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EA200200614A1 - Новые сложные эфиры, производные (rr, ss)-3-(2-диметиламинометил-1-гидроксициклогексил) фенил 2-гидроксибензоата - Google Patents

Новые сложные эфиры, производные (rr, ss)-3-(2-диметиламинометил-1-гидроксициклогексил) фенил 2-гидроксибензоата

Info

Publication number
EA200200614A1
EA200200614A1 EA200200614A EA200200614A EA200200614A1 EA 200200614 A1 EA200200614 A1 EA 200200614A1 EA 200200614 A EA200200614 A EA 200200614A EA 200200614 A EA200200614 A EA 200200614A EA 200200614 A1 EA200200614 A1 EA 200200614A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydroxybenzoate
phenyl
derivatives
hydroxycyclogexyl
dimetylaminomethyl
Prior art date
Application number
EA200200614A
Other languages
English (en)
Other versions
EA004770B1 (ru
Inventor
Хуан Хугуэт Клотет
Марисабель Моурелье Мансини
Элизабет Де Рамон Амат
Original Assignee
Вита-Инвест, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вита-Инвест, С.А. filed Critical Вита-Инвест, С.А.
Publication of EA200200614A1 publication Critical patent/EA200200614A1/ru
Publication of EA004770B1 publication Critical patent/EA004770B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Изобретение относится к новым сложным эфирам, производным (RR,SS)-3-(2-диметиламинометил-1 -гидроксициклогексил)фенил 2-гидроксибензоата, аналогам трамадола, способу получения этих сложных эфиров и применению данных соединений для производства медикаментов с аналгезирующими свойствами. Эти новые продукты общей формулы (I) обладают более высокой аналгезирующей активностью, чем трамадол.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200614A 1999-12-30 2000-12-26 Новые сложные эфиры, производные (rr, ss)-3-(2-диметиламинометил -1-гидроксициклогексил)фенил 2-гидроксибензоата EA004770B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200000060A ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
PCT/ES2000/000486 WO2001049650A1 (es) 1999-12-30 2000-12-26 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil)fenilo

Publications (2)

Publication Number Publication Date
EA200200614A1 true EA200200614A1 (ru) 2002-12-26
EA004770B1 EA004770B1 (ru) 2004-08-26

Family

ID=8491916

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200614A EA004770B1 (ru) 1999-12-30 2000-12-26 Новые сложные эфиры, производные (rr, ss)-3-(2-диметиламинометил -1-гидроксициклогексил)фенил 2-гидроксибензоата

Country Status (30)

Country Link
US (1) US6894076B2 (ru)
EP (1) EP1251120B1 (ru)
JP (1) JP2003519208A (ru)
KR (1) KR20020063281A (ru)
CN (1) CN1414946A (ru)
AP (1) AP1234A (ru)
AT (1) ATE284380T1 (ru)
AU (1) AU775918B2 (ru)
BG (1) BG106883A (ru)
BR (1) BR0016882A (ru)
CA (1) CA2395976A1 (ru)
CZ (1) CZ20022189A3 (ru)
DE (1) DE60016631D1 (ru)
EA (1) EA004770B1 (ru)
EE (1) EE200200365A (ru)
ES (1) ES2160534B1 (ru)
HR (1) HRP20020559A2 (ru)
HU (1) HUP0204147A3 (ru)
IL (1) IL150392A0 (ru)
IS (1) IS6440A (ru)
MA (1) MA26862A1 (ru)
MX (1) MXPA02006514A (ru)
NO (1) NO20023098D0 (ru)
NZ (1) NZ520263A (ru)
OA (1) OA12132A (ru)
PL (1) PL356056A1 (ru)
SK (1) SK9252002A3 (ru)
WO (1) WO2001049650A1 (ru)
YU (1) YU50902A (ru)
ZA (1) ZA200205193B (ru)

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DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
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US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
JP5774853B2 (ja) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 医薬投薬形
NZ588863A (en) 2008-05-09 2012-08-31 Gruenenthal Chemie Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
US8058469B2 (en) * 2008-11-03 2011-11-15 Sabic Innovative Plastics Ip B.V. Method for making carbamates, ureas and isocyanates
PL2456424T3 (pl) 2009-07-22 2013-12-31 Gruenenthal Gmbh Stabilizowana przed utlenianiem odporna na naruszenie postać dawkowania
PL2456427T3 (pl) 2009-07-22 2015-07-31 Gruenenthal Gmbh Wytłaczana na gorąco postać dawki o kontrolowanym uwalnianiu
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
AU2011297901B2 (en) 2010-09-02 2014-07-31 Grunenthal Gmbh Tamper resistant dosage form comprising inorganic salt
KR20130137627A (ko) 2010-09-02 2013-12-17 그뤼넨탈 게엠베하 음이온성 중합체를 포함하는 내변조성 투여형
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
ES2648129T3 (es) 2011-07-29 2017-12-28 Grünenthal GmbH Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
PT2736495T (pt) 2011-07-29 2017-11-30 Gruenenthal Gmbh Comprimido resistente à adulteração proporcionando libertação imediata de fármaco
EP2819656A1 (en) 2012-02-28 2015-01-07 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
AR090695A1 (es) 2012-04-18 2014-12-03 Gruenenthal Gmbh Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
EP3003279A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
MX2015016254A (es) 2013-05-29 2016-04-20 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal.
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
AU2014356581C1 (en) 2013-11-26 2020-05-28 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
MX2016014738A (es) 2014-05-12 2017-03-06 Gruenenthal Gmbh Formulacion en capsula de liberacion inmediata resistente a alteraciones que comprende tapentadol.
JP2018517676A (ja) 2015-04-24 2018-07-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時放出および溶媒抽出に対する耐性を有する改変防止製剤
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
CN107001347B (zh) 2015-10-15 2019-09-24 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用

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DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
DE1518663A1 (de) 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
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US3562589A (en) * 1968-09-09 1971-02-09 Ite Imperial Corp Electrically resetting undervoltage trip for circuit breakers
US5470885A (en) * 1993-09-29 1995-11-28 The Research Foundation Of The State University Of New York Fluorocarbons as anti-inflammatory agents
DE19525137C2 (de) 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
GB9924604D0 (en) * 1999-10-18 1999-12-22 European Molecular Biology Lab Embl Genetic switch

Also Published As

Publication number Publication date
MA26862A1 (fr) 2004-12-20
EP1251120B1 (en) 2004-12-08
NZ520263A (en) 2004-07-30
IL150392A0 (en) 2002-12-01
ES2160534B1 (es) 2002-04-16
HRP20020559A2 (en) 2004-02-29
ES2160534A1 (es) 2001-11-01
US20030100598A1 (en) 2003-05-29
EP1251120A1 (en) 2002-10-23
HUP0204147A2 (hu) 2003-04-28
OA12132A (en) 2006-05-05
MXPA02006514A (es) 2004-07-30
KR20020063281A (ko) 2002-08-01
SK9252002A3 (en) 2003-04-01
CA2395976A1 (en) 2001-07-12
WO2001049650A1 (es) 2001-07-12
ZA200205193B (en) 2003-06-27
EE200200365A (et) 2003-10-15
HUP0204147A3 (en) 2003-10-28
JP2003519208A (ja) 2003-06-17
BR0016882A (pt) 2002-11-05
AP1234A (en) 2003-12-28
YU50902A (sh) 2006-01-16
NO20023098L (no) 2002-06-26
IS6440A (is) 2002-06-25
PL356056A1 (en) 2004-06-14
CZ20022189A3 (cs) 2003-03-12
EA004770B1 (ru) 2004-08-26
NO20023098D0 (no) 2002-06-26
AU2012601A (en) 2001-07-16
CN1414946A (zh) 2003-04-30
AP2002002571A0 (en) 2002-09-30
DE60016631D1 (de) 2005-01-13
BG106883A (en) 2003-05-30
US6894076B2 (en) 2005-05-17
ATE284380T1 (de) 2004-12-15
AU775918B2 (en) 2004-08-19

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Legal Events

Date Code Title Description
PD1A Registration of transfer to a eurasian application by order of succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU