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EA200200990A1 - Ингибиторы фосфатидилинозитол-3-киназы дельта человека - Google Patents

Ингибиторы фосфатидилинозитол-3-киназы дельта человека

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Publication number
EA200200990A1
EA200200990A1 EA200200990A EA200200990A EA200200990A1 EA 200200990 A1 EA200200990 A1 EA 200200990A1 EA 200200990 A EA200200990 A EA 200200990A EA 200200990 A EA200200990 A EA 200200990A EA 200200990 A1 EA200200990 A1 EA 200200990A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pi3kδ
methods
inhibiting
activity
delta
Prior art date
Application number
EA200200990A
Other languages
English (en)
Other versions
EA008241B1 (ru
Inventor
Чанчал Садху
Кен Дик
Дженнифер Трайберг
К. Грегори Сауэлл
Эдвард А. Кесицки
Эйми Оливер
Original Assignee
Айкос Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Айкос Корпорейшн filed Critical Айкос Корпорейшн
Publication of EA200200990A1 publication Critical patent/EA200200990A1/ru
Publication of EA008241B1 publication Critical patent/EA008241B1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • C07D487/04—Ortho-condensed systems

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Abstract

Раскрыты способы ингибирования активности изоформы фосфатидилинозитол-3-киназы дельта (PI3Kδ) и способы лечения заболеваний, таких как нарушения иммунитета или воспаление, в которых PI3Kδ играет роль в функции лейкоцитов. Преимущественно способы используют активные агенты, которые селективно ингибируют PI3Kδ, в то время как незначительно ингибируют активность других изоформ PI3K. Обеспечены соединения, которые ингибируют активность PI3Kδ, включая соединения, которые селективно ингибируют активность PI3Kδ. Обеспечены способы использования соединений, ингибирующих PI3Kδ, для ингибирования роста или пролиферации раковых клеток. Соответственно, изобретение обеспечивает способы применения соединений, ингибирующих PI3Kδ, для ингибирования процессов, опосредованных PI3Kδ, in vitro и in vivo.Отчет о международном поиске был опубликован 2002.03.21.
EA200200990A 2000-04-25 2001-04-24 Ингибиторы фосфатидилинозитол-3-киназы дельта человека EA008241B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19965500P 2000-04-25 2000-04-25
US23805700P 2000-10-05 2000-10-05
PCT/US2001/013315 WO2001081346A2 (en) 2000-04-25 2001-04-24 Inhibitors of human phosphatidyl-inositol 3-kinase delta

Publications (2)

Publication Number Publication Date
EA200200990A1 true EA200200990A1 (ru) 2003-06-26
EA008241B1 EA008241B1 (ru) 2007-04-27

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EA200200990A EA008241B1 (ru) 2000-04-25 2001-04-24 Ингибиторы фосфатидилинозитол-3-киназы дельта человека

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US (2) US6518277B1 (ru)
EP (3) EP1278748B1 (ru)
JP (1) JP4642309B2 (ru)
KR (1) KR100785363B1 (ru)
CN (1) CN1440408B (ru)
AT (1) ATE502941T1 (ru)
AU (2) AU5566701A (ru)
BR (1) BRPI0110371B8 (ru)
CA (1) CA2406278C (ru)
CY (1) CY1117672T1 (ru)
DE (1) DE60144277D1 (ru)
DK (3) DK1939203T3 (ru)
EA (1) EA008241B1 (ru)
ES (3) ES2788383T3 (ru)
GE (1) GEP20084317B (ru)
HR (1) HRP20020838A2 (ru)
HU (1) HU230554B1 (ru)
IL (3) IL152275A0 (ru)
IS (1) IS2822B (ru)
MX (1) MXPA02010618A (ru)
NO (2) NO329136B1 (ru)
NZ (1) NZ522076A (ru)
PT (3) PT3029041T (ru)
RS (1) RS51458B (ru)
SI (2) SI3029041T1 (ru)
WO (1) WO2001081346A2 (ru)

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