흡기 증후군 바이러스(prrsv) 재조합아비폭스바이러스 백신
WO2001095919A2 (en) * 2000-06-15 2001-12-20 The Governement Of The United States Of America, As Represented By The Secretary Departement Of Hea Lth And Human Services A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses
HK1054329B (zh) * 2000-07-11 2005-10-07 Aicuris Gmbh & Co. Kg 羊副痘病毒屬株在生產抗病毒藥物或者抗癌藥物中的應用
DE10042598A1 (de) * 2000-08-30 2002-03-28 Gsf Forschungszentrum Umwelt Rekombinantes MVA mit der Fähigkeit zur Expression des HER-2/Neu-GENS
US7445924B2 (en) * 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
US7628980B2 (en) 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7097842B2 (en) * 2000-11-23 2006-08-29 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
AU3163902A (en) 2000-11-23 2002-06-03 Bavarian Nordic Res Inst As Modified vaccinia ankara virus variant
US20040091995A1 (en) * 2001-06-15 2004-05-13 Jeffrey Schlom Recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses
CN101397574A (zh) * 2001-12-04 2009-04-01 巴法里安诺迪克有限公司 黄病毒ns1亚单位疫苗
JP4801880B2 (ja) 2002-04-19 2011-10-26 バヴァリアン・ノルディック・アクティーゼルスカブ 新生仔予防接種用変異ワクシニアウイルスアンカラ
KR101138067B1 (ko) * 2002-05-16 2012-04-24 버베리안 노딕 에이/에스 수두 바이러스 게놈내로 삽입된 상동 유전자를 발현하는 재조합 수두 바이러스
RU2337835C2 (ru) * 2003-09-10 2008-11-10 Ра Брэндз, Л.Л.С. Процесс выполнения вдавленного узора на композитной вентилируемой планке
WO2005046614A2 (en) * 2003-11-12 2005-05-26 Therion Biologics Corporation System for treating and preventing breast cancer
US7618980B2 (en) * 2004-07-14 2009-11-17 Bristol-Myers Squibb Company Pyrrolo(oxo)quinolines as 5HT ligands
EP1835031A1 (en) 2006-03-14 2007-09-19 Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe Use of a recombinant modified vaccinia virus Ankara (MVA) for the treatment of type I hypersensitivity in a living animal including humans
EP1925318A1 (en) 2006-11-20 2008-05-28 Paul-Ehrlich-Institut Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu
US8613936B2 (en) * 2009-03-13 2013-12-24 Bavarian Nordic A/S Replication deficient recombinant viruses expressing antigens regulated by transcriptional control elements comprising multiple elements

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