[go: up one dir, main page]

EA200400942A1 - Составы, содержащие хинаприл и подобные асе-ингибиторы - Google Patents

Составы, содержащие хинаприл и подобные асе-ингибиторы

Info

Publication number
EA200400942A1
EA200400942A1 EA200400942A EA200400942A EA200400942A1 EA 200400942 A1 EA200400942 A1 EA 200400942A1 EA 200400942 A EA200400942 A EA 200400942A EA 200400942 A EA200400942 A EA 200400942A EA 200400942 A1 EA200400942 A1 EA 200400942A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hinapril
similar
compositions containing
earth metal
formulations
Prior art date
Application number
EA200400942A
Other languages
English (en)
Other versions
EA007981B1 (ru
Inventor
Рейнир Эйолфссон
Original Assignee
Актавис Груп Хф.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Актавис Груп Хф. filed Critical Актавис Груп Хф.
Publication of EA200400942A1 publication Critical patent/EA200400942A1/ru
Publication of EA007981B1 publication Critical patent/EA007981B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Устойчивые составы соединений АСЕ - ингибиторов, таких как хинаприл, могут быть получены с использованием наполнителей, включающих основное соединение, предпочтительно карбонат щелочного или щелочно-земельного металла, и нерастворимый карбонат щелочного или щелочно-земельного металла, и нерастворимый гидрофосфат щелочного или щелочно-земельного металла. Приготовленные из этих составов таблетки обладают хорошей устойчивостью при хранении, хорошей растворимостью и пригодны для использования в лекарственных композициях.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400942A 2002-01-15 2003-01-14 Фармацевтический состав, содержащий хинаприл или фармацевтически приемлемую его соль EA007981B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IS6233 2002-01-15
PCT/IS2003/000002 WO2003059388A1 (en) 2002-01-15 2003-01-14 Formulations of quinapril and related ace inhibitors

Publications (2)

Publication Number Publication Date
EA200400942A1 true EA200400942A1 (ru) 2004-12-30
EA007981B1 EA007981B1 (ru) 2007-02-27

Family

ID=36701209

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400942A EA007981B1 (ru) 2002-01-15 2003-01-14 Фармацевтический состав, содержащий хинаприл или фармацевтически приемлемую его соль

Country Status (10)

Country Link
US (1) US20050118259A1 (ru)
EP (1) EP1513555B1 (ru)
AT (1) ATE357933T1 (ru)
AU (1) AU2003235579A1 (ru)
DE (1) DE60312857T2 (ru)
EA (1) EA007981B1 (ru)
ES (1) ES2283774T3 (ru)
IS (1) IS2440B (ru)
UA (1) UA78542C2 (ru)
WO (1) WO2003059388A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003270245A1 (en) * 2003-09-23 2005-04-11 Texcontor Etablissement Stable quinapril compositions
EA011862B1 (ru) * 2004-03-24 2009-06-30 Актавис Груп Хф. Композиции рамиприла
ES2603856T3 (es) * 2004-03-29 2017-03-01 Les Laboratoires Servier Procedimiento para preparar una composición farmacéutica sólida
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
GB0518129D0 (en) * 2005-09-06 2005-10-12 Arrow Int Ltd Ramipril formulation
GB2431579A (en) * 2005-10-28 2007-05-02 Arrow Int Ltd Ramipril formulations
US20070098782A1 (en) * 2005-10-28 2007-05-03 Selamine Limited Ramipril Formulation
WO2007144175A2 (en) 2006-06-16 2007-12-21 Lek Pharmaceuticals D.D. Pharmaceutical composition comprising hydrochlorothiazide and telmisartan
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624082D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril metal salts
WO2008132756A1 (en) * 2007-05-01 2008-11-06 Lupin Limited Stable pharmaceutical compositions of ramipril
TR200906322A2 (tr) 2009-08-17 2011-07-21 Bi̇lgi̇ç Mahmut Çözünürlük ve stabilite özellikleri geliştirilmiş granüller.
PL227900B1 (pl) 2012-11-15 2018-01-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Kompozycja farmaceutyczna zawierająca inhibitor ACE i bloker kanałów wapniowych, sposób jej wytwarzania i jednostka dawkowania zawierająca tę kompozycję

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743450A (en) * 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
HU222489B1 (hu) * 1990-07-25 2003-07-28 Novartis Ag. Stabilizált gyógyszerkészítmények és eljárás az előállításukra
US5292520A (en) * 1990-09-13 1994-03-08 Akzo N.V. Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer
US5573780A (en) * 1995-08-04 1996-11-12 Apotex Usa Inc. Stable solid formulation of enalapril salt and process for preparation thereof
NZ508544A (en) * 1998-06-05 2002-10-25 Warner Lambert Co Angiotensin converting enzyme inhibitors, such as quinapril, enalapril and indolapril, stabilised with 1-90 wt% magnesium oxide
WO2000027380A2 (en) * 1998-11-06 2000-05-18 G.D. Searle & Co. Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease
RU2165251C1 (ru) * 2000-09-06 2001-04-20 Федеральное государственное унитарное предприятие Московское производственное химико-фармацевтическое объединение им. Н.А. Семашко Твердая лекарственная форма эналаприла и способ ее получения

Also Published As

Publication number Publication date
ATE357933T1 (de) 2007-04-15
IS2440B (is) 2008-11-15
UA78542C2 (en) 2007-04-10
AU2003235579A1 (en) 2003-07-30
DE60312857T2 (de) 2008-01-17
EA007981B1 (ru) 2007-02-27
DE60312857D1 (de) 2007-05-10
US20050118259A1 (en) 2005-06-02
EP1513555B1 (en) 2007-03-28
ES2283774T3 (es) 2007-11-01
IS7394A (is) 2004-08-11
EP1513555A1 (en) 2005-03-16
WO2003059388A1 (en) 2003-07-24

Similar Documents

Publication Publication Date Title
EA200400942A1 (ru) Составы, содержащие хинаприл и подобные асе-ингибиторы
AR024384A1 (es) UNA FORMA DE DOSIFICACIoN FARMACÉUTICA DE DISOLUCIoN INSTANTÁNEA Y UN MÉTODO PARA PREPARARLA
NO20024221L (no) Blandinger inneholdende alfa-2-adrenerge agonistkomponenter
TR200103186T2 (tr) MEK enzimlerinin inhibitörleri olarak kinolin türevleri
ATE374016T1 (de) Tablette mit hohem wirkstoffgehalt
WO2001076574A3 (en) Novel medical use of aldosterone synthase inhibitors alone or in combination with at1-receptor antagonists
WO2006024490A3 (en) Methods and compositions for the treatment of cell proliferation
MY144992A (en) Substituted 1,2,3,4-tetrahydroisoquinoline derivatives.
WO2000040205A3 (en) Sustained release formulation with reduced moisture sensitivity
NO20024891L (no) Farmasöytiske sammensetninger
JP2004514737A5 (ru)
EP1346732A3 (en) Dosage forms for hygroscopic active ingredients
ATE470443T1 (de) Indol-1-yl-essigsäurederivate
CY1111698T1 (el) Συνδυασμος που περιλαμβανει εναν ανταγωνιστη υποδοχεα ατ1 και εναν ενισχυτη εκκρισης ινσουλινης ή εναν ευαισθητοποιητη ινσουλινης
WO2006097943A3 (en) Pharmaceutical compositions of amlodipine and benazepril
PL1608346T3 (pl) Kompozycje dostarczające lek zawierające estry alfa-hydroksykwasów i sposób ich zastosowania
WO2006050236A3 (en) Compounds and methods of use thereof
MY131488A (en) Low dose liquid entecavir formulations and use
HK1086548A1 (en) Deuterated catecholamine derivatives and medicaments comprising said compounds
WO2005054244A3 (en) Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain
WO2006071844A8 (en) Oxygen-impervious packaging and methods for storing thyroid hormone
MXPA05008403A (es) Uso de acido comestible en formas de dosis solidas farmaceuticas de rapida dispersion.
ATE274337T1 (de) Polyelektrolytzement
NZ331083A (en) Pharmaceutical preparations of cilansetron stabilized against racemization
MXPA04005033A (es) Composicion farmaceutica que comprende una combinacion de metformina y acido 4-oxobutanoico y el uso de la misma para el tratamiento contra diabetes.

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU