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EA200300948A1 - Водная композиция амфотерицина b - Google Patents

Водная композиция амфотерицина b

Info

Publication number
EA200300948A1
EA200300948A1 EA200300948A EA200300948A EA200300948A1 EA 200300948 A1 EA200300948 A1 EA 200300948A1 EA 200300948 A EA200300948 A EA 200300948A EA 200300948 A EA200300948 A EA 200300948A EA 200300948 A1 EA200300948 A1 EA 200300948A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
amphotericin
amphotericine
water composition
autoclaving
Prior art date
Application number
EA200300948A
Other languages
English (en)
Other versions
EA006241B1 (ru
Inventor
Срикантх Паи
Сангеета Риванкар
Original Assignee
Бхарат Сирумс Энд Вэксинс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бхарат Сирумс Энд Вэксинс Лтд. filed Critical Бхарат Сирумс Энд Вэксинс Лтд.
Publication of EA200300948A1 publication Critical patent/EA200300948A1/ru
Publication of EA006241B1 publication Critical patent/EA006241B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Описаны низкотоксичные парентеральные, не содержащие диметилсульфоксид, водные композиции, содержащие амфотерицин B. Композиции существенно состоят, в дополнение к амфотерицину B, из фосфолипидов и хлорида натрия. Композиции стерилизуют автоклавированием. Описан способ приготовления этих композиций без использования растворителей для растворения амфотерицина B. Композиции показаны для лечения инвазивных грибковых инфекций.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300948A 2001-03-01 2001-03-16 Водная композиция амфотерицина b EA006241B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN217MU2001 IN188924B (ru) 2001-03-01 2001-03-01
PCT/IN2001/000040 WO2002069983A1 (en) 2001-03-01 2001-03-16 Amphotericin b aqueous composition

Publications (2)

Publication Number Publication Date
EA200300948A1 true EA200300948A1 (ru) 2004-04-29
EA006241B1 EA006241B1 (ru) 2005-10-27

Family

ID=11097223

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300948A EA006241B1 (ru) 2001-03-01 2001-03-16 Водная композиция амфотерицина b

Country Status (23)

Country Link
US (1) US20040137049A1 (ru)
EP (1) EP1368041B1 (ru)
JP (1) JP2004523566A (ru)
KR (1) KR100810067B1 (ru)
CN (1) CN1255114C (ru)
AT (1) ATE274913T1 (ru)
AU (1) AU2001250643B2 (ru)
BG (1) BG108188A (ru)
BR (1) BR0116922A (ru)
CA (1) CA2438847A1 (ru)
CZ (1) CZ20032264A3 (ru)
DE (1) DE60105322T2 (ru)
DK (1) DK1368041T3 (ru)
EA (1) EA006241B1 (ru)
ES (1) ES2227172T3 (ru)
IN (1) IN188924B (ru)
MX (1) MXPA03007777A (ru)
NZ (1) NZ528281A (ru)
PT (1) PT1368041E (ru)
SK (1) SK10742003A3 (ru)
WO (1) WO2002069983A1 (ru)
YU (1) YU75403A (ru)
ZA (1) ZA200307307B (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
JP2006069929A (ja) * 2004-08-31 2006-03-16 Konica Minolta Medical & Graphic Inc 真菌症治療製剤およびその製造方法
WO2006030450A2 (en) * 2004-09-13 2006-03-23 Bharat Serums & Vaccines Ltd. Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
CN100418536C (zh) * 2005-04-06 2008-09-17 河南省眼科研究所 一种用于眼科的抗真菌药物组合物
CN101453982B (zh) 2006-05-30 2011-05-04 精达制药公司 两件式内部通道渗透递送系统流动调节器
DK2359808T3 (da) 2006-08-09 2013-08-05 Intarcia Therapeutics Inc Osmotiske leveringssystemer og stempelaggregater
EP2157967B1 (en) 2007-04-23 2013-01-16 Intarcia Therapeutics, Inc Suspension formulations of insulinotropic peptides and uses thereof
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
DK2462246T3 (da) 2009-09-28 2017-11-06 Intarcia Therapeutics Inc Hurtig etablering og/eller afslutning af væsentlig steady-state-lægemiddelafgivelse
KR101629521B1 (ko) * 2010-03-16 2016-06-13 우석대학교 산학협력단 난용성 약물 가용화 및 생체막 투과증진을 위한 알코올성 수상을 내상으로 하는 리포좀, 리포좀 조성물 및 리포좀의 제조방법
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN102525921B (zh) * 2012-02-06 2013-08-07 西安力邦制药有限公司 2,2’,6,6’-四异丙基-4,4’-二联苯酚脂微球制剂及其制备方法
WO2013142184A1 (en) * 2012-03-19 2013-09-26 Yale University Antimicrobial compositions and methods
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3302354B1 (en) 2015-06-03 2023-10-04 i2o Therapeutics, Inc. Implant placement systems
EP3222324B1 (en) 2016-03-23 2020-05-13 Wayne State University Valproate as a topical anti-fungal treatment
MA53353A (fr) 2016-05-16 2021-06-09 Intarcia Therapeutics Inc Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
KR20190104039A (ko) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법
CN108344811A (zh) * 2017-01-24 2018-07-31 北京泰德制药股份有限公司 一种注射用脂质体中有机溶剂残留的检测方法
CN108309955B (zh) * 2018-04-27 2020-06-02 武昌理工学院 一种聚明胶肽结合型紫杉醇纳米颗粒的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US5100662A (en) * 1989-08-23 1992-03-31 The Liposome Company, Inc. Steroidal liposomes exhibiting enhanced stability
FR2651680B1 (fr) * 1989-09-14 1991-12-27 Medgenix Group Sa Nouveau procede de preparation de microparticules lipidiques.
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
JP3956402B2 (ja) * 1996-03-04 2007-08-08 日本油脂株式会社 アンホテリシンｂ運搬体
US6180136B1 (en) * 1998-11-10 2001-01-30 Idexx Laboratories, Inc. Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use

Also Published As

Publication number Publication date
DE60105322D1 (de) 2004-10-07
MXPA03007777A (es) 2003-12-08
EP1368041A1 (en) 2003-12-10
WO2002069983A1 (en) 2002-09-12
ZA200307307B (en) 2004-04-20
ES2227172T3 (es) 2005-04-01
YU75403A (sh) 2006-05-25
EA006241B1 (ru) 2005-10-27
KR20040018337A (ko) 2004-03-03
CZ20032264A3 (cs) 2003-12-17
CA2438847A1 (en) 2002-09-12
BG108188A (bg) 2004-09-30
JP2004523566A (ja) 2004-08-05
PT1368041E (pt) 2005-01-31
EP1368041B1 (en) 2004-09-01
CN1505519A (zh) 2004-06-16
AU2001250643B2 (en) 2007-03-22
US20040137049A1 (en) 2004-07-15
BR0116922A (pt) 2004-04-27
ATE274913T1 (de) 2004-09-15
DK1368041T3 (da) 2005-01-17
NZ528281A (en) 2006-11-30
CN1255114C (zh) 2006-05-10
IN188924B (ru) 2002-11-23
KR100810067B1 (ko) 2008-03-05
SK10742003A3 (sk) 2004-01-08
DE60105322T2 (de) 2005-09-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MK4A Patent expired

Designated state(s): RU