EA200300420A1 - Isolated nucleic acid molecules, isolated polypeptides AND METHOD FOR PRODUCTION THEREOF, METHOD FOR DETECTING THEM present in the sample (VARIANTS) host cell (VARIANTS) antibody kit (OPTIONS), a method of modulating activity of a polypeptide, IDENTIFICATION METHOD (VARIANTS) AND APPLICATION OF COMPOUNDS METHOD OF IDENTIFICATION OF THE SUBJECT (OPTIONS) AND METHOD OF TREATING THE SUBJECT WITH DAMAGE ASSOCIATED WITH POTASSIUM CHANNELS (OPTIONS) - Google Patents
Isolated nucleic acid molecules, isolated polypeptides AND METHOD FOR PRODUCTION THEREOF, METHOD FOR DETECTING THEM present in the sample (VARIANTS) host cell (VARIANTS) antibody kit (OPTIONS), a method of modulating activity of a polypeptide, IDENTIFICATION METHOD (VARIANTS) AND APPLICATION OF COMPOUNDS METHOD OF IDENTIFICATION OF THE SUBJECT (OPTIONS) AND METHOD OF TREATING THE SUBJECT WITH DAMAGE ASSOCIATED WITH POTASSIUM CHANNELS (OPTIONS)Info
- Publication number
- EA200300420A1 EA200300420A1 EA200300420A EA200300420A EA200300420A1 EA 200300420 A1 EA200300420 A1 EA 200300420A1 EA 200300420 A EA200300420 A EA 200300420A EA 200300420 A EA200300420 A EA 200300420A EA 200300420 A1 EA200300420 A1 EA 200300420A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
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- identification
- nucleic acid
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
В изобретении представлены выделенные молекулы нуклеиновых кислот, сконструированные молекулы нуклеиновой кислоты PCIP, которые кодируют белки, связывающие калиевые каналы и модулирующие активности, опосредованные калиевыми каналами. Изобретение представляет также антисмысловые молекулы нуклеиновой кислоты, рекомбинантные экспрессионные векторы, содержащие молекулы нуклеиновой кислоты PCIP, клетки-хозяева, в которые интродуцированы экспрессионные векторы, и трансгенные животные, которым интродуцирован или у которых разрушен ген PCIP. Кроме того, в изобретении предложены выделенные белки PCIP, слитые белки, антигенные пептиды и антитела против PCIP. Предложены также способы диагностики, в которых используются композиции, соответствующие изобретению.Отчет о международном поиске был опубликован 2003.03.13.The invention provides isolated nucleic acid molecules, designed PCIP nucleic acid molecules that encode proteins that bind potassium channels and modulate activities mediated by potassium channels. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which expression vectors have been introduced, and transgenic animals that have been introduced or in which the PCIP gene has been destroyed. In addition, the invention provides isolated PCIP proteins, fusion proteins, antigenic peptides and antibodies against PCIP. Diagnostic methods are also proposed that use compositions according to the invention. The international search report was published 2003.03.13.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/670,756 US7078481B1 (en) | 1998-11-20 | 2000-09-27 | Potassium channel interactors and uses therefor |
| US09/703,094 US7556938B1 (en) | 1998-11-20 | 2000-10-31 | Nucleic acids encoding potassium channel interactors |
| PCT/US2001/030463 WO2002026984A2 (en) | 2000-09-27 | 2001-09-27 | Potassium channel interactors and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200300420A1 true EA200300420A1 (en) | 2004-04-29 |
Family
ID=27100393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200300420A EA200300420A1 (en) | 2000-09-27 | 2001-09-27 | Isolated nucleic acid molecules, isolated polypeptides AND METHOD FOR PRODUCTION THEREOF, METHOD FOR DETECTING THEM present in the sample (VARIANTS) host cell (VARIANTS) antibody kit (OPTIONS), a method of modulating activity of a polypeptide, IDENTIFICATION METHOD (VARIANTS) AND APPLICATION OF COMPOUNDS METHOD OF IDENTIFICATION OF THE SUBJECT (OPTIONS) AND METHOD OF TREATING THE SUBJECT WITH DAMAGE ASSOCIATED WITH POTASSIUM CHANNELS (OPTIONS) |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1322759A2 (en) |
| JP (1) | JP2004525610A (en) |
| KR (1) | KR20030074604A (en) |
| CN (1) | CN1498271A (en) |
| AU (1) | AU2001296393A1 (en) |
| BR (1) | BR0114383A (en) |
| CA (1) | CA2420960A1 (en) |
| CZ (1) | CZ20031154A3 (en) |
| EA (1) | EA200300420A1 (en) |
| IL (1) | IL154962A0 (en) |
| MX (1) | MXPA03002557A (en) |
| NO (1) | NO20031369L (en) |
| WO (1) | WO2002026984A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067312B1 (en) | 2001-09-19 | 2006-06-27 | Myriad Genetics, Inc. | PN7718 nucleic acids and use thereof |
| CA2501523A1 (en) * | 2002-11-01 | 2004-05-21 | Inga Reynisdottir | Human type ii diabetes gene-kv channel-interacting protein (kchip1) located on chromosome 5 |
| US9029080B2 (en) * | 2008-11-06 | 2015-05-12 | Basf Se | Screening assay for insecticides |
| CN105483276B (en) * | 2016-02-01 | 2019-06-11 | 成都望路医药技术有限公司 | The application of KCNIP4 gene and its expression product in rectal adenocarcinoma diagnosis and treatment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4758997A (en) * | 1996-10-17 | 1998-05-11 | Nps Pharmaceuticals, Inc. | Potassium channel blocking compounds and their use |
| US6117989A (en) * | 1998-03-26 | 2000-09-12 | Incyte Pharmaceuticals, Inc. | Human calcium-binding proteins |
| CN1346368A (en) * | 1998-11-20 | 2002-04-24 | 千年药品公司 | Potassium channel interactors and uses therefor |
| AU5151100A (en) * | 1999-05-19 | 2000-12-05 | Incyte Genomics, Inc. | Extracellular signaling molecules |
| WO2001053312A1 (en) * | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
-
2001
- 2001-09-27 KR KR10-2003-7004460A patent/KR20030074604A/en not_active Withdrawn
- 2001-09-27 JP JP2002530747A patent/JP2004525610A/en active Pending
- 2001-09-27 EP EP01977260A patent/EP1322759A2/en not_active Withdrawn
- 2001-09-27 IL IL15496201A patent/IL154962A0/en unknown
- 2001-09-27 CN CNA018191681A patent/CN1498271A/en active Pending
- 2001-09-27 AU AU2001296393A patent/AU2001296393A1/en not_active Abandoned
- 2001-09-27 CZ CZ20031154A patent/CZ20031154A3/en unknown
- 2001-09-27 BR BR0114383-2A patent/BR0114383A/en not_active IP Right Cessation
- 2001-09-27 EA EA200300420A patent/EA200300420A1/en unknown
- 2001-09-27 MX MXPA03002557A patent/MXPA03002557A/en unknown
- 2001-09-27 WO PCT/US2001/030463 patent/WO2002026984A2/en not_active Application Discontinuation
- 2001-09-27 CA CA002420960A patent/CA2420960A1/en not_active Abandoned
-
2003
- 2003-03-26 NO NO20031369A patent/NO20031369L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL154962A0 (en) | 2003-10-31 |
| WO2002026984A3 (en) | 2003-03-13 |
| BR0114383A (en) | 2005-04-12 |
| NO20031369L (en) | 2003-05-22 |
| EP1322759A2 (en) | 2003-07-02 |
| KR20030074604A (en) | 2003-09-19 |
| JP2004525610A (en) | 2004-08-26 |
| AU2001296393A1 (en) | 2002-04-08 |
| WO2002026984A2 (en) | 2002-04-04 |
| CZ20031154A3 (en) | 2003-09-17 |
| CA2420960A1 (en) | 2002-04-04 |
| CN1498271A (en) | 2004-05-19 |
| NO20031369D0 (en) | 2003-03-26 |
| MXPA03002557A (en) | 2004-09-10 |
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